Search clinical trials for: P falciparum Controlled Human Malaria Infection (CHMI)

Total 96 results

University of Oxford

Completed

VAC063C: A Study to Assess Repeat Blood-stage P. Falciparum Infection

Malaria

United Kingdom
U.S. Army Medical Research and Development Command
GlaxoSmithKline; United States Agency for International Development (USAID); Walter... and other collaborators

Completed

Phase 1 Clinical Trial With Controlled Human Malaria Infection (CHMI) to Evaluate the Safety and Efficacy of the Plasmodium Falciparum Vaccine Candidate FMP012 Administered Intramuscularly With AS01B Adjuvant System in Healthy Malaria-Naïve Adults

Malaria

United States
National Institute of Allergy and Infectious Diseases...

Completed

A Systems Biology Approach to Malaria Immunity

Plasmodium Falciparum Infection

United States
U.S. Army Medical Research and Development Command
United States Agency for International Development (USAID); University of Oxford and other collaborators

Completed

Trial to Evaluate the Safety, Immunogenicity, and Efficacy of Malaria Infection in Malaria Naïve Adults

Malaria

United States
Radboud University Medical Center
Bill and Melinda Gates Foundation

Completed

Chemoprophylaxis and Plasmodium Falciparum NF54 Sporozoite Immunization Challenged by Heterologous Infection (BMGF2b)

Malaria

Netherlands
Radboud University Medical Center
The PATH Malaria Vaccine Initiative (MVI); QIMR Berghofer Medical Research...

Completed

Controlled Human Malaria Infection Model for Evaluation of Transmission-blocking Interventions - Study 2 (CHMI-trans2)

Transmission | Malaria,Falciparum | Controlled Human Malaria Infection | Gametocytes

Netherlands
Karolinska University Hospital

Completed

Efficacy and Cost Effectiveness of Malaria Diagnosis Procedures and the Rational Use of ACT in Zanzibar (ZRDT)

Malaria

Tanzania
Malaria Vaccine and Drug Development Center
Ministerio de la Protección Social, Colombia.

Completed

Establishment of a Sporozoite Challenge Model for Plasmodium Vivax in Human Volunteers (ChallengeII)

Malaria, Vivax

Colombia
Radboud University Medical Center
The PATH Malaria Vaccine Initiative (MVI)

Terminated

Safety and Efficacy of NF135 CPS Immunization (CPS135)

Malaria,Falciparum | Controlled Human Malaria Infection | Immunization; Infection

Netherlands
Medicines for Malaria Venture
GlaxoSmithKline; ICON plc; QIMR Berghofer Medical Research Institute; Swiss BioQuant... and other collaborators

Completed

Phase 1b MMV367 PK/PD and Safety in Healthy Adult Volunteers Experimentally Infected With Blood Stage P. Falciparum

Pathologic Processes | Infections | Systemic Inflammatory Response Syndrome | Inflammation | Vector Borne Diseases | Parasitic Diseases | Protozoan Infections | Malaria | Parasitemia | Malaria,Falciparum | Anti-Infective Agents | Antimalarials

Australia
University of Oxford

Completed

A Challenge Study to Assess the Protective Efficacy of Two Malaria Vaccine Candidates (VAC045)

Plasmodium Falciparum Malaria

United Kingdom
Leiden University Medical Center

Not yet recruiting

Durability of Protection After Single Immunisation With GA2 Sporozoites (CoGA-Rechallenge)

Malaria,Falciparum
Radboud University Medical Center
Erasmus Medical Center; The PATH Malaria Vaccine Initiative (MVI); Havenzieke...

Completed

Safety and Protective Efficacy of Pb(PfCS@UIS4) (PbVac)

Plasmodium Falciparum | Malaria,Falciparum | Plasmodium Berghei | Controlled Human Malaria Infection (CHMI)

Netherlands
University of Oxford

Completed

A Phase I/IIa Sporozoite Challenge Study to Assess the Efficacy of Candidate Combination Malaria Vaccine Approaches Using the ChAd63 and MVA Vectors Encoding the Antigens ME-TRAP, CS and AMA1

Plasmodium Falciparum Malaria

United Kingdom
Medicines for Malaria Venture
QIMR Berghofer Medical Research Institute; Children's Health Queensland Hospital... and other collaborators

