Search clinical trials for: Modified release hydrocortisone

Total 7444 results

Diurnal Limited

Completed

Chronocort Versus Plenadren Replacement Therapy in Adults With Adrenal Insufficiency (CHAMPAIN)

Primary Adrenal Insufficiency

Germany, United Kingdom
Ulla Feldt-Rasmussen

Unknown

Modified-release Compared to Conventional Hydrocortisone on Diurnal Fatigue in Secondary Hypoadrenalism (PlenadrEMA)

Adrenal Insufficiency
Diurnal Limited

Completed

Comparison of Chronocort Versus Standard Hydrocortisone Replacement Therapy in Participants Aged 16 Years and Over With Congenital Adrenal Hyperplasia (CONnECT)

Congenital Adrenal Hyperplasia

France, United States, Japan
Diurnal Limited
National Institutes of Health Clinical Center (CC)

Completed

Comparison of Two Forms of Hydrocortisone in Patients With Congenital Adrenal Hyperplasia

Adrenogenital Syndrome | Congenital Adrenal Hyperplasia | 21-Hydroxylase Deficiency

United States
The Adelaide and Meath Hospital, incorporating...

Unknown

Optimising Steroid Replacement in Patients With Adrenal Insufficiency

Adrenal Insufficiency

Ireland
Diurnal Limited
National Institutes of Health (NIH)

Completed

Pilot Study to Characterize and Examine the Pharmacokinetics and Efficacy of Chronocort® in Adults With CAH

Congenital Adrenal Hyperplasia | Adrenal Insufficiency | Endocrine Disease

United States
Diurnal Limited

Enrolling by invitation

Long-term Safety Study of Chronocort in the Treatment of Participants With Congenital Adrenal Hyperplasia

Congenital Adrenal Hyperplasia

United States, France, Japan
Shire

Completed

Once-daily Oral Modified Release Hydrocortisone in Patients With Adrenal Insufficiency

Adrenal Insufficiency
Vastra Gotaland Region
Sahlgrenska University Hospital, Sweden; The Gothenburg Society of Medicine; Åke... and other collaborators

Not yet recruiting

Treatment Study in Patients Treated With Both Insulin & Hydrocortisone (INSCORT)

Diabetes Mellitus | Adrenal Insufficiency | Polyglandular Autoimmune Syndrome

Sweden
Pfizer
ViiV Healthcare

Completed

Study to Estimate the Pharmacokinetics, Bioavailability and Effect of Food on Single Dose Modified-release Lersivirine 500 mg in Healthy Subjects

Healthy Volunteer

Belgium
Diurnal Limited
Simbec Research

Completed

Effect of Slow Release Hydrocortisone on Fed & Fasting Volunteers; Immediate Release on Fasting Only

Healthy
Heptares Therapeutics Limited
Quotient Clinical

Completed

Relative Bioavailability Study in Healthy Subjects to Evaluate the Pharmacokinetics of HTL0009936 After One Dose of Prototype Formulation

Alzheimer's Disease

United Kingdom
Alexion Pharmaceuticals
Achillion, a wholly owned subsidiary of Alexion

Completed

A Study of Modified Release Formulations of Danicopan in Healthy Adult Participants

Healthy

United Kingdom
GlaxoSmithKline
Quotient Clinical

Completed

A Study to Compare the Pharmacokinetics (PK) of GSK2982772 Following Administration of Different Modified Release (MR) Formulations in Capsule and MR Tablet Formulations Relative to an Immediate Release (IR) Tablet Formulation and to Check the PK of MR Formulation in Capsule Following Repeat Doses

Autoimmune Diseases

United Kingdom
GlaxoSmithKline
Quotient Sciences

Completed

A Study to Investigate the Pharmacokinetics (PK) of Modified Release (MR) Prototype Coated Tablet Formulations of GSK2982772

Autoimmune Diseases

United Kingdom
KalVista Pharmaceuticals, Ltd.

Completed

Phase 1 Crossover Study in Healthy Subjects to Evaluate the PK Profile of KVD824 Following Single and Multiple Doses of Modified Release (MR) Formulations

Hereditary Angioedema

United Kingdom
Centre Hospitalier Régional d'Orléans

Terminated

Effect of Hydrocortison on Post-ischemic Flow-mediated Dilation and on Thenar Oxygen Saturation in Human Septic Shock. (HyStOON)

Septic Shock | Adult

France
Amgen

Completed

Study to Evaluate Pharmacokinetics of Prototype Modified-Release Formulations Of Apremilast in Healthy Men

Healthy Volunteers

United States
Seattle Institute for Biomedical and Clinical Research
National Alliance for Research on Schizophrenia and Depression

Completed

Effect of Estrogen & Stress for Postmenopausal Women

Aging
University of Palermo

Completed

Effects of Steroid Replacement Therapy on Metabolic, Cardiovascular and Bone Outcomes in Adrenal Insufficiency

Adrenal Insufficiency
Max-Planck-Institute of Psychiatry
Novo Nordisk A/S

Terminated

Neuropsychological Effects of Hydrocortisone in Patients With Partial Adrenal Insufficiency (CSMünchen01)

Partial Corticotrope Insufficiency

Germany
GlaxoSmithKline

Completed

A Study to Compare the Safety and Drug Levels in Blood When Using Various Forms of GSK189075 Given to Healthy Subjects

Diabetes Mellitus, Type 2 | Type 2 Diabetes Mellitus

United States
GlaxoSmithKline

Completed

First-Time-in-Humans Study to Assess Safety, Pharmacokinetics & Pharmacodynamics of SB756050

