Search clinical trials for: LEE-011

Total 4793 results

Locus Biosciences
Parexel

Recruiting

A Study of LBP-EC01 in the Treatment of Acute Uncomplicated UTI Caused by Drug Resistant E. Coli (ELIMINATE Trial) (ELIMINATE)

Urinary Tract Infections

United States
Ohio State University Comprehensive Cancer Center

Recruiting

Acalabrutinib in Combination With Venetoclax or Obinutuzumab for the Treatment of Treatment-naive Chronic Lymphocytic Leukemia

Chronic Lymphocytic Leukemia | Small Lymphocytic Lymphoma

United States
Hutchison Medipharma Limited

Recruiting

A Phase 3 Study to Evaluate Surufatinib Plus Toripalimab in the Treatment of Advanced Neuroendocrine Carcinoma

Advanced Neuroendocrine Carcinoma

China
L.V. Prasad Eye Institute
Allergan

Recruiting

CHED - Congenital Hereditary Endothelial Dystrophy: New Paradigm Shift in Therapy Using Topical Eye Drops

Congenital Hereditary Endothelial Dystrophy of Cornea

India
Kaken Pharmaceutical

Active, not recruiting

A Study to Determine the Effect of KP-001 on Metformin and Midazolam Pharmacokinetics and the Effect of Clarithromycin on KP-001 Pharmacokinetics in Healthy Adult Participants

Healthy Adults

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Levonorgestrel-Releasing Intrauterine System With or Without Everolimus in Treating Patients With Atypical Hyperplasia or Stage IA Grade 1 Endometrial Cancer (LEVER)

Atypical Endometrial Hyperplasia | FIGO Grade 1 Endometrial Endometrioid Adenocarcinoma | FIGO Grade 2 Endometrial Endometrioid Adenocarcinoma

United States
Alexion Pharmaceuticals, Inc.

Active, not recruiting

A Study to Evaluate the Efficacy and Safety of CAEL-101 in Patients With Mayo Stage IIIb AL Amyloidosis

AL Amyloidosis

United States, Germany, Spain, Russian Federation, France, Korea, Republic of, Poland, Israel, Netherlands, Japan, Belgium, Greece, Switzerland, Australia, Austria, Brazil, Canada, China, Czechia, Italy, United Kingdom
University of Miami

Completed

The Effect of Upneeq (Oxymetazoline Hydrochloride 0.1%) on Eyelid Position, Eye Redness, and Eye Appearance

Eye Manifestations | Ptosis, Eyelid | Conjunctiva Inflamed

United States
Rigshospitalet, Denmark

Completed

Xylometazoline and Cocaine for Nasal Vasoconstriction

Epistaxis

Denmark
NeuroRx, Inc.
Target Health Inc.

Completed

NRX101 Glx Biomarker Validation Study (NRX-GLX)

Suicidal Ideation | Bipolar Depression

United States
Alto Neuroscience

Withdrawn

Leveraging EEG for Antidepressant Prediction With Duloxetine and Bupropion (LEAP-DB)

Major Depressive Disorder
Taichung Tzu Chi Hospital

Unknown

The Changes of Ryodoraku and HRV After PPI Treatment in GERD Patients

Barrett's Esophagus | Non-erosive Reflux Disease

Taiwan
Ankara University

Completed

Intrathecal Morphine for Inguinal Hernia Repair.

Nausea | Vomiting | Postoperative Pain | Inguinal Hernia | Pruritus

Turkey
Allergan

Completed

A Safety and Efficacy Study of ALPHAGAN® P and LUMIGAN® in Subjects Previously Treated With Latanoprost for Glaucoma and Ocular Hypertension

Ocular Hypertension | Glaucoma

United States
Alcon Research

Completed

Pharmacokinetic Evaluation of Moxifloxacin in Vigadexa® in Aqueous Humor Samples Following Preoperative Antibiotic/Steroid Dosing in Cataract Surgery Patients

Cataract
Medical University of Vienna
Croma-Pharma GmbH

Completed

Assessment of Safety and Tolerability of Chitosan-N-acetylcysteine Eye Drops in Subjects While Wearing Contact Lenses and Before Insertion of Contact Lenses

Dry Eye Syndrome

Austria
Garden State Cancer Center at the Center for Molecular...

Completed

Radioimmunotherapy With or Without Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Thyroid Cancer

Head and Neck Cancer

United States
Allergan

Completed

Brimonidine 0.1% Versus Brinzolamide 1% as Adjunctive Therapy to Latanoprost 0.005%

Ocular Hypertension | Glaucoma

United States
Pfizer

Completed

A Study To Estimate The Effect of PF-06650833 On The Pharmacokinetics (PK) of Oral Contraceptive (OC)

Healthy

United States
National Cancer Institute (NCI)

Completed

Radiation Therapy and Chemotherapy in Treating Children With CNS Relapse From Acute Lymphoblastic Leukemia

Leukemia

United States, Canada, Puerto Rico, Switzerland
Huai'an First People's Hospital
Zhenjiang First People's Hospital; The Affiliated Hospital of Xuzhou Medical... and other collaborators

Recruiting

Clinical Study Protocol for the Treatment of ND-AML and RR-AML With KMT2A Gene Abnormalities Using VHEA.

