Search clinical trials for: Leukine

Total 310 results

NuSirt Biopharma

Completed

An Extension Protocol to Evaluate Dose Comparisons of Leucine-Metformin Combinations in Type 2 Diabetic Patients

Type 2 Diabetes Mellitus

United States
Northwell Health

Completed

Pilot Phase I/II Study of Amino Acid Leucine in Treatment of Patients With Transfusion-Dependent Diamond Blackfan Anemia (LeucineDBA)

Pure Red Cell Aplasia | Diamond Blackfan Anemia | Blackfan Diamond Syndrome | DBA | Congenital Hypoplastic Anemia

United States
Children's Hospital Medical Center, Cincinnati
Genzyme, a Sanofi Company; Virginia Commonwealth University

Completed

Inhaled Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) in Hereditary Pulmonary Alveolar Proteinosis (PAP) (FAMPAP)

Hereditary Pulmonary Alveolar Proteinosis

United States
Immatics Biotechnologies GmbH

Completed

IMA901 in Advanced Renal Cell Carcinoma Patients With Measurable Disease (IMA901-202)

Renal Cell Carcinoma

Spain, Germany, Bulgaria, United Kingdom, Austria, Hungary, Poland, Romania, Slovakia, Switzerland
Washington University School of Medicine

Completed

Collaborative Research Group for Necrotizing Enterocolitis

Necrotizing Enterocolitis | Prematurity

United States
Mayo Clinic
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); National... and other collaborators

Completed

Hydroxyproline Influence on Oxalate Metabolism

Hyperoxaluria

United States
University of Texas Southwestern Medical Center

Terminated

Rapid Antidepressant Effects of Leucine

Major Depressive Disorder

United States
University of Birmingham

Completed

Can Supplemental Leucine Offset Disuse-induced Muscle Atrophy? (LEU-DIMA)

Muscle Disuse Atrophy

United Kingdom
Genzyme, a Sanofi Company

Terminated

Comparison Study of Rituximab Plus Sargramostim to Rituximab Alone for Relapsed Follicular B-cell Lymphoma, a Form of Non-Hodgkin's Lymphoma (PREMIER)

Lymphoma, Follicular

United States, Puerto Rico
Hospital Clinic of Barcelona

Completed

Study to Assess the Effect of Leucine Along With Resistance Exercise on Muscle Strength and Quality of Life in Elders

Ageing

Spain
McMaster University

Completed

Effect of Supplementing a Mixed Macronutrient Beverage With Graded Doses of Leucine on Myofibrillar Protein Synthesis

Muscle Protein Synthesis

Canada
University of Aarhus

Completed

Leucine and Beta-hydroxy-beta-methylbutyrate (HMB) as Anabolic Nutrients After 36 Hours of Fasting

Fasting | Metabolism | Nutrition Support

Denmark
Texas A&M University

Unknown

EAA Intake to Optimize Protein Anabolism in COPD

Chronic Obstructive Pulmonary Disease

United States
Columbia University

Completed

The Effects of Leucine on Body Weight

Obesity | Overweight

United States
Texas A&M University

Unknown

Casein Protein and Leucine Supplementation in Chronic Obstructive Pulmonary Disease (COPD)

COPD

United States
NuSirt Biopharma

Completed

Dose Comparisons of Leucine-Metformin Combinations on Blood Glucose Levels In Type 2 Diabetic Patients

Type 2 Diabetes Mellitus

United States
The Hospital for Sick Children

Completed

Upper Limit of Leucine Intake in Adults

Healthy

Canada
The Hospital for Sick Children
Canadian Institutes of Health Research (CIHR)

Completed

Requirement for Leucine in Adults Over 60 Years

Healthy

Canada
The Hospital for Sick Children
Canadian Institutes of Health Research (CIHR)

Completed

Leucine Requirement in Adult Men and Women

Healthy

Canada
Washington University School of Medicine
Association of Frontotemporal Degeneration; Tau Consortium

Completed

Human CNS Tau Kinetics in Tauopathies (TANGLES)

Progressive Supranuclear Palsy (PSP) | Corticobasal Degeneration (CBD) | Frontotemporal Dementia (FTD MAPT Mutation)

United States
University of Valencia
Armonea Group - La Saleta; Bonusan BV

Completed

Leucine Supplementation in Sarcopenic Older Individuals

Frail Elderly Syndrome | Sarcopenia

Spain
Federal Scientific Clinical Centre of Pediatric...

Unknown

L-leucine in Diamond Blackfan Anemia Patients

Diamond Blackfan Anemia

Russian Federation
Galena Biopharma, Inc.

Completed

Efficacy and Safety Study of NeuVax™ (Nelipepimut-S or E75) Vaccine to Prevent Breast Cancer Recurrence (PRESENT)

Breast Cancer With Low to Intermediate HER2 Expression

United States, United Kingdom, France, Israel, Germany, Canada, Russian Federation, Romania, Bulgaria, Czech Republic, Hungary, Poland, Ukraine
University Hospital, Ghent
Flanders Institute of Biotechnology

Completed

Sargramostim in Patients With Acute Hypoxic Respiratory Failure Due to COVID-19 (SARPAC) (SARPAC)

COVID-19

Belgium
Maastricht University Medical Center
Top Institute Food and Nutrition

Completed

The Effect of Leucine on Body Composition and Muscle Characteristics in Elderly, Type 2 Diabetes Patients

Type 2 Diabetes

Netherlands
University of British Columbia
International Council on Amino Acid Science

Completed

Determination of the UL of Leucine in Healthy Elderly Men

Elderly Men

Canada
University of Sao Paulo

Completed

Leucine Supplementation in Young Subjects Undergoing Resistance Training

Healthy Volunteers

Brazil
Washington University School of Medicine
Ajinomoto Co., Inc.

