Search clinical trials for: Optimal medical therapy

Total 27014 results

University of Leicester

Unknown

Combination Chemotherapy With or Without Filgrastim Before Surgery, High-Dose Chemotherapy, and Radiation Therapy Followed by Isotretinoin With or Without Monoclonal Antibody in Treating Patients With Neuroblastoma

Neuroblastoma

Ireland, United Kingdom, France, Switzerland, Austria, Italy, Spain, Norway, Belgium, Denmark, Israel, Portugal, Sweden
Memorial Sloan Kettering Cancer Center
National Cancer Institute (NCI)

Unknown

Bevacizumab, Doxorubicin, and Cyclophosphamide Followed By Paclitaxel Albumin-Stabilized Nanoparticle Formulation and Bevacizumab in Treating Patients Who Have Undergone Surgery for Early-Stage Breast Cancer

Breast Cancer

United States
Children's Cancer and Leukaemia Group

Unknown

Combination Chemotherapy in Treating Infants With Newly Diagnosed Neuroblastoma Who Are Undergoing Surgery With or Without Autologous Bone Marrow or Peripheral Stem Cell Transplant

Neuroblastoma
Chimeric Therapies

Completed

Treatment of Bone Marrow to Prevent Graft-Versus-Host Disease in Patients With Acute or Chronic Leukemia Undergoing Bone Marrow Transplantation

Myelodysplastic Syndromes | Leukemia | Graft Versus Host Disease

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Interferon Alfa With or Without Combination Chemotherapy Plus Interleukin-2 in Treating Patients With Melanoma

Melanoma | Skin Cancer

United States
Roswell Park Cancer Institute
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Donor Umbilical Cord Blood Transplantation in Treating Patients With Leukemia, Lymphoma, or Nonmalignant Hematologic Disorders

Lymphoma | Myelodysplastic Syndromes | Leukemia | Myelodysplastic-Myeloproliferative Diseases

United States
Temple University

Completed

Bone Marrow Transplant Plus Cyclophosphamide and Total-Body Irradiation in Treating Patients With Hematologic Cancer

Myelodysplastic Syndromes | Leukemia | Myelodysplastic/Myeloproliferative Diseases

United States
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Completed

Gemtuzumab Ozogamicin, Fludarabine, and Total-body Irradiation Followed by Peripheral Stem Cell or Bone Marrow Transplantation in Treating Patients With Advanced Acute Myeloid Leukemia or Myelodysplastic Syndrome

Myelodysplastic Syndromes | Leukemia

United States
Yale University

Completed

Adjuvant High-Dose, Sequential Chemotherapy in Treating Patients With Resected Breast Cancer

Breast Cancer

United States
Children's Oncology Group
National Cancer Institute (NCI)

Active, not recruiting

Treatment With Dinutuximab, Sargramostim (GM-CSF), and Isotretinoin in Combination With Irinotecan and Temozolomide After Intensive Therapy for People With High-Risk Neuroblastoma (NBL)

Neuroblastoma | Ganglioneuroblastoma, Nodular

United States, Australia, Canada, New Zealand
Universiti Kebangsaan Malaysia Medical Centre
Institue of Microengineering and Nanoelectronics (IMEN), Universiti Kebangsaan... and other collaborators

Completed

Efficacy of Transdermal Microneedle Patch for Topical Anesthesia Enhancement in Paediatric Thalassemia Patients

Thalassemia in Children

Malaysia
Mack Mitchell
National Institute on Alcohol Abuse and Alcoholism (NIAAA); The Cleveland Clinic and other collaborators

Completed

Efficacy Study of Anakinra, Pentoxifylline, and Zinc Compared to Methylprednisolone in Severe Acute Alcoholic Hepatitis

Acute Alcoholic Hepatitis

United States
Guangdong Provincial People's Hospital
Sun Yat-sen University

Unknown

Safety and Efficacy Study of Allogenic Mesenchymal Stem Cells to Treat Extensive Chronic Graft Versus Host Disease

Graft Versus Host Disease

China
University of Rochester NCORP Research Base
National Cancer Institute (NCI)

Completed

Netupitant/Palonosetron Hydrochloride and Dexamethasone With or Without Prochlorperazine or Olanzapine in Improving Chemotherapy-Induced Nausea and Vomiting in Patients With Breast Cancer

