Search clinical trials for: Pegylated Irinotecan

Total 2139 results

BBB-Therapeutics B.V.

Terminated

Safety, Pharmacokinetics and Pharmacodynamics Study With 2B3-201 in Healthy Subjects and Multiple Sclerosis(MS) Patients

Multiple Sclerosis | Healthy Volunteers

Netherlands
Janssen-Ortho Inc., Canada

Completed

A Study Assessing Safety and Effectiveness of BORTEZOMIB Combination Therapy (Bortezomib + Doxorubicin Hydrochloride + Dexamethasone) in Previously Untreated Multiple Myeloma Patients

Multiple Myeloma
Sheba Medical Center

Unknown

Clinical Trial to Assess Safety and Efficacy of Combination Therapy: Hydroxychloroquine, Pegylated Interferon Alpha-2a and Ribavirin in Chronic Hepatitis C Subjects Non-responders to the Standard of Care Therapy.

Chronic Hepatitis C
Nektar Therapeutics

Completed

A Study in Cancer Patients With Hepatic Impairment to Evaluate the Pharmacokinetics and Safety of NKTR-102 (Etirinotecan Pegol)

Advanced or Metastatic Solid Tumors in Patients With Hepatic Impairment

United States
Holy Name Medical Center, Inc.
Biogen

Unknown

Evaluating the Use of Prednisone to Decrease Pegylated Interferon Beta-1a Side Effects

Multiple Sclerosis

United States
Biogen

Completed

Vaccination Response in Tecfidera-Treated Versus Interferon-Treated Participants With Relapsing Forms of Multiple Sclerosis.

Relapsing Forms of Multiple Sclerosis

United States
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Completed

Combination Chemotherapy in Treating Patients With Relapsed or Refractory Hodgkin's Lymphoma

Lymphoma

United States, Puerto Rico
Merck Sharp & Dohme LLC

Completed

Treatment of Chronic Hepatitis C With Pegylated Interferon and Ribavirin in Participants With/Without Substitution Therapy (P05255)

Hepatitis C, Chronic
Vertex Pharmaceuticals Incorporated

Terminated

A Study to Treat Subjects With Telaprevir, Ribavirin, and Peginterferon Who Are Coinfected With HIV and Hepatitis C Virus (HCV)

Hepatitis C

United States, Canada, Germany, Puerto Rico, Spain
Roswell Park Cancer Institute
Ortho Biotech, Inc.

Terminated

Bortezomib, Doxorubicin Hydrochloride Liposome, and Rituximab in Treating Patients With Diffuse Large B-Cell Lymphoma That Has Relapsed or Not Responded to Treatment

Lymphoma

United States
M.D. Anderson Cancer Center

Completed

Doxil, Gemcitabine, and Velcade (PS341) in Advanced Cancer Patients

Solid Tumors

United States
National Cancer Institute (NCI)

Completed

Paclitaxel Compared With Doxorubicin in Treating Patients With Advanced AIDS-Related Kaposi's Sarcoma

AIDS-related Kaposi Sarcoma

United States
Case Comprehensive Cancer Center

Recruiting

Disulfiram With Copper Gluconate and Liposomal Doxorubicin in Treatment-Refractory Sarcomas

Relapsed Sarcomas

United States
Replicor Inc.

Available

Replicor Compassionate Access Program (RCAP)

Decompensated Cirrhosis | Hepatocellular Carcinoma | Cirrhosis, Liver | Ascites Hepatic | Viral Hepatitis B | Viral Hepatitis D | Varices, Esophageal

Austria, France, Israel
Chinese PLA General Hospital

Unknown

Combined Inhibition of PD-1 and DNA Hypomethylating Agent +/- Chemotherapy in High-risk AML or Elderly Patients With AML Who Are Unfit for Intensive Chemotherapy

Acute Myeloid Leukemia, in Relapsed or Refractory | Acute Myeloid Leukemia, Elderly, Unfit | Acute Myeloid Leukemia With Positive Minimal Residual Disease

China
Zhejiang University
Zhejiang Cancer Hospital; First People's Hospital of Hangzhou; Second Affiliated... and other collaborators

Unknown

Efficacy and Safety of Neoadjuvant DC-T in Breast Cancer Patients (ESNDBCP)

Breast Cancer

China
Merck Sharp & Dohme LLC

Completed

Effects of Pegylated Interferon Alfa-2b and Ribavirin After Orthotopic Liver Transplantation in Subjects With Chronic Hepatitis C Recurrence (P04590AM3)(COMPLETED)

