Search clinical trials for: Metformin and insulin

Total 270328 results

Novo Nordisk A/S

Completed

Observational Study on Efficacy and Safety in Patients Using NovoMix® 30 for the Treatment of Diabetes (UPGRADE)

Diabetes Mellitus, Type 2 | Diabetes | Diabetes Mellitus, Type 1

Korea, Republic of
RISE Study Group
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Completed

RISE Adult Medication Study (RISE Adult)

Type 2 Diabetes | Prediabetes

United States
Eli Lilly and Company

Completed

A Study of Dulaglutide (LY2189265) in Participants With Type II Diabetes (AWARD-9)

Diabetes Mellitus, Type 2

United States, Czechia, Hungary, Italy, Puerto Rico, Spain, United Kingdom
Sanofi

Completed

Evaluation of Insulin Glargine/Lixisenatide Fixed Ratio Combination in Patients With Type 2 Diabetes Insufficiently Controlled With Oral Antidiabetic Drug(s) (Lixilan-O-AP)

Type 2 Diabetes Mellitus

China, Korea, Republic of, Malaysia, Taiwan
AstraZeneca
Eli Lilly and Company

Completed

Effects of Exenatide and Insulin Glargine in Subjects With Type 2 Diabetes

Type 2 Diabetes Mellitus

Finland, Netherlands, Sweden
IKFE Institute for Clinical Research and Development
Sanofi-Synthelabo

Completed

Performance Evaluation of Blood Glucose Monitoring Systems (Polaris)

Diabetes Mellitus

Germany
Novo Nordisk A/S

Completed

Efficacy and Safety of Biphasic Insulin Aspart 30 in Type 2 Diabetes Mellitus When Failing on OADs (IMPROVE)

Diabetes Mellitus, Type 2 | Diabetes

Turkey
Novo Nordisk A/S

Completed

Efficacy of Biphasic Insulin Aspart 30 in Type 2 Diabetics Failing on OADs

Diabetes Mellitus, Type 2 | Diabetes

United States
Population Health Research Institute
Merck Sharp & Dohme LLC

Completed

Remission Evaluation of a Metabolic Intervention in Type 2 Diabetes With Sitagliptin (REMIT-Sita)

Type 2 Diabetes Mellitus

Canada
Assistance Publique Hopitaux De Marseille

Completed

Effect of GLP-1 Receptor (GLP-1R) Agonists on Cardiac Function and on Epicardial Adipose Tissue (EAT) Volume and on Myocardial TG Content in Obese Diabetics

Obesity | Diabetes

France
Sun Yat-sen University

Completed

Efficacy Study of Liraglutide vs.Sitagliptin vs. Glargine on Liver Fat in T2DM Subjects (LIGHT-ON)

Non-alcoholic Fatty Liver Disease

China
Sanofi

Completed

Efficacy Assessment of Insulin Glargine Versus LiraglutidE After Oral Agents Failure (EAGLE)

Diabetes Mellitus, Type 2

Brazil, United States, Finland, Spain, Austria, Canada, Czech Republic, France, Greece, Ireland, Israel, Mexico, Netherlands, Russian Federation, Slovakia, Sweden, Turkey
Sanofi

Completed

A Study on Safety, Pharmacokinetics and Pharmacodynamics of Lixisenatide in Pediatric Patients With Type 2 Diabetes Mellitus (T2DM)

Type 2 Diabetes Mellitus

Mexico, South Africa, United States, Mauritius, Spain, Turkey
AstraZeneca

Completed

Evaluate the Efficacy and Safety of Saxagliptin Added to Insulin Monotherapy or to Insulin Combined With Metformin in Chinese Subjects With Type 2 Diabetes Who Have Inadequate Glycaemic Control

Type 2 Diabetes Mellitus

China
Heidelberg University

Unknown

Prospective Influence of Bedtime Insulin Glargine on Mobilization and Function of Endothelial Progenitor Cells

Type 2 Diabetes

Germany
Assistance Publique - Hôpitaux de Paris

Recruiting

Impact of Metformin on Peripheral Arterial Calcification in Type 1 Diabetes (IMPACT-1D)

Type 1 Diabetes | Peripheral Arterial Calcification

France
Merck Sharp & Dohme LLC

Completed

A Pooled Analysis of the Safety and Efficacy of MK-0431A and MK-0431A XR in Pediatric Participants With Type 2 Diabetes Mellitus With Inadequate Glycemic Control on Metformin Therapy (Alone or in Combination With Insulin) (MK-0431A-170/MK-0431A-289)