Breast Carcinoma

United States
Mayo Clinic

Recruiting

The Effects of Acute and Chronic Exercise on Immune Phenotype of Indolent Non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia Patients

Indolent Non-hodgkin Lymphoma | Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

United States
Camillians Saint Mary's Hospital Luodong

Recruiting

Comparison of the Effects for Lightening the Shiners Among Different Treatments for Rhinitis

Allergic Rhinitis | Vasomotor Rhinitis

Taiwan
Changhai Hospital

Not yet recruiting

Optimal Timing of Endoscopic Intervention in the Treatment of Chronic Pancreatitis. (TEST)

Pancreatitis, Chronic

China
Beth Israel Deaconess Medical Center

Recruiting

Gait Analysis in Neurological Disease

Parkinson's Disease | Parkinsonian Disorders | Multiple System Atrophy | Corticobasal Degeneration | Progressive Supranuclear Palsy | Huntington Disease | Atypical Parkinson Disease | Gait, Frontal

United States
Hoffmann-La Roche

Active, not recruiting

A Two-Arm Study to Evaluate the Pharmacokinetics, Efficacy, and Safety of Subcutaneous Administration of the Fixed-Dose Combination of Pertuzumab and Trastuzumab in Combination With Chemotherapy in Chinese Participants With HER2-Positive Early Breast Cancer

HER2-positive Early Breast Cancer

China
Latin American Cooperative Oncology Group
Merck Sharp & Dohme LLC

Active, not recruiting

Study of a Pembrolizumab-based Organ Preservation Strategy for Locally Advanced Larynx Cancers (SMART-KEY)

Squamous Cell Carcinoma of Larynx

Brazil
TriHealth Inc.

Completed

Effect of Multimodal Analgesia on Pain With Insertion of Levonorgestrel-releasing IUD

Contraception

United States
Idorsia Pharmaceuticals Ltd.

Completed

To Study the Effect of Cenerimod on the Electrical Activity of the Heart, in Men and Women. To Study the Effect of Cenerimod on the Use of Oral Contraceptives in Women. To Study the Effect That Charcoal Has on the Elimination of Cenerimod From the Body, in Women and Men.

Healthy Subjects

France
Duke University

Completed

Mobile Contingency Management for Concurrent Abstinence From Alcohol and Smoking

Alcohol Drinking | Smoking Cessation

United States
Case Comprehensive Cancer Center

Completed

Treating Patients With Prostate Cancer That Did Not Respond to Hormone Therapy

Prostate Cancer

United States
University of Milan
Fondazione "Un Cuore per Milano" - a no profit foundation

Completed

Enhanced Platelet Inhibition in Critically Ill Patients With COVID-19 (PIC-19)

Pneumonia, Viral | Embolism and Thrombosis | Respiratory Failure | Corona Virus Infection

Italy
Roswell Park Cancer Institute

Completed

Chemotherapy, Radiation Therapy, and Umbilical Cord Blood Transplantation in Treating Patients With Hematologic Cancer

Lymphoma | Myelodysplastic Syndromes | Leukemia | Multiple Myeloma and Plasma Cell Neoplasm | Graft Versus Host Disease

United States
Boston Children's Hospital
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Completed

Adrenal and Gonadal Hormone Replacement in Anorexia Nervosa

Anorexia Nervosa

United States
Janssen Sciences Ireland UC

Completed

Relative Bioavailability and Food Effect for Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide Fixed Dose Combination

Healthy

Belgium
Sanofi
Regeneron Pharmaceuticals

Completed

Efficacy, Safety, and Tolerability of Dupilumab in Patients With Persistent Moderate to Severe Eosinophilic Asthma

Asthma

United States
GlaxoSmithKline

Completed

Establishing Predictors of Enlarged Prostate Treatment Adherence: Linking Symptom Improvement to Adherence

Prostatic Hyperplasia
Boston Scientific Corporation

Completed

Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy Post Approval Registry (MADIT-CRT PAR)

Heart Failure

United States
Orexigen Therapeutics, Inc

Completed

A Study of the Safety and Efficacy of Two Doses of Naltrexone SR/Bupropion SR and Placebo in Overweight and Obese Subjects

Obesity | Overweight

United States
University of Southern California
National Cancer Institute (NCI)

Completed

Radiation Therapy Plus Paclitaxel in Treating Patients With Stage IIB or Stage III Breast Cancer