Completed

Pyronaridine in Healthy Adult Participants Infected With Blood Stage Malaria

Protozoan Infections | Malaria | Parasitemia | Malaria,Falciparum | Parasitic Disease | Malaria Recrudescence

Australia
University of Oxford
Ifakara Health Institute

Completed

A Study of Blood-stage Controlled Human Plasmodium Falciparum Malaria Infection in Tanzania

Malaria | Plasmodium Falciparum

Tanzania
CSL Behring

Completed

Human C1 Esterase Inhibitor (C1-INH) in Subjects With Acute Abdominal or Facial Hereditary Angioedema (HAE) Attacks

Hereditary Angioedema

Bulgaria, United States, Poland, Spain, Hungary, United Kingdom, Russian Federation, Macedonia, The Former Yugoslav Republic of, Argentina, Australia, Canada, Czech Republic, Israel, Romania, Sweden
Seattle Children's Research Institute (SCRI)

Completed

Malaria Challenge in Healthy Volunteers (ITV)

Malaria

United States
Radboud University Medical Center
The PATH Malaria Vaccine Initiative (MVI); QIMR Berghofer Medical Research...

Completed

Controlled Human Malaria Infection Model for Evaluation of Transmission-Blocking Interventions - Study 1 (CHMI-trans1)

Malaria

Netherlands
Centre Hospitalier Universitaire Dijon

Completed

Open and Exploratory Trial to Investigate the Pharmacokinetic of Ceftobiprole Medocaril in Patients With CSF Device (BASILE)

Inflamed Meninges | Suspected Meningitis | Ventriculitis

France
Radboud University Medical Center
ZonMw: The Netherlands Organisation for Health Research and Development

Completed

Immunization With Plasmodium Falciparum Sporozoites Under Chloroquine Versus Mefloquine Prophylaxis

Malaria | Plasmodium Falciparum

Netherlands
Radboud University Medical Center
Bill and Melinda Gates Foundation

Completed

Target Antigens Induced by Plasmodium Falciparum Sporozoite Immunization Under Chemoprophylaxis (BMGF1)

Malaria

Netherlands
National Taiwan University Hospital
E-DA Hospital

Unknown

Comparison of the Efficacy of Levofloxacin-based Sequential Therapy and Triple Therapy as Second Line Therapy

Eradication Rate for Helicobacter

Taiwan
Centers for Disease Control and Prevention
Columbia University; United States Agency for International Development (USAID)

Completed

Ethiopia Malaria Therapeutic Efficacy Study

Malaria

Ethiopia
West China Hospital

Not yet recruiting

Accelerated Recovery for Total Knee Replacement Surgery With Preoperative Intravenous Iron Combined With Human Erythropoietin for Rapid Hematopoietic Mobilization to Prevent Postoperative Anemia (Hematoboost)

Total Knee Arthroplasty

China
Dragonboat Biopharmaceutical Company Limited
Shanghai East Hospital

Unknown

Phase I Clinical Trial of Human Anti-PD-L1 Antibody Injection (LDP) in Patients With Advanced Malignant Tumors

Advanced Tumors

China
Dragonboat Biopharmaceutical Company Limited
Fudan University

Recruiting

the Efficacy and Safety of LDP in Patients With Urinary and Male Genital Tumors

Bladder Cancer | Renal Carcinoma | Advanced Penile Carcinoma

China
Synermore Biologics (Suzhou) Co., Ltd.

Completed

A Bridging Study of the SYN023 on Healthy Adult Subjects

Vaccine Reaction | Rabies Human | Immunisation Reaction | Zoonotic Disease | Communicable Disease Transmission

China
Dragonboat Biopharmaceutical Company Limited
West China Hospital

Recruiting

An Exploratory Clinical Study of LDP Combined With CDP1 in Patients With Advanced Malignant Tumor

Advanced Malignant Tumor

China
GlaxoSmithKline

Completed

Long-Term Follow-up of Children for a 2-Year Period to Confirm the Safety and Immunogenicity of GSK 257049 Vaccine

Malaria

Mozambique
Idorsia Pharmaceuticals Ltd.