Type 2 Diabetes Mellitus
Geropharm

Completed

Comparative Study of Rinsulin R (GEROPHARM) and Humulin Regular (Eli Lilly) Euglycemic Hyperinsulinemic Clamp Method

Bioequivalence | Therapeutic Equivalency

Russian Federation
Emory University
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Recruiting

Oral Anti Diabetic Agents in the Hospital

Diabetes Mellitus

United States
Eli Lilly and Company

Completed

The DURABLE Trial: Evaluating the Durability of Starter Insulin Regimens in Patients With Type 2 Diabetes (IOOV) (IOOV)

Diabetes Mellitus, Type 2

United States, Canada, India, Puerto Rico, Australia, Spain, Netherlands, Hungary, Brazil, Greece, Romania, Argentina
Xijing Hospital
Xi'an Central Hospital; First Affiliated Hospital Xi'an Jiaotong University; Shaanxi... and other collaborators

Completed

Comparison of Exenatide vs. Biphasic Insulin Aspart 30 on Glucose Variability in Type 2 Diabetes

Type 2 Diabetes Mellitus

China
Maya Guglin

Withdrawn

Effects of Metformin in Heart Failure Patients

Type 2 Diabetes Mellitus
Second Xiangya Hospital of Central South University
The First Affiliated Hospital with Nanjing Medical University; Beijing Hospital and other collaborators

Completed

Protective Effects of Saxagliptin (And Vitamin D3) on β Cell Function in Adult-onset Latent Autoimmune Diabetes

Diabetes Mellitus, Type 1

China
Medstar Health Research Institute

Completed

Stop Emergency Room Visits for Hyperglycemia Project - District of Columbia (DC) (STEP-DC)

Type 2 Diabetes Mellitus

United States
The University of Texas Health Science Center,...

Completed

Metformin Versus Insulin in Pregnant Women With Type 2 Diabetes

Pregnancy Complications

United States
Munich Municipal Hospital
Novo Nordisk A/S

Unknown

Insulin Effects on Metabolism and Cardiovascular Function in Type 2 Diabetes

Type 2 Diabetes Mellitus

Germany
Mike O'Callaghan Military Hospital

Terminated

Cinnamon Bark, Water-Soluble Cinnamon Extract, and Metformin for Treatment of Type 2 DM.

Diabetes

United States
Sanofi

Completed

GLP-1 Receptor Agonist Lixisenatide in Patients With Type 2 Diabetes for Glycemic Control and Safety Evaluation, on Top of Basal Insulin (GETGOAL-L)

Diabetes Mellitus, Type 2

United States, France, Canada, Brazil, Russian Federation, Germany, Italy, Turkey, India, Mexico, Egypt, United Kingdom, Korea, Republic of, Chile, Puerto Rico
Sanofi

Completed

Insulin Glargine in Type 2 Diabetic Patients (TARGET)

Diabetes Mellitus, Type 2

China
National Institute of Neurosciences and Hospital...

Completed

Insulin for Hyperglycemia in Stroke Trial

Hyperglycemia | Stroke, Acute

Bangladesh
Third Affiliated Hospital, Sun Yat-Sen University

Completed

The Effects of Metformin on Glycemic Control and Insulin Sensitivity in Adolescents With T1DM

Diabetes Mellitus, Type 1

China
Jagiellonian University

Active, not recruiting

dataBase for Analysis of Rectal Cancer Oncological Results (BARO)

Rectal Cancer | Lymph Node Metastases | Metformin | Overall Survival | Disease-free Survival

Poland
Merck Sharp & Dohme LLC
Pfizer

Completed

A Study To Evaluate The Efficacy And Safety Of Ertugliflozin In Participants With Type 2 Diabetes Mellitus And Inadequate Glycemic Control On Metformin Monotherapy (MK-8835-007).

