Search clinical trials for: Glycerol Phenylbutyrate 1100 MG/ML [Ravicti]

Total 181 results

Weill Medical College of Cornell University
Children's Hospital Colorado; SLC6A1 Connect; STXBP1 Foundation; Clara Inspired; University... and other collaborators

Enrolling by invitation

Phenylbutyrate for Monogenetic Developmental and Epileptic Encephalopathy

Developmental and Epileptic Encephalopathy | STXBP1 Encephalopathy With Epilepsy, SLC6A1 Neurodevelopmental Disorder

United States
Kaplan Medical Center
Weizmann Institute of Science

Recruiting

Glycerol-Phenylbutyrate Treatment in Children With MCT Mutation (Allan-Herndon- Dudley Syndrome)

Monocarboxylate Transporter 8 Deficiency

Israel
Technical University of Munich

Recruiting

PROFIL Study to Investigate the Effect of GPB on NfL Levels in Patients With Corticobasal Syndrome (CBS) (PROFIL)

Corticobasal Syndrome (CBS)

Germany
Horizon Therapeutics, LLC

Completed

A Study of the Safety, Efficacy and Pharmacokinetics of Glycerol Phenylbutyrate in Pediatric Subjects Under 2 Years of Age With Urea Cycle Disorders

Urea Cycle Disorder

United States, Canada
Horizon Therapeutics, LLC

Completed

Study of Glycerol Phenylbutyrate & Sodium Phenylbutyrate in Phenylbutyrate Naïve Patients With Urea Cycle Disorders (UCDs)

Urea Cycle Disorder

United States, Spain, Italy, Switzerland
University of Pittsburgh
Horizon Pharma Ireland, Ltd., Dublin Ireland

Completed

Use of Ravicti™ in Patients With MCAD Deficiency With the 985A>G (K304E) Mutation

Medium-chain Acyl-CoA Dehydrogenase (MCAD) Deficiency

United States
Horizon Therapeutics, LLC

Completed

To Evaluate the Safety of Long-term Use of HPN-100 in the Management of Urea Cycle Disorders (UCDs)

Urea Cycle Disorders

United States, Canada
National Jewish Health
Johns Hopkins University; Children's Hospital of Philadelphia; University of... and other collaborators

Terminated

Glycerol Phenylbutyrate Corrector Therapy For CF (Cystic Fibrosis) (GPBA)

Cystic Fibrosis

United States
Robert Squires, Jr.

No longer available

Expanded Access Protocol for an Intermediate Size Population - RAVICTI for Byler Disease

Byler Disease
Horizon Pharma Ireland, Ltd., Dublin Ireland

Completed

Study of the Safety, Pharmacokinetics and Efficacy of HPN-100, in Pediatric Subjects With Urea Cycle Disorders (UCDs)

Urea Cycle Disorders

United States
University of Colorado, Denver

Completed

Phenylbutyrate Response as a Biomarker for Alpha-synuclein Clearance From the Brain

Parkinson's Disease

United States
University of Pittsburgh

No longer available

Transition From Buphenyl to RAVICTI for the Therapy of Byler Disease

Byler Disease
Horizon Pharma Ireland, Ltd., Dublin Ireland

Completed

Efficacy and Safety of HPN-100 for the Treatment of Adults With Urea Cycle Disorders

Urea Cycle Disorders

United States, Canada
Horizon Pharma Ireland, Ltd., Dublin Ireland

Completed

Study of the Safety of HPN (Hyperion)-100 for the Long-Term Treatment of Urea Cycle Disorders (Treat UCD)

Urea Cycle Disorders

United States, Canada
Horizon Pharma Ireland, Ltd., Dublin Ireland

Completed

Study of the Safety and Tolerability of HPN-100 Compared to Sodium Phenylbutyrate in Children With Urea Cycle Disorders

Urea Cycle Disorders

United States, Canada
Novo Nordisk A/S

Completed

A Research Study of How a New Medicine NNC0365-3769 (Mim8) Works in the Body of Healthy People

Healthy Volunteers - Haemophilia A

Germany
Adynxx, Inc.

