Search clinical trials for: GDC-0449 oral capsules (non-labeled)

Total 94 results

Genentech, Inc.

Completed

A Study of the Hedgehog Pathway Inhibitor GDC-0449 in Healthy Female Subjects of Non-Childbearing Potential

Healthy
Genentech, Inc.

Completed

An Absolute Bioavailability Study in Healthy Participants Comparing Oral to Intravenous Administration of GDC-0973 (Cobimetinib)

Healthy Volunteers
Tesaro, Inc.

Completed

Absorption, Metabolism, Excretion, and the Determination of Absolute Bioavailability of Niraparib in Subjects With Cancer

Cancer

Netherlands
National Institute of Allergy and Infectious Diseases...
SIGA Technologies

Recruiting

Study of Tecovirimat for Human Monkeypox Virus (STOMP)

Monkeypox | MPOX

United States, Puerto Rico, Brazil, South Africa, Argentina, Mexico, Japan, Thailand, Peru
Genentech, Inc.

Completed

A Study of Vismodegib (GDC-0449) in Patients Treated With Vismodegib in a Previous Genentech-sponsored Phase I or II Cancer Study

Metastatic Colorectal Cancer | Ovarian Cancer | Basal Cell Carcinoma

United States
Genentech, Inc.

Completed

A Study of Pharmacokinetic Drug Interaction Study of the Hedgehog Pathway Inhibitor GDC-0449 in Combination With Rosiglitazone or Combined Oral Contraceptive in Patients With Locally Advanced or Metastatic Solid Tumors That Are Refractory to Standard Therapy or for Whom No Standard Therapy Exists

Solid Cancers

United States
Nucleo De Pesquisa E Desenvolvimento De Medicamentos...
University of Campinas, Brazil

Completed

Effect of Stomach Reduction Surgery on the Parameters of Amoxicillin

Bariatric Surgery Candidate

Brazil
Blade Therapeutics

Completed

Dedicated Drug-Drug Interaction (DDI) Study in Healthy Volunteers

Drug Drug Interaction

United States
Tillotts Pharma AG
University Hospital, Basel, Switzerland; University of Basel; SocraTec R&D GmbH; Swiss Commission for Technology and Innovation

Completed

Pharmaco-Scintigraphic Study to Evaluate the Release Profile of Metronidazole Benzoate Capsules

Healthy

Switzerland
Genentech, Inc.

Completed

A Study of Vismodegib (GDC-0449, Hedgehog Pathway Inhibitor) With Concurrent Chemotherapy and Bevacizumab As First-Line Therapy for Metastatic Colorectal Cancer

Metastatic Colorectal Cancer
Shanghai Zhongshan Hospital
Beijing Continent Pharmaceutical Co, Ltd.

Active, not recruiting

Pirfenidone Treat Myocardial Fibrosis After Acute Myocardial Infarction (PROTECT-AMI)

Myocardial Fibrosis

China
Columbia University

Withdrawn

Growth Hormone and Exclusion Diet Therapy in Juvenile Crohn's Disease

Crohn's Disease

United States
Defense and Veterans Center for Integrative Pain...

Completed

Comparing Effectiveness of IV vs Oral Acetaminophen Given Perioperatively for Lap Choles for Pain Control,

Laparoscopic Cholecystectomy

United States
Esperion Therapeutics, Inc.

Completed

Bempedoic Acid + Ezetimibe Fixed-Dose Combination (FDC) Study in Patients With Type 2 Diabetes and Elevated LDL-C

Diabetes Mellitus, Type 2 | Diabetes | Cholesterolemia

United States
Indonesia University

Completed

The Effect of Oral Nanocurcumin as an Adjuvant Therapy for Anogenital Warts: Evaluation of Clinical Improvement, NFĸB, IFN-γ, and FOXP3+TReg From Lesions Tissue

Anogenital Wart

Indonesia
University of Iowa
University of Michigan

Recruiting

Omega-3 Fatty Acid Lipidomics in Diabetes Peripheral Neuropathy

Diabetic Neuropathies

United States
University of Edinburgh
British Heart Foundation; National Health Service, United Kingdom

Completed

PAracetamol Treatment in Hypertension: Effect on Blood Pressure (PATH-BP) Study (PATH-BP)

Blood Pressure

United Kingdom
Excalibur Pharmaceuticals, Inc.

