Search clinical trials for: Estradiol , estriol , progesterone

Total 1476 results

Lexicon Pharmaceuticals
Sanofi

Completed

Dose-ranging Study in Patients With Type 1 Diabetes Mellitus (inTandem4)

Type 1 Diabetes Mellitus

United States
Lexicon Pharmaceuticals
Sanofi

Completed

A Phase 3 Study to Evaluate the Safety of Sotagliflozin in Patients With Type 1 Diabetes Who Have Inadequate Glycemic Control With Insulin Therapy Alone (inTandem3)

Type 1 Diabetes Mellitus (T1DM) | High Level of Sugar (Glucose) in the Blood

United States, Australia, Spain, Belgium, Argentina, Bulgaria, Canada, Colombia, Czechia, France, Germany, Hungary, Israel, Italy, New Zealand, Poland, Slovakia, South Africa, United Kingdom
Lexicon Pharmaceuticals

Completed

Study to Determine the Absorption, Metabolism, and Excretion of [14C]LX4211 in Healthy Male Subjects (AME)

Healthy

United States
Lexicon Pharmaceuticals
Sanofi

Completed

Safety and Efficacy of Sotagliflozin (LX4211) in Patients With Inadequately Controlled Type 1 Diabetes Mellitus

Type 1 Diabetes Mellitus

United States
Lexicon Pharmaceuticals

Completed

PK Study of Sotagliflozin in Subjects With Hepatic Impairment

Healthy | Hepatic Impairment

United States
Royan Institute

Completed

The Effect of Ethinyl Estradiol on Polycystic Ovary Syndrome Women Undergoing Intrauterine Insemination

Infertility

Iran, Islamic Republic of
Sanofi

Completed

Sotagliflozin Bioequivalence Study

Type 2 Diabetes Mellitus

United States
Lexicon Pharmaceuticals

Completed

Study to Evaluate Sotagliflozin in Subjects With Varying Degrees of Renal Function

Healthy | Renal Impairment

United States
Sanofi

Terminated

Efficacy and Safety of Sotagliflozin Versus Placebo in Chinese Patients With Type 2 Diabetes Mellitus Not Adequately Controlled by Diet and Exercise

Type 2 Diabetes Mellitus

China
Lexicon Pharmaceuticals
Sanofi

Terminated

Efficacy and Bone Safety of Sotagliflozin 400 and 200 mg Versus Placebo in Participants With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control (SOTA-BONE)

Type 2 Diabetes Mellitus

United States, Australia, Canada, Korea, Republic of, Mexico, New Zealand, Russian Federation, Taiwan
Lexicon Pharmaceuticals
Sanofi

Completed

Efficacy and Safety of Sotagliflozin Versus Placebo and Empagliflozin in Participants With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control While Taking a DPP4 Inhibitor Alone or With Metformin (SOTA-EMPA)

Type 2 Diabetes Mellitus

United States, Bulgaria, Canada, Czechia, France, Italy, Latvia, Mexico, Russian Federation, Slovakia, Spain, United Kingdom
Lexicon Pharmaceuticals
Sanofi

Completed

Efficacy, Safety, and Tolerability Study of Sotagliflozin as Adjunct Therapy in Adult Patients With Type 1 Diabetes Mellitus Who Have Inadequate Glycemic Control With Insulin Therapy (inTandem1)

Type 1 Diabetes Mellitus

United States, Canada
University of Pennsylvania
National Heart, Lung, and Blood Institute (NHLBI)

Not yet recruiting

Sodium Glucose Co-transporter (SGLT) Inhibitors in Nonobstructive Hypertrophic Cardiomyopathy (SOTA-CROSS HCM)

Hypertrophic Cardiomyopathy Without Obstruction
Steno Diabetes Center Copenhagen
King's College London; Juvenile Diabetes Research Foundation; Glostrup University...