Completed

Study to Evaluate Safety/Efficacy of a Single Pre-Op Dose of AYX1 Injection to Treat Pain After Knee Replacement Surgery

Postsurgical Pain

United States
Ixchelsis Limited

Completed

Relative Bioavailability Study of IX-01 Caplet Versus Aqueous Dispersion and Food Effect of the Caplet in Healthy Males (IX-0106 RBA)

Healthy

United States
AstraZeneca

Completed

A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD5718 After Single and Multiple Ascending Dose Administration to Healthy Male Subjects

Cardiovascular Disease | Healthy Male Subjects

United Kingdom
Massachusetts General Hospital
National Heart, Lung, and Blood Institute (NHLBI); National Institutes of Health... and other collaborators

Recruiting

Impact of Intravenous Iron Repletion On Mechanisms of Exercise InTolerance in HFpEF (IRONMET-HFpEF) (IRONMETHFpEF)

Iron-deficiency | Heart Failure With Preserved Ejection Fraction

United States
Boehringer Ingelheim

Terminated

Dose Escalation Study of BIBF 1120 in Combination With Carboplatin and PLD in Relapsed Ovarian Cancer (OC)

Ovarian Neoplasms

Japan
PT Bernofarm
PT Pharma Metric Labs

Completed

Bioequivalence Study of Cefixime Trihydrate Dry Syrup in Indonesia Healthy Volunteers

Drug Use

Indonesia
Boehringer Ingelheim

Completed

BIBF 1120 + Carboplatin/Pegylated Liposomal Doxorubicin (PLD) in Patients With Advanced Ovarian Cancer, Fallopian Tube Carcinoma or Primary Peritoneal Cancer

Ovarian Neoplasms | Peritoneal Neoplasms

Spain
University of Michigan Rogel Cancer Center

Withdrawn

Abemaciclib With or Without Atezolizumab in Metastatic Castration Resistant Prostate Cancer

Prostate Cancer

United States
Hugo W. Moser Research Institute at Kennedy Krieger...

Recruiting

Epidiolex® for Anxiety in Pediatric Epilepsy

Epilepsy | Anxiety

United States
IRCCS Azienda Ospedaliero-Universitaria di Bologna

Unknown

Enoxaparin in COVID-19 Moderate to Severe Hospitalized Patients (INHIXACOV19)

COVID-19

Italy
Alvotech Swiss AG

Completed

Comparative Safety, Tolerability, Pharmacokinetic Study of AVT02 (100MG/ML) and Humira (100MG/ML) in Healthy Volunteers (ALVOPAD)

Healthy Volunteers

Australia
BioCryst Pharmaceuticals

Terminated

Study of Forodesine Hydrochloride in Patients With Relapsed/Refractory Precursor T-Lymphoblastic Leukemia/Lymphoma Who Have Failed Two or More Prior Treatment Regimens

Lymphoma | Leukemia

United States
Pfizer

Completed

A 2-part Study to Assess Local Tolerability, Safety and Pharmacokinetics of Ceftaroline in Healthy Subjects

Healthy

United Kingdom
Bausch Health Americas, Inc.

Completed

Study to Evaluate the Safety and Efficacy of VIRAZOLE® in Hospitalized Adult Participants With Respiratory Distress Due to COVID-19

COVID19

Greece, Mexico
Oslo University Hospital
University of Oslo; Norwegian University of Science and Technology; St. Olavs... and other collaborators

Completed

Effect of the Interleukin-6 Receptor Antagonist Tocilizumab in Non-ST Elevation Myocardial Infarction

Non-ST Elevation Myocardial Infarction

Norway
Bausch Health Americas, Inc.

Withdrawn

Study to Evaluate the Safety and Efficacy of VIRAZOLE® in Hospitalized Adult Participants With Respiratory Distress Due to COVID-19

COVID19
University of California, Los Angeles
Merck Sharp & Dohme LLC

Active, not recruiting

Applying Best Clinical Practices to Patients at High Risk of Respiratory Complications

Obstructive Sleep Apnea | Respiratory Complication

United States
Shanghai Henlius Biotech

Active, not recruiting

A Clinical Trial Comparing HLX10 With Placebo Combined With Chemotherapy (Cisplatin + 5-fu) in the First-line Treatment of Locally Advanced/Metastatic Esophageal Squamous Cell Carcinoma (ESCC)

