Search clinical trials for: LOXL2 Inhibitor PAT-1251

Total 1276 results

M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Withdrawn

PAT-1251 in Treating Patients With Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocytosis Myelofibrosis

Primary Myelofibrosis | Polycythemia Vera, Post-Polycythemic Myelofibrosis Phase | Myelofibrosis Transformation in Essential Thrombocythemia

United States
PharmAkea, Inc.

Completed

Single and Multiple Dose Safety, Tolerability, PK and Food Effect Study of PAT-1251 in Healthy Adult Subjects

Healthy

United Kingdom
Avid Radiopharmaceuticals

Completed

18F-LY3950321-01 Biodistribution and Safety Study

Radiation Exposure | Diagnostic Agent Adverse Reaction

United States
Neil M Rofsky, MD, MHA

Completed

Cognitive Decline and Alzheimer's Disease in the Dallas Lifespan Brain Study

Alzheimer Disease | Cognitive Decline

United States
Merrimack Pharmaceuticals

Terminated

Phase 1 Combination Study of MM-151 With MM-121, MM-141, or Trametinib

Colorectal Cancer | Squamous Cell Carcinoma of the Head and Neck | Non-small Cell Lung Cancer

United States
Avid Radiopharmaceuticals

Completed

18F-AV-1451 Autopsy Study

Alzheimer's Disease

United States, Australia
Avid Radiopharmaceuticals

Completed

A Study of Flortaucipir PET in Healthy Volunteers and Cognitively Impaired Subjects

Alzheimer's Disease

United States
Avid Radiopharmaceuticals

Completed

Tau Screening Study in Patients With Early Symptomatic AD

Alzheimer Disease

United States, Canada
Uppsala University

Completed

Neo-adjuvant Chemo + Peritonectomy + Hyperthermic Intraperitoneal Chemo in Peritoneal Carcinomatosis From Gastric Cancer

Gastric Cancer | Peritoneal Carcinomatosis

Sweden
Avid Radiopharmaceuticals

Completed

Tau Imaging in Subjects With Progressive Supranuclear Palsy, Corticobasal Degeneration and Healthy Volunteers

Corticobasal Degeneration | Progressive Supranuclear Palsy

United States
GlaxoSmithKline

Completed

A Study in Cancer Patients to Evaluate the Bioequivalence of Alternative Formulations of Lapatinib

Neoplasms, Breast

United States, Korea, Republic of
Avid Radiopharmaceuticals

Terminated

Imaging Characteristics of a Follow-up 18F-AV-1451 Scan

Alzheimer's Disease

United States
Mayo Clinic
Yale University; Columbia University; National Institute on Aging (NIA); Brigham... and other collaborators

Completed

Continuation of The Kronos Early Estrogen Prevention Study (KEEPS) (KEEPS)

Alzheimer Dementia

United States
Ascentage Pharma Group Inc.
Suzhou Yasheng Pharmaceutical Co., Ltd.

Recruiting

A Study of APG-1252 Plus Osimertinib(AZD9291) in EGFR TKI Resistant NSCLC Patients

EGFR Positive Non-small Cell Lung Cancer

China
Allarity Therapeutics
Danish Breast Cancer Cooperative Group; Smerud Medical Research International...

Active, not recruiting

Investigation of Anti-tumour Effect and Tolerability of the PARP Inhibitor 2X-121 in Patients With Metastatic Breast Cancer Selected by the 2X-121 DRP

Metastatic Breast Cancer

Denmark
Arog Pharmaceuticals, Inc.

Recruiting

Study Investigating the Efficacy of Crenolanib With Chemotherapy vs Chemotherapy Alone in R/R FLT3 Mutated AML

Relapsed/Refractory Acute Myeloid Leukemia With FLT3 Activating Mutations

United States, Germany, Spain, Italy, France, Canada
Celgene
The Leukemia and Lymphoma Society

Completed

Study of ACY-1215 Alone and in Combination With Bortezomib and Dexamethasone in Multiple Myeloma (ACY-1215)

Multiple Myeloma

United States
Gilead Sciences

Completed

A Study on the Safety and Effectiveness of Adefovir Dipivoxil in Combination With Anti-HIV Therapy (HAART) in HIV-Positive Patients

HIV Infections

United States, United Kingdom, Germany, Canada, France
MBQ Pharma
Congressionally Directed Medical Research Programs

Recruiting

A Study of Oral MBQ-167 in Participants With Advanced Breast Cancer

Breast Cancer | Breast Neoplasm | Breast Cancer Stage IV

Puerto Rico
Kamada, Ltd.

