- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00002809
Bone Marrow Transplant Plus Cyclophosphamide and Total-Body Irradiation in Treating Patients With Hematologic Cancer
Unrelated Bone Marrow Transplantation With Cyclophosphamide and Total Body Irradiation For Hematologic Malignancies and Bone Marrow Failure States
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage cancer cells. Combining chemotherapy and radiation therapy together with bone marrow transplant may allow the doctor to give higher doses of chemotherapy drugs and kill more cancer cells.
PURPOSE: This phase II trial is studying how well giving bone marrow transplant from an unrelated donor together with cyclophosphamide and total-body irradiation works in treating patients with hematologic cancer.
Study Overview
Status
Detailed Description
OBJECTIVES:
- Study the curative potential of high-dose cyclophosphamide and total-body irradiation followed by rescue with bone marrow from volunteer HLA-matched donors in patients with a variety of hematologic malignancies and bone marrow failure states.
- Study the toxic effects associated with matched unrelated bone marrow transplantation in this patient population.
- Participate in collaborative research studies with the National Marrow Donor Program.
OUTLINE: All patients receive myeloablative therapy with high-dose cyclophosphamide and total body irradiation over 4 days; patients with severe aplastic anemia also receive antithymocyte globulin. Patients then undergo allogeneic bone marrow transplantation. Filgrastim (G-CSF) is given after transplant to accelerate engraftment. Sargramostim (GM-CSF) may be given in case of graft failure.
All patients receive graft-versus-host-disease (GVHD) prophylaxis with tacrolimus, methotrexate, and gamma globulin. Established GVHD is treated with corticosteroids and, as necessary, antithymocyte globulin.
Patients are followed at 100 days, 6 months, and 1 year after transplant, then annually thereafter.
PROJECTED ACCRUAL: A total of 10 patients per year will be accrued for this study over 5 years.
Study Type
Enrollment (Anticipated)
Phase
- Phase 2
Contacts and Locations
Study Locations
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-
Pennsylvania
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Philadelphia, Pennsylvania, United States, 19111-2442
- Fox Chase-Temple Cancer Center
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-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
DISEASE CHARACTERISTICS:
One of the following hematologic malignancies/disorders:
Acute lymphoblastic leukemia
- In second or subsequent complete remission (CR)
- In first CR with high-risk features (e.g., Philadelphia chromosome-positive)
- In first relapse and failed conventional salvage therapy
Acute myelogenous leukemia (AML)
- In second or subsequent CR
- In early first relapse
- In full first relapse and failed conventional salvage therapy
In first CR with high-risk features, e.g., trisomy 8 or FAB 6/7
- Standard-risk AML offered conventional-dose consolidation chemotherapy or autologous bone marrow transplantation
Chronic myelogenous leukemia in chronic, accelerated, or second chronic phase
- No blast crisis
- Severe aplastic anemia that has failed at least 1 course of immunosuppressive therapy
- Paroxysmal nocturnal hemoglobinuria with high-risk features (e.g., disseminated intravascular coagulation, thrombotic events)
Myelodysplastic syndrome, i.e.:
- Symptomatic, transfusion-dependent refractory anemia with excess blasts
- (RAEB) or RAEB in transformation
- Secondary leukemia in CR following conventional-dose induction chemotherapy
- Unrelated marrow donor available who is 8 out of 10-, 9 out of 10-, or 10 out of 10-antigen serologically HLA-matched at A, B, C, DRb, and DQB loci by molecular typing
- No CNS malignancy
PATIENT CHARACTERISTICS:
Age:
- 17 to 60
Performance status:
- Karnofsky 70-100%
Life expectancy:
- No reduction due to other serious illness
Hematopoietic:
- Not specified
Hepatic:
- Bilirubin less than 3 mg/dL
- AST/ALT no greater than twice normal
Renal:
- Creatinine no greater than 2.0 mg/dL
- Creatinine clearance greater than 60 mL/min
Cardiovascular:
- Left ventricular ejection fraction at least 45%
- No severe hypertension
Pulmonary:
- DLCO, FEV_1, and FVC at least 50%
Other:
- HIV negative
- No active infection at time of transplant
- No advanced diabetes
- No significant neurologic deficit
- No active drug or substance abuse
- No emotional disorders
- Able to participate in frequent medical care for at least 1-2 years
- Willing to comply with National Marrow Donor Program policies
PRIOR CONCURRENT THERAPY:
Biologic therapy
- See Disease Characteristics
Chemotherapy
- See Disease Characteristics
Endocrine therapy
- Not specified
Radiotherapy
- Not specified
Surgery
- Not specified
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Masking: None (Open Label)
Collaborators and Investigators
Sponsor
Investigators
- Study Chair: Kenneth F. Mangan, MD, FACP, Fox Chase Cancer Center
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
- refractory anemia
- refractory anemia with excess blasts
- refractory anemia with excess blasts in transformation
- previously treated myelodysplastic syndromes
- adult acute myeloid leukemia with 11q23 (MLL) abnormalities
- adult acute myeloid leukemia with inv(16)(p13;q22)
- adult acute myeloid leukemia with t(15;17)(q22;q12)
- adult acute myeloid leukemia with t(16;16)(p13;q22)
- adult acute myeloid leukemia with t(8;21)(q22;q22)
- secondary acute myeloid leukemia
- chronic phase chronic myelogenous leukemia
- recurrent adult acute myeloid leukemia
- atypical chronic myeloid leukemia
- myelodysplastic/myeloproliferative disease, unclassifiable
- adult acute myeloid leukemia in remission
- refractory chronic lymphocytic leukemia
- recurrent adult acute lymphoblastic leukemia
- accelerated phase chronic myelogenous leukemia
- adult acute lymphoblastic leukemia in remission
Additional Relevant MeSH Terms
- Neoplasms by Histologic Type
- Neoplasms
- Bone Marrow Diseases
- Hematologic Diseases
- Precancerous Conditions
- Myelodysplastic Syndromes
- Leukemia
- Preleukemia
- Myeloproliferative Disorders
- Myelodysplastic-Myeloproliferative Diseases
- Physiological Effects of Drugs
- Molecular Mechanisms of Pharmacological Action
- Nucleic Acid Synthesis Inhibitors
- Enzyme Inhibitors
- Antirheumatic Agents
- Antimetabolites, Antineoplastic
- Antimetabolites
- Antineoplastic Agents
- Immunosuppressive Agents
- Immunologic Factors
- Antineoplastic Agents, Alkylating
- Alkylating Agents
- Myeloablative Agonists
- Dermatologic Agents
- Reproductive Control Agents
- Abortifacient Agents, Nonsteroidal
- Abortifacient Agents
- Folic Acid Antagonists
- Calcineurin Inhibitors
- Cyclophosphamide
- Antibodies
- Immunoglobulins
- Immunoglobulins, Intravenous
- Methotrexate
- Tacrolimus
- gamma-Globulins
- Rho(D) Immune Globulin
- Sargramostim
- Antilymphocyte Serum
Other Study ID Numbers
- CDR0000064937
- TUHSC-2803
- NCI-V96-0950
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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