- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04376268
Comparison of the Efficacy of Boric Acid Mouthwashes in Different Concentrations
August 20, 2023 updated by: levent Cigerim, Yuzuncu Yıl University
Comparison of the Efficacy of Boric Acid Mouthwashes in Different Concentrations in the Lower Third Molar Surgery in the Postoperative Period
Surgical removal of impacted third molars is one of the most frequent procedures carried out in the oral and maxillofacial surgery clinics.
There are a varying range of postoperative complications including pain, edema and swelling.
Antibiotics, analgesics and mouthwashes are usually prescribed for the treatment of these complications.
Patients undergoing impacted third molar surgery are frequently prescribed chlorhexidine mouthwashes with/without benzydamine hydrochloride.
However, there has been a search for alternatives with anti-inflammatory, antibacterial and analgesic properties as part of the oral care routine following surgical removal of impacted third molars.
Thus, this multicenter study was aimed to evaluate the effects of chlorhexidine mouthwashes with different boric acid concentrations (%0.1, %0.5, %1, %1.5, %2 and %2.5), and boric acid mouthwash on the postoperative complications and compared with chlorhexidine mouthwash after the removal of impacted wisdom teeth.
Study Overview
Status
Active, not recruiting
Conditions
Intervention / Treatment
- Drug: Chlorhexidine mouthwash
- Procedure: Chlorhexidine mouthwash with boric acid (0.1%)
- Procedure: Chlorhexidine mouthwash with boric acid (0.5%)
- Procedure: Chlorhexidine mouthwash with boric acid (1%)
- Procedure: Chlorhexidine mouthwash with boric acid (1.5%)
- Procedure: Chlorhexidine mouthwash with boric acid (2%)
- Procedure: Chlorhexidine mouthwash with boric acid (2.5%)
- Procedure: Boric acid mouthwash (2%)
Study Type
Interventional
Enrollment (Actual)
80
Phase
- Phase 4
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
-
Van, Turkey, 65080
- Van Yuzuncu Yil University, Faculty of Dentistry
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 40 years (Adult)
Accepts Healthy Volunteers
No
Description
Inclusion Criteria:
- absence of any systemic disease
- having impacted mandibular third molar teeth in a similar position
- absence of allergy to any of the drugs used in the study,
- absence of pregnancy/lactating state,
- no history of any medication use during at least 2 week before the operation.
Exclusion Criteria:
- not regularly coming to the controls,
- not using their medicines regularly
- using any additional medication that may affect the outcome of the study
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Prevention
- Allocation: Randomized
- Interventional Model: Factorial Assignment
- Masking: Quadruple
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: Chlorhexidine gluconate
Chlorhexidine is one of the most commonly used medications after tooth extraction.
It exhibits a wide spectrum of antiseptic, bactericidal and bacteriostatic effects.
|
After anesthesia, the horizontal incision was made with no. 15 scalpel blade and a full thickness mucoperiosteal flap was raised.
In all surgical procedures, bone removal and/or tooth sectioning were performed under abundant irrigation.
Following the extraction, granulation tissues were removed, and post extraction cavity was irrigated with sterile 0.9% saline solution.
After the bleeding was controlled, the mucoperiosteal flap was repositioned by 3.0 silk sutures.
The patients were postoperatively prescribed paracetamol (Parol® 500 mg, Atabay Chemical Industry, Istanbul, Turkey) to use when required with a maximum of 4 doses per day.
Patients were instructed to maintain a soft diet, and refrain from mouth washing, brushing and flossing during the first 24 hour.
They were also instructed to rinse their mouth with 15 ml of mouthwash for 30 seconds, 3 times a day, and continue until the 7th postoperative day.
Other Names:
|
Active Comparator: Chlorhexidine mouthwash with boric acid (0.1%)
Due to its antibacterial properties, boric acid is effective on gram (+) and gram (-) microorganisms such as candida albicans, streptococcus mutans, staphylococcus aureus, enterococcus faecalis, enterococcus faesium, escherichia coli, klebsiella pneumonia and pseudomonas aeruginosa.
With these features, it is used in periodontology, endodontics and restorative therapy as a antiseptic.
|
After anesthesia, the horizontal incision was made with no. 15 scalpel blade and a full thickness mucoperiosteal flap was raised.
In all surgical procedures, bone removal and/or tooth sectioning were performed under abundant irrigation.
Following the extraction, granulation tissues were removed, and post extraction cavity was irrigated with sterile 0.9% saline solution.
After the bleeding was controlled, the mucoperiosteal flap was repositioned by 3.0 silk sutures.
