Search clinical trials for: Investigational drug

Total 256398 results

University of Washington

Completed

Nivolumab and Ipilimumab and Stereotactic Body Radiation Therapy in Treating Patients With Salivary Gland Cancers

Metastatic Malignant Neoplasm in the Bone | Salivary Gland Carcinoma | Metastatic Malignant Neoplasm in the Lung | Stage IV Major Salivary Gland Cancer AJCC v8 | Stage IVA Major Salivary Gland Cancer AJCC v8 | Stage IVB Major Salivary Gland Cancer AJCC v8 | Stage IVC Major Salivary Gland Cancer...

United States
Vertex Pharmaceuticals Incorporated

Completed

A Study of VX-121 Combination Therapy in Participants With Cystic Fibrosis (CF) Who Are Homozygous for F508del, Heterozygous for F508del and a Gating (F/G) or Residual Function (F/RF) Mutation, or Have At Least 1 Other Triple Combination Responsive (TCR) CFTR Mutation and No F508del Mutation

Cystic Fibrosis

United States, United Kingdom, Belgium, Netherlands, France, Denmark, Israel, New Zealand, Australia, Ireland, Sweden, Canada, Germany, Poland, Switzerland, Italy, Austria, Hungary, Greece, Norway
Mohammed Najeeb Al Hallak
National Cancer Institute (NCI)

Completed

Gemcitabine, Nab-paclitaxel and KPT-330 in Advanced Pancreatic Cancer

Acinar Cell Adenocarcinoma of the Pancreas | Duct Cell Adenocarcinoma of the Pancreas | Stage IV Pancreatic Cancer

United States
CTI BioPharma
Covance

Completed

Drug-Interaction Study to Evaluate the Effect of Rifampin, a Potent CYP3A4 Inducer, on the Systemic Exposure of Pacritinib in Healthy Subjects

Healthy Subjects

United States
University of Washington
Genentech, Inc.; Oncotelic Therapeutics, Inc.

Withdrawn

OT-101 in Combination With Atezolizumab for the Treatment of Metastatic or Recurrent Non-Small Cell Lung Cancer

Metastatic Lung Non-Small Cell Carcinoma | Stage IV Lung Cancer AJCC v8 | Recurrent Lung Non-Small Cell Carcinoma

United States
Biokosmes Srl
Opera CRO, a TIGERMED Group Company

Completed

Open-label Trial Evaluating Four Oral Hygiene Regimens Using a Manual Toothbrush, Toothpaste, and Mouthwash

Oral Hygiene | Dental Plaque | Toothbrushing

Italy
Yuzuncu Yıl University

Active, not recruiting

Comparison of the Efficacy of Boric Acid Mouthwashes in Different Concentrations

Impacted Third Molar Tooth

Turkey
Jonsson Comprehensive Cancer Center
National Cancer Institute (NCI)

Terminated

Ipilimumab, Nivolumab, and Talimogene Laherparepvec Before Surgery in Treating Participants With Localized, Triple-Negative or Estrogen Receptor Positive, HER2 Negative Breast Cancer-deleted

Anatomic Stage I Breast Cancer AJCC v8 | Anatomic Stage IA Breast Cancer AJCC v8 | Anatomic Stage IB Breast Cancer AJCC v8 | Anatomic Stage II Breast Cancer AJCC v8 | Anatomic Stage IIA Breast Cancer AJCC v8 | Anatomic Stage IIB Breast Cancer AJCC v8 | Anatomic Stage IIIA Breast Cancer AJCC v8 | Anatomic... and other conditions

United States
The George Institute
Sunnybrook Health Sciences Centre; Imperial College London

Completed

Selective Decontamination of the Digestive Tract in Intensive Care Unit Patients (SuDDICU)

Sepsis | Critical Illness | Septic Shock | Ventilator Associated Pneumonia

Australia, Canada, United Kingdom
Cambridge University Hospitals NHS Foundation Trust
University of Cambridge

Completed

INvestigating the Lowest Threshold of Vascular bENefits From LDL Lowering With a PCSK9 InhibiTor in healthY Volunteers

Cardiovascular Diseases | Atherosclerosis

United Kingdom
Breath of Life International Pharma Ltd

Completed

A Phase I Open Label Study to Assess PK and Safety of Plant Cannabis Extract

Healthy

Israel
Vanderbilt University Medical Center
Thomas Jefferson University; Medtronic; The Cooper Health System; Valley Health...

