Search clinical trials for: ET-1 Inhibition Placebo

Total 3567 results

Anwaar Saeed
AstraZeneca; Exelixis

Active, not recruiting

Cabozantinib Plus Durvalumab With or Without Tremelimumab in Patients With Gastroesophageal Cancer and Other Gastrointestinal Malignancies (CAMILLA)

Hepatocellular Carcinoma | Gastric Cancer | Colorectal Cancer | Esophageal Adenocarcinoma

United States
Edward Kim
Bristol-Myers Squibb; National Cancer Institute (NCI)

Terminated

BMS-986205 and Nivolumab as First or Second Line Therapy in Treating Patients With Liver Cancer

Unresectable Hepatocellular Carcinoma | Stage III Hepatocellular Carcinoma AJCC v8 | Stage IIIA Hepatocellular Carcinoma AJCC v8 | Stage IV Hepatocellular Carcinoma AJCC v8 | Stage IVA Hepatocellular Carcinoma AJCC v8 | Stage IVB Hepatocellular Carcinoma AJCC v8 | Stage IIIB Hepatocellular Carcinoma... and other conditions

United States
Nationwide Children's Hospital
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Recruiting

Targeted Reversal of Inflammation in Pediatric Sepsis-induced MODS (TRIPS)

Pediatric Sepsis-induced Multiple Organ Dysfunction Syndrome (MODS)

United States
State-Financed Health Facility "Samara Regional...
Clinics of the Federal State Budgetary Educational Institution SSMU; Samara...

Completed

Evaluation of Safety and Efficiency of Method of Exosome Inhalation in SARS-CoV-2 Associated Pneumonia. (COVID-19EXO)

COVID-19 | Covid19 | SARS-CoV-2 PNEUMONIA

Russian Federation
S&D Pharma SK s.r.o.

Unknown

Prevention of Febrile Neutropenia by Synbiotics in Pediatric Cancer Patients (FENSY)

Cancer | Neutropenia | Febrile Neutropenia | Infection in an Immunocompromised Host

Slovakia
Betta Pharmaceuticals Co., Ltd.
Quintiles, Inc.

Completed

Icotinib Hydrochloride Cream in Healthy Adults and Psoriasis Patients

Psoriasis

New Zealand
GlaxoSmithKline
PATH

Completed

A Study to Investigate the Safety and Pharmacodynamics of Repeat Intranasal Administration of the TLR7 Agonist GSK2245035 in Subjects With Respiratory Allergies

Asthma and Rhinitis

Canada
Cortria Corporation

Completed

The Safety of a Hypolipidemic Agent in Healthy Normal Volunteers (Cortria-002)

Healthy
Rigshospitalet, Denmark
Novo Nordisk A/S; University of Copenhagen

Completed

Mechanisms of Insulin Resistance in Critical Illness: Role of Systemic Inflammation and GLP-1

Hypoglycaemia

Denmark
Amgen

Completed

Juvenile Rheumatoid Arthritis

Juvenile Chronic Arthritis
Wuhan Union Hospital, China
Peking University First Hospital

Recruiting

High Risk Population of Cardiovascular Disease in Hubei Province Screening and Intervention Program

Cardiovascular Diseases | Coronary Disease | Diabetes Mellitus, Type 2

China
University of Michigan Rogel Cancer Center
CSL Behring; The Leukemia and Lymphoma Society

Completed

A Pilot Study of Alpha-1-Antitrypsin (AAT) in Steroid Refractory Acute Graft vs Host Disease

Graft vs Host Disease

United States
Fondazione Poliambulanza Istituto Ospedaliero

Completed

Prevention of Hypoglycaemia by Oral 40% Destrogel

Hypoglycaemia Neonatal

Italy
University of Maryland, Baltimore

Active, not recruiting

GLP-1 and Hypoglycemia

Type 2 Diabetes Mellitus

United States
GlaxoSmithKline
PPD

Withdrawn

Albiglutide Versus Placebo Added-on to Basal-Bolus Insulin Therapy in Subjects With Type 2 Diabetes Mellitus

Diabetes Mellitus, Type 2
GlaxoSmithKline

Active, not recruiting

A Study on the Reactogenicity, Safety, Immune Response, and Efficacy of a Targeted Immunotherapy Against HSV in Healthy Participants Aged 18-40 Years or in Participants Aged 18-60 Years With Recurrent Genital Herpes

Herpes Simplex

Germany, United States, Belgium, Canada, Spain, United Kingdom, Estonia, Australia
Pfizer

Completed

Clinical Lot Consistency for RSVpreF in a Population of Healthy Adults 18 to ≤49 Years of Age

RSV

United States
Virginia Commonwealth University

Terminated

Treatment of Acute Pericarditis With Anakinra

Acute Pericarditis

United States
Trevena Inc.

