Search clinical trials for: HMPL-453

Total 6957 results

Northwestern University
National Cancer Institute (NCI)

Withdrawn

SGT-53, Carboplatin, and Pembrolizumab for the Treatment of Metastatic Triple Negative Inflammatory Breast Cancer

Anatomic Stage IV Breast Cancer AJCC v8 | Prognostic Stage IV Breast Cancer AJCC v8 | Metastatic Triple-Negative Breast Carcinoma | Breast Inflammatory Carcinoma

United States
National Institute of Allergy and Infectious Diseases...

Completed

Evaluating the Safety and Drug Interaction of PA-824, an Investigational Tuberculosis Medication, Together With Efavirenz, Ritonavir-Boosted Lopinavir, or Rifampin

Tuberculosis

United States
University of Virginia
Rutgers University; Haydom Lutheran Hospital

Not yet recruiting

Precision Rifampin Trial for Personalized Dosing (P-RIF)

Tuberculosis
Hospital Universitari Vall d'Hebron Research Institute
Radboud University Medical Center; University Medical Center Groningen; Centro... and other collaborators

Not yet recruiting

Rifampicin at High Dose for Difficult-to-Treat Tuberculosis (RIAlta)

Tuberculosis

Spain, Netherlands, Paraguay, Portugal
Suzhou Yabao Pharmaceutical R&D Co., Ltd.

Completed

A Drug Interaction Study of SY-004 Capsules in Healthy Subjects

Type 2 Diabetes

China
Pfizer

Completed

Study to Evaluate the Effect of Repeat-Dose Rifampin on the Pharmacokinetics (PK) of PF-06651600

Healthy Volunteers

Belgium
Hospices Civils de Lyon

Completed

Staphylococcal Acute Post-Operative PJI Treated With 'DAIR' And Impact Of Rifampin (IPASTAPH)

Bone and Joint Infection | Antibiotic Resistant Staphylococcus Aureus Infection

France
Idorsia Pharmaceuticals Ltd.

Completed

A Study in Healthy Male Subjects to Investigate Whether Administration of Rifampicin Can Affect the Fate of Clazosentan in the Body of Clazosentan

Healthy Subjects

Netherlands
PTC Therapeutics

Completed

Effects of Rifampin on the Pharmacokinetics of Ataluren

Healthy

Canada
Boehringer Ingelheim

Completed

DDI Strong CYP3A4 Inducer

Healthy

Germany
Drexel University

Completed

Immune Activation and Drug Absorption in HIV-Infected Patients

HIV Infection

United States
Tibotec Pharmaceuticals, Ireland

Completed

TMC278-TiDP6-C215: A Clinical Trial in Treatment Naive HIV-subjects Patients Comparing TMC278 to Efavirenz in Combination With 2 Nucleoside/Nucleotide Reverse Transcriptase Inhibitors

HIV Infections | HIV-1

United States, France, United Kingdom, China, Belgium, Germany, Spain, Chile, Mexico, Portugal, Costa Rica, Panama, South Africa, Canada, Brazil, Puerto Rico, Russian Federation, Thailand, Australia, India
Bayer

Completed

Effect of Rifampin on the Pharmacokinetics of BAY73-4506

Neoplasms

United States
Astellas Pharma Europe B.V.
Medivation, Inc.

Completed

A Study to Evaluate How a Drug That Alters Liver Enzymes (Rifampin) Affects the Metabolism of Enzalutamide in Men

Healthy Subjects | Drug-Drug Interaction (DDI) | Pharmacokinetics of Enzalutamide

Germany
All India Institute of Medical Sciences, New Delhi
National AIDS Control Organisation

Completed

Efficacy and Safety of Concomitant Use of Nevirapine and Rifampicin With HIV-TB ("NVP")

HIV/TB Co-infection

India
University of Oulu

Completed

Effects of Pregnane X Receptor (PXR) Activation on Human Glucose, Lipid and Hormone Homeostasis (Rifa-2)

