Search clinical trials for: GABA Modulators

Total 22327 results

Atea Pharmaceuticals, Inc.
Hoffmann-La Roche

Completed

Drug-drug Interaction Study of Midazolam and AT-527 (R07496998)

Healthy Volunteer Study

Canada
Pfizer's Upjohn has merged with Mylan to form Viatris...

Withdrawn

Bioequivalence of a New Sublingual and a Reference Alprazolam Immediate Release Tablet Formulation

Healthy
Boehringer Ingelheim

Completed

This Study in Healthy Men Tests How Different Doses of BI 1358894 Are Taken up in the Body and How Well They Are Tolerated. The Study Also Tests How BI 1358894 Affects the Way the Body Breaks Down Midazolam

Healthy

Germany
Charite University, Berlin, Germany

Completed

Lormetazepam Versus Midazolam in Critically Ill Patients: a Retrospective Cohort Trial (RetroLoveMi)

Critical Illness
Hamad Medical Corporation

Completed

Efficacy and Safety of Intramuscular Midazolam Compared to Buccal Midazolam in Pediatric Seizures

Seizures

Qatar
Columbia University

Completed

Volumes of Administration for Intranasal Midazolam

Children Requiring Sedation to Facilitate Laceration Repair

United States
Consorci Sanitari de l'Anoia

Completed

Could Music be an Alternative to Sedation in Patients Treated Total Knee Arthroplasty With Regional Anesthesia?

Pain | Anxiety | Surgery | Anesthesia | Drug Toxicity
Paion UK Ltd.
Premier Research Group plc

Completed

Dose-Finding Safety Study Evaluating Remimazolam (CNS 7056) in Patients Undergoing Diagnostic Upper GI Endoscopy

Endoscopy | Procedural Sedation

United States
Sherief Abd-Elsalam

Unknown

Propofol Versus Midazolam for Lower Gastrointestinal Endoscopy

Cirrhosis, Liver

Egypt
Centre Hospitalier Universitaire, Amiens

Completed

Pharmacokinetic Evaluation of MDZ028 (MIDAZOLAM)

Midazolam
Pfizer

Completed

A Phase 1 Study To Characterize The Safety, Tolerability, PK And PK Of Repeat Doses Of PF-06648671 In Healthy Adults And Healthy Elderly Subjects

Healthy Adult Subjects and Healthy Elderly Subjects

Belgium
Columbia University
Upsher-Smith Laboratories

Terminated

Pharmacodynamics of Nasal and Buccal Midazolam Using EEG (nMDZ-EEG)

Epilepsy

United States
Pfizer

Completed

A Study To Test The Safety, Amount And Effects Of PF-06282999 In Healthy Overweight Adults And A Study To Test The Effects Of PF-06282999 On The Amount Of The Approved Drug, Midazolam, In Healthy Adults (B521MAD)

Healthy

Belgium
Melbourne Health

Completed

A Study of Methods to Reduce Anxiety in Preoperative Elective Surgical Patients

Anxiety

Australia
Advocate Hospital System
Emergency Medicine Foundation

Completed

The Effect of Etomidate on Patient Outcomes After Single Bolus Doses

Sepsis | Trauma

United States
Orasi Medical, Inc.

Unknown

Acute Effect of Lorazepam on Brain Activity Measured by Magnetoencephalograpy (MEG) and Electroencephalography (EEG)

Healthy Subjects

United States
Assistance Publique - Hôpitaux de Paris

Completed

Comparison Between Lorazepam, Clonazepam and Clonazepam + Fosphenytoin for the Treatment of Out-of-hospital Generalized Status Epilepticus (LORACLOFT)

Epilepsy | Status Epilepticus

France
Mclean Hospital

Terminated

Spectroscopic Imaging at 4T: A Drug Challenge Study (CEBRA2)

AOD Effects and Consequences

United States
University of Pennsylvania

Recruiting

Music vs Midazolam During Preop Nerve Block Placement - Part 2 Study On Anxiolytic Options Before Peripheral Nerve Blocks

Anxiety | Preoperative Anxiety | Peripheral Nerve Block

United States
Arcus Biosciences, Inc.

Completed

Study to Investigate the Safety, Tolerability, and Pharmacokinetic Profile With Oral AB521 in Healthy Volunteers (ARC-14)

Healthy Participants

Netherlands
Mylan Pharmaceuticals Inc

Completed

Fasting Study of Alprazolam Extended-Release Tablets 1 mg to Xanax XR Tablets 1 mg

Healthy

United States
Mylan Pharmaceuticals Inc

Completed

Fed Study of Alprazolam Extended-release Tablets 3 mg to Xanax XR® Tablets 3 mg

Healthy

United States
Blueprint Medicines Corporation

Completed

A Drug-drug Interaction Study of Avapritinib and Midazolam

Gastrointestinal Stromal Tumors | GIST | Non-resectable Advanced Solid Tumors | Recurrent or Unresectable Central Nervous System (CNS) Tumors

United States
Boehringer Ingelheim

Active, not recruiting

A Study to Test Different Doses of BI 1823911 Alone and Combined With Other Medicines in People With Different Types of Advanced Cancer With KRAS Mutation

Solid Tumors, KRAS Mutation

Spain, United Kingdom, United States, Belgium
University of Liege

Completed

Impact of Virtual Reality Hypno-sedation on Functional Recovery and Anxiety in Foot Surgery With Regional Anesthesia

