Search clinical trials for: Epithelial Sodium Channel Blockers

Total 7762 results

Overseas Pharmaceuticals, Ltd.
Beijing Capton Pharmaceutical Technology Development Co., LTD

Not yet recruiting

An Open Label, Balanced, Randomized, Two-Treatment, Two-Period, Two-Sequence, Two-way Crossover, Oralcomparative Pharmacokinetic（PK）Study of Lacosamide Extended-Release Tablets , Adult, Human Subjects Under Fasting Conditions.

Epilepsy

China
Ottawa Hospital Research Institute

Recruiting

RAFF4 Trial: Vernakalant vs. Procainamide for Acute Atrial Fibrillation in the Emergency Department

Atrial Fibrillation

Canada
Assistance Publique - Hôpitaux de Paris
Fonds de Dotation ACTION

Active, not recruiting

Assessment of Flecainide to Lower the Patent Foramen Ovale Closure Risk of Atrial Arrhythmia or Tachycardia (AFLOAT)

Patent Foramen Ovale | Cryptogenic Stroke | Atrial Arrhythmia

France
David Filgueiras-Rama
Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III

Completed

Predictive Factors to Effectively Terminate Paroxysmal Atrial Fibrillation by Blocking Atrial Selective Ionic Currents (SELECTCARFAP)

Paroxysmal Atrial Fibrillation

Spain
Daiichi Sankyo, Inc.

Completed

Relative Bioavailability DS-1971a Suspension and Tablets and Food Effect on DS-1971a Tablets

Healthy

United Kingdom
Sunovion

Completed

Eslicarbazepine Acetate Monotherapy Long Term Study

Epilepsy

United States, Canada, Bulgaria, Ukraine, Czechia, Serbia
Bial - Portela C S.A.

Completed

Pharmacokinetics, Efficacy and Tolerability of BIA 2-093

Epilepsy

Romania
Bjorn Oskarsson, MD
University of California, Davis; ALS Association

Completed

Mexiletine for the Treatment of Muscle Cramps in ALS

Muscle Cramps in Amyotrophic Lateral Sclerosis

United States
Bial - Portela C S.A.

Completed

An Open-label, Multiple-dose, Single-centre Study, Investigating the Pharmacokinetics of BIA 2-093

Epilepsy

South Africa
UCB Pharma

Completed

A Trial to Investigate Safety and Efficacy of SPM927 in Painful Diabetic Neuropathy

Painful Diabetic Neuropathy
Instituto de Investigacion Sanitaria La Fe

Completed

Observational Retrospective Study of Effectivity and Tolerability in Patients With Lacosamide Medication

Epilepsy

Spain
Duke University

Terminated

Seizure Prophylaxis in Patients With Glioma or Brain Metastasis

Glioma | Brain Tumor | Glioma of Brain

United States
Bial - Portela C S.A.

Completed

Eslicarbazepine Acetate (BIA 2 093) as Therapy for Refractory Partial Seizures in Children

Partial Epilepsy in Children and Adolescents

United Kingdom, Spain, Serbia, Italy, Austria, Bosnia and Herzegovina, Croatia, Czechia, France, Germany, Hungary, Malaysia, Moldova, Republic of, Philippines, Poland, Portugal, Romania, Russian Federation, Slovakia, Taiwan, Ukr...
Bial - Portela C S.A.

Completed

Effects of Eslicarbazepine Acetate (Esl, Bia 2-093) on Cognitive Function in Children With Partial Onset Seizures

Partial Epilepsy

Netherlands, Poland, Italy, Russian Federation, Ukraine
UCB Pharma

Completed

Three-way-cross-over Study to Evaluate Safety and Pharmacokinetics of Lacosamide in Healthy Japanese and Chinese Males

Healthy Volunteers

Germany
Lupin Ltd.

Withdrawn

Study to Investigate the Efficacy and Safety of Mexiletine in Patients With Myotonic Dystrophy Type 1 and Type 2 (MIND)

Myotonic Dystrophy Type 1 and Type 2
UCB Biopharma S.P.R.L.

Completed

A Study to Investigate the Bioequivalence of Lacosamide Tablet (200mg) and Syrup (10mg/ml) in Healthy Chinese Male Subjects

Healthy Male Volunteers

China
UCB Biopharma S.P.R.L.

Completed

A Study to Demonstrate the Bioequivalence of Lacosamide Tablets and Dry Syrup in Healthy Male Japanese Subjects

Healthy Volunteers

United Kingdom
Indiana University School of Medicine
VA Office of Research and Development

Withdrawn

Effects of Lacosamide on Post-operative Opioid Requirements After a Total Hip Arthroplasty:

Osteoarthritis | Rheumatoid Arthritis | Avascular Necrosis

United States
St George's, University of London

Unknown

The Response To Ajmaline Provocation in Healthy Subjects

Sudden Death | Brugada Syndrome

United Kingdom
Eisai Inc.

Completed

Study of Rufinamide in Pediatric Subjects 1 to Less Than 4 Years of Age With Lennox-Gastaut Syndrome Inadequately Controlled With Other Anti-epileptic Drugs

Lennox-Gastaut Syndrome

France, Poland, United States, South Africa, Italy, Canada, Greece
Bial - Portela C S.A.

Completed

The Tolerability and Effect of Food on the Pharmacokinetics of a Single 800 mg Oral Dose of BIA 2-093

Epilepsy
Bial - Portela C S.A.