Glucose Metabolism

Finland
Centers for Disease Control and Prevention

Completed

High Dose Rifapentine Pharmacokinetics, Tolerability and Safety Dosage Rifapentine for Treatment of Tuberculosis (TBTC-29PK)

Smear Positive, Pan-sensitive, Pulmonary Tuberculosis

United States, South Africa, Uganda
Mahidol University

Unknown

Colistin Plus Rifampicin in MDR P. Aeruginosa and A. Baumanii

Drug Safety

Thailand
University of Oulu

Completed

Pregnane X Receptor (PXR) Agonist Rifampicin Effects on Glucose, Lipid and Hormone Homeostasis

Glucose Tolerance

Finland
Glaxo Wellcome

Completed

Safety and Effectiveness of Lamivudine When Given Once a Day Versus Twice a Day in Combination With Other Anti-HIV Drugs in HIV-Infected Adults Who Have Never Received Anti-HIV Drugs

HIV Infections

United States, Canada, Argentina, Brazil, Puerto Rico
Dupont Merck

Completed

A Study of Efavirenz in HIV-Infected Patients Who Have Never Taken Anti-HIV Drugs

HIV Infections

United States
Neurocrine Biosciences

Completed

Study to Assess the Efficacy and Safety of NBI-1065845 in Adults With Major Depressive Disorder (MDD) (SAVITRI)

Major Depressive Disorder

United States, Czechia, Bulgaria, Poland, Slovakia, Sweden
Akros Pharma Inc.

Completed

Study to Evaluate the Efficacy and Safety of JTE-451 in Subjects With Moderate to Severe Plaque Psoriasis (IMPACT-PS)

Skin Diseases | Psoriasis | Plaque Psoriasis

United States, Canada, Poland
Cytokinetics

Completed

Pharmacokinetics and Safety Study of Omecamtiv Mecarbil in Healthy Japanese Adults

Healthy Volunteer

Japan
Samuel Lunenfeld Research Institute, Mount Sinai...

Terminated

The Response Patterns to the Electrical Stimulation of Epidural Catheters With Varying Pulse Widths in Term Pregnant Women

Labor Pain

Canada
Shenzhen SiBiono GeneTech Co.,Ltd

Unknown

p53 Gene Therapy for Head and Neck Malignant Tumors in Advanced Stage

Neoplasms

China
Boehringer Ingelheim

Completed

Effects of Steady-state Efavirenz 600 mg QD (Sustiva®) on Tipranavir Concentration at Steady-state in Healthy Adult Volunteers

Healthy
Leiden University Medical Center
Radboud University Medical Center; University Medical Center Groningen; Erasmus... and other collaborators

Recruiting

Rifampicin Combination Therapy Versus Monotherapy for Staphylococcal Prosthetic Joint Infection (RiCOTTA)

Prosthetic-joint Infection | Infection Hip | Infection; Knee, Joint

Netherlands
Nanjing Sanhome Pharmaceutical, Co., Ltd.

Not yet recruiting

The Effect of Itraconazole and Rifampicin on the Pharmacokinetics of SH-1028

Healthy Male Volunteers

China
National Institute of Allergy and Infectious Diseases...
AIDS Clinical Trials Group

Completed

Safety, Tolerability, and Blood Levels of Ritonavir-Boosted Atazanavir and Rifampin When Taken Together in HIV Uninfected Adults

HIV Infections | Tuberculosis

United States
Ascletis Pharmaceuticals Co., Ltd.

Completed

Study to Evaluate the Effects of Itraconazole and Rifampin on the Pharmacokinetics of ASC40 in Healthy Subjects

Healthy

China
Odonate Therapeutics, Inc.