Completed

A Study to Explore the Efficacy of TRV027 in Patients Hospitalized for Acute Decompensated Heart Failure (BLAST-AHF)

Acute Decompensated Heart Failure

United States, Bulgaria, Poland, Russian Federation, Germany, Romania, Argentina, Canada, Czechia, Hungary, Israel, Slovakia
GlaxoSmithKline

Completed

Safety and Efficacy Study in Patients With Major Depressive Disorder

Depressive Disorder

Russian Federation
GlaxoSmithKline

Completed

The Safety, Tolerability, PK and PD of GSK2586881 in Patients With Acute Lung Injury

Lung Injury, Acute

United States, Canada
Massimo Imazio

Completed

AnakInRa for Treatment of Recurrent Idiopathic Pericarditis (AIRTRIP) (AIR TRIP)

Idiopathic Recurrent Pericarditis

Italy
Michelle Hernandez, MD
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

Effect of Interleukin-1 Receptor Antagonist on Inhalation of 20,000 EU Clinical Ctr Reference Endotoxin in Normal Volunteers (Kintox)

Healthy Control Subjects

United States
Pfizer

Terminated

Analgesic Efficacy and Safety Study of T-62 in Subjects With Postherpetic Neuralgia

Postherpetic Neuralgia

United States
United Therapeutics

Withdrawn

Safety and Efficacy of Inhaled Treprostinil in Patients With PAH (INTREPID)

Pulmonary Arterial Hypertension
Aronora, Inc.
Celerion

Completed

Safety and Efficacy Study of AB002 (E-WE Thrombin) in End Stage Renal Disease Patients on Chronic Hemodialysis

Thrombosis | End Stage Renal Disease

United States
University Hospital, Basel, Switzerland

Recruiting

Hyperinsulinemia in Prediabetes Mediated by Interleukin-1β (Hyper-PreDIL)

PreDiabetes | Hyperinsulinemia

Switzerland
Oxford University Clinical Research Unit, Vietnam
Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam

Recruiting

Anakinra in Dengue With Hyperinflammation ( AnaDen )

Cytokine Storm | Dengue | Severe Dengue | Macrophage Activation Syndrome | Anakinra | Dengue With Warning Signs | Anti-inflammatory Agents | Hyperinflammatory Syndrome | Immuno-modulation

Vietnam
Virginia Commonwealth University

Recruiting

Interleukin-1 Blockade In Recently Decompensated Heart Failure - 2 (REDHART2)

Inflammation | Heart Failure, Systolic

United States
Corvus Pharmaceuticals, Inc.

Terminated

CPI-006 Plus Standard of Care Versus Placebo Plus Standard of Care in Mild to Moderately Symptomatic Hospitalized Covid-19 Patients

Covid-19

United States, Colombia, Spain, Canada, Peru, Brazil, Italy, Argentina, Chile, Germany, Mexico, Ukraine
Olga Tyumina
Clinics of the Federal State Budgetary Educational Institution SSMU; Samara...

Unknown

Safety and Efficiency of Method of Exosome Inhalation in COVID-19 Associated Pneumonia (COVID-19EXO2)

COVID-19 | Covid19 | SARS-CoV-2 PNEUMONIA

Russian Federation
MedImmune LLC

Completed

A Study to Assess the Safety of MEDI7836 in Healthy Adults.

Healthy Adults

United Kingdom
Team Foods Colombia S.A.
Biopolis S.L.

Unknown

Study to Evaluate the Effect of a Vegetal Oil on Cognitive Impairment

Alzheimer Disease | Cognitive Impairments

Spain
KGK Science Inc.
Lonza Inc.