Completed

Randomized, Crossover, Multi-Dose Pharmacokinetics of EXCL-100 Pirfenidone-Sustained Release Tablet and Esbriet in Healthy Volunteers

Idiopathic Pulmonary Fibrosis

United States
Reckitt Benckiser Healthcare (UK) Limited
Premier Research Group plc

Completed

Ibuprofen Liquid Capsules 2 x 200 mg Efficacy and PK/PD Study in Surgical Removal of Impacted Third Molars

Stomatognathic Diseases | Tooth Diseases | Tooth, Impacted

United States
Prof. Johann Bauer

Recruiting

Rigosertib for RDEB-SCC

Epidermolysis Bullosa Dystrophica | Squamous Cell Carcinoma

Austria
RenJi Hospital

Unknown

Pirfenidone as Treatment of Skin Fibrosis in Systemic Sclerosis

Systemic Sclerosis

China
Michael Dill
University of Cologne; German Cancer Research Center; Heidelberg University; Universitätsmedizin... and other collaborators

Not yet recruiting

Fecal Microbiota Transfer in Liver Cancer to Overcome Resistance to Atezolizumab/Bevacizumab (FLORA) (FLORA)

Immunotherapy

Germany
MedImmune LLC

Active, not recruiting

A Study of Durvalumab or Tremelimumab Monotherapy, or Durvalumab in Combination With Tremelimumab or Bevacizumab in Advanced Hepatocellular Carcinoma

Hepatocellular Carcinoma

United States, Italy, Spain, Taiwan, Korea, Republic of, China, Hong Kong, Japan, Singapore
Shanghai Cell Therapy Group Co.,Ltd

Not yet recruiting

The Exploratory Study on the Biological Function of Dendritic Cells In Vivo Supported by Nicotinamide Mononucleotide (Vital NAD)

Postoperative Prevention of Tumor

China
Chinese University of Hong Kong
Queen Elizabeth Hospital, Hong Kong; Alice Ho Miu Ling Nethersole Hospital; Tseung...

Completed

Aminosalicylic Acid Withdrawal Study in Long Standing Inactive Ulcerative Colitis

Colitis, Ulcerative | Aminosalicylic Acid

Hong Kong
Thammasat University

Completed

Efficacy of Ginger Extract (Compare Between the Ginger Preparation of Ancient Concept of Thai Traditional Practitioner, Standard Drug and Placebo) by Using Pain Score to Evaluate After Pain of Three Groups of First Normal Postpartum Women.

Postpartum Disorder

Thailand
Cairo University

Completed

Short Term Effect of Vitamin D Supplementation on the Clinical Outcomes in Patients Undergoing Valve Replacement Surgery

Cardiac Valve Replacement Complication

Egypt
Oslo University Hospital

Recruiting

Teriflunomide vs. Placebo During Gluten Challenge in Celiac Disease

Celiac Disease

Norway
Instituto Venezolano de Investigaciones Cientificas
Seguros Caracas Foundation; National Fund for Science and Technology, Science...

Completed

Low Dose β-carotene Supplementation Diminishes Oxidative Stress in Type 2 Diabetics and Healthy Individuals

Diabetes Mellitus | Iron Metabolism Disorders | Oxidative Stress

Venezuela
Bangabandhu Sheikh Mujib Medical University, Dhaka...