Completed

Perioperative Antibiotic Therapy to Prevent Cardiac Implantable Electronic Device Infections. (ENVELOPE)

Syncope | Sick Sinus Syndrome | Complete Heart Block | Chronic Systolic Heart Failure

United States
University of Cincinnati

Completed

Darunavir/Ritonavir and Rosuvastatin Pharmacokinetic Study

HIV Infections

United States
Stanford University

Completed

Yttrium-90 (Y90) Glass Microspheres PET/CT in Imaging Patients With Liver Tumors

Primary Malignant Liver Neoplasm

United States
National Institute of Allergy and Infectious Diseases...

Completed

A Comparison of Three Drug Combinations Containing Clarithromycin in the Treatment of Mycobacterium Avium Complex (MAC) Disease in Patients With AIDS

HIV Infections | Mycobacterium Avium-intracellulare Infection

United States, Tanzania
National Institute of Allergy and Infectious Diseases...

Completed

A Study to Compare the Effectiveness of Different Anti-HIV Drug Regimens in Keeping Levels of HIV in the Blood as Low as Possible

HIV Infections

United States
National Cancer Institute (NCI)

Completed

Vorinostat and Radiation Therapy Followed by Maintenance Therapy With Vorinostat in Treating Younger Patients With Newly Diagnosed Diffuse Intrinsic Pontine Glioma

Gliosarcoma | Anaplastic Oligoastrocytoma | Anaplastic Astrocytoma | Diffuse Intrinsic Pontine Glioma

United States, Canada, Australia
Thomas Hope

Completed

Gallium-68 PSMA-11 Positron Emission Tomography (PET) Imaging in Patients With Biochemical Recurrence

Prostate Cancer

United States
Burnasyan Federal Medical Biophysical Center

Completed

An Open Randomized Study of Dalargin Efectiveness in Combination With Leitragin Drug in Patients With Severe and Critical Manifestations of SARS-COVID-19

Pneumonia | Septic Shock | Hypoxemia | Acute Respiratory Insufficiency | Acute Respiratory Tract Infection

Russian Federation
University of Hawaii
Oxford University Clinical Research Unit, Vietnam; Hospital for Tropical Diseases... and other collaborators

Completed

Hepatic Safety of Raltegravir Versus Efavirenz as HIV Therapy for Patients With HIV and HCV Coinfection

HIV Infection | Hepatitis C, Chronic

Vietnam
CareFusion

Completed

Test for Pre Operative Skin Preparations

Topical Antisepsis

United States
Ichnos Sciences SA
Glenmark Pharmaceuticals S.A.

Terminated

Study of ISB 1302 (CD3 Bispecific Ab) in HER2-positive Metastatic Breast Cancer

Breast Cancer

United States
University of California, San Francisco

Completed

Gallium-68 PSMA-11 PET in Intermediate to High-risk Preprostatectomy Patients (PSMA PreRP)

Prostate Cancer

United States
Jonsson Comprehensive Cancer Center

Completed

Fluorine F 18 Clofarabine PET/CT in Imaging Patients With Autoimmune or Inflammatory Diseases

Rheumatoid Arthritis | Systemic Lupus Erythematosus | Crohn Disease | Takayasu Arteritis | Autoimmune Disease | Inflammatory Disorder

United States
Assistance Publique - Hôpitaux de Paris

Completed

Pharmacological Interaction of Rifampicin on Clindamycin in Staphylococcic Osteoarticular Infections (DALARI)