Analgesia | Foot Deformities | Regional Anesthesia Morbidity | Valgus; Hallux

Belgium
Orion Corporation, Orion Pharma

Active, not recruiting

Safety and Pharmacokinetics of ODM-208 in Patients With Metastatic Castration-resistant Prostate Cancer (CYPIDES)

Prostate Cancer Metastatic

France, United Kingdom, Finland, United States
Pfizer

Completed

A Study of PF-07258669 In Healthy Adult Participants

Healthy Participants

Belgium
Takeda

Completed

A Study of Soticlestat in Healthy Adult Nondependent Recreational Drug Users With Central Nervous System (CNS) Depressant Experience

Healthy Volunteers

United States
AbbVie

Completed

A Study to Assess the Pharmacokinetics and Safety of Co-administered Oral Galicaftor, Navocaftor, and ABBV-576 in Healthy Adults for the Treatment of Cystic Fibrosis (ABBV-576 DDI)

Healthy Volunteers

United States
Karaman Training and Research Hospital

Completed

Effect of Midazolam Premedication on Mask Ventilation Difficulty

Anesthesia Complication

Turkey
Boehringer Ingelheim

Completed

This Study in Healthy Men Tests How Different Doses of BI 705564 Are Taken up in the Body and How Well They Are Tolerated. The Study Also Tests How BI 705564 Affects the Way the Body Breaks Down Midazolam

Healthy

Germany
Claudia Spies

Completed

Comparison of Lormetazepam and Midazolam Used as Sedatives for Patients That Require Intensive Care

Sedation in Intensive Care Unit Patients

Germany
Sage Therapeutics

Completed

A Study to Evaluate Efficacy and Safety of SAGE-547 in Participants With Severe Postpartum Depression (547-PPD-202B)

Postpartum Depression

United States
Nourhan M.Aly
Alexandria University

Completed

Buccal Versus Intranasal Route of Administration of Midazolam Spray in Behavior Management of Pre-School Patients

Dental Anxiety

Egypt
Eli Lilly and Company

Completed

A Study of LY3295668 Erbumine in Participants With Breast Cancer That Has Spread to Other Parts of the Body

Metastatic Breast Cancer

Belgium, United States
Eli Lilly and Company

Completed

A Study of the Effect of LY2216684 on Lorazepam

Major Depressive Disorder

United Kingdom
Valley Anesthesiology Consultants
Phoenix Children's Hospital; KindVR

Unknown

Effects of Virtual Reality on Pre-Operative Anxiety and Induction of Anesthesia in Children and Adolescents

Tonsillectomy

United States
Mayo Clinic

Completed

The Cognitive Effects of Lorazepam in Healthy Older Individuals With TOMM40 Variable-length Polymorphisms

Alzheimer's Disease (AD)

United States
Infante, Javier Molina, M.D.

Completed

Propofol vs. Midazolam-based Balanced Propofol for Nonanesthesiologist Moderate Sedation in Colonoscopy (MIDAPROP)

Procedural Sedation

Spain
Eunice Kennedy Shriver National Institute of Child...
The Emmes Company, LLC

Completed

Lorazepam for the Treatment of Status Epilepticus in Children

Status Epilepticus

United States
Virginia Commonwealth University

Withdrawn

Pilot Study Evaluating Stress Response and Immune Function in Mechanically Ventilated Patients With Alcohol Use Disorders Treated With Propofol or Midazolam

Alcoholism | Respiration, Artificial

United States
Makerere University
University of Mississippi Medical Center

Completed

Catatonia in Nodding Syndrome and Lorazepam Treatment (CINS)

Catatonia | Nodding Syndrome
Jiangsu Kanion Pharmaceutical Co., Ltd

Completed

A Drug-Drug Interaction Study To Investigate The Ginkgolides Meglumine Injection To Alter The Pharmacokinetics Of Midazolam

Pharmacokinetics

China
Jed E. Rose
National Institute on Drug Abuse (NIDA)

Completed

Proof-Of-Concept Investigation With a Neurosteroid Analog (Ganaxolone) as a Smoking Cessation Candidate (Ganaxolone)

Smoking Cessation

United States
Hospices Civils de Lyon

Completed

Reduction of Preoperative Anxiety in Children: Electronic Tab vs Midazolam (IPAD)

Paediatric Outpatient Surgery

France
Subei People's Hospital of Jiangsu Province

Unknown

A Clinical Trial of the Effect of Midazolam on the Cerebral Metabolism and Inflammatory Response in Patients With Moderate and Severe Traumatic Brain Injury

Traumatic Brain Injury

China
Pfizer

Completed

Multiple Dose Safety Toelrability, Pharmacokinetics and Midazolam Interaction In Healthy Overweight And Obese Subjects

Glucose Metabolism Disorders | Diabetes Mellitus, Type 2 | Diabetes Mellitus

United States
Takeda

Completed

Behavioral and Subjective Efficacy of Ramelteon in Subjects With a History of Polydrug Abuse

Drug Abuse

United States
All India Institute of Medical Sciences, New Delhi

Completed

Nasal Versus Venous Lorazepam for Control of Acute Seizures in Children (INLOR)

Seizures | Status Epilepticus

India
University Hospital, Toulouse
Merz Pharmaceuticals GmbH

Completed

Study of the Effects on Motor Recovery of Early Post-stroke Spasticity Treatment (BacloTox)

Muscle Spasticity

France

3

Subscribe