The patients were postoperatively prescribed paracetamol (Parol® 500 mg, Atabay Chemical Industry, Istanbul, Turkey) to use when required with a maximum of 4 doses per day.
Patients were instructed to maintain a soft diet, and refrain from mouth washing, brushing and flossing during the first 24 hour.
They were also instructed to rinse their mouth with 15 ml of mouthwash for 30 seconds, 3 times a day, and continue until the 7th postoperative day.
|
Active Comparator: Chlorhexidine mouthwash with boric acid (0.5%)
Due to its antibacterial properties, boric acid is effective on gram (+) and gram (-) microorganisms such as candida albicans, streptococcus mutans, staphylococcus aureus, enterococcus faecalis, enterococcus faesium, escherichia coli, klebsiella pneumonia and pseudomonas aeruginosa.
With these features, it is used in periodontology, endodontics and restorative therapy as a antiseptic.
|
After anesthesia, the horizontal incision was made with no. 15 scalpel blade and a full thickness mucoperiosteal flap was raised.
In all surgical procedures, bone removal and/or tooth sectioning were performed under abundant irrigation.
Following the extraction, granulation tissues were removed, and post extraction cavity was irrigated with sterile 0.9% saline solution.
After the bleeding was controlled, the mucoperiosteal flap was repositioned by 3.0 silk sutures.
The patients were postoperatively prescribed paracetamol (Parol® 500 mg, Atabay Chemical Industry, Istanbul, Turkey) to use when required with a maximum of 4 doses per day.
Patients were instructed to maintain a soft diet, and refrain from mouth washing, brushing and flossing during the first 24 hour.
They were also instructed to rinse their mouth with 15 ml of mouthwash for 30 seconds, 3 times a day, and continue until the 7th postoperative day.
|
Active Comparator: Chlorhexidine mouthwash with boric acid (1%)
Due to its antibacterial properties, boric acid is effective on gram (+) and gram (-) microorganisms such as candida albicans, streptococcus mutans, staphylococcus aureus, enterococcus faecalis, enterococcus faesium, escherichia coli, klebsiella pneumonia and pseudomonas aeruginosa.
With these features, it is used in periodontology, endodontics and restorative therapy as a antiseptic.
|
After anesthesia, the horizontal incision was made with no. 15 scalpel blade and a full thickness mucoperiosteal flap was raised.
In all surgical procedures, bone removal and/or tooth sectioning were performed under abundant irrigation.
Following the extraction, granulation tissues were removed, and post extraction cavity was irrigated with sterile 0.9% saline solution.
After the bleeding was controlled, the mucoperiosteal flap was repositioned by 3.0 silk sutures.
The patients were postoperatively prescribed paracetamol (Parol® 500 mg, Atabay Chemical Industry, Istanbul, Turkey) to use when required with a maximum of 4 doses per day.
Patients were instructed to maintain a soft diet, and refrain from mouth washing, brushing and flossing during the first 24 hour.
They were also instructed to rinse their mouth with 15 ml of mouthwash for 30 seconds, 3 times a day, and continue until the 7th postoperative day.
|
Active Comparator: Chlorhexidine mouthwash with boric acid (1.5%)
Due to its antibacterial properties, boric acid is effective on gram (+) and gram (-) microorganisms such as candida albicans, streptococcus mutans, staphylococcus aureus, enterococcus faecalis, enterococcus faesium, escherichia coli, klebsiella pneumonia and pseudomonas aeruginosa.
With these features, it is used in periodontology, endodontics and restorative therapy as a antiseptic.
|
After anesthesia, the horizontal incision was made with no. 15 scalpel blade and a full thickness mucoperiosteal flap was raised.
In all surgical procedures, bone removal and/or tooth sectioning were performed under abundant irrigation.
Following the extraction, granulation tissues were removed, and post extraction cavity was irrigated with sterile 0.9% saline solution.
After the bleeding was controlled, the mucoperiosteal flap was repositioned by 3.0 silk sutures.
The patients were postoperatively prescribed paracetamol (Parol® 500 mg, Atabay Chemical Industry, Istanbul, Turkey) to use when required with a maximum of 4 doses per day.
Patients were instructed to maintain a soft diet, and refrain from mouth washing, brushing and flossing during the first 24 hour.
They were also instructed to rinse their mouth with 15 ml of mouthwash for 30 seconds, 3 times a day, and continue until the 7th postoperative day.
|
Active Comparator: Chlorhexidine mouthwash with boric acid (2%)
Due to its antibacterial properties, boric acid is effective on gram (+) and gram (-) microorganisms such as candida albicans, streptococcus mutans, staphylococcus aureus, enterococcus faecalis, enterococcus faesium, escherichia coli, klebsiella pneumonia and pseudomonas aeruginosa.