Staphylococcal Infections

France
Southwest Oncology Group
National Cancer Institute (NCI)

Terminated

S1300: Pemetrexed Disodium With or Without Crizotinib in Treating Patients With Stage IV Non-Small Cell Lung Cancer That Has Progressed After Crizotinib

Recurrent Non-small Cell Lung Cancer | Stage IV Non-small Cell Lung Cancer | Adenocarcinoma of the Lung | Large Cell Lung Cancer

United States
University of Texas Southwestern Medical Center
Bristol-Myers Squibb; GlaxoSmithKline

Completed

Mechanisms of Lipodystrophy in HIV-Infected Pateints

HIV Infections

United States
National Cancer Institute (NCI)

Withdrawn

Nivolumab or Expectant Observation Following Ipilimumab, Nivolumab, and Surgery in Treating Patients With High Risk Localized, Locoregionally Advanced, or Recurrent Mucosal Melanoma

Cervical Carcinoma | Recurrent Melanoma | Vaginal Carcinoma | Esophageal Carcinoma | Mucosal Melanoma | Mucosal Melanoma of the Head and Neck | Oral Cavity Mucosal Melanoma | Stage II Vulvar Cancer AJCC v7 | Stage III Vulvar Cancer AJCC v7 | Stage IIIA Vulvar Cancer AJCC v7 | Stage IIIB Vulvar Cancer AJCC v7 and other conditions

United States
OHSU Knight Cancer Institute
National Cancer Institute (NCI)

Completed

Sorafenib, Epirubicin, Ifosfamide, and Radiation Therapy Followed By Surgery in Treating Patients With High-Risk Stage II or Stage III Soft Tissue Sarcoma

Sarcoma

United States
AbbVie

Completed

Study to Evaluate the Efficacy and Safety of ABT-450/Ritonavir/ABT-267 (ABT-450/r/ABT-267) in Japanese Adults With Subgenotype 1b Chronic Hepatitis C Virus (HCV) Infection (GIFT I)

Chronic Hepatitis C Infection
Yongtao Sun, MD, PhD
China Medical University, China; Beijing YouAn Hospital; Zhejiang University; Tang-Du... and other collaborators

Unknown

Early cART and cART in Combination With Autologous HIV-1 Specific Cytotoxic T Lymphocyte (CTL) Infusion in The Treatment of Acute HIV-1 Infected Adults

Acute HIV Infection

China
McGill University
Canadian Institutes of Health Research (CIHR)

Completed

Rifampin Versus Isoniazid for the Treatment of Latent Tuberculosis Infection in Children (P4v9)

Latent Tuberculosis Infection

Canada, Australia, Benin, Brazil, Ghana, Guinea, Indonesia
McGill University
Canadian Institutes of Health Research (CIHR)

Completed

Randomized Clinical Trial Comparing 4RIF vs. 9INH for LTBI Treatment-effectiveness

Latent Tuberculosis Infection

Canada, Australia, Benin, Brazil, Ghana, Indonesia, Guinea, Korea, Republic of, Saudi Arabia
AbbVie

Terminated

A Study to Evaluate the Safety and Efficacy of Ombitasvir/Paritaprevir/r With or Without Dasabuvir and With or Without Ribavirin in Chronic Hepatitis C Virus Genotype 1 or 4 Infected Adults With Successfully Treated Early Stage Hepatocellular Carcinoma (GEODE - I)

Chronic Hepatitis C Infection
City of Hope Medical Center

Completed

A Pilot Feasibility Study of Oral 5-Fluorocytosine and Genetically-Modified Neural Stem Cells Expressing E.Coli Cytosine Deaminase for Treatment of Recurrent High Grade Gliomas

Recurrent High Grade Glioma | Adult Anaplastic Astrocytoma | Adult Anaplastic Oligodendroglioma | Adult Giant Cell Glioblastoma | Adult Glioblastoma | Adult Gliosarcoma | Adult Mixed Glioma | Recurrent Adult Brain Tumor | Recurrent Grade III Glioma | Adult Brain Tumor | Recurrent Grade IV Glioma | Adult Anaplastic...