Not yet recruiting

Prevention of Chronic Kidney Disease(CDK) Progression in Type 1 Diabetes With Long Term Use of Sodium-Glucose-coTransporter Inhibitors Avoiding Kidney hypOxia (PLUTO)

Hypoxia | Diabetes Mellitus, Type 1 | Diabetic Nephropathies | Albuminuria | Nephropathy | Diabetic Complications Renal | Diabetic Complications Cardiovascular

Denmark
Juan Badimon

Recruiting

Sotagliflozin in Heart Failure With Preserved Ejection Fraction (HFpEF) Patients

Heart Failure With Preserved Ejection Fraction

United States
Sanofi

Completed

A Study to Evaluate the Effect of Food on the Pharmacokinetics of Sotagliflozin and to Explore the Relative Bioavailability in Healthy Subjects

Diabetes Mellitus

United Kingdom
Lexicon Pharmaceuticals
Sanofi

Completed

A Study to Evaluate Safety and Effects of Sotagliflozin 400 and 200 mg on Glucose Control in Participants With Type 2 Diabetes, Severe Impairment of Kidney Function and Inadequate Blood Sugar Control (SOTA-CKD4)

Type 2 Diabetes Mellitus | Chronic Kidney Disease Stage 4

United States, Argentina, Brazil, Colombia, Germany, Hungary, Israel, Italy, Mexico, Poland, Romania, Russian Federation, South Africa, Spain, Ukraine
Lexicon Pharmaceuticals
Sanofi

Completed

Efficacy and Safety of Sotagliflozin Versus Placebo in Patients With Type 2 Diabetes Mellitus on Background of Metformin

Type 2 Diabetes Mellitus

United States, Canada, Hungary, Slovakia
Sanofi

Completed

Sotagliflozin Multiple-dose Study in Healthy Chinese Subjects

Diabetes Mellitus

China
Lexicon Pharmaceuticals
Sanofi

Completed

Efficacy and Safety of Sotagliflozin Versus Placebo in Patients With Type 2 Diabetes Mellitus Not Currently Treated With Antidiabetic Therapy

Type 2 Diabetes Mellitus

United States, Canada, Mexico
Lexicon Pharmaceuticals
Sanofi

Terminated

Safety, Tolerability and Pharmacodynamic Activity of Sotagliflozin in Hemodynamically Stable Participants With Worsening Heart Failure

Cardiac Failure Aggravated

United States, Canada, Netherlands
Kowa Research Institute, Inc.

Completed

Pharmacokinetic Drug-Drug Interaction Study Between K-877 and CSG452 in Healthy Adult Volunteers

Healthy

United States
Lexicon Pharmaceuticals

Completed

Study to Evaluate the Pharmacodynamic and Pharmacokinetic Effects of LX4211 in Subjects With Type 2 Diabetes and Renal Impairment

Type 2 Diabetes Mellitus | Renal Impairment

United States
Lexicon Pharmaceuticals
Sanofi

Completed

Efficacy and Safety of Sotagliflozin Versus Placebo in Participants With Type 2 Diabetes Mellitus on Background of Sulfonylurea Alone or With Metformin

Type 2 Diabetes Mellitus

United States, Bulgaria, Estonia, Hungary, Korea, Republic of, Poland, Romania, Slovakia, Ukraine, United Kingdom
Massachusetts Eye and Ear Infirmary

Recruiting

Dropless Pars Plana Vitrectomy Study (DVS)

Rhegmatogenous Retinal Detachment

United States
Shinshu University
Kowa Company, Ltd.

Recruiting

Effect of Tofogliflozin on UACR Compared to Metformin Hydrochloride in Diabetic Kidney Disease (TRUTH-DKD) (TRUTH-DKD)

T2DM (Type 2 Diabetes Mellitus) | Metformin | SGLT2-Inhibitors

Japan
Lexicon Pharmaceuticals

Completed

Study of LX4211 in Subjects With Type 2 Diabetes Mellitus

Type 2 Diabetes Mellitus

United States
Lexicon Pharmaceuticals

Recruiting

A Study to Evaluate the Efficacy and Safety of Sotagliflozin in Symptomatic Obstructive and Non-obstructive Hypertrophic Cardiomyopathy (SONATA-HCM)

Non-obstructive Hypertrophic Cardiomyopathy | Obstructive Cardiomyopathy, Hypertrophic

United States
University Medical Center Groningen
Juvenile Diabetes Research Foundation; Lexicon Pharmaceuticals

Not yet recruiting

Ambrisentan Sotagliflozin and Prevention of Renal Injury; a Randomized Evaluation (ASPIRE)

Type 1 Diabetes Mellitus With Diabetic Nephropathy

Netherlands, United States, Canada, Denmark, Finland
University of California, San Diego
Juvenile Diabetes Research Foundation

Not yet recruiting

Combination Adjunctive Therapy to Address Multiple Metabolic Imbalances in Type 1 Diabetes (SOTA)

Type 1 Diabetes
Lexicon Pharmaceuticals
Sanofi; Juvenile Diabetes Research Foundation

