Search clinical trials for: Glucopyranosyl Lipid Adjuvant-Stable Emulsion (GLA-SE)

Total 37 results

Immune Design

Completed

A Proof-of-Concept Trial of GLA-SE in Patients With Merkel Cell Carcinoma

Merkel Cell Carcinoma

United States
National Institute of Allergy and Infectious Diseases...

Completed

A Clinical Trial in Healthy, HIV-1-Uninfected Adult Participants to Compare the Safety, Tolerability and Immunogenicity of CH505TF gp120 Produced From Stably Transfected Cells to CH505TF gp120 Produced From Transiently Transfected Cells

HIV Infections

United States
Oswaldo Cruz Foundation
IDRI; Biomedical Research Center EPLS; Orygen Biotecnologia SA

Completed

Anti-Schistosomiasis Vaccine: Sm14 Phase 2b-Sn in School Children

Schistosomiasis

Senegal
Oswaldo Cruz Foundation
IDRI; Biomedical Research Center EPLS; Orygen Biotecnologia SA

Completed

Study of Safety and Immune Response of the Sm14 Vaccine in Adults of Endemic Regions

Schistosomiasis

Senegal
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Completed

TLR4 Agonist GLA-SE and Radiation Therapy in Treating Patients With Soft Tissue Sarcoma That Is Metastatic or Cannot Be Removed by Surgery

Stage III Adult Soft Tissue Sarcoma | Stage IV Adult Soft Tissue Sarcoma

United States
Mayo Clinic
National Cancer Institute (NCI)

Completed

MART-1 Antigen With or Without TLR4 Agonist GLA-SE in Treating Patients With Stage II-IV Melanoma That Has Been Removed by Surgery

Stage IV Skin Melanoma | Stage IIIB Skin Melanoma | Stage IIIC Skin Melanoma | Stage IIA Skin Melanoma | Stage IIB Skin Melanoma | Stage IIC Skin Melanoma | Stage IIIA Skin Melanoma

United States
HIV Vaccine Trials Network
National Institute of Allergy and Infectious Diseases (NIAID); National Institutes... and other collaborators

Active, not recruiting

Evaluating the Safety and Immunogenicity of HIV-1 Vaccines Based on Chimpanzee Serotypes of Ad Expressing Clade C gp140 and a CH505TF gp120 Protein Boost in Healthy, HIV- Uninfected Adult Participants (HVTN139)

HIV Infections

South Africa
Immune Design
Merck Sharp & Dohme LLC

Terminated

Study of Intratumoral G100 With Or Without Pembrolizumab or Rituximab In Participants With Follicular Non-Hodgkin's Lymphoma (MK-3475-174/IMDZ-G142)

Follicular Low Grade Non-Hodgkin's Lymphoma
Worcester HIV Vaccine
Brigham and Women's Hospital; Access to Advanced Health Institute (AAHI)

Completed

Evaluating the Safety and Immunogenicity of Polyvalent DNA/gp120 HIV Vaccine in Healthy, HIV-uninfected Adults

HIV Infections

United States
National Institute of Allergy and Infectious Diseases...

Completed

Evaluating the Safety and Immunogenicity of Env (A,B,C,A/E)/Gag (C) DNA and gp120 (A,B,C,A/E) Protein/GLA-SE HIV Vaccines, Given Individually or Co-administered, in Healthy, HIV-1-Uninfected Adults

HIV Infections

United States
Institut Bergonié
Merck Sharp & Dohme LLC; Ministry of Health, France; Immune Design

Active, not recruiting

Combination of MK3475 and Metronomic Cyclophosphamide in Patients With Advanced Sarcomas : Multicentre Phase II Trial (PEMBROSARC)

Sarcoma

France
Oswaldo Cruz Foundation

Recruiting

Anti-Schistosomiasis Sm14-vaccine in Senegal

Vaccination; Infection | Schistosomiasis Mansoni | Schistosomiasis Haematobium

Senegal
HIV Vaccine Trials Network
National Institute of Allergy and Infectious Diseases (NIAID)

Active, not recruiting

Evaluating Safety and Immune Response to the HIV-1 CH505 Transmitted/Founder gp120 Adjuvanted With GLA-SE in Healthy, HIV-exposed Uninfected Infants (HVTN 135)

HIV Infections

South Africa
Sanofi

Completed

A Study to Assess Primarily the Tolerability and Safety of SAR439794 After Repeated Sublingual Daily Administration in Peanut Allergic Adult and Adolescent Patients

Food Allergy

United States
National Institute of Allergy and Infectious Diseases...

Completed

Evaluating the Safety and Immunogenicity of EnvSeq-1 and CH505 M5 gp120 Envs Adjuvanted With GLA-SE in Healthy, HIV-Uninfected Adults

HIV Infections

United States
University Hospital Tuebingen
University of Copenhagen; Institut de Recherche pour le Developpement; Université... and other collaborators

Completed

Safety and Immunogenicity of the Placental Malaria Vaccine Candidate PAMVAC Variously Adjuvanted (PAMVAC)

Malaria, Antepartum

Benin
Postgraduate Institute of Medical Education and...