Completed

Study of the Safety and Efficacy of Intravenous Alpha-1 Antitrypsin in Type 1 Diabetes Mellitus

Type 1 Diabetes Mellitus

Israel
Rhizen Pharmaceuticals SA

Completed

Safety and Efficacy Study of a Dual PI3K Delta/Gamma Inhibitor in Hematological Malignancies (PI3K)

Lymphoma, B-Cell | T-Cell Lymphoma

France, Italy
Merrimack Pharmaceuticals

Completed

Safety Study of the Drug MM-151 in Patients With Advanced Solid Tumors Resisting Ordinary Treatment

Colorectal Cancer | Non Small Cell Lung Cancer | Advanced Solid Tumors | Triple Negative Breast Cancer | Squamous Cell Head and Neck Cancer

United States
NeuroBo Pharmaceuticals Inc.

Recruiting

Study to Evaluate the Efficacy and Safety of DA-1241 in Subjects With Presumed NASH

NON-ALCOHOLIC STEATOHEPATITIS

United States
Acetylon Pharmaceuticals Incorporated

Completed

Alternative 10 mg/mL Liquid Formulation of ACY 1215 (Ricolinostat) in Healthy Subjects

Healthy

United States
Jennifer Amengual
Acetylon Pharmaceuticals Incorporated

Completed

ACY-1215 for Relapsed/Refractory Lymphoid Malignancies

Lymphoma | Lymphoid Malignancies

United States
National Taiwan University Hospital Hsin-Chu Branch

Unknown

Peripheral Artery Disease and Sepsis Outcomes

Sepsis | Peripheral Artery Disease | Diagnosis | Peripheral Artery Occlusion

Taiwan
Regenacy Pharmaceuticals LLC

Completed

Ricolinostat in Patients With Painful Diabetic Peripheral Neuropathy

Painful Diabetic Peripheral Neuropathy

United States
Olema Pharmaceuticals, Inc.
Pfizer

Recruiting

A Phase 1 Study of Oral OP-1250 in Combination With Palbociclib in HR+/HER2- Breast Cancer Patients

Breast Cancer

Australia
Theravance Biopharma

Completed

A Fixed-Sequence, Two-Period, Open-Label Drug-Drug Interaction Study to Assess the Effect of an Inhibitor of Cytochrome P450 Isoenzyme 3A4 and Permeability Glycoprotein 1 on the Pharmacokinetics of TD-1211

Healthy

United States
Bispebjerg Hospital

Completed

Effect of ACE-Inhibition on Microvascular Function in Women With Assessed Microvascular Dysfunction

Microvascular Angina

Denmark
Novartis Pharmaceuticals

Completed

A Study to Investigate the Pharmacokinetics and Safety of Remibrutinib in Participants With Hepatic Impairment Compared With Matched Healthy Participants

Hepatic Impairment

Hungary
Masonic Cancer Center, University of Minnesota

Suspended

Study of PAT in Patients With Solid Tumor Cancers

Solid Tumor | Metastasis

United States
Ashley Downs Bioscience

Unknown

ZeroTolerance Mucositis: Managing Oral and Alimentary Mucositis With High Potency Sucralfate - ProThelial

Nausea | Vomiting | Diarrhea | Oral Mucositis

United States
AstraZeneca

Completed

AZD8186 First Time In Patient Ascending Dose Study

Advanced Castrate-resistant Prostate Cancer CRPC | Squamous Non-Small Cell Lung Cancer sqNSCLC | Triple Negative Breast Cancer TNBC

Spain, Canada, United States, United Kingdom
Organon and Co

Completed

A Two-Part 26-Week Study of Etoricoxib as Treatment for Ankylosing Spondylitis (AS) (MK-0663-108)

Spondylitis, Ankylosing
Eli Lilly and Company

Completed

Notch Inhibitor in Advanced Cancer

Advanced Cancer

United States
Universitätsklinikum Hamburg-Eppendorf

Unknown

The Approach and Avoidance Task (AAT) in Smoking Cessation

Smoking Cessation

Germany
University of Nebraska

Completed

Impact of a High-fat Meal on Assessment of Clopidogrel-induced Platelet Inhibition in Healthy Subjects

Healthy

United States
Shanghai YingLi Pharmaceutical Co. Ltd.

