Search clinical trials for: Pevonedistat Infusion

Total 4540 results

Vanderbilt-Ingram Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Pevonedistat and Azacitidine in MDS or MDS/MPN Patients Who Fail Primary Therapy With DNA Methyl Transferase Inhibitors

Myelodysplastic Syndromes | Myeloproliferative Neoplasm

United States
Millennium Pharmaceuticals, Inc.

Completed

A Study of Pevonedistat in Adult East Asian Participants

Myelodysplastic Syndromes | Leukemia, Myeloid, Acute

Japan, Taiwan, Korea, Republic of
The University of New South Wales

Completed

Faecal Microbiota Transplantation in Ulcerative Colitis (FOCUS)

Ulcerative Colitis | Inflammatory Bowel Disease

Australia
Millennium Pharmaceuticals, Inc.

Completed

A Study of [14 C]-Pevonedistat in Participants With Advanced Solid Tumors

Advanced Solid Tumors, Neoplasms, Advanced Solid

Hungary
Memorial Sloan Kettering Cancer Center
M.D. Anderson Cancer Center

Terminated

Pevonedistat Alone and in Combination With Chemotherapy in Patients With Mesothelioma

Mesothelioma

United States
Boston Medical Center

Completed

Platysma Incision Cosmesis

Wound Heal

United States
LaTonya J. Hickson

Active, not recruiting

Stem Cell Therapy for Chronic Kidney Disease

Diabetes Mellitus, Type 2 | Diabetes Mellitus | Chronic Kidney Diseases | Diabetes Mellitus, Type 1 | Diabetic Nephropathies

United States
Millennium Pharmaceuticals, Inc.

Completed

Study of MLN4924, a Novel Inhibitor of Nedd8 Activating Enzyme, in Adult Patients With Lymphoma or Multiple Myeloma

Lymphoma | Multiple Myeloma | Hodgkin Lymphoma | Hematologic Malignancies

United States
PhaseBio Pharmaceuticals Inc.

Completed

Phase 1, Randomized, Double-Blind, Placebo-Controlled Exploratory Study That Will Assess the Safety, Tolerability, Pharmacokinetics and Hemodynamic Response to a Single 30 Minute Intravenous Infusion of Vasomera™ (PB1046) in Adult Subjects With Stage 1 or 2 Essential Hypertension

Essential Hypertension

United States
Millennium Pharmaceuticals, Inc.

Completed

Study of MLN4924 in Adult Patients With Nonhematologic Malignancies

Advanced Nonhematologic Malignancies

United States
Millennium Pharmaceuticals, Inc.

Completed

Dose Escalation Study of MLN4924 in Adults With Melanoma

Metastatic Melanoma

United States
University of Leipzig
Millennium Pharmaceuticals, Inc.

Completed

Treatment of MDS/AML Patients With an Impending Hematological Relapse With AZA or ATA and Pevonedistat

Myelodysplastic Syndromes | Minimal Residual Disease | Acute Myeloid Leukemia in Remission

Germany
Milton S. Hershey Medical Center
Takeda; Millennium Pharmaceuticals, Inc.

Terminated

Pevonedistat and Azacitidine as Maintenance Therapy After Allogeneic Stem Cell Transplantation for Non-Remission AML

Acute Myeloid Leukemia (AML)

United States
AM-Pharma

Completed

Recombinant Human Alkaline Phosphatase in Healthy Japanese Subjects

Healthy

Japan
The University of Texas Health Science Center,...
United States Department of Defense; U.S. Army Medical Research and Development...

Active, not recruiting

Autologous Stem Cell Study for Adult TBI (Phase 2b)

TBI (Traumatic Brain Injury) | Brain Injuries, Traumatic | Brain Injuries, Acute

United States
Jianming Tan

Unknown

Mesenchymal Stem Cell for Osteonecrosis of the Femoral Head

Osteochondritis of the Femoral Head

China
Bispebjerg Hospital
Psychiatric Centre Rigshospitalet

Completed

Effects of Ketone Bodies on Cognition in Type 2 Diabetes (KETOCOGNITION)

Cognitive Change | Type2 Diabetes | Ketonemia

Denmark
Hospital Universitari Vall d'Hebron Research Institute

Completed

Conditioning Effect of Previous Symptoms on the Responses to Meal Ingestion

Healthy

Spain
Dompé Farmaceutici S.p.A

Completed

Reparixin in Prevention of Delayed Graft Function After Kidney Transplantation

Kidney Diseases | Ischemia-Reperfusion Injury

United States, France, Italy, Spain
Far Eastern Memorial Hospital

Recruiting

Gravity Versus Pump Infusion of Distending Media for Hysteroscopic Myomectomy

Hysteroscopic Myomectomy

Taiwan
Jozef Bartunek
King's College London

Terminated

A Trial Using CD133 Enriched Bone Marrow Cells Following Primary Angioplasty for Acute Myocardial Infarction (SELECT-AMI)

