Search clinical trials for: KRAS TCR-Transduced PBL

Total 74 results

National Institutes of Health Clinical Center (CC)

No longer available

A Single Patient Will be Treated With Individual Patient TCR-Transduced PBL
Cell Medica Ltd
University College, London; Cell Therapy Catapult

Completed

WT1 TCR Gene Therapy for Leukaemia: A Phase I/II Safety and Toxicity Study

Acute Myeloid Leukaemia | Chronic Myeloid Leukaemia

United Kingdom
University College, London

Suspended

Study of Adoptive Immunotherapy With Donor-derived CMV-specific T Cells for Recipients of Allo-HSCT (CMV_TCR-001)

CMV Infection | Haematological Malignancies

United Kingdom
The Netherlands Cancer Institute

Unknown

Study With T-cel Receptor Gene Therapy in Metastatic Melanoma (TCR)

Stage IV Skin Melanoma | Eye; Melanoma

Netherlands
IRCCS San Raffaele
Fondazione Telethon

Completed

Gene Therapy for ADA-SCID

Severe Combined Immunodeficiency Syndrome
T-knife GmbH

Terminated

A Phase 1/ 2, First-in-Human, Open-Label, Accelerated-Titration, Two-Part Clinical Trial of TK-8001 in Patients With HLA-A*02:01 Genotype and Advanced-Stage/ Metastatic MAGE-A1+ Solid Tumors (IMAG1NE)

Advanced Solid Tumors

Germany, Belgium, Spain, Netherlands, United Kingdom
Safaa AA Khaled

Unknown

Value of CD26 Positive Leukemic Stem Cell in Myeloproliferative Neoplasm

Myeloproliferative Neoplasm
National Cancer Institute (NCI)

Recruiting

Autologous T-cells Genetically Engineered to Express Receptors Reactive Against KRAS Mutations in Conjunction With a Vaccine Directed Against These Antigens in Participants With Metastatic Cancer

Breast Cancer | Colorectal Cancer | Ovarian Cancer | Non-Small Cell Lung Cancer | Gastrointestinal Cancer | Genitourinary Cancer | Metastatic Solid Cancers

United States
Cell Medica Ltd
University College, London; Cell Therapy Catapult

Completed

A Phase I/II Study of Gene-modified WT1 TCR Therapy in MDS & AML Patients

Myelodysplastic Syndromes (MDS) | Acute Myeloid Leukaemia (AML)

United Kingdom, Germany, Belgium
Cepheid

Completed

Clinical Evaluation of a Test for Monitoring Patients Diagnosed With Chronic Myeloid Leukemia (CML)

Leukemia, Myelogenous, Chronic

United States
University of Nove de Julho

Not yet recruiting

TCA Peel and Photobiomodulation for Hand Rejuvenation

Skin Aging

Brazil
China Medical University Hospital

Completed

Pulse Spectrum Analysis of Pregnant Women

Harmonic Wave

Taiwan
The University of Hong Kong

Withdrawn

Novel Assays for Detection of Influenza Virus

Influenza A Virus

Hong Kong
QIAGEN Gaithersburg, Inc
Amgen

Recruiting

Therascreen® KRAS RGQ PCR Kit

Colo-rectal Cancer

United Kingdom
QIAGEN Gaithersburg, Inc
Amgen

Active, not recruiting

Clinical Study Testing DNA Extracted From Tumour Tissue Biopsy Samples, Using the Therascreen® KRAS RGQ PCR Kit

Non-small Cell Lung Cancer

United Kingdom
QIAGEN Gaithersburg, Inc
Amgen

Active, not recruiting

Clinical Performance Study Protocol for Therascreen® KRAS RGQ PCR Kit

Colorectal Cancer | Non-Small Cell Lung Cancer

United Kingdom
University of Pennsylvania
Children's Hospital of Philadelphia

Recruiting

CD22 Redirected Autologous T Cells for ALL

B Cell Lymphomas | B Cell Leukemias

United States
Peking Union Medical College Hospital

Unknown

A Study of Using Parenchymal Blood Volume(PBV) for Endovascular Treatment of Renal Arterial Stenosis

Renal Artery Stenosis | Renal Blood Perfusion

China
QIAGEN Gaithersburg, Inc
Amgen

Active, not recruiting

Testing of DNA Extracted From Tumor Tissue Biopsy Samples Using Therascreen KRAS RGQ PCR Kit