Type 2 Diabetes Mellitus
Novo Nordisk A/S

Completed

Comparison of NN5401 Plus Insulin Aspart With Insulin Detemir Plus Insulin Aspart in Type 1 Diabetes (BOOST™)

Diabetes | Diabetes Mellitus, Type 1

United States, Poland, Puerto Rico, Russian Federation, United Kingdom, Denmark, France, Israel, Australia, Romania
Sanofi

Completed

iGlarLixi vs IDegAsp in Chinese Participants After OAD(s)

Type 2 Diabetes Mellitus

China
Yale University

Completed

Evaluation of Pharmacokinetics and Pharmacodynamic Properties of Rapid-Acting Insulin Analogs (PK/PD)

Diabetes Mellitus, Type I
Merck Sharp & Dohme LLC

Completed

Randomized Sitagliptin Withdrawal Study (MK-0431-845)

Type 2 Diabetes Mellitus
John H. Stroger Hospital
Eli Lilly and Company

Completed

Insulin Therapy in the Hospital Comparing Two Protocols

Diabetes Mellitus, Type 2

United States
Sanofi

Completed

A Study to Demonstrate Bioequivalence Between Insulin Glulisine U300 and Insulin Glulisine U100 After a Single Subcutaneous Dose Using the Euglycemic Clamp Technique, in Patients With Type 1 Diabetes Mellitus

Type1 Diabetes Mellitus

Germany
Brigham and Women's Hospital
Patient-Centered Outcomes Research Institute; McGill University; VA Boston Healthcare...

Active, not recruiting

Comparative Effectiveness and Safety of Four Second Line Pharmacological Strategies in Type 2 Diabetes Study (CER-4-T2D)

Type2 Diabetes | Renal Disease | Cardiovascular Events

United States
Novo Nordisk A/S

Completed

A Trial Investigating the Efficacy and Safety of Insulin Degludec/Insulin Aspart Once Daily Plus Insulin Aspart for the Remaining Meals Versus Insulin Detemir Once or Twice Daily Plus Meal Time Insulin Aspart in Children and Adolescents With Type 1 Diabetes Mellitus

Diabetes | Diabetes Mellitus, Type 1

United States, India, Russian Federation, Belgium, Spain, Israel, Croatia, Serbia, North Macedonia, South Africa, Slovenia, Brazil, Poland, Canada, Czechia
Novo Nordisk A/S

Completed

Comparison of Insulin Detemir Plus Insulin Aspart With Insulin NPH Plus Human Soluble Insulin in Subjects With Type 1 Diabetes

Diabetes | Diabetes Mellitus, Type 1

Croatia, Italy, Slovakia, Denmark, Macedonia, The Former Yugoslav Republic of, Norway, Russian Federation, Finland, France, Poland, Greece, Romania, Sweden, Czech Republic, Argentina
Novo Nordisk A/S

Completed

Effects of Biphasic Insulin Aspart 70/30 vs. Exenatide in Type 2 Diabetes Patients Not Reaching Blood Glucose Targets on Metformin and a Sulfonylurea.

Diabetes Mellitus, Type 2 | Diabetes

United States
Universidad de Guanajuato

Completed

Insulin Schemes for Type 2 Diabetes Control

Type 2 Diabetes Mellitus

Mexico
Novo Nordisk A/S

Completed

A 26-week Trial Comparing Efficacy and Safety of Insulin Degludec/Insulin Aspart BID and Insulin Degludec OD Plus Insulin Aspart in Subjects With Type 2 Diabetes Mellitus Treated With Basal Insulin in Need of Treatment Intensification With Mealtime Insulin

Diabetes Mellitus, Type 2 | Diabetes

United States, France, Austria, Norway, Algeria
Majianhua

Completed

Effects of Hypoglycemic Drugs on Testosterone Levels in Type 2 Diabetes Patients

Type 2 Diabetes

China
Sanofi

Completed

Optimal Oral Hypoglycaemic Agents (OHA) for Combination With Insulin Glargine (Sulfonylurea vs. Metformin)

Type 2 Diabetes Mellitus

Korea, Republic of
Abbott Diabetes Care

Completed

Ease of Use of New Blood Glucose Meter With In-built Insulin Calculator at Home Study (IHUT)

Diabetes Mellitus

United Kingdom
Wockhardt

Completed

Comparative Glucose Clamp Study of Wockhardt's Insulin Human Regular for Injection and Novolin R, in Healthy Subjects.

Diabetes Mellitus

United States
Rabin Medical Center
Sanofi

Terminated

Treatment Satisfaction of Insulin Glargine Plus Insulin Apidra Compared With NPH Insulin Plus Insulin Apidra in Recently Diagnosed Type 1 Diabetes Children and Adolescents

Diabetes Type 1

Israel

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