Search clinical trials for: GABA Modulators

Total 22236 results

Marinus Pharmaceuticals

Completed

Adjunctive Ganaxolone Treatment (Part A) in TSC Followed by Long-term Treatment (Part B) (TSC)

Tuberous Sclerosis

United States
Marinus Pharmaceuticals

Enrolling by invitation

Open-label Study of Adjunctive GNX Treatment in Children and Adults With TSC-related Epilepsy

Tuberous Sclerosis Complex

United States, Spain, United Kingdom, Australia, China, Italy, Israel, Germany, France, Canada, Belgium
Marinus Pharmaceuticals

Completed

A Clinical Trial of Oral Ganaxolone in Women With Postpartum Depression

Behavioral Symptoms | Depressive Disorder | Depression | Mood Disorders | Pregnancy Complications | Depression, Postpartum | Mental Disorder | Postpartum Disorder | PPD | Postpartum Blues

United States
Sage Therapeutics

Completed

A Study to Assess the Safety of Brexanolone in the Treatment of Adolescent Female Participants With Postpartum Depression (PPD)

Post Partum Depression

United States
Marinus Pharmaceuticals

Terminated

Open-label Extension to Protocol 1042-0500

Infantile Spasms

United States
Pfizer

Completed

A Study to Examine the Distribution of PF-06372865 in the Brain of Healthy Volunteers Using Positron Emission Tomography and a Radioactive Tracer Following Oral Administration of One Dose of PF-06372865

Healthy

United States
University of North Carolina, Chapel Hill
Sage Therapeutics

Recruiting

Effects Zulresso on Postpartum Psychosis

Postpartum Psychosis

United States
Marinus Pharmaceuticals

Recruiting

Randomized Therapy In Status Epilepticus (RAISE)

Status Epilepticus

United States, Australia, Canada
Marinus Pharmaceuticals

Completed

A Randomized, Controlled Trial of Ganaxolone in Patients With Infantile Spasms

Infantile Spasms

United States
Pfizer

Completed

A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Repeat Doses of PF-06372865 in Healthy Subjects

Healthy Volunteers

United States
Parkway Medical Center

Terminated

A Randomized, Double-Blind, Placebo-Controlled Trial of Flumazenil for the Treatment of Obsessive Compulsive Disorder (OCD)

Obsessive Compulsive Disorder

United States
Dr. Reddy's Laboratories Limited

Completed

Bioequivalence Study of Primidone Tablets 50 mg of Dr. Reddy's Under Fasting Conditions

Healthy

India
Marinus Pharmaceuticals

No longer available

Ganaxolone Expanded Access Program Compassionate Use (CDD)

CDKL5 Disorder
Marinus Pharmaceuticals

Completed

A Clinical Trial of Intravenous (IV) Ganaxolone in Women With Postpartum Depression

Behavioral Symptoms | Mental Disorders | Depressive Disorder | Depression | Mood Disorders | Pregnancy Complications | Depression, Postpartum | Puerperal Disorders | Postpartum | PPD

United States
Jazz Pharmaceuticals

Completed

Study of Intranasal Clonazepam in Adult Subjects With Epileptic Seizures

Epilepsy

United States, Finland
Pfizer

Terminated

POC Study in Partially Responsive Generalized Anxiety Disorder

Generalized Anxiety Disorder

United States
Steno Diabetes Center Copenhagen
Juvenile Diabetes Research Foundation

Unknown

GABA Treatment in Subjects With Type 1 Diabetes (GABA-1)

Type 1 Diabetes Mellitus

Denmark
Korea University Guro Hospital

Completed

Impact of Flumazenil on the Emergence Delirium

Anesthesia, General

Korea, Republic of
Pfizer

Completed

Food Effect Study for PF-06372865

Healthy

Belgium
Palo Alto Veterans Institute for Research
University of California, Los Angeles; Stanford University

Withdrawn

Clonazepam Effects on Brain Oscillations and Cognition in Schizophrenia (KGB)

Schizophrenia | Schizoaffective Disorder | Schizophreniform Disorder

United States
Lynn Marie Trotti
Georgia Research Alliance

Completed

Flumazenil for the Treatment of Primary Hypersomnia

Idiopathic Hypersomnia | Hypersomnia | Narcolepsy Without Cataplexy | Primary Hypersomnia

United States
Pfizer

Completed

A Study to Evaluate Safety, Toleration and Time Course of Plasma Concentration of Multiple Oral Doses of PF-06372865 in Healthy Subjects of Two AgeGroups, Aged 18-55 Years (Group 1) and Aged 56-75 Years (Group 2)

Healthy

Belgium
Marinus Pharmaceuticals

Completed

Open-Label PoC Trial of Ganaxolone in Children With PCDH19 Female Pediatric Epilepsy and Other Rare Genetic Epilepsies

Epilepsy

United States, Italy
Marinus Pharmaceuticals

Completed

Open-label Extension to Protocol 1042-0600

Epilepsies, Partial

United States
University of Michigan
National Institute of Neurological Disorders and Stroke (NINDS)