Non Small Cell Lung Cancer

United Kingdom
National Cancer Institute (NCI)

Terminated

Gene Therapy Using Anti-CEA Cells to Treat Metastatic Cancer

Metastatic Cancer

United States
Providence Health & Services

Active, not recruiting

Hotspot TCR-T: A Phase I/Ib Study of Adoptively Transferred T-cell Receptor Gene-engineered T Cells (TCR-T)

Malignant Epithelial Neoplasms

United States
Providence Health & Services
Celldex Therapeutics

Enrolling by invitation

Personalized TCR-T: Study of Adoptively Transferred T-cell Receptor Gene-engineered T Cells (TCR-T)

Malignant Epithelial Neoplasms

United States
National Cancer Institute (NCI)

Withdrawn

Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Mutated or Viral Neoantigens in a Patient With Metastatic Cancer Plus the Administration of Pembrolizumab

Metastatic HPV-16 Positive Squamous Cell Anal Cancer

United States
Changhai Hospital

Recruiting

Mutant KRAS G12V-specific TCR Transduced T Cell Therapy for Advanced Pancreatic Cancer

Pancreatic Neoplasms | Pancreatic Cancer | Advanced Cancer | Pancreatic Ductal Adenocarcinoma

China
Memorial Sloan Kettering Cancer Center
National Cancer Institute (NCI)

Completed

Vaccine Therapy in Treating Patients With Chronic Myelogenous Leukemia

Leukemia

United States
National Cancer Institute (NCI)

Recruiting

Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12D Variant of Mutated RAS in HLA-A*11:01 Patients

Gastric Cancer | Pancreatic Cancer | Rectal Cancer | Colon Cancer | Gastrointestinal Cancer

United States
National Cancer Institute (NCI)

Recruiting

Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12V Variant of Mutated RAS in HLA-A*11:01 Patients

Gastric Cancer | Pancreatic Cancer | Rectal Cancer | Colon Cancer | Gastrointestinal Cancer

United States
National Dental Centre, Singapore
Osteopore International

Recruiting

3D Printed Scaffold Device for Ridge Preservation After Tooth Extraction

Bone Resorption After Tooth Extraction

Singapore
H. Lee Moffitt Cancer Center and Research Institute
Incyte Corporation

Completed

Ruxolitinib in Combination With Nilotinib in Chronic Myeloid Leukemia (CML) Patients

Chronic Phase Chronic Myeloid Leukemia

United States
National Institutes of Health Clinical Center (CC)

No longer available

Single Patient Protocol: A Phase II Study Using the Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Mutated Neoantigens in a Patient With Metastatic Cancer Plus the Administration of Pembrolizumab
National Cancer Institute (NCI)

Recruiting

Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Neoantigens in People With Metastatic Cancer

Breast Cancer | Multiple Myeloma | Ovarian Cancer | Non-Small Cell Lung Cancer | Neuroendocrine Tumors | Gastrointestinal/Genitourinary Cancers | Endocrine Tumors

United States
National Cancer Institute (NCI)

Terminated

Phase 1/2 Study of Metastatic Renal Cancer Using T-Cells Transduced With a T-Cell Receptor Which Recognizes TRAIL Bound to the DR4 Receptor

Kidney Cancer | Renal Cancer

United States
Xijing Hospital

Unknown

Exploratory Study of 3D Printed Biodegradable Cervical Interbody Fusion Cage

Symptomatic Cervical Disc Disease
Tehran University of Medical Sciences

Completed

Safety Assessment of a Multipeptide-gene Vaccine in CML

Leukemia, Myeloid, Chronic

Iran, Islamic Republic of
OHSU Knight Cancer Institute
National Cancer Institute (NCI)

Terminated

Vaccine Therapy in Treating Patients With Chronic Phase Chronic Myelogenous Leukemia

Leukemia

United States
Jonsson Comprehensive Cancer Center

Active, not recruiting

Gene and Vaccine Therapy in Treating Patients With Advanced Malignancies

Malignant Neoplasm

United States
Jonsson Comprehensive Cancer Center
National Cancer Institute (NCI)