Completed

A Pilot Clinical Trial on the Efficacy of Two Carnitine-Based Products on Muscle Function in Healthy Older Adults (15CAHL)

Muscle Function

Canada
Boehringer Ingelheim

Completed

Safety, Tolerability and Pharmacodynamics of BIIX 1 XX in Healthy Young Male Volunteers

Healthy
Regeneron Pharmaceuticals

Completed

Study to Evaluate the Safety and Tolerability of Two Doses of Rilonacept in Pediatric Subjects With Active Systemic Juvenile Idiopathic Arthritis (SJIA)

Systemic Juvenile Idiopathic Arthritis

United States
Virginia Commonwealth University
American Heart Association

Completed

Pilot Feasibility Study of the Safety and Efficacy of Anakinra in Heart Failure With Preserved Ejection Fraction

Heart Failure

United States
Laura Cavallone

Completed

Fenobam on Heat/Capsaicin Induced Hyperalgesia in Healthy Volunteers

Hyperalgesia | Allodynia

United States
The Second Affiliated Hospital of Shandong First...

Recruiting

Clinical Study of Sintilimab Combined With Chemotherapy in Neoadjuvant Treatment of Non-small Cell Lung Cancer

Non-small Cell Lung Cancer

China
Fujian Cancer Hospital

Withdrawn

Study of FMT Combined With Nivolumab in Gastric Cancer

Gastric Adenocarcinoma | Esophagus Adenocarcinoma | Esophagogastric Junction Adenocarcinoma

China
Wellesley Pharmaceuticals, LLC

Completed

Paxerol™ for Treatment of Nocturia - A Phase II Placebo-Controlled Trial

Nocturia

United States
Montreal Heart Institute
Novartis Pharmaceuticals

Terminated

ARNI Versus plAcebo in Patients With Congenital sYStemic Right Ventricle Heart Failure (PARACYS-RV)

Heart Failure | Systemic Right Ventricle

Canada
Hoffmann-La Roche

Completed

A Study of P38 Inhibitor (4) Monotherapy in Patients With Active Rheumatoid Arthritis

Rheumatoid Arthritis

Czech Republic, France, Italy, Spain, Canada, United States, Mexico, South Africa, Taiwan, Croatia, Serbia, Romania
Hunan Cancer Hospital
Jiangsu HengRui Medicine Co., Ltd.

Unknown

Clinical Study of PD-1 Monoclonal Antibody SHR-1210 and Apatinib in Advanced NSCLC, Soft Tissue Sarcoma, and Uterine Cancer

Soft Tissue Sarcoma | Uterine Cancer | Advanced Non Small Cell Lung Cancer

China
National Cancer Institute (NCI)

Terminated

Gamma-secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced, Metastatic, or Recurrent Triple Negative Invasive Breast Cancer

Male Breast Cancer | Stage IV Breast Cancer | Stage IIIA Breast Cancer | Stage IIIB Breast Cancer | Triple-negative Breast Cancer | Stage IIIC Breast Cancer | Recurrent Breast Cancer | Estrogen Receptor-negative Breast Cancer | Progesterone Receptor-negative Breast Cancer | HER2-negative Breast Cancer

Canada
Sun Yat-sen University

Recruiting

PD-1 Antibody and Lenvatinib Plus TACE-HAIC for Potential Resectable HCC: a Single-arm, Phase 2 Clinical Trial (PLATIC)

Hepatocellular Carcinoma

China
Tianjin Medical University Cancer Institute and...

Unknown

Study of PD-1 Inhibitor Combination With Autologous Cell Immunotherapy in the Metastatic Renal Cell Carcinoma

Renal Cell Carcinoma | Clear Cell Renal Cell Carcinoma

China
Jason J. Luke, MD

Recruiting

Evaluating Length of Treatment With PD-1/PD-L1 Inhibitor in Advanced Solid Tumors

Melanoma | Cervical Cancer | Hepatocellular Carcinoma | Gastric Cancer | Colorectal Cancer | NSCLC | Advanced Solid Tumors | Cholangiocarcinoma | Bladder Cancer | Renal Cancer | Anal Cancer | Merkel Cell Carcinoma | HNSCC

United States
Hunan Cancer Hospital

Completed

Fruquintinib Plus PD-1 in Refractory MSS Metastatic Colorectal Cancer

Colorectal Cancer

China
Kamada, Ltd.

Completed

Phase II Study of the Safety and Efficacy of Inhaled Alpha-1 Antitrypsin (AAT ) in Cystic Fibrosis Patients

Cystic Fibrosis

Israel

Search clinical trials for: ET-1 Inhibition Placebo

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