Breast Cancer

United States
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Neuroblastoma

Neuroblastoma

United States, Australia
Northside Hospital, Inc.
Blood and Marrow Transplant Group of Georgia

Terminated

Donor Stem Cell Transplant in Treating Patients With High-Risk Hematologic Cancer

Lymphoma | Myelodysplastic Syndromes | Leukemia | Myelodysplastic/Myeloproliferative Diseases

United States
Scottish Cancer Therapy Network

Completed

Tamoxifen Following Combination Chemotherapy in Treating Women With Operable Invasive Breast Cancer

Breast Cancer

United Kingdom
Scottish Cancer Therapy Network

Completed

Tamoxifen With or Without Combination Chemotherapy in Treating Postmenopausal Women With Operable Invasive Breast Cancer

Breast Cancer

United Kingdom
Newron Pharmaceuticals SPA

Completed

MOTION, Safinamide in Early IPD, as add-on to Dopamine Agonist (MOTION)

Idiopathic Parkinson's Disease

United States, Spain, Brazil, Peru, Colombia, Germany, Argentina, India, Croatia, Czech Republic, Italy, South Africa, Finland, Portugal, Canada, Slovakia, Bulgaria, Chile, Mexico, Poland
Gesellschaft fur Padiatrische Onkologie und Hamatologie...

Completed

Chemotherapy and Radiation Therapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Neuroblastoma

Neuroblastoma

Germany, Netherlands, Switzerland
Children's Cancer and Leukaemia Group

Unknown

Radiation Therapy or Combination Chemotherapy in Treating Young Patients With Hodgkin's Lymphoma

Lymphoma
Children's Cancer and Leukaemia Group

Unknown

Chemotherapy Followed by Surgery and Radiation Therapy With or Without Stem Cell Transplant in Treating Patients With Relapsed or Refractory Wilms' Tumor or Clear Cell Sarcoma of the Kidney

Kidney Cancer

United Kingdom, Ireland
Memorial Sloan Kettering Cancer Center
National Cancer Institute (NCI)

Completed

Combination Chemotherapy, Radiation Therapy, and Peripheral Stem Cell Transplantation in Treating Patients With Stage III or Stage IV Mantle Cell Lymphoma

Lymphoma

United States
Buddhist Tzu Chi General Hospital

Terminated

Efficacy of Seven-day Combined Rabeprazole Plus Levofloxacin Plus Augmentin for Eradication of Helicobacter Pylori

Helicobacter Pylori Infection

Taiwan
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Completed

Combination Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Stage II or Stage IIIA Breast Cancer

Breast Cancer

United States
Assiut University

Not yet recruiting

Coronary Artery Ectasia, Efficacy of Various Anti Thrombotic Regimens.

Coronary Artery Ectasia
Mercy Health Ohio
Northeast Ohio Medical University

Recruiting

Single Dose Aminoglycosides for Acute Uncomplicated Cystitis in the Emergency Department Setting

Urinary Tract Infections

United States
Sun Yat-sen University

Recruiting

Corticosteroid Combining Noncorticosteroid Systemic Immunomodulatory Therapy in VKH

Vogt Koyanagi Harada Disease (VKH)

China
University of Washington
National Cancer Institute (NCI)

Terminated

Image Guided Hypofractionated Radiation Therapy, Nelfinavir Mesylate, Pembrolizumab, Nivolumab and Atezolizumab in Treating Patients With Advanced Melanoma, Lung, or Kidney Cancer

Stage IV Cutaneous Melanoma AJCC v6 and v7 | Stage IV Renal Cell Cancer AJCC v7 | Recurrent Lung Non-Small Cell Carcinoma | Metastatic Kidney Carcinoma | Stage IV Lung Non-Small Cell Cancer AJCC v7

United States
Southwest Oncology Group
National Cancer Institute (NCI)

Completed

S0313 Cyclophosphamide, Doxorubicin, Vincristine, Prednisone, and Radiation Therapy Followed By Rituximab and Yttrium Y 90 Ibritumomab Tiuxetan in Treating Patients With Stage I or Stage II Non-Hodgkin's Lymphoma

Lymphoma

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI); Cancer Prevention Research Institute of Texas

Completed

Fucosylated T Cells for Graft Versus Host Disease (GVHD) Prevention

Lymphoma | Leukemia

United States

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