Search clinical trials for: Multiple ascending doses SUL-238

Total 216 results

Hospital Regional Dr. Rafael Estévez
Complejo Hospitalario Dr. Arnulfo Arias Madrid; Hospital Santo Tomas; Hospital... and other collaborators

Completed

Use of Multiple Doses of Convalescent Plasma in Mechanically Intubated Patients With COVID-19

COVID-19

Panama
Virginia Commonwealth University
Gilead Sciences

Withdrawn

Rituximab, Idelalisib, and Venetoclax in Relapsed/Refractory CLL/SLL (RIVe-CLL/SLL)

Chronic Lymphocytic Leukemia | Refractory Chronic Lymphocytic Leukemia | Small Lymphocytic Lymphoma | CLL | Refractory Small Lymphocytic Lymphoma | SLL | Relapsed CLL | Relapsed Chronic Lymphocytic Leukemia | Relapsed Small Lymphocytic Lymphoma
Respivert Ltd

Completed

A Study to Investigate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Repeat Doses of RV1729 for 28 Days in Patients With COPD

Chronic Obstructive Pulmonary Disease

United Kingdom
Cellectar Biosciences, Inc.

Recruiting

Study of Iopofosine I 131 (CLR 131) in Select B-Cell Malignancies (CLOVER-1) and Pivotal Expansion in Waldenstrom Macroglobulinemia (CLOVER-WaM)

Multiple Myeloma | Waldenstrom Macroglobulinemia | Mantle Cell Lymphoma | Marginal Zone Lymphoma | Chronic Lymphocytic Leukemia | Lymphoplasmacytic Lymphoma | Diffuse Large B Cell Lymphoma | Small Lymphocytic Lymphoma | Central Nervous System Lymphoma

United States, Australia, Czechia, Greece, Israel, Brazil, Finland, France, Spain, Turkey, United Kingdom
Takeda

Withdrawn

A Safety and Efficacy Study of Ramelteon Tablets for Sublingual Administration (TAK-375SL) in the Maintenance Treatment of Bipolar 1 Disorder

Bipolar Disorder
ImmuneMed, Inc.

Completed

Safety, Tolerability, Pharmacokinetics of hzVSf-v13 in Healthy Adults (Intravenous and Subcutaneous Administration)

Healthy Volunteers

Australia
Guohua Zeng

Unknown

Comparison of Multiple-, Single- and Zero-dose of Ciprofloxacin Prophylaxis in Retrograde Intrarenal Surgery (RIRS)

Kidney Stones

China
Estetra

Completed

Safety, Tolerability and Pharmacokinetics of Estetrol (E4) After Single and Multiple Oral Doses in Healthy Female Volunteers

Menopause | Contraception

Bulgaria
Noah Merin
Johns Hopkins University

Terminated

Convalescent Plasma in ICU Patients With COVID-19-induced Respiratory Failure

Covid-19 | Sars-CoV2

United States
Asan Medical Center
JW Pharmaceutical

Completed

Drug Interaction and Safety Between Pitavastatin and Valsartan (CWP-PTV-101)

Healthy

Korea, Republic of
University Hospital Schleswig-Holstein

Recruiting

Evaluation of Safety and Pharmacokinetics of Oral Controlled-ileal-release Nicotinic Acid (CIR-NA) Compared to Immediate-release Nicotinic Acid and Placebo in Healthy Subjects and Subjects With Prediabetes

Safety Issues | Pharmacokinetic

Germany
Institute for Clinical and Experimental Medicine

Recruiting

INSULIN THERAPY DE-INTENSIFICATION WITH iGlarLixi (IDEAL)

Type 2 Diabetes Treated With Insulin

Czechia
Oasis Pharmaceuticals, LLC
Mayo Clinic; National Institute of Diabetes and Digestive and Kidney Diseases...

Recruiting

Safety Study of OA-235i in Subjects With Nonalcoholic Steatohepatitis

Nonalcoholic Steatohepatitis | Nonalcoholic Fatty Liver

United States
Pfizer
AbbVie

Not yet recruiting

A Study to Learn About the Study Medicine Aztreonam-Avibactam (ATM-AVI) in Infants and Newborns Admitted in Hospitals With Bacterial Infection (CHERISH) (CHERISH)

Gram-negative Bacterial Infection
Labopharm Inc.