Acute Myeloid Leukemia

China
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Nivolumab and Azacitidine With or Without Ipilimumab in Treating Patients With Refractory/Relapsed or Newly Diagnosed Acute Myeloid Leukemia

Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome | Chronic Myelomonocytic Leukemia | Secondary Acute Myeloid Leukemia | Myelodysplastic Syndrome | Recurrent Acute Myeloid Leukemia | Refractory Acute Myeloid Leukemia | Therapy-Related Acute Myeloid Leukemia | Acute Bilineal Leukemia and other conditions

United States
Alexandria University

Completed

Evaluation of Diode Laser and Topical Steroid Therapy in the Treatment of Erosive Oral Lichen Planus

Erosive Oral Lichen Planus

Egypt
Jonsson Comprehensive Cancer Center
Bristol-Myers Squibb; National Cancer Institute (NCI); Vaccinex Inc.

Terminated

Anti-SEMA4D Monoclonal Antibody VX15/2503 With Nivolumab or Ipilimumab in Treating Patients With Stage III or IV Melanoma

Metastatic Melanoma | Stage III Cutaneous Melanoma AJCC v7 | Stage IV Cutaneous Melanoma AJCC v6 and v7 | Stage IIIC Cutaneous Melanoma AJCC v7 | Stage IIIA Cutaneous Melanoma AJCC v7 | Stage IIIB Cutaneous Melanoma AJCC v7

United States
National Cancer Institute (NCI)

Terminated

Radiolabeled Monoclonal Antibody Plus Rituximab With and Without Filgrastim and Interleukin-11 in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma

Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Nodal Marginal Zone B-cell Lymphoma | Recurrent Grade 1 Follicular Lymphoma | Recurrent Grade 2 Follicular Lymphoma | Recurrent Grade 3 Follicular Lymphoma | Recurrent Marginal Zone Lymphoma | Splenic Marginal Zone... and other conditions

United States
Cardiff University
National Institute for Social Care and Health Research

Completed

Prostaglandin F2-alpha Eye Drops in Thyroid Eye Disease (Bima Study) (BIMA)

Graves' Ophthalmopathy

United Kingdom
Università degli Studi di Brescia

Completed

NSAIDs and PGE2 Levels in Vitrectomy Patients

Vitreous Inflammation
National Cancer Institute (NCI)

Completed

R-(-)-Gossypol Acetic Acid in Treating Patients With Recurrent Extensive-Stage Small Cell Lung Cancer

Extensive Stage Small Cell Lung Cancer | Recurrent Small Cell Lung Cancer

United States
Herbert Irving Comprehensive Cancer Center
National Cancer Institute (NCI)

Unknown

Surgery, Chemotherapy, and Radiation Therapy in Treating Patients With Peritoneal Cancer

Malignant Mesothelioma

United States
University of California, Davis

Unknown

Monoclonal Antibody Therapy, Paclitaxel, and Cyclosporine in Treating Patients With Recurrent or Refractory Non-Hodgkin's Lymphoma

Lymphoma

United States
Dr. Reddy's Laboratories Limited

Completed

Bioequivalence Study of Fexofenadine HCl 180 mg + Pseudoephedrine HCl 240 mg ER Tablets of Dr. Reddy's and Allegra D 24 Hour ER Tablets Under Fasting Conditions

Healthy

India
OHSU Knight Cancer Institute
Oregon Health and Science University; Incyte Corporation

Recruiting

Axatilimab in Combination With Retifanlimab and Paclitaxel for the Treatment of Patients With Advanced or Metastatic Solid Tumors

Advanced Malignant Solid Neoplasm | Refractory Malignant Solid Neoplasm | Recurrent Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm

United States
Bayer

Completed

Comparative Trial in Hormone Withdrawal Associated Symptoms

Oral Contraceptive

Switzerland, Portugal, Chile, Italy, Korea, Republic of, Venezuela, Philippines, Colombia, Thailand, Argentina, Germany, Russian Federation, United Kingdom, Czech Republic
First Affiliated Hospital of Zhejiang University

Recruiting

Development and Application of Comprehensive Intervention Techniques for Adolescent Depression

Adolescent | Depressive Disorder

China
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Recruiting

Atezolizumab, Obinutuzumab, and Venetoclax in Treating Patients With Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, or Relapsed or Refractory Richter Syndrome