Completed

Modulation of GABA-A Receptors in Parkinson Disease-Flumazenil Arm

Parkinson Disease

United States
Par Pharmaceutical, Inc.
Cetero Research, San Antonio

Completed

Bioavailability Study of Clonazepam Tablets Under Fasting Conditions

To Determine Bioequivalence Under Fasting Conditions
University of North Carolina, Chapel Hill
Sage Therapeutics; Baszucki Brain Research Fund

Recruiting

Dynamic Neural Mechanisms of Brexanolone-induced Antidepressant Effects in Postpartum Depression (BRX-PPD)

Postpartum Depression

United States
Cerevel Therapeutics, LLC

Enrolling by invitation

An Open-label Extension Trial of CVL-865 as Adjunctive Therapy in the Treatment of Focal Onset Seizures

Seizures

United States, Spain, Australia, Poland, Ukraine
Rajesh Narendran

Completed

Characterization of [11C]Flumazenil to Image GABA Transmission in Healthy Adult Subjects and Subjects With Alcohol Dependence

Alcoholism

United States
Coeruleus Ltd.

Completed

Safety and Pharmacokinetic Study of Sublingual Flumazenil (CRLS035) in Healthy Adults

Insomnia

Israel
Marinus Pharmaceuticals

Terminated

A Two-year Open-label Extension Study of Ganaxolone in Patients With Drug-resistant Partial-onset Seizures

Drug Resistant Partial Onset Seizure

United States
Par Pharmaceutical, Inc.
Cetero Research, San Antonio

Completed

Bioavailability Study of Clonazepam ODT Under Fasting Conditions

To Determine Bioequivalence Under Fasting Conditions
Yao Yusheng
West China Hospital

Completed

Effects of Dexmedetomidine Premedication on Emergence Agitation After Strabismus Surgery in Children

Delirium on Emergence | Inhalational Anesthetics Adverse Reaction | Strabismus Following Ocular Surgery

China
Donald Jeffrey Newport
Sage Therapeutics

Recruiting

An Open Label Pilot Study of IV Brexanolone for the Treatment of Post-Traumatic Stress Disorder

Post-Traumatic Stress Disorder

United States
New York State Psychiatric Institute
National Institute on Drug Abuse (NIDA)

Completed

Effect of Clonazepam on Cannabis Withdrawal and Relapse in Treatment-seeking Patients

Cannabis Use Disorder

United States
University Hospital, Montpellier

Completed

Clonazepam in Children Status Epilepticus (UHAPA)

Epilepticus Status

France
Yale University
National Institute on Drug Abuse (NIDA)

Completed

Rapid Benzodiazepine Detoxification Using Flumazenil - 1

Substance-Related Disorders

United States
Per-Ola Carlsson
Diamyd Medical AB

Completed

Evaluation of Safety and Diabetes Status Upon Oral Treatment With GABA in Patients With Longstanding Type-1 Diabetes

Type 1 Diabetes Mellitus

Sweden
National Institute on Drug Abuse (NIDA)

Completed

Effectiveness of GABA Agonists in Reducing the Reinforcing Effects of Cocaine

Cocaine-Related Disorders

United States
Marinus Pharmaceuticals
U.S. Army Medical Research and Development Command; INTRuST, Post-Traumatic...

Completed

Ganaxolone in Posttraumatic Stress Disorder (PTSD)

PTSD

United States
Massachusetts General Hospital

Completed

Augmentation of Treatment-Resistant Depression With An Analog of the Neuroactive Steroid Allopregnanolone

Major Depressive Disorder

United States
University of Zagreb

Completed

Acupuncture Versus Clonazepam in Burning Mouth Syndrome (ACUCLONBMS)

Burning Mouth Syndrome
Marinus Pharmaceuticals
University of California, Davis; U.S. Army Medical Research and Development...

Completed

Ganaxolone Treatment in Children With Fragile X Syndrome

Fragile x Syndrome

Belgium, United States
Seoul National University Hospital
Ministry of Food and Drug Safety, Korea

Completed

Effect of Clonazepam on REM Sleep Behavior Disorder in Patients With Parkinsonism

REM Sleep Behavior Disorder

Korea, Republic of
National Aeronautics and Space Administration (NASA)

Completed

Optimize Astronaut Sleep Medication Efficacy and Individual Effects

Sleep | Cognition | Pharmacologic Actions
Marinus Pharmaceuticals

Recruiting

Safety and Efficacy Study of IV Ganaxolone as Adjuvant Therapy for Established Status Epilepticus (ESE)

Status Epilepticus

United States
Universidad de Murcia

Completed

Inflammatory Markers in Saliva of Patients With Burning Mouth Syndrome (burningmouth)

Burning Mouth Syndrome

Spain
Marinus Pharmaceuticals

Completed

Phase 3 Study of Adjunctive Ganaxolone in Adults With Drug-resistant Partial Onset Seizures and Open-label Extension

Drug Resistant Partial Onset Seizure

United States, Australia, Russian Federation, Bulgaria, Germany, Poland
Sage Therapeutics

Completed

Evaluate SAGE-547 in Participants With Essential Tremor

Essential Tremor

United States
Sage Therapeutics

Completed

Evaluate SAGE-547 in Female Participants With Severe Postpartum Depression

Postpartum Depression

United States

Search clinical trials for: GABA Modulators

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