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Search clinical trials for: Folic Acid Antagonists

Total 2399 results

NCT00000395

Completed

Antifolate Effectiveness in Arthritis

Conditions: Rheumatoid Arthritis; Adjuvant Arthritis
NCT00137657

Completed

Impact of Cotrimoxazole Prophylaxis for HIV-Infected Adults on Antifolate Resistance

Conditions: HIV; Malaria; Diarrhea; Pneumonia; Opportunistic Infections
NCT01746199

Completed

Efficacy of Antifolates Against Malaria in HIV-infected Pregnant Women and the Emergence of Induced Resistance in Plasmodium Falciparum

Conditions: Malaria in Pregnancy; HIV Infection
NCT03431974

Active, not recruiting

Once-Weekly Oral Aminopterin for the Treatment of Subjects With Moderate-To-Severe Psoriasis

Conditions: Psoriasis
NCT03748186

Recruiting

Study of STRO-002, an Anti-Folate Receptor Alpha (FolRα) Antibody Drug Conjugate in Ovarian & Endometrial Cancers

Conditions: Ovarian Cancer; Ovarian Carcinoma; Ovary Cancer; Endometrial Cancer; Endometrioid Adenocarcinoma; Fallopian Tube Cancer; Primary Peritoneal Carcinoma
NCT02764333

Active, not recruiting

TPIV200/huFR-1 (A Multi-Epitope Anti-Folate Receptor Vaccine) Plus Anti-PD-L1 MEDI4736 (Durvalumab) in Patients With Platinum Resistant Ovarian Cancer

Conditions: Ovarian Cancer
NCT01769547

Terminated

A Phase II Study of Single-agent DOVitinib in Advanced Malignant PlEural Mesothelioma Which Has Progressed Following Prior Platinum-Antifolate Chemotherapy

Conditions: Advanced Malignant Pleural Mesothelioma; MPM
NCT02376478

Completed

On the Impact of Therapeutic Tumor Necrosis Factor-alpha Inhibition on Anogenital Human Papillomavirus Infection

Conditions: Psoriasis; Inflammatory Bowel Diseases
NCT01397305

Completed

An Extended Feasibility Phase I/II Study of Methylenetetrahydrofolate (Arfolitixorin) and Pemetrexed Single Agent, Given as Neoadjuvant Treatment in Patients With Resectable Rectal Cancer

Conditions: Rectal Cancer
NCT02606539

Unknown status

Surgery Plus Single Agent Chemotherapy Versus Primary Chemotherapy for Gestational Trophoblastic Neoplasms

Conditions: Gestational Trophoblastic Neoplasms
NCT00916630

Completed

Treatment of Recurrent Primary or Secondary Central Nervous System (CNS) Lymphoma With ALIMTA (Pemetrexed)

Conditions: Central Nervous System Lymphoma
NCT00944255

Completed

Pharmacogenetics of Antifolate Drugs in Autoimmune Diseases in Taiwan

Conditions: Rheumatoid Arthritis
NCT00944320

Completed

Pharmacogenetics of Antifolate Disease Modifying Anti-Rheumatic Drugs in Rheumatoid Arthritis in Taiwan

Conditions: Rheumatoid Arthritis
NCT03744793

Recruiting

Pemetrexed and Avelumab in Treating Patients With MTAP-Deficient Metastatic Urothelial Cancer

Conditions: Infiltrating Bladder Urothelial Carcinoma Sarcomatoid Variant; Infiltrating Bladder Urothelial Carcinoma With Glandular Differentiation; Infiltrating Bladder Urothelial Carcinoma With Squamous Differentiation; Infiltrating Bladder Urothelial Carcinoma, Micropapillary Variant; Infiltrating Bladder Urothelial Carcinoma, Plasmacytoid Variant; Metastatic Urothelial Carcinoma; MTAP Negative
NCT01947140

Recruiting

Pralatrexate + Romidepsin in Relapsed/Refractory Lymphoid Malignancies

Conditions: Lymphoid Malignancies; Multiple Myeloma; Lymphoma; Hodgkin Lymphoma; Non-hodgkin Lymphoma
NCT01724931

Completed

Aminopterin Dose Finding Treatment for Methotrexate-Naïve Rheumatoid Arthritis

Conditions: Rheumatoid Arthritis
NCT00937027

Completed

Aminopterin Pharmacokinetic Study In Moderate to Severe Psoriasis

Conditions: Psoriasis
NCT00470405

Completed

Pemetrexed and Oxaliplatin in Treating Patients With Metastatic Solid Tumors or Lymphoma

Conditions: Lymphoma; Solid Tumor
NCT03086538

Recruiting

Pemetrexed Plus Tarceva as Salvage Treatment in EGFR Overexpressed Metastatic Colorectal Cancer Patients Who Were Failed After Standard Chemotherapy

Conditions: Colo-rectal Cancer
NCT03793179

Recruiting

Testing the Timing of Pembrolizumab Alone or With Chemotherapy as First Line Treatment and Maintenance in Non-small Cell Lung Cancer

Conditions: Lung Non-Squamous Non-Small Cell Carcinoma; Stage IIIB Lung Cancer AJCC v8; Stage IIIC Lung Cancer AJCC v8; Stage IV Lung Cancer AJCC v8; Stage IVA Lung Cancer AJCC v8; Stage IVB Lung Cancer AJCC v8
NCT00508144

Completed

Single Agent Alimta in Poor Performance Status in Non-small Cell Lung Cancer

Conditions: Lung Cancer
NCT04061590

Recruiting

Pembrolizumab With or Without Chemotherapy Before Surgery in Treating Patients With Stage I-IIIA Non-Small Cell Lung Cancer

Conditions: Lung Non-Small Cell Carcinoma; Stage I Lung Cancer AJCC v8; Stage IA1 Lung Cancer AJCC v8; Stage IA2 Lung Cancer AJCC v8; Stage IA3 Lung Cancer AJCC v8; Stage IB Lung Cancer AJCC v8; Stage II Lung Cancer AJCC v8; Stage IIA Lung Cancer AJCC v8; Stage IIB Lung Cancer AJCC v8; Stage IIIA Lung Cancer AJCC v8
NCT03083847

Completed

Dose Escalation PfSPZ-CVac

Conditions: Malaria
NCT02511054

Completed

Sanaria PfSPZ Challenge With Pyrimethamine Chemoprophylaxis (PfSPZ-CVac Approach): Phase 1 Trial to Determine Safety and Protective Efficacy of Sanaria PfSPZ Challenge With Concurrent Pyrimethamine Treatment That Inhibits Development of Asexual B...

Conditions: Malaria
NCT00491075

Terminated

Pemetrexed Plus Gemcitabine in Renal Cell Cancer

Conditions: Renal Cell Carcinoma