Liver Transplantation | Liver Cirrhosis | Hepatitis C, Chronic
Boehringer Ingelheim

Completed

BI 6727 (Volasertib) Randomised Trial in Ovarian Cancer

Ovarian Neoplasms

Belgium, France, Slovakia, Spain, Sweden
Albert Einstein College of Medicine
National Institute on Drug Abuse (NIDA)

Completed

Directly Observed Hepatitis C Treatment in Methadone Clinics

Hepatitis C | Medication Adherence

United States
Merck Sharp & Dohme LLC

Withdrawn

A Study to Compare Efficacy and Safety of Tenofovir Used Alone or in Combination With Pegylated Interferon Alpha-2b in Participants With Chronic Hepatitis B and Elevated Alanine Aminotransferase (MK-4031-384)

Hepatitis B
Pfizer

Completed

A Randomized Study of Daily and Intermittent Prophylactic Regimens for the Prevention of Disseminated Mycobacterium Avium Complex (MAC) and Fungal Infections in HIV-Infected Patients

HIV Infections | Mycoses | Mycobacterium Avium-Intracellulare Infection

United States
Sun Yat-sen University

Recruiting

Neoadjuvant Treatment With mFOLFOXIRI Plus Cadonilimab (AK104) Versus mFOLFOX6 in Locally Advanced Colorectal Cancer (OPTICAL-2)

Colorectal Cancer

China
University Hospital, Grenoble
NETRIS Pharma

Recruiting

Study Investigating the Association of NP137 With mFOLFIRINOX in Locally Advanced Pancreatic Ductal Adenocarcinoma (LAP-NET1)

Pancreatic Ductal Adenocarcinoma

France
Sun Yat-sen University

Recruiting

mFOLFOXIRI Versus mFOLFOX6 as Adjuvant Chemotherapy for Locally Advanced Colorectal Cancer (FANTASTIC)

Colorectal Cancer

China
Sumitomo Pharma Co., Ltd.

Completed

A Study of BBI608 Administrated With FOLFIRI + Bevacizumab in Adult Patients With Metastatic Colorectal Cancer

Metastatic Colorectal Cancer

Japan
Prof. Dr. Werner Scheithauer

Completed

Efficacy And Safety Of Xeliri + Avastin Followed By Xelox + Avastin Or Reverse Sequence In Metastatic Colorectal Cancer (PASSION)

Metastatic Colorectal Cancer

Austria
Sanofi
Regeneron Pharmaceuticals

Completed

A Study of Aflibercept in Combination With FOLFIRI in Patients With Second-Line Metastatic Colorectal Cancer in Japan

Colorectal Cancer Metastatic

Japan
Hoffmann-La Roche

Completed

A Study of Bevacizumab (Avastin) in Combination With Chemotherapy in Participants With Metastatic Cancer of the Colon or Rectum

Colorectal Cancer

Taiwan
Amgen

Completed

Evaluating Panitumumab (ABX-EGF) in Patients With Metastatic Colorectal Cancer

Colorectal Cancer
H. Lee Moffitt Cancer Center and Research Institute
Merck Sharp & Dohme LLC

Completed

A Phase I Trial of Vorinostat in Combination With Bevacizumab & Irinotecan in Recurrent Glioblastoma

Glioblastoma

United States
Fudan University

Recruiting

Circulating Tumor DNA Methylation Guided Postoperative Adjuvant Chemotherapy for High-risk Stage II/III Colorectal Cancer

Stage III Colorectal Cancer | High-risk Stage II Colorectal Cancer | Circulating Tumor DNA Methylation

China
Janssen Research & Development, LLC

Recruiting

A Study of Amivantamab Monotherapy and in Addition to Standard-of-Care Chemotherapy in Participants With Advanced or Metastatic Colorectal Cancer (OrigAMI-1)

Advanced or Metastatic Colorectal Cancer

United States, Korea, Republic of, Taiwan, Malaysia, Germany, Italy, Spain, Belgium, Canada, Puerto Rico, China
John Neoptolemos
Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest; Deutsches... and other collaborators

Not yet recruiting

Adjuvant Trial in Patients With Resected PDAC Randomized to Allocation of Oxaliplatin- or Gemcitabine-based Chemotherapy by Standard Clinical Criteria or by a Transcriptomic Treatment Specific Stratification Signature

Pancreatic Ductal Adenocarcinoma

Sweden, Germany
First Affiliated Hospital of Wenzhou Medical University

Recruiting

mFOLFOXIRI Compared to mFOLFOX6 or CapeOx as Adjuvant Chemotherapy for Stage IIIB or IIIC Colorectal Cancer

Colorectal Cancer

China
Second Affiliated Hospital, School of Medicine,...