Completed

Serum Creatinine Change / Renal Adverse Effect With Use of Non-steroidal Painkillers in Axial Spondyloarthritis Patients

Axial Spondyloarthritis
Ain Shams University

Completed

Doubling the Iron Dose to Prevent IDA in Twin Pregnant Women (IDA)

Hematologic Pregnancy Complications

Egypt
University of Wisconsin, Madison
American Heart Association; American Diabetes Association

Completed

Mechanisms of Cerebrovascular Control

Metabolic Syndrome X

United States
Syarif Hidayatullah State Islamic University Jakarta

Completed

Role of Alphacalcidol Supplement to Reduce Pain and COMP in Geriatric Knee Osteoarthritis Patients

Osteoarthritis, Knee | Aged

Indonesia
University Hospital Rijeka
University of Rijeka, Medical Faculty; Belupo; University of Rijeka, Faculty...

Withdrawn

Silymarin in NAFLD (SINF)

Non-Alcoholic Fatty Liver Disease

Croatia
Zhejiang Chinese Medical University
Red Cross Hospital, Hangzhou, China; The Third Affiliated hospital of Zhejiang... and other collaborators

Completed

Different Kinds of Acupuncture Treatment for Knee Osteoarthritis

Knee Osteoarthritis

China
Wayne State University
National Institute of Mental Health (NIMH)

Recruiting

Effects of Delta9-tetrahydrocannabinol (THC) on Retention of Memory for Fear Extinction Learning in PTSD: R33 Study

Posttraumatic Stress Disorder

United States
Montefiore Medical Center

Completed

Ibuprofen With or Without Acetaminophen for Low Back Pain

Low Back Pain

United States
University Hospital, Basel, Switzerland

Completed

Trauma as a Trigger for Autoimmunity (TATA)

Autoimmunity

Switzerland
United States Department of Defense
GlaxoSmithKline

Unknown

Effects of Omega-3 EPA/DHA for Soldiers at Risk for Mood Disorders

Depression | Mood Disorders | Combat Disorders | Stress Disorders

Iraq
GlaxoSmithKline

Completed

Bioavailability Study of Fixed Dose Combination (FDC) Dutasteride and Tamsulosin Hydrochloride (HCl) Relative to One Dutasteride and One Tamsulosin HCl Tablet in Healthy Male Subjects

Prostatic Hyperplasia

United States
Indiana University

Completed

Effect of an H1 Receptor Antagonist on Exercise Performance in Hypoxia

Hypoxia, Altitude

United States
Columbia University

Recruiting

Postpartum Low-Dose Aspirin and Preeclampsia

Preeclampsia Postpartum

United States
Federal University of São Paulo

Completed

Evaluation of Effectiveness of Acetylsalicylic Acid on Markers of Vascular Dysfunction in Scleroderma Patients

Systemic Sclerosis

Brazil
HITEC-Institute of Medical Sciences

Not yet recruiting

Vitamin D Supplementation in Acne

Acne Vulgaris

Pakistan
Federal University of São Paulo

Unknown

Efficacy and Safety of Low-dose Oral Isotretinoin for Seborrhea

Quality of Life | Seborrheic Dermatitis | Seborrhea

Brazil
Hackensack Meridian Health

Withdrawn

Pain Control Without Opioids

Perioperative Pain

United States
SocraTec R&D GmbH
SocraMetrics GmbH

Completed

Ibuprofen Bioavailability Trial With Oral Single Dose Administration.

Bioequivalence

Germany
Major Extremity Trauma Research Consortium

Completed

Improving Pain Management and Long Term Outcomes Following High Energy Orthopedic Trauma (Pain Study) (PAIN)

Orthopaedic Fractures

United States
Columbia University
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Completed

Aspirin for Exercise in Multiple Sclerosis (ASPIRE) (ASPIRE)

Multiple Sclerosis

United States
Universidad Autonoma de Baja California

Completed

The Outcome of Preoperative Administration of Single-dose Ketorolac, Non-steroidal Anti-inflammatory Drug and Placebo (PreOp)

Pulpitis - Irreversible

Mexico

Search clinical trials for: GDC-0449 oral capsules (non-labeled)

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