Chronic Lymphocytic Leukemia | Small Lymphocytic Lymphoma | Richter Syndrome | Recurrent Transformed Chronic Lymphocytic Leukemia | Refractory Transformed Chronic Lymphocytic Leukemia

United States
New York State Psychiatric Institute
National Institute of Mental Health (NIMH)

Completed

Paroxetine/Bupropion in Depression With Suicide Attempt or Thoughts: fMRI Study

Depression | Suicidal Ideation

United States
Alcon Research

Completed

Topical Treatment of Acute Otitis Media Through Tympanostomy Tubes (AOMT) and Its Effect on Microbial Flora

Acute Otitis Media

United States
Dr. Reddy's Laboratories Limited

Completed

Bioequivalence Study of Fexofenadine HCl 180 mg + Pseudoephedrine HCl 240 mg ER Tablets of Dr.Reddy's Under Fed Conditions

Healthy

India
North Suffolk Mental Health Association

Completed

Nicotine Replacement Therapy for Smoking Cessation in Schizophrenia

Schizophrenia | Schizoaffective Disorder

United States
Orexigen Therapeutics, Inc

Completed

Safety and Efficacy of Different Combinations of Zonisamide-CR Plus Bupropion-SR to Treat Uncomplicated Obesity

Obesity

United States
LEO Pharma

Completed

LEO 90100 in the Treatment of Psoriasis Vulgaris

Psoriasis Vulgaris

United States
Ain Shams Maternity Hospital

Completed

Post-Caesarean Section Incisional Infiltration With Lidocaine Versus Lidocaine and Epinephrine

Pain, Postoperative

Egypt
Xia Zhongjun
Antengene Corporation

Recruiting

Selinexor Plus VRd in High Risk Newly Diagnosed Multiple Myeloma

Multiple Myeloma

China
National Cancer Institute (NCI)

Active, not recruiting

Testing the Combination of XL184 (Cabozantinib), Nivolumab, and Ipilimumab for Poorly Differentiated Neuroendocrine Tumors

Metastatic Neuroendocrine Neoplasm | Metastatic Neuroendocrine Carcinoma | Metastatic Large Cell Neuroendocrine Carcinoma | Metastatic Small Cell Neuroendocrine Carcinoma

United States, Canada
University of Washington

Completed

Nivolumab and Ipilimumab and Stereotactic Body Radiation Therapy in Treating Patients With Salivary Gland Cancers

Metastatic Malignant Neoplasm in the Bone | Salivary Gland Carcinoma | Metastatic Malignant Neoplasm in the Lung | Stage IV Major Salivary Gland Cancer AJCC v8 | Stage IVA Major Salivary Gland Cancer AJCC v8 | Stage IVB Major Salivary Gland Cancer AJCC v8 | Stage IVC Major Salivary Gland Cancer...

United States
University of Washington
Genentech, Inc.; Oncotelic Therapeutics, Inc.

Withdrawn

OT-101 in Combination With Atezolizumab for the Treatment of Metastatic or Recurrent Non-Small Cell Lung Cancer

Metastatic Lung Non-Small Cell Carcinoma | Stage IV Lung Cancer AJCC v8 | Recurrent Lung Non-Small Cell Carcinoma

United States
Yuzuncu Yıl University

Active, not recruiting

Comparison of the Efficacy of Boric Acid Mouthwashes in Different Concentrations

Impacted Third Molar Tooth

Turkey
Jonsson Comprehensive Cancer Center
National Cancer Institute (NCI)

Terminated

Ipilimumab, Nivolumab, and Talimogene Laherparepvec Before Surgery in Treating Participants With Localized, Triple-Negative or Estrogen Receptor Positive, HER2 Negative Breast Cancer-deleted

Anatomic Stage I Breast Cancer AJCC v8 | Anatomic Stage IA Breast Cancer AJCC v8 | Anatomic Stage IB Breast Cancer AJCC v8 | Anatomic Stage II Breast Cancer AJCC v8 | Anatomic Stage IIA Breast Cancer AJCC v8 | Anatomic Stage IIB Breast Cancer AJCC v8 | Anatomic Stage IIIA Breast Cancer AJCC v8 | Anatomic... and other conditions

United States
ECOG-ACRIN Cancer Research Group
National Cancer Institute (NCI)

Completed

Bendamustine Hydrochloride and Rituximab With or Without Bortezomib Followed by Rituximab With or Without Lenalidomide in Treating Patients With High-Risk Stage II, Stage III, or Stage IV Follicular Lymphoma

Lymphoma

United States
Galderma R&D

Completed

Adapalene BPO Gel Pump, Moisturizer SPF 30 and Foam Wash in Patients With Mild to Moderate Acne Vulgaris

Acne

United States

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