Recruiting

A Study of YL-17231 in Patients With Advanced Solid Tumors

Advanced Solid Tumor

China
Zhongnan Hospital

Recruiting

Fibroblast Activation Protein Inhibitor PET/CT Imaging in Malignant Tumor of Digestive System

Gastrointestinal Cancer

China
Universität des Saarlandes

Completed

Alpha-1-Antitrypsin-Deficiency in COVID-19 (CORSAAR-AAT)

Covid19

Germany
CSPC ZhongQi Pharmaceutical Technology Co., Ltd.

Terminated

Clinical Study of Liposomal Mitoxantrone Hydrochloride Injection Combined With Pegaspargase in the Treatment of NKTCL

Extranodal NK/T-cell Lymphoma, Nasal Type

China
John Levine
National Cancer Institute (NCI)

Completed

A Proof of Concept Pilot Trial of Alpha-1-Antitrypsin for Pre-Emption Of Steroid-Refractory Acute GVHD

GVHD | Graft-versus-host-disease

United States
GeneMedicine Co., Ltd.

Recruiting

GM103 Intratumoral Injection in Patients With Locally Advanced, Unresectable, Refractory and/or Metastatic Solid Tumors

Renal Cell Carcinoma | Cervical Cancer | Breast Cancer | Head and Neck Cancer | Colorectal Cancer | Malignant Melanoma

Korea, Republic of
University of Colorado, Denver
Omni Bio Pharmaceutical, Inc.

Completed

The Effects of Alpha-1 Antitrypsin (AAT) on the Progression of Type 1 Diabetes

Diabetes | Type 1 Diabetes

United States
Tempest Therapeutics

Completed

TPST-1120 as Monotherapy and in Combination With Nivolumab in Subjects With Advanced Cancers

Sarcoma | Renal Cell Carcinoma | Hepatocellular Carcinoma | Colorectal Cancer | Pancreatic Cancer | Squamous Cell Carcinoma of Head and Neck | Cholangiocarcinoma | Non-small Cell Lung Cancer | Urothelial Carcinoma | GastroEsophageal Cancer | Triple-Negative Breast Cancer | Metastatic Castration Resistant Prostate...

United States
Dana-Farber Cancer Institute
Acetylon Pharmaceuticals Incorporated

Active, not recruiting

ACY-1215 in Combination With BCR Pathway Inhibitors in Relapsed CLL

Recurrent Chronic Lymphoid Leukemia

United States
National Institute of Allergy and Infectious Diseases...
Glaxo Wellcome; Upjohn

Completed

A Phase I Concentration-Controlled Trial to Assess the Safety, Tolerance, Pharmacokinetics and Development of Decreased HIV-1 Susceptibility to the Combination of Atevirdine Mesylate (U-87201E), Zidovudine (AZT), and Didanosine (ddI)

HIV Infections

United States
National Cancer Institute (NCI)

Recruiting

Testing the Combination of APG-1252 (Pelcitoclax) and Cobimetinib in Recurrent Ovarian and Endometrial Cancers

Recurrent Fallopian Tube Carcinoma | Recurrent Primary Peritoneal Carcinoma | Recurrent Endometrial Carcinoma | Stage III Uterine Corpus Cancer AJCC v8 | Stage IV Uterine Corpus Cancer AJCC v8 | Recurrent Platinum-Resistant Ovarian Carcinoma | Metastatic Fallopian Tube Carcinoma | Metastatic Primary... and other conditions

United States
Amsterdam UMC, location VUmc

Completed

Tumor Kinase Inhibitor Concentrations Measured by PET (PIKTURE)

Disseminated Malignant Neoplasm

Netherlands

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