United States
ViiV Healthcare
GlaxoSmithKline

Completed

DDI Study of BMS-663068 With Etravirine (ETR) and/or Darunavir (DVR) + Ritonavir (RTV)

Infection, Human Immunodeficiency Virus
Hebei Medical University Fourth Hospital

Completed

Neoadjuvant Chemotherapy With a Combination of Pegylated Liposomal Doxorubicin (Caelyx®) and Paclitaxel in Breast Cancer

Breast Cancer

China
AbbVie

Completed

Ombitasvir/Paritaprevir/Ritonavir and Dasabuvir Co-Administered With Sofosbuvir With and Without Ribavirin in Treatment-Naive HCV Genotype 1-Infected Adults

Chronic Hepatitis C Virus (HCV Infection Genotype 1)
National Cancer Institute (NCI)

Completed

Veliparib With or Without Mitomycin C in Treating Patients With Metastatic, Unresectable, or Recurrent Solid Tumors

Solid Neoplasm

United States
Gilead Sciences

Completed

D/C/F/TAF Versus COBI-boosted DRV Plus FTC/TDF in HIV-1 Infected, Antiretroviral Treatment Naive Adults

HIV Infections | Acquired Immunodeficiency Syndrome

United States, Puerto Rico
Johns Hopkins University
Boehringer Ingelheim

Completed

Pharmacokinetic (PK) Study of Single-dose Rosuvastatin and Tipranavir/Ritonavir in Healthy Subjects

HIV Infections

United States
National Cancer Institute (NCI)

Terminated

Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097, Paclitaxel, and Carboplatin Before Surgery in Treating Patients With Stage II or Stage III Triple-Negative Breast Cancer

Stage IIIA Breast Cancer | Stage IIIB Breast Cancer | Stage IIA Breast Cancer | Stage IIB Breast Cancer | Stage IIIC Breast Cancer | Estrogen Receptor Negative | HER2/Neu Negative | Progesterone Receptor Negative | Triple-Negative Breast Carcinoma

United States
Hospital Clinic of Barcelona

Completed

Study Comparing Two Alternatives of Antiretroviral Therapy as Post-exposure Prophylaxis to HIV-1:FOVIR+EMTRICITABINA + LOPINAVIR/RITONAVIR VS TENOFOVIR+EMTRICITABINA + MARAVIROC (MARAVI-PEP)

HIV Infection

Spain
International Medical Center of Japan
Ministry of Health, Labour and Welfare, Japan

Completed

Comparing the Effectiveness Between Ritonavir Boosted Atazanavir and Efavirenz for the First HIV Treatment

HIV Infection

Japan
University of British Columbia
Boehringer Ingelheim; Abbott; CIHR Canadian HIV Trials Network

Completed

NRTI-Sparing Pilot Study

HIV | Mitochondrial Toxicity

Canada
Boehringer Ingelheim

Completed

Bioavailability of 2 Different Nevirapine Extended Release Formulations Compared to Viramune® in HIV-1 Infected Subjects

HIV Infections
ViiV Healthcare
GlaxoSmithKline

Completed

A Study to Investigate the Safety, Tolerability and Pharmacokinetics of Repeat Dose Administration of Long-Acting GSK1265744 and Long-Acting TMC278 Intramuscular and Subcutaneous Injections in Healthy Adult Subjects

Infection, Human Immunodeficiency Virus

United States
Dexa Medica Group

Completed

Bioequivalence Study of Two Formulations of Perindopril 4 mg Tablet Under Fasting Condition

Healthy

Indonesia
Mutual Pharmaceutical Company, Inc.

Completed

Drug-Drug Interaction Study Between Fenofibric Acid and Efavirenz

Healthy
Mutual Pharmaceutical Company, Inc.

Completed

A Drug-Drug Interaction Study Between Fenofibric Acid and Efavirenz

Healthy

United States

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