Terminated

Gene-Modified T Cells, Vaccine Therapy, and Ipilimumab in Treating Patients With Locally Advanced or Metastatic Malignancies

Unspecified Adult Solid Tumor, Protocol Specific

United States
Royal Cornwall Hospitals Trust
Biocartis

Completed

KEBI-Cyto Study - Use of the Biocartis Idylla

Pancreatic Adenocarcinoma | Lung Cancer

United Kingdom
National Cancer Institute (NCI)

Terminated

Modified White Blood Cells That Secrete IL-2 and Express a Protein That Targets the ESO-1tumor Protein for Metastatic Cancer

Metastatic Cancer | Metastatic Melanoma | Metastatic Renal Cancer

United States
Shenzhen Second People's Hospital
Shenzhen Institute for Innovation and Translational Medicine

Unknown

T Cell Receptor-transduced T Cells Targeting NY-ESO-1 for Treatment of Patients With NY-ESO-1- Expressing Malignancies

Melanoma | Breast Cancer | Multiple Myeloma | Ovarian Cancer | Lung Cancer | Neuroblastoma | Bladder Carcinoma | Synovial Sarcoma | Esophagus Carcinoma | Other Metastatic Solid Cancers

China
City of Hope Medical Center

Active, not recruiting

Gene Therapy After Frontline Chemotherapy in Treating Patients With AIDS-Related Non-Hodgkin Lymphoma

HIV Infection | AIDS-related Non-Hodgkin Lymphoma | AIDS-related Plasmablastic Lymphoma | AIDS-related Primary Effusion Lymphoma

United States
Fred Hutchinson Cancer Center
National Cancer Institute (NCI); Affini-T Therapeutics, Inc.

Active, not recruiting

Gene-Modified Immune Cells (FH-MCVA2TCR) in Treating Patients With Metastatic or Unresectable Merkel Cell Cancer

Other Skin

United States
Mie University
Fiverings Co., Ltd.; Shionogi; Takara Bio Inc.; Statcom Co. Ltd.

Completed

Investigator Initiated Phase 1 Study of TBI-1201

Solid Tumors

Japan
Mie University
Fiverings Co., Ltd.; Shionogi; Takara Bio Inc.; Statcom Co. Ltd.

Unknown

Investigator Initiated Phase 1 Study of TBI-1301

Solid Tumors

Japan
National Cancer Institute (NCI)

Completed

Radiation, Chemotherapy, Vaccine and Anti-MART-1 and Anti-gp100 Cells for Patients With Metastatic Melanoma

Melanoma | Skin Cancer

United States
Guangzhou Institute of Respiratory Disease
Guangdong Xiangxue Precision Medical Technology Co., Ltd.; Xiangxue Life Science... and other collaborators

Unknown

NY-ESO-1 TCR （TAEST16001）for Patients With Advanced NSCLC

Lung Cancer, Nonsmall Cell, Recurrent

China
National Cancer Institute (NCI)

Recruiting

Administering Peripheral Blood Lymphocytes Transduced With a CD70-Binding Chimeric Antigen Receptor to People With CD70 Expressing Cancers

Melanoma | Breast Cancer | Pancreatic Cancer | Ovarian Cancer | Renal Cell Cancer

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Active, not recruiting

Genetically Modified T-cell Infusion Following Peripheral Blood Stem Cell Transplant in Treating Patients With Recurrent or High-Risk Non-Hodgkin Lymphoma

Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Nodal Marginal Zone B-cell Lymphoma | Recurrent Adult Burkitt Lymphoma | Recurrent Adult Diffuse Large Cell Lymphoma | Recurrent Adult Diffuse Mixed Cell Lymphoma | Recurrent Adult Diffuse Small Cleaved Cell Lymphoma and other conditions

United States
Gruppo Italiano Malattie EMatologiche dell'Adulto

Completed

Vaccine Therapy in Treating Patients With Philadelphia Chromosome-Positive Chronic Myelogenous Leukemia (CML0206)

Leukemia

Italy
National Cancer Institute (NCI)

Terminated

CAR T Cell Receptor Immunotherapy Targeting Mesothelin for Patients With Metastatic Cancer

Cervical Cancer | Pancreatic Cancer | Ovarian Cancer | Lung Cancer | Mesothelioma

United States

Search clinical trials for: KRAS TCR-Transduced PBL

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