Completed

Single-dose Pharmacokinetics and Relative Bioavailability of an Oral Suspension and Two Tablet Formulations of BIA 2-093

Epilepsy

Portugal
Xiangya Hospital of Central South University

Recruiting

Improvement Effect of Lacosamide and Levetiracetam on Cognitive in Alzheimer's Disease Patients With Epilepsy

Epilepsy | Alzheimer Disease 3

China
IRCCS Policlinico S. Donato

Completed

Right Ventricle Morphology and Hemodynamics in BrS (RV-BrS)

Brugada Syndrome

Italy
Pharmtechnology LLC
Altasciences Company, Inc.

Completed

Bioequivalence Study of Two Formulations of Propafenone 300 mg Film-coated Tablets in Healthy Adult Volunteers After a Single Oral Dose Administration Under Fasting Conditions

Bioequivalence

Canada
Sunovion

Withdrawn

A Pediatric Drug Study to Determine the Long-term Safety and Tolerability in Children and Adolescents (4-17 Years in Age) Taking the Drug

Epilepsy

United States
University of Zurich

Withdrawn

Effect of Rufinamide on Chronic Postthoracotomy Pain Syndrome (RUFPTPS)

Pain | Peripheral Nerve Injuries

Switzerland
Bial - Portela C S.A.

Completed

Food Effect and Dosage Form Proportionality Study of Eslicarbazepine Acetate

Epilepsy
Valduce Hospital

Completed

Efficacy and Safety of Electrical Versus Pharmacological Cardioversion in Early Atrial Fibrillation

Atrial Fibrillation

Italy
TSH Biopharm Corporation Limited

Completed

Propafenone in the Treatment of Atrial Fibrillation

Atrial Fibrillation

Taiwan
UCB Pharma SA
UCB Japan Co. Ltd.

Completed

A Trial to Evaluate the Efficacy and Safety of Adjunctive Therapy With Lacosamide in Adults With Partial-Onset Seizures

Epilepsy | Partial Onset Seizures

China, Japan
UCB Japan Co. Ltd.
Parexel

Completed

Open-label Study to Evaluate the Safety and Tolerability of iv Lacosamide in Japanese Adults With Partial-onset Seizures

Epilepsy | Partial-onset Seizures

Japan
Bial - Portela C S.A.

Completed

Disposition of Eslicarbazepine Acetate and Its Metabolites S-licarbazepine and R-licarbazepine

Epilepsy

Germany
Wojciech Zareba

Completed

Pilot Randomized Trial With Flecainide in ARVC Patients

Arrhythmogenic Right Ventricular Cardiomyopathy

United States
Vanderbilt University
National Heart, Lung, and Blood Institute (NHLBI)

Terminated

New Formulations of Propafenone to Treat Atrial Fibrillation

Atrial Fibrillation

United States
UCB Pharma SA
UCB Japan Co. Ltd.

Completed

Study to Evaluate the Safety, Tolerability, and Efficacy of Long-term Adjunctive Therapy With Lacosamide in Adults With Partial-onset Seizures

Epilepsy | Partial-onset Seizures

China, Japan
Brigham and Women's Hospital

Completed

Add on Lacosamide Versus High Dose Monotherapy

Epilepsy

United States
University of Alabama at Birmingham
UCB Pharma

Terminated

A Pilot Study of NSICU Assessment of Seizure Prophylaxis With Lacosamide

Traumatic Brain Injury

United States
Jason Andrade
Medtronic; Ottawa Heart Institute Research Corporation; Baylis Medical Company

Active, not recruiting

Early Aggressive Invasive Intervention for Atrial Fibrillation (EARLY-AF)

Atrial Fibrillation

Canada
Novartis

Completed

The Efficacy and Safety of Oral Oxcarbazepine 300-1200 mg/Day as Adjuvant Therapy in the Treatment of Bipolar Disorder I or II This Study is Not Being Conducted in the United States.

Bipolar Disorder
Bial - Portela C S.A.

Completed

A Single Centre, Phase I, Double-blind, Randomised, Placebo-controlled Study to Investigate the Safety, Tolerability, Pharmacokinetic Profile and Effects on EEG of Single Rising Oral Doses of BIA 2-093

Epilepsy

United Kingdom
Bial - Portela C S.A.

Completed

Efficacy and Safety of Eslicarbazepine Acetate as Preventive Therapy for Subjects With Migraine

Migraine
UCB BIOSCIENCES, Inc.

Completed

Study to Assess the Long-term Safety of Oral Lacosamide in Subjects With Partial-onset Seizures

Partial Epilepsies | Partial Onset Seizures

United States
University of Rochester

Completed

Clinical Efficacy Trial of Mexiletine for Myotonic Dystrophy Type 1

Myotonic Dystrophy

United States
Bial - Portela C S.A.

Completed

Comparative Bioavailability Study of Two Different Sources of Eslicarbazepine Acetate

Epilepsy
Bial - Portela C S.A.

Completed

Efficacy and Safety of Eslicarbazepine Acetate (BIA 2-093) in Acute Manic Episodes Associated With Bipolar I Disorder

Bipolar I Disorder
Atrial Fibrillation Network
German Research Foundation; German Federal Ministry of Education and Research; Meda Pharmaceuticals

Completed

Flecainide-Short Long Study (Flec-SL)

Atrial Fibrillation
Vanderbilt University Medical Center

Completed

Flecainide for Catecholaminergic Polymorphic Ventricular Tachycardia

Catecholaminergic Polymorphic Ventricular Tachycardia

United States
UCB BIOSCIENCES, Inc.

Completed

Safety and Efficacy of Lacosamide as Additional Therapy in Patients Suffering From Epileptic Tonic-Clonic Seizures (VALUE)

Epilepsy

United States, Australia, Brazil, Bulgaria, China, Czechia, France, Germany, Hungary, Israel, Italy, Japan, Korea, Republic of, Mexico, Poland, Portugal, Romania, Russian Federation, Slovakia, Spain, Taiwan

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