Esophageal Squamous Cell Carcinoma

China
Ain Shams University

Completed

Preemptive and Postoperative Intra-articualr Injection of Levobupivacaine and Tramadol

Pain After Knee Arthroscop

Egypt
UCB Pharma SA

Completed

Comparison of Brivaracetam Oral Tablet (10 mg, 50 mg, 75 mg and 100 mg) and Brivaracetam Injection (100 mg) in Healthy Volunteers

Healthy Volunteers

Netherlands
Radboud University Medical Center

Completed

The Immunomodulatory Effect of Sugammadex After Total Hip Replacement Surgery Under Neuraxial Anaesthesia: a Pilot Study (MAGIC)

Osteoarthritis, Hip | Innate Inflammatory Response

Netherlands
Zealand University Hospital
University of Copenhagen

Active, not recruiting

Cannabidiol for Prevention of Chemotherapy-induced Peripheral Neuropathy (CINCAN-2)

Chemotherapy-induced Peripheral Neuropathy

Denmark
Stanford University

Completed

Effect of Tranexamic Acid on Postoperative Bleeding Following Sinus and Nasal Surgery

Chronic Sinusitis | Nasal Obstruction | Turbinate; Hypertrophy Mucous Membrane | Deviated Nasal Septum - Congenital | Deviated Nasal Septum Acquired

United States
Shanghai Henlius Biotech

Active, not recruiting

A Clinical Study to Compare the Efficacy, Safety and Immunogenicity of HLX04 and Bevacizumab Combined XELOX or mFOLFOX6 in the First-line Treatment of mCRC

Metastatic Colorectal Cancer (mCRC)

China
Jazz Pharmaceuticals
Evidilya S.r.l.

Not yet recruiting

Epidyolex® in Lennox Gastaut and Dravet Syndrome: an Observational Study in ITALY (EpiTALY)

Dravet Syndrome | Lennox Gastaut Syndrome

Italy
Hoffmann-La Roche

Recruiting

A Study Of The Efficacy, Safety, And Pharmacokinetics Of The Port Delivery System With Ranibizumab In Chinese Patients With Neovascular Age-Related Macular Degeneration

Neovascular Age Related Macular Degeneration | nAMD

China
dr. P. Noordzij
Pharmacosmos A/S

Recruiting

Intravenous Iron to Treat Postoperative Anemia in Older Cardiac Surgery Patients (AGE-ANEMIA)

Iron Deficiency Anemia

Netherlands
University of Michigan
Food and Drug Administration (FDA)

Completed

Correlation of Mesalamine Pharmacokinetics With Local Availability

Local Drug Concentration in Gastrointestinal Tract

United States
TrippBio, Inc.

Not yet recruiting

A Relative Bioavailability Study With a Novel PanCytoVir™ Oral Suspension (100 mg/ml)

Relative Bioavailability
Baylor College of Medicine
Pharmacosmos Therapeutics, Inc.

Recruiting

IV Iron Trial for Anemia Related to Uterine Bleeding in Female Patients Presenting to the Emergency Department

Anemia, Iron Deficiency | Uterine Bleeding

United States
Pharmacosmos A/S
CRO Max Neeman

Completed

A Prospective, Comparative Study of Intravenous Iron Isomaltoside 1000 (Monofer®) Administered by Infusions to Non-Anaemic Patients Undergoing Elective or Sub-Acute Coronary Artery Bypass Graft, Valve Replacement or a Combination Thereof (CABG-01)

Non-anaemic Patients Undergoing Cardiac Surgery

Denmark
University of Washington
National Center for Complementary and Integrative Health (NCCIH)

Withdrawn

Effects of Echinacea in Children

Upper Respiratory Infections
Bausch Health Americas, Inc.

Completed

Safety, Tolerability, and Pharmacokinetics of Inhaled Virazole Administered Via Air-Jet Nebulizer in Healthy Volunteers

Healthy

Canada
Gruppo Oncologico Italiano di Ricerca Clinica

Recruiting

Atezolizumab Versus Placebo for the Adjuvant Treatment of Malignant Pleural Mesothelioma (Atezomeso) (AtezoMeso)

Mesotheliomas Pleural

Italy

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