With these features, it is used in periodontology, endodontics and restorative therapy as a antiseptic.
|
After anesthesia, the horizontal incision was made with no. 15 scalpel blade and a full thickness mucoperiosteal flap was raised.
In all surgical procedures, bone removal and/or tooth sectioning were performed under abundant irrigation.
Following the extraction, granulation tissues were removed, and post extraction cavity was irrigated with sterile 0.9% saline solution.
After the bleeding was controlled, the mucoperiosteal flap was repositioned by 3.0 silk sutures.
The patients were postoperatively prescribed paracetamol (Parol® 500 mg, Atabay Chemical Industry, Istanbul, Turkey) to use when required with a maximum of 4 doses per day.
Patients were instructed to maintain a soft diet, and refrain from mouth washing, brushing and flossing during the first 24 hour.
They were also instructed to rinse their mouth with 15 ml of mouthwash for 30 seconds, 3 times a day, and continue until the 7th postoperative day.
|
Active Comparator: Chlorhexidine mouthwash with boric acid (2.5%)
Due to its antibacterial properties, boric acid is effective on gram (+) and gram (-) microorganisms such as candida albicans, streptococcus mutans, staphylococcus aureus, enterococcus faecalis, enterococcus faesium, escherichia coli, klebsiella pneumonia and pseudomonas aeruginosa.
With these features, it is used in periodontology, endodontics and restorative therapy as a antiseptic.
|
After anesthesia, the horizontal incision was made with no. 15 scalpel blade and a full thickness mucoperiosteal flap was raised.
In all surgical procedures, bone removal and/or tooth sectioning were performed under abundant irrigation.
Following the extraction, granulation tissues were removed, and post extraction cavity was irrigated with sterile 0.9% saline solution.
After the bleeding was controlled, the mucoperiosteal flap was repositioned by 3.0 silk sutures.
The patients were postoperatively prescribed paracetamol (Parol® 500 mg, Atabay Chemical Industry, Istanbul, Turkey) to use when required with a maximum of 4 doses per day.
Patients were instructed to maintain a soft diet, and refrain from mouth washing, brushing and flossing during the first 24 hour.
They were also instructed to rinse their mouth with 15 ml of mouthwash for 30 seconds, 3 times a day, and continue until the 7th postoperative day.
|
Active Comparator: Boric acid mouthwash (2%)
Due to its antibacterial properties, boric acid is effective on gram (+) and gram (-) microorganisms such as candida albicans, streptococcus mutans, staphylococcus aureus, enterococcus faecalis, enterococcus faesium, escherichia coli, klebsiella pneumonia and pseudomonas aeruginosa.
With these features, it is used in periodontology, endodontics and restorative therapy as a antiseptic.
|
After anesthesia, the horizontal incision was made with no. 15 scalpel blade and a full thickness mucoperiosteal flap was raised.
In all surgical procedures, bone removal and/or tooth sectioning were performed under abundant irrigation.
Following the extraction, granulation tissues were removed, and post extraction cavity was irrigated with sterile 0.9% saline solution.
After the bleeding was controlled, the mucoperiosteal flap was repositioned by 3.0 silk sutures.
The patients were postoperatively prescribed paracetamol (Parol® 500 mg, Atabay Chemical Industry, Istanbul, Turkey) to use when required with a maximum of 4 doses per day.
Patients were instructed to maintain a soft diet, and refrain from mouth washing, brushing and flossing during the first 24 hour.
They were also instructed to rinse their mouth with 15 ml of mouthwash for 30 seconds, 3 times a day, and continue until the 7th postoperative day.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Postoperative Pain
Time Frame: Postoperative 1st day
|
In order to evaluate the postoperative pain, a seven-day scheduled pain diary was given to the patients.
To record the level of pain, patients were instructed to rate it on a 10-cm visual analog scales (VAS) was used wherein 0 indicated no pain and 10 indicated the worst pain imaginable.
|
Postoperative 1st day
|
Postoperative Swelling
Time Frame: Postoperatif 1st day
|
Facial swelling was assessed using thread and millimeter ruler and five following measurements were taken: Distance I (from angle of the mandible to labial commissure); Distance II (from angle of the mandible to nasal border); Distance III (from angle of the mandible to external corner of the eye); Distance IV (from angle of the mandible to tragus) and Distance V (from angle of the mandible to soft pogonion).
|
Postoperatif 1st day
|
Postoperative Trismus
Time Frame: Postoperative 1st day
|
The maximum mouth opening (MMO) was measured in millimeters with a caliper from the incisal edge of the right upper and lower incisor teeth.