Completed

A Comparative Bioavailability/Food Effect Study of Immediate-Release and Extended-Release Tramadol HCl/Acetaminophen Combination Products Following Single-Dose and Multiple-Dose Administration in Healthy Adult Volunteers

Healthy

United Kingdom
Respivert Ltd

Completed

A Study to Investigate the Safety, Tolerability and Pharmacokinetics of Single and Repeat Doses of RV1729 for up to 28 Days

Asthma | Healthy Volunteers

United Kingdom
Respivert Ltd

Terminated

A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Repeat Doses of RV6153

Asthma | Healthy Volunteers

United Kingdom
Human Genome Sciences Inc.
GlaxoSmithKline

Completed

Study of Belimumab Administered Subcutaneously to Healthy Subjects

Healthy

United States
Haukeland University Hospital
Møre og Romsdal Hospital Trust

Active, not recruiting

The NORDSTEN Studies/ The Spinal Stenosis Study (NORDSTEN/SST)

Lumbar Spinal Stenosis

Norway
Tonix Pharmaceuticals, Inc.

Completed

Comparative Pharmacokinetics and Safety of 3 Different Formulations of TNX-102 2.8 mg SL Tablets and Cyclobenzaprine 5 mg Oral Tablet in Healthy Adults

Healthy Adults

Canada
University Medicine Greifswald

Completed

Pharmacokinetic and Pharmacodynamic Interactions Between the Cholesterol-lowering Ezetimibe and the Non-nucleoside Reverse Transcriptase Inhibitor Efavirenz During Chronic Treatment in Healthy Volunteers With Reference to Intestinal Expression of CYP3A4, UGT1A1, ABCB1 and ABCC2

Pharmacokinetics | Pharmacodynamics | Drug Interactions | Intestinal Transporter Expression

Germany
Abu Dhabi Stem Cells Center

Recruiting

Efficacy of Extracorporeal Photopheresis (ECP) in the Treatment of Type 1 Diabetes Mellitus (OPERA)

Type 1 Diabetes

United Arab Emirates
Zhejiang Cancer Hospital

Recruiting

Different Radiation Dose of Neoadjuvant Chemoradiation for Resectable Thoracic Esophageal Squamous Carcinoma (Neo-DRATEC)

Surgery | Esophageal Carcinoma | Neoadjuvant Chemoradiotherapy

China
XOMA (US) LLC

Completed

An Open-Label Study of XOMA 358 in Patients With Hypoglycemia After Gastric Bypass Surgery (XOMA 358)

Hypoglycemia

United States
Imperial College London

Completed

Frequency of Common Medical Conditions in People With and Without HHT

Hereditary Hemorrhagic Telangiectasia (HHT)

United Kingdom
Ain Shams University

Completed

Long Acting Insulin Versus Multiple Dose Regimen for Control of Gestational Diabetes Mellitus

Long Acting Insulin in Control of Gestational Diabetes Mellitus

Egypt
Tonix Pharmaceuticals, Inc.

Terminated

Repeat of: A Study to Evaluate Efficacy and Safety of Sublingual TNX-102 SL Tablet Taken at Bedtime in Patients With Fibromyalgia (RE-AFFIRM)

Nervous System Diseases | Musculoskeletal Diseases | Rheumatic Diseases | Muscular Diseases | Neuromuscular Diseases | Fibromyalgia | Myofascial Pain Syndromes

United States
AstraZeneca

Completed

Study to Evaluate the 2-Way Interaction Between Multiple Doses of Epanova™ and a Single Dose of Rosuvastatin (Crestor®) (ECLIPSEIII)

Hypertriglyceridemia

United States
PhaseBio Pharmaceuticals Inc.

Completed

Phase 1/2a, Randomized, Double-Blind, Placebo-Controlled, Study to Assess Safety, Tolerability, PK and PD Response of PB1023 Injection Following Single and Multiple SQ Doses in Adults With Type 2 Diabetes Mellitus

Diabetes Mellitus, Type 2

United States
Sinovac Research and Development Co., Ltd.