Diabetes Mellitus, Type 2

United States
Genzyme, a Sanofi Company

Completed

Study Comparing Thyrogen Versus a Modified Release of Recombinant Human Thyroid Stimulating Hormone

Healthy

United States
Cairo University

Completed

Corticosteroids in Community Acquired Pneumonea

Community Acquired Pneumonia
University of Texas at Austin

Completed

Sensitivity of Short and Long Allele Carriers of the 5-HTTLPR to Environmental Threat Post Hydrocortisone Administration (5-HTTLPR)

Anxiety Disorders | Major Depressive Disorder

United States
The University of Texas at San Antonio
The University of Texas Health Science Center at San Antonio

Unknown

FE-SaLiR: Function Improvement Exercise

Cognitive Impairment | Disability Physical

United States
Bayer

Withdrawn

Efficacy/Safety Study to Explore a New Topical Formulation in Atopic Dermatitis (Phoenix)

Dermatitis, Atopic

Germany
Diurnal Limited
National Institutes of Health (NIH)

Withdrawn

Open-label Comparison of Chronocort® Versus Standard Glucocorticoid Replacement Therapy (RESTORE)

Congenital Adrenal Hyperplasia

United States
Bayer

Completed

Sinecort Pilot Efficacy Study (Sinecort Pilot)

Atopic Dermatitis

Germany
Pfizer

Completed

A Phase 1 Study To Evaluate The Pharmacokinetics And Safety Of Three Modified Release And One Immediate Release Formulations Of Tofacitinib (CP-690,550) In Healthy Volunteers

Healthy

Singapore
Kent State University
National Institute of Mental Health (NIMH)

Unknown

Prevention of Posttraumatic Stress Disorder (PTSD) With Early Hydrocortisone Treatment: Pilot

Posttraumatic Stress Disorder

United States
University of Ljubljana, Faculty of Medicine

Completed

The Influence of Psychobiological Adversity to Children and Adolescents With Type 1 Diabetes

Stress | Type 1 Diabetes

Slovenia
London School of Hygiene and Tropical Medicine
University of Cambridge; University of Liverpool

Completed

TUNE! Teaching the UK About Noise Exposure: A Pilot Study (gildeaf1)

Noise-induced Hearing Loss and Tinnitus

United Kingdom
Mansoura University

Unknown

Evaluation of Posterior Component Separation Modified TAR Technique "Transversus Abdominids Release" in the Treatment of Parastomal Hernia

TAR Technique

Egypt
UNION therapeutics

Active, not recruiting

Study to Assess the Efficacy and Safety of Orismilast in Atopic Dermatitis (ADESOS)

Skin Diseases | Atopic Dermatitis

Poland, United States, Hungary, Germany
UNION therapeutics

Completed

Study to Assess the Efficacy and Safety of Orismilast in Psoriasis (IASOS)

Skin Diseases | Psoriasis

United Kingdom, Poland, United States, Germany
University of Roma La Sapienza

Completed

Dual RElease Hydrocortisone Versus conventionAl Glucocorticoid replaceMent Therapy in Hypocortisolism (DREAM) (DREAM)

Secondary Adrenal Insufficiency | Primary Adrenal Insufficiency

Italy
Lung Biotechnology PBC

Completed

Extension of BPS-MR-PAH-203 in Pulmonary Arterial Hypertension (PAH) Patients

Pulmonary Arterial Hypertension

United States, Belgium, Czechia, Germany, Ireland, Romania
GlaxoSmithKline

Completed

Healthy Volunteer Study Using 3 Different Formulations of Firategrast

Multiple Sclerosis, Relapsing-Remitting

Australia
Federico II University

Recruiting

Congenital Adrenal Hyperplasia Once Daily Hydrocortisone Treatment (CareOnTIME)

Congenital Adrenal Hyperplasia

Italy
Lung Biotechnology PBC

Completed

An Open-Label Extension of BPS-MR-PAH-201 in Pulmonary Arterial Hypertension (PAH) Patients

Pulmonary Arterial Hypertension

United States, Belgium, Ireland
Eye & ENT Hospital of Fudan University

Unknown

The Clinical Effects of Modified TRS Treatment

Tinnitus, Subjective

China
Noorik Biopharmaceuticals AG

Terminated

A Study Evaluating the Utility of Ambrisentan in Lowering Portal Pressure in Patients With Liver Cirrhosis

Cirrhosis | Ascites | Portal Hypertension

Spain
Icahn School of Medicine at Mount Sinai
U.S. Department of Education

Completed

Effectiveness of Controlled-Release Morphine for Chronic Neuropathic Pain After Spinal Cord Injury

Neuropathic Pain | Spinal Cord Injury

United States
Rock Creek Pharmaceuticals, Inc.

Completed

Safety, Tolerability, and Pharmacokinetics of Modified and Immediate Release Anatabine Citrate Formulations

Pharmacokinetics of Anatabine

United Kingdom
Asan Medical Center

Completed

The Treatment of Posterior Semicircular Canal Benign Paroxysmal Positional Vertigo (BPPV)

Benign Paroxysmal Positional Vertigo

Korea, Republic of
NYU Langone Health

Completed

Water Oxygenation and Brain Activity

Muscle Damage

United States
Boehringer Ingelheim

Completed

Headache Study to Compare Aggrenox Full Dose and Reduced Dose

Cerebrovascular Accident

Taiwan
China Medical University Hospital

Completed

Evaluation of the Erector Spinae Muscle in Different Position and the Change After Receiving Myofascial Release.

Low Back Pain

Taiwan

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