Completed

To Study the Effects of Lipid Emulsion on Hemodynamics in Organophosphate Compound Poisoning

Organophosphate Poisoning

India
Institut National de la Santé Et de la Recherche...
EVI Industries, Inc.; Recherche Clinique Paris Descartes Necker Cochin Sainte... and other collaborators

Completed

Trial to Evaluate the Safety and Immunogenicity of a Placental Malaria Vaccine Candidate (PRIMVAC ) in Healthy Adults (PRIMALVAC)

Malaria

Burkina Faso, France
Medicago
McGill University Health Centre/Research Institute of the McGill University... and other collaborators

Completed

Immunogenicity, Safety, Tolerability of a Plant-made H5 Virus-like-particle (VLP) Influenza Vaccine.

RNA Virus Infections | Virus Diseases | Respiratory Tract Infections | Respiratory Tract Diseases

Canada
Institut National de la Santé Et de la Recherche...
EVI Industries, Inc.; BPRC; Recherche Clinique Paris Descartes Necker Cochin... and other collaborators

Completed

Safety and Immunogenicity of Recombinant Pichia Pastoris AMA1-DiCo Candidate Malaria Vaccine With GLA-SE and Alhydrogel ® as Adjuvant in Healthy Malaria Non-Exposed European and Malaria Exposed African Adults (AMA1-DiCo)

Malaria, Falciparum

Burkina Faso, France
National Institute of Allergy and Infectious Diseases...

Completed

A Phase I, Randomized, Double-Blind, Placebo-Controlled, Clinical Trial to Compare the Safety and Immunogenicity of Recombinant Envelope Protein rgp120/HIV-1SF2 (BIOCINE) Combined With Seven Adjuvants in Healthy HIV-1 Uninfected Individuals

HIV Infections

United States
University of Manitoba
Canadian Institutes of Health Research (CIHR)

Completed

Can Cholesterol Lowering Drugs Influence Circulating Omega-3 Fatty Acid Levels

Hypercholesterolemia | Hyperlipidemia

Canada
University of Washington
Novartis; Institute for Prostate Cancer Research (IPCR)

Not yet recruiting

Vorinostat and 177Lu-PSMA-617 for the Treatment of PSMA-Low Metastatic Castration-Resistant Prostate Cancer

Castration-Resistant Prostate Carcinoma | Stage IVB Prostate Cancer AJCC v8 | Metastatic Prostate Adenocarcinoma

United States
Baylor College of Medicine
George Washington University

Completed

Safety and Immunogenicity of the Na-APR-1 Hookworm Vaccine in Healthy Adults

Hookworm Infection | Hookworm Disease

United States
Biogen

Completed

Simvastatin as an Add-on Treatment to Interferon-beta-1a for the Treatment of Relapsing-Remitting Multiple Sclerosis (SIMCOMBIN)

Multiple Sclerosis

Denmark
Aya Sabry Mohamed Mohamed

Recruiting

Assessing The Role Of Intravenous Lipid Emulsion As A Life Saving Therapy In Pesticides Toxicity

Pesticide Poisoning

Egypt
Chong Kun Dang Pharmaceutical

Completed

CKD-346 DDI Study(Telmisartan/S-Amlodipine, Rosuvastatin)

Hypertension | Hyperlipidemia

Korea, Republic of
Ludwig Institute for Cancer Research
Bristol-Myers Squibb

Terminated

Phase I Study of Intralesional Bacillus Calmette-Guerin (BCG) Followed by Ipilimumab in Advanced Metastatic Melanoma

Metastatic Melanoma

Australia
Peking University First Hospital
Peking University Cancer Hospital & Institute

Terminated

Dexamethasone, Flurbiprofen Axetil and Long-term Survival After Lung Cancer Surgery

Carcinoma, Non-Small-Cell Lung | Surgery | Dexamethasone | Long-term Effects Secondary to Cancer Therapy in Adults | Flubiprofen Axetil

China
GlaxoSmithKline

Completed

Effects of Dabrafenib on the Single Dose Pharmacokinetics (PK) of Rosuvastatin and Midazolam

Cancer

Spain, United States
AstraZeneca

Completed

Study to Evaluate the 2-Way Interaction Between Multiple Doses of Epanova™ and a Single Dose of Rosuvastatin (Crestor®) (ECLIPSEIII)

Hypertriglyceridemia

United States
Washington State University
National Center for Complementary and Integrative Health (NCCIH)

Completed

Assessing Goldenseal-drug Interactions Using a Probe Drug Cocktail Approach

Interaction Drug Food

United States
Université de Sherbrooke

Completed

Activation of Brown Adipose Tissue Thermogenesis in Humans Using Formoterol Fumarate (GB10) (GB10)

Obesity | Type 2 Diabetes

Canada
University College, London
National University Hospital, Singapore; Singapore Clinical Research Institute...

Completed

Two-month Regimens Using Novel Combinations to Augment Treatment Effectiveness for Drug-sensitive Tuberculosis (TRUNCATE-TB)

Tuberculosis, Pulmonary

Singapore, Uganda, Thailand, Indonesia, Philippines, India
Reata, a wholly owned subsidiary of Biogen
Covance

Completed

A Clinical Drug-Drug Interaction (DDI) Study With Omaveloxolone

Healthy Adult Subjects

United States
Celgene

Completed

A Study to Evaluate Potential Cytochrome P450 and Transporter Protein Interactions With CC-99677

Healthy Volunteer

United Kingdom
Vanderbilt University Medical Center
UMC Utrecht

Completed

Decision Support for Intraoperative Low Blood Pressure

Hypotension

United States

Search clinical trials for: Glucopyranosyl Lipid Adjuvant-Stable Emulsion (GLA-SE)

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