For evaluation of trismus, the percentage of difference in MMO during postoperative period was calculated by subtracting the preoperative measurement from the postoperative measurement then divided by the preoperative measurement and multiplied by 100.
|
Postoperative 1st day
|
Postoperative Pain
Time Frame: Postoperative 2nd day
|
In order to evaluate the postoperative pain, a seven-day scheduled pain diary was given to the patients.
To record the level of pain, patients were instructed to rate it on a 10-cm visual analog scales (VAS) was used wherein 0 indicated no pain and 10 indicated the worst pain imaginable.
|
Postoperative 2nd day
|
Postoperative Pain
Time Frame: Postoperative 3rd day
|
In order to evaluate the postoperative pain, a seven-day scheduled pain diary was given to the patients.
To record the level of pain, patients were instructed to rate it on a 10-cm visual analog scales (VAS) was used wherein 0 indicated no pain and 10 indicated the worst pain imaginable.
|
Postoperative 3rd day
|
Postoperative Swelling
Time Frame: Postoperatif 3rd day
|
Facial swelling was assessed using thread and millimeter ruler and five following measurements were taken: Distance I (from angle of the mandible to labial commissure); Distance II (from angle of the mandible to nasal border); Distance III (from angle of the mandible to external corner of the eye); Distance IV (from angle of the mandible to tragus) and Distance V (from angle of the mandible to soft pogonion).
|
Postoperatif 3rd day
|
Postoperative Trismus
Time Frame: Postoperative 3rd day
|
The maximum mouth opening (MMO) was measured in millimeters with a caliper from the incisal edge of the right upper and lower incisor teeth.
For evaluation of trismus, the percentage of difference in MMO during postoperative period was calculated by subtracting the preoperative measurement from the postoperative measurement then divided by the preoperative measurement and multiplied by 100.
|
Postoperative 3rd day
|
Postoperative Pain
Time Frame: Postoperative 4th day
|
In order to evaluate the postoperative pain, a seven-day scheduled pain diary was given to the patients.
To record the level of pain, patients were instructed to rate it on a 10-cm visual analog scales (VAS) was used wherein 0 indicated no pain and 10 indicated the worst pain imaginable.
|
Postoperative 4th day
|
Postoperative Pain
Time Frame: Postoperative 5th day
|
In order to evaluate the postoperative pain, a seven-day scheduled pain diary was given to the patients.
To record the level of pain, patients were instructed to rate it on a 10-cm visual analog scales (VAS) was used wherein 0 indicated no pain and 10 indicated the worst pain imaginable.
|
Postoperative 5th day
|
Postoperative Pain
Time Frame: Postoperative 6th day
|
In order to evaluate the postoperative pain, a seven-day scheduled pain diary was given to the patients.
To record the level of pain, patients were instructed to rate it on a 10-cm visual analog scales (VAS) was used wherein 0 indicated no pain and 10 indicated the worst pain imaginable.
|
Postoperative 6th day
|
Postoperative Pain
Time Frame: Postoperative 7th day
|
In order to evaluate the postoperative pain, a seven-day scheduled pain diary was given to the patients.
To record the level of pain, patients were instructed to rate it on a 10-cm visual analog scales (VAS) was used wherein 0 indicated no pain and 10 indicated the worst pain imaginable.
|
Postoperative 7th day
|
Postoperative Swelling
Time Frame: Postoperatif 7th day
|
Facial swelling was assessed using thread and millimeter ruler and five following measurements were taken: Distance I (from angle of the mandible to labial commissure); Distance II (from angle of the mandible to nasal border); Distance III (from angle of the mandible to external corner of the eye); Distance IV (from angle of the mandible to tragus) and Distance V (from angle of the mandible to soft pogonion).
|
Postoperatif 7th day
|
Postoperative Trismus
Time Frame: Postoperative 7th day
|
The maximum mouth opening (MMO) was measured in millimeters with a caliper from the incisal edge of the right upper and lower incisor teeth.
For evaluation of trismus, the percentage of difference in MMO during postoperative period was calculated by subtracting the preoperative measurement from the postoperative measurement then divided by the preoperative measurement and multiplied by 100.
|
Postoperative 7th day
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
January 15, 2019
Primary Completion (Estimated)
November 15, 2023
Study Completion (Estimated)
December 15, 2023
Study Registration Dates
First Submitted
May 2, 2020
First Submitted That Met QC Criteria
May 2, 2020
First Posted (Actual)
May 6, 2020
Study Record Updates
Last Update Posted (Actual)
August 22, 2023
Last Update Submitted That Met QC Criteria
August 20, 2023
Last Verified
August 1, 2023
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 01.08.2018/07
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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