Recruiting

SALIRI Based Regimen as First-line Treatment for Advanced Metastatic Colorectal Cancer

Advanced Metastatic Colorectal Cancer

China
University of Chicago

Recruiting

Safety of Combining Irinotecan With 5-FU, Leucovorin/Folinic Acid, Oxaliplatin, and Docetaxel Chemotherapies (I-FLOAT)

Adenocarcinoma | Pancreatic Adenocarcinoma | Gastroesophageal Junction Adenocarcinoma

United States
Actuate Therapeutics Inc.

Recruiting

9-ING-41 in Pediatric Patients With Refractory Malignancies.

Neuroblastoma | Pediatric Cancer | Diffuse Intrinsic Pontine Glioma | Pediatric Brain Tumor | Refractory Cancer | Refractory Neoplasm | Refractory Tumor | Cancer Pediatric | Neuroblastoma Recurrent | Pediatric Lymphoma | Pediatric Meningioma

United States
Gruppo Oncologico del Nord-Ovest

Active, not recruiting

AVELUMAB and CETUXIMAB and mFOLFOXIRI as Initial Therapy for Unresectable Metastatic Colorectal Cancer Patients (AVETRIC)

Metastatic Colorectal Cancer

Italy
National Cheng-Kung University Hospital

Unknown

The Efficacy of Bevacizumab Combined With m-FOLFOXIRI in Borderline Resectable Colorectal Liver Metastases (CBL)

Colorectal Cancer

Taiwan
Genentech, Inc.

Completed

Safety and Efficacy Study of MEHD7945A + FOLFIRI Versus Cetuximab + FOLFIRI as Second Line Therapy in Participants With KRAS Wild-Type Metastatic Colorectal Cancer (mCRC)

Colorectal Cancer

Australia, Belgium, Spain, United States, New Zealand, United Kingdom, Italy, Romania, France, Germany
SCRI Development Innovations, LLC
Amgen

Completed

FOLFOXIRI Plus Panitumumab Patients With Metastatic KRAS Wild-Type Colorectal Cancer With Liver Metastases Only

Colorectal Cancer

United States
Fudan University

Unknown

Phase II Study of 2-weekly RAILIRI Versus FOLFIRI as Second-line Treatment in Advanced Colorectal Cancer Patients

Colorectal Carcinoma

China
Duke University
Genentech, Inc.; Schering-Plough

Completed

Avastin in Combination With Radiation (XRT) & Temozolomide, Followed by Avastin, Temozolomide and Irinotecan for Glioblastoma (GBM) and Gliosarcomas

Glioblastoma | Brain Tumor | Gliosarcoma

United States
Hokkaido Gastrointestinal Cancer Study Group
Hokkaido University Hospital

Suspended

IRIS Followed by mFOLFOX6 or the Reverse Sequence in Advanced Colorectal Cancer

Metastatic Colorectal Cancer

Japan
Sun Yat-sen University

Recruiting

Cetuximab and Envafolimab Plus mFOLFOXIRI as First-line Treatment for RAS/BRAF Wild-type, MSS, Unresectable Left-side Metastatic Colorectal Cancer (CEIL)

Metastatic Colorectal Cancer

China
Sun Yat-sen University

Terminated

FUDR/Oxaliplatin HAI Plus Irinotecan vs. FOLFOXIRI Chemotherapy in Treating Initially Unresectable CRCLM

Metastatic Colorectal Cancer | Liver Metastases

China
University Health Network, Toronto
Hoffmann-La Roche

Completed

A Phase II Study of Bevacizumab, Irinotecan and Capecitabine in Patients With Previously Untreated Metastatic Colorectal Cancer

Colorectal Cancer

Canada
Bristol-Myers Squibb

Completed

Combination of Brivanib With 5-Fluorouracil/Leucovorin (5FU/LV) and 5-Fluorouracil/Leucovorin/Irinotecan (FOLFIRI)

Gastro-Intestinal Cancer

United States, Canada, France
Katy Peters
Genentech, Inc.

Completed

Avastin/Temozolomide/Irinotecan for Unresectable/Multifocal Glioblastoma Multiforme

Glioblastoma Multiforme | Gliosarcoma

United States
Hellenic Oncology Research Group
University Hospital of Crete

Completed

Combination of CPT-11 and LoHP vs Combination of 5-FU, Leucovorin and LoHP as 1st Line Treatment in Gastric Patients

Gastric Cancer

Greece

3

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