Completed

Calorie Restriction With Leucine Supplementation

Obesity | Menopause | Sarcopenia | Osteoporosis

United States
Washington University School of Medicine
National Institutes of Health (NIH); BrightFocus Foundation

Completed

CNS Tau Kinetics in Healthy Aging and Alzheimer's Disease

Mental Disorders | Brain Diseases | Central Nervous System Diseases | Nervous System Diseases | Neurodegenerative Diseases | Dementia | Tauopathies | Alzheimer's Disease | Delirium, Dementia, Amnestic, Cognitive Disorders

United States
University of Sao Paulo

Completed

Leucine Supplementation and Skeletal Muscle Disuse

Disuse Atrophy

Brazil
University of Sao Paulo

Suspended

Branched-chain Amino Acids Supplementation and Resistance Exercise-induced Muscle Damage and Inflammation

Inflammation | Muscle Damage

Brazil
Maastricht University Medical Center

Completed

Leucine Supplementation in Elderly Men

Atrophy | Sarcopenia | Aging

Netherlands
McMaster University
Canadian Institutes of Health Research (CIHR); University of California, Davis and other collaborators

Completed

Role of Leucine in the Regulation of Human Myofibrillar Protein Synthesis at Rest and Following Resistance Exercise

Regulation of Muscle Protein Synthesis

Canada
Nobelpharma

Completed

A Phase II/III Study of Sargramostim

COVID-19

Japan
Lindenwood University
Ingenious Ingredients, L.P.

Completed

Dileucine and Resistance Training Adaptations (DTS)

Hypertrophy | Strength Training Adaptations | Weight-Bearing Strengthening Program

United States
University of Sao Paulo

Suspended

Effects of Chronic Leucine Supplemetion on Glucose Homeostasis, Body Compositin, Muscle Mass and Strength of Healthy and Young Subjects

Effect of Chronic Leucine Supplementation on Glucose Homeostasis, Lipid Profile, Body Composition, and Muscle Mass and Strenght

Brazil
McMaster University
Canadian Institutes of Health Research (CIHR)

Completed

Leucine Co-ingestion and Myofibrillar Protein Synthesis in Older Adults

Sarcopenia | Aging

Canada
Texas Woman's University

Completed

The Effects of Leucine and Isoleucine on Glucose Metabolism (AA+GLU)

Hyperglycemia
Massachusetts General Hospital
Brain & Behavior Research Foundation; J Willard and Alice S. Marriott Foundation

Recruiting

BezafibrateTreatment for Bipolar Depression: A Proof of Concept Study

Bipolar Disorder | Depressive Episode

United States
St Mary's University College
University of Gloucestershire

Unknown

10-week Leucine Supplementation in Cerebral Palsy

Cerebral Palsy | Cerebral Palsy Ataxic | Cerebral Palsy, Mixed

United Kingdom
Mark Hall
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Completed

GM-CSF for Immunomodulation Following Trauma (GIFT) Study (GIFT)

Critical Injury (Trauma) in Children

United States
Sanofi

Withdrawn

Open Label Study of Sargramostim Among Patients Receiving Myelosuppressive Induction Chemotherapy for Acute Myelogenous Leukemia

Acute Myeloid Leukemia NOS
University of Illinois at Urbana-Champaign

Completed

Nutritional Strategies to Augment the Postprandial Muscle Protein Synthetic Response to the Ingestion of a Low Dose of Protein in Middle-aged Women

Aging

United States
IntraBio Inc

Completed

N-Acetyl-L-Leucine for GM2 Gangliosidosis (Tay-Sachs and Sandhoff Disease)

GM2 Gangliosidosis | Tay-Sachs Disease | Sandhoff Disease

United States, Germany, Spain, United Kingdom
Genzyme, a Sanofi Company

Terminated

Efficacy (Induction of Response/Remission) and Safety Study in Patients With Moderate to Severe Crohn's Disease

Crohn Disease

Israel, United States, Romania, Ukraine, South Africa, Canada, Australia, Bulgaria, Russian Federation, New Zealand, Brazil
Genzyme, a Sanofi Company

Completed

Study in Patients With Crohn's Disease Who Are Steroid Dependent, Despite Previous Unsuccessful Attempts to Reduce Steroids Due to Worsening of Crohn's Disease

Crohn Disease
Genzyme, a Sanofi Company

Terminated

Study of Sargramostim in Moderately to Severely Active Crohn's Disease

Crohn's Disease
Innoventus Project AB
Uppsala University

Completed

A Safety/Tolerability and Pharmakokinetic Study of Sargramostim Administrated in the Gingiva

Periodontitis

Sweden
Emory University
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Granulocyte-Macrophage Stimulating Factor (GM-CSF) in Peripheral Arterial Disease (GPAD-3)

Peripheral Artery Disease (PAD)

United States
University of Nebraska
Partner Therapeutics, Inc.

Active, not recruiting

Biomarker Validation Following Sargramostim Treatment in Parkinson's Disease

Parkinson's Disease and Parkinsonism

United States

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