Completed

Study on Combined Vaccination With SARS-CoV-2 Inactivated Vaccine and Quadrivalent Influenza Vaccine

COVID-19 | Influenza

China
Xiangbei Welman Pharmaceutical Co., Ltd

Suspended

Study on Ceftazidime and Sulbactam Sodium for Injection (2:1) for Treatment of Respiratory and Urinary Tract Infection (CAZ-SBT)

Respiratory Tract Infections | Urinary Tract Infections

China
Cubist Pharmaceuticals LLC

Completed

Plasma Pharmacokinetics (PK) & Lung Penetration of Ceftolozane/Tazobactam in Participants With Pneumonia (MK-7625A-007)

Pneumonia | Critically Ill
Castilla-La Mancha Health Service
Universidad de Córdoba; University of Castilla-La Mancha

Completed

Continuous Subcutaneous Insulin Infusion Versus Multiple Dose Insulin Injections in Routine Clinical Practice (real-ECIMI)

Type 1 Diabetes Mellitus

Spain
Acerus Pharmaceuticals Corporation

Completed

PK Study of Testosterone Nasal Gel (TBS-2) in Healthy Premenopausal Women

Female Sexual Dysfunction

United States
Xi'an Xintong Pharmaceutical Research Co.,Ltd.

Recruiting

Safety, Tolerability Phase Ia Study of XT1061 in Single and Multiple Doses in Healthy Subjects (XT1061)

Chronic Hepatitis b

China
Mansoura University

Recruiting

Dual Trigger Versus GnRHa Trigger Combined With Luteal HCG Administration

Infertility

Egypt
Makerere University

Completed

Single Dose Ceftriaxone and Metronidazole Versus Multiple Doses for Antibiotic Prophylaxis at Elective Cesarean Section. (SDvMD)

Post Operative Infections

Uganda
H. Lundbeck A/S

Completed

Pharmacokinetic Properties of Vortioxetine in Healthy Young Chinese Men and Women

Pharmacokinetics

China
Boehringer Ingelheim

Completed

FLOMAX® Versus HYTRIN® in Patients With the Signs and Symptoms of Benign Prostatic Hyperplasia

Prostatic Hyperplasia
University Hospital Tuebingen
Dr. Falk Pharma GmbH; Principal Investigator: Univ. Hosp. Tuebingen, Dept....

Completed

Pharmacokinetic Interaction Study Between Budesonide and Metronidazole in Healthy Volunteers

Healthy
Beijing Tongren Hospital

Recruiting

The Phase I Study of Recombinant Human Nerve Growth Factor Injection

Injury of Optic Nerve

China
Antonios Likourezos

Recruiting

Nebulized Sub-dissociative Dose Ketamine at Three Different Dosing Regimens for Treating Acute Pain in the Pediatric ED

Pain

United States
Novavax

Completed

RSV-F Vaccine and Influenza Vaccine Co-Administration Study in the Elderly

Respiratory Syncytial Virus (RSV)

United States
Jiangsu Province Centers for Disease Control and...
Academy of Military Medical Sciences，Academy of Military Sciences，PLA ZHONGYIANKE...

Recruiting

Immunogenicity and Safety of Recombinant COVID-19 Vaccine (CHO Cells)

COVID-19

China
University Medicine Greifswald

Completed

Pharmacokinetics and Distribution of Dapsone in Leucocytes After Single-dose and Multiple-dose Administration

Methemoglobinemia | Linear IgA Bullous Dermatosis

Germany
Novavax

Completed

A Study to Evaluate the Safety and Immunogenicity of an (Omicron Subvariant) COVID-19 Vaccine Booster Dose in Previously Vaccinated Participants and Unvaccinated Participants. (COVID-19)

COVID-19

United States
Rajiv Gandhi Cancer Institute & Research Center...
Varian, a Siemens Healthineers Company

Recruiting

Dose Escalation Using Hypoxia-adjusted Radiotherapy (DE-HyART)

Head and Neck Squamous Cell Carcinoma

India
Boehringer Ingelheim

Completed

Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Single and Multiple Doses of Linagliptin Tablets in Patients With Different Degrees of Renal Impairment in Comparison to Subjects With Normal Renal Function

Renal Insufficiency
Hutchison Medipharma Limited

Recruiting

A Study of HMPL-295S1 in Patients With Advanced Malignant Solid Tumors

Advanced Malignant Solid Tumors

China
Cancer Institute and Hospital, Chinese Academy...

Recruiting

ABOD2011 in Patients With Advanced Solid Tumors Progressed After Standard Systemic Therapy

Patients With Advanced Solid Tumors

China

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