Terminated

The Effect of Tesetaxel on the QTc Interval and the Effect of Food, Itraconazole, and Rifampin on Tesetaxel Pharmacokinetics in Patients With Advanced Solid Tumors

Advanced Solid Tumors

United States
Bayer

Completed

COPANLISIB (BAY80-6946) Drug-drug Interaction and Cardiovascular Safety Study in Advanced Solid Tumor and Non-Hodgkin's Lymphoma Patients

Medical Oncology

Canada, United States
Janssen Research & Development, LLC

Completed

A Study to Assess the Effects of Itraconazole and Rifampicin on the Single-Dose Pharmacokinetics of JNJ-53718678 in Healthy Adults

Healthy

United States
Vanderbilt University

Completed

Investigation of the Efficacy of Antibiotics on Pulmonary Sarcoidosis (CLEAR Lung)

Pulmonary Sarcoidosis | Lung Function

United States
LG Life Sciences

Completed

Pharmacokinetic Drug Interaction Study in Healthy Male Subjects

Healthy Male Volunteers

Korea, Republic of
Sanofi

Terminated

LEVOS - Levofloxacin and Rifampicin Therapy in the Treatment of OsteoArticular Prothethic Infection

Infection

France
Massachusetts General Hospital

Not yet recruiting

Pragmatic Amiodarone Trial to Reduce Postoperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery (PATRONUS)

Atrial Fibrillation | Surgery, Cardiac
Groupe Hospitalier Pitie-Salpetriere

Completed

Modeling of Amiodarone Effect on Heart Rate Control in Critically Ill Patients With Atrial Tachyarrhythmias (AMIRA)

Atrial Fibrillation | Atrial Tachycardia
Prism Pharmaceuticals

Withdrawn

A Randomized, Placebo-Controlled, Double-Blind, Double Dummy Trial To Determine The Relative Effect Of Pm101 Versus Placebo And Amiodarone IV On Blood Pressure In Subjects With Stable Congestive Heart Failure

Blood Pressure
Texas Cardiac Arrhythmia Research Foundation
Stanford University; Case Western Reserve University; University of Kansas; California... and other collaborators

Completed

Effect of Amiodarone on the Procedure Outcome in Long-standing Persistent Atrial Fibrillation Undergoing Pulmonary Vein Antral Isolation (SPECULATE)

Atrial Fibrillation

United States
Kevin W Hatton, MD, PhD

Terminated

Repeated Amiodarone Dosing In Cardiac surgicaL Procedures (RADICAL)

Atrial Fibrillation

United States
Centre Hospitalier Universitaire de Saint Etienne
Ministry of Health, France

Terminated

Comparison of Treatment of Atrial Fibrillation (AF) Between Surgical Ultrasonic Technology or Drug Therapy for Patients With AF Requiring Mitral Valve Surgery (EPICAF)

Atrial Fibrillation | Mitral Valvulopathy

France
Aarhus University Hospital

Unknown

Amiodarone Prophylaxis for Atrial Fibrillation in Patients Undergoing Surgery for Lung Cancer (PASCART)

Atrial Fibrillation

Denmark
University of Aarhus

Completed

Reduction of Atrial Fibrillation Study in Patients Undergoing Coronary Artery Bypass Grafting. (RASCABG 1 Study)

Atrial Fibrillation | Coronary Artery Bypass Grafting

Denmark
Hutchison Medipharma Limited

Recruiting

A Phase 3 Study to Evaluate Surufatinib Plus Toripalimab in the Treatment of Advanced Neuroendocrine Carcinoma

Advanced Neuroendocrine Carcinoma

China
AbbVie

Completed

A Study to Evaluate the Efficacy and Safety of ABT-493/ABT-530 in Adults With Chronic Hepatitis C Virus (HCV) Genotype 2 Infection (ENDURANCE-2)

Chronic Hepatitis C Virus (HCV) Infection
ViRx

Completed

ABT-378/Ritonavir and Efavirenz in HIV-Infected Patients Who Have Taken More Than One Protease Inhibitor in the Past

HIV Infections

United States
Indiana University
Purdue University; Indiana University Health

Completed

Prevention of Atrial Fibrillation Following Esophagectomy

Atrial Fibrillation | Esophagectomy

United States
Indiana University
Purdue University

Completed

Prevention of Atrial Fibrillation Following Noncardiac Thoracic Surgery

Atrial Fibrillation

United States

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