Completed

Effect of ACT-451840 Against Early Plasmodium Falciparum Blood Stage Infection in Healthy Subjects

Healthy Subjects

Australia
Merck Sharp & Dohme LLC

Recruiting

A Study to Evaluate Antimalarial Activity and Safety of MK-7602 in Healthy Adults (MK-7602-003)

Malaria

Australia
Brown University

Recruiting

Intranasal Insulin for Treatment of Alcohol Use Disorder (ITA)

Alcohol Use Disorder

United States
University of Oxford
Sanaria Inc.; KEMRI-Wellcome Trust Collaborative Research Program; Kenya Medical...

Suspended

Controlled Human Malaria Infection Transmission Model - Phase A (CHMI-TransMod)

Malaria,Falciparum

Kenya
Innovent Biologics (Suzhou) Co. Ltd.

Completed

Comparative Clinical Trial to Evaluate Bioequivalency and Safety of Monoclonal Antibody Injection and Adalimumab in Chinese Healthy Volunteers

Healthy
Merck KGaA, Darmstadt, Germany

Completed

A Study of Efalizumab in Participants With Moderate to Severe Chronic Psoriasis Who Have Failed, Have a Contraindication to, or Are Intolerant of Other Systemic Therapies

Psoriasis

United Kingdom
Clinica Alemana de Santiago

Not yet recruiting

Acetazolamide or Metolazone in Acute Heart Failure (ACME-AHF)

Decompensated Heart Failure | Heart Failure Acute
Boehringer Ingelheim

Completed

Bioequivalence of Two Different Oral Solutions Tipranavir Administered in Combination With Ritonavir to Healthy Volunteers

Healthy
The Affiliated Hospital of Qingdao University

Completed

Pharmacokinetic Study of Recombinant Monoclonal Antibody Against Human Epidermal Growth Factor Receptor Injection

Healthy Volunteers

China
Scynexis, Inc.

Suspended

A Phase 3, Randomized, Double-blind Study for Patients With Invasive Candidiasis Treated With IV Echinocandin Followed by Either Oral Ibrexafungerp or Oral Fluconazole (MARIO)

Candidemia | Candidiasis, Invasive

United States, Korea, Republic of, Greece, Canada, France, Belgium, Germany, Italy, Spain, South Africa, Bulgaria, Israel
Peking University Cancer Hospital & Institute

Not yet recruiting

Study of Oncolytic Virus in Combination With HX-008 and Radiotherapy in Melanoma Patients With Liver Metastasis

Melanoma Stage IV
Boehringer Ingelheim

Completed

Pharmacokinetic of Tadalafil Co-administered With Tipranavir/Ritonavir to Healthy Male Volunteers

Healthy
Boehringer Ingelheim

Completed

Effects of Tipranavir/Ritonavir on the Pharmacokinetic Characteristics of Triple Drug Nucleoside and Non-nucleoside Reverse Transcriptase Inhibitor Therapy in HIV-1-infected Subjects

HIV Infections
Shandong University
The Second Hospital of Shandong University

Recruiting

Population Pharmacokinetics and Dosage Individualization of Antibiotics in Elderly Patients

Elderly Infection

China
National Institute of Arthritis and Musculoskeletal...

Recruiting

Effects of Treatments on Atopic Dermatitis

Skin Diseases | Skin Diseases, Genetic | Dermatitis | Eczema | Dermatitis, Atopic

United States
Arrevus Inc.

Terminated

Safety and Efficacy of CEM-102 With Rifampin Compared to Standard Therapy in Patients With Prosthetic Joint Infections or Spacer Infection

Prosthetic Joint Infections of Hip | Prosthetic Joint Infections of Knee | Infected Spacers

United States
Medicines for Malaria Venture
Shin Poong Pharmaceuticals

Completed

Pyronaridine/Artesunate -Ritonavir Drug Drug Interaction Study

Malaria

Switzerland
CytoDyn, Inc.

Completed

Study of PRO 140 by Subcutaneous Administration in Adult Subjects With HIV -1 Infection

HIV Infections | HIV -1 Infection

United States
Peking University Cancer Hospital & Institute

Not yet recruiting

Study of Oncolytic Virus in Combination With HX-008 and Axitinib in Melanoma Patients With Liver Metastasis

Melanoma Stage IV
National Cancer Institute (NCI)

Completed

Bevacizumab and Interleukin-2 in Treating Patients With Metastatic Kidney Cancer

Recurrent Renal Cell Carcinoma | Stage IV Renal Cell Cancer

United States

Search clinical trials for: P falciparum Controlled Human Malaria Infection (CHMI)

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