Completed

Efficacy and Safety of Sotagliflozin in Young Adult Patients With Type 1 Diabetes Mellitus and Elevated Hemoglobin A1C

Type 1 Diabetes Mellitus

United States
Lexicon Pharmaceuticals

Completed

A Study to Evaluate the Interaction of LX4211 and Metformin in Healthy Subjects

Type 2 Diabetes Mellitus

United States
Brigham and Women's Hospital
University of Utah

Withdrawn

Genetic Mechanisms in Human Hypertension Renin-angiotensin-aldosterone System (RAAS) Inhibition Study

Hypertension

United States
Sanofi

Terminated

Efficacy and Safety of Sotagliflozin Versus Placebo in Chinese Patients With Type 2 Diabetes Mellitus Not Adequately Controlled by Metformin With or Without Sulfonylurea

Type 2 Diabetes Mellitus

China
Lexicon Pharmaceuticals

Completed

Study to Determine the Safety, Tolerability and Pharmacokinetics Following Multiple Doses of LX4211 in Healthy Subjects

Healthy

United States
Scripps Translational Science Institute

Completed

Hypertensive Ambulatory Trial to Compare the Efficacy of HCTZ and Lisinopril (1HAT)

Hypertension | Hypertension, Grade 1 | Hypertension Treatment | N of 1 Study Design

United States
Sanofi

Completed

Comparison of Pharmacodynamic Effects of Sotagliflozin and Empagliflozin in T2DM Patients With Mild to Moderate Hypertension

Diabetes Mellitus

Germany
Lexicon Pharmaceuticals

Completed

Study to Evaluate the Effect of Single Doses of LX4211 and Canagliflozin on Intestinal Glucose Absorption in Healthy Adult Subjects

Healthy Subjects

United States
Kowa Research Institute, Inc.

Recruiting

Study to Evaluate the Efficacy and Safety of K-877-ER and CSG452 in Participants With NASH With Liver Fibrosis

NASH

United States, Canada, Spain, Japan, Bulgaria
Lexicon Pharmaceuticals

Completed

Safety and Efficacy of LX4211 With Metformin in Type 2 Diabetes Patients With Inadequate Glycemic Control on Metformin

Type 2 Diabetes Mellitus

United States
Kowa Research Institute, Inc.

Completed

Study to Demonstrate the Bioequivalence of Single Oral Administration of K-001 Relative to Single Oral Coadministration of Separate Tablets of K-877-ER and CSG452

Healthy

United States
Kowa Company, Ltd.
Sanofi

Completed

Tofogliflozin GLP-1 Analogue Combination Trial

Type 2 Diabetes Mellitus

Japan
Sanofi
Kowa Company, Ltd.

Completed

TOFO Insulin Combination Trial

Type 2 Diabetes Mellitus

Japan
Sanofi

Completed

Study To Determine Bioavailability of Sotagliflozin in Healthy Male and Female Subjects

Type 2 Diabetes Mellitus | Healthy Subjects

United Kingdom
Wake Forest University Health Sciences

Terminated

Benazepril Hydrochloride, Lisinopril, Ramipril, or Losartan Potassium in Treating Hypertension in Patients With Solid Tumors

Hypertension | Unspecified Adult Solid Tumor, Protocol Specific

United States
University of Milano Bicocca
Azienda Ospedaliera Universitaria Integrata Verona; Azienda Socio Sanitaria... and other collaborators

Recruiting

Dual Anti-glutamate Therapy in Super-refractory Status Epilepticus After Cardiac Arrest (SUPER-CAT)

Cardiac Arrest | Status Epilepticus

Italy
Sanofi

Completed

A Drug to Drug Interaction Study of Sotagliflozin With Hydrochlorothiazide

Type 2 Diabetes Mellitus

United States
Kanazawa University
Kowa Company, Ltd.

Completed

SGLT2 Inhibitor Versus Sulfonylurea on Type 2 Diabetes With NAFLD

Non-alcoholic Fatty Liver Disease

Japan
Lexicon Pharmaceuticals
Sanofi

Completed

Efficacy and Safety of Sotagliflozin Versus Placebo in Participants With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control While Taking Insulin Alone or With Other Oral Antidiabetic Agents (SOTA-INS)

Type 2 Diabetes Mellitus

United States, Bulgaria, Canada, Czechia, France, Hungary, Slovakia, United Kingdom
Lexicon Pharmaceuticals

Completed

Study of Two Oral Formulations of LX4211 in Patients With Type 2 Diabetes Mellitus

Type 2 Diabetes Mellitus

United States

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