Acute Myocardial Infarction

Netherlands, France, Belgium, United Kingdom
Mayo Clinic

Completed

Hemin in Healthy Subjects

Healthy Volunteers

United States
Yale University

Withdrawn

The Effect of Human Albumin Infusion on VEGF Levels in Women at Risk for Ovarian Hyperstimulation Syndrome

Ovarian Hyperstimulation Syndrome

United States
Mongi Slim Hospital

Completed

Continuous Versus Intermittent Administration of Epidural Analgesia During Labor

Epidural; Analgesia

Tunisia
Third Military Medical University

Completed

Intraosseous Infusion for Neonatal Asphyxiated Resuscitation

Asphyxia Neonatorum

China
FlowMedica, Inc.

Withdrawn

Post-Market Observational Study of Intra-Renal Drug Delivery (PROVIDE)

Targeted Renal Therapy

United States
American CryoStem Corporation

Active, not recruiting

ATCell™ Expanded Autologous, Adipose-Derived Mesenchymal Stem Cells Deployed Via Intravenous Infusion

Post-Concussion Syndrome

United States
Takeda

No longer available

Expanded Access Program With Pevonedistat (Given With Azacitidine) for Adults With Higher-risk Myelodysplastic Syndromes

Myelodysplastic Syndromes
Harvest Technologies

Completed

Retrograde Delivery of BMAC (Bone Marrow Aspirate Concentrate) for Congestive Heart Failure

Congestive Heart Failure

Germany, India, Peru
Millennium Pharmaceuticals, Inc.

Completed

An Efficacy and Safety Study of Pevonedistat Plus Azacitidine Versus Single-Agent Azacitidine in Participants With Higher-Risk Myelodysplastic Syndromes (HR MDS), Chronic Myelomonocytic Leukemia (CMML) and Low-Blast Acute Myelogenous Leukemia (AML)

Myelodysplastic Syndromes | Leukemia, Myeloid, Acute | Leukemia, Myelomonocytic, Chronic

United States, Israel, Spain, France, Ireland, Canada, Germany, Czechia, Italy, Netherlands, Belgium, Bulgaria
PETHEMA Foundation
Millennium Pharmaceuticals, Inc.; Dynamic Science S.L.

Active, not recruiting

Study to Compare Azacitidine Plus Pevonedistat Versus Azacitidine in Patients With Acute Myeloid Leukemia Not Eligible for Standard Chemotherapy (PEVOLAM)

Leukemia, Myeloid, Acute

Spain, Portugal
Millennix

Unknown

Chemotherapy and Photodynamic Therapy in Treating Patients With Cutaneous T-Cell Lymphoma

Lymphoma

United States
Millennium Pharmaceuticals, Inc.

Completed

Study of MLN4924 Plus Azacitidine in Treatment-naive Participants With Acute Myelogenous Leukemia (AML) Who Are 60 Years or Older

Acute Myelogenous Leukemia

United States
Medtronic Diabetes

Completed

Evaluation of Extended Wear Infusion Set (EWIS) in Patients With Type 1 Diabetes

Diabetes

United States
Andalusian Initiative for Advanced Therapies -...
Iniciativa Andaluza en Terapias Avanzadas

Completed

Treatment With MSC in HIV-infected Patients With Controlled Viremia and Immunological Discordant Response

Discordant Immunological Response in HIV Infected Subjects

Spain
David D'Alessio, M.D.
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Completed

Incretin Action in Physiology and Diabetes

Insulin Secretion

United States
Göteborg University

Completed

Effects of Total Parenteral Nutrition on Skeletal Muscle Genomics.

Wasting;Muscle(S)

Sweden
Assistance Publique - Hôpitaux de Paris
Celladon Corporation

Terminated

AAV1-CMV-Serca2a GENe Therapy Trial in Heart Failure (AGENT-HF)

Ischemic Cardiomyopathy | Non-ischemic Cardiomyopathy | Heart Failure Congestive

France
University of Pennsylvania

Completed

Ghrelin in Healthy and Frail Older Women

Frailty

United States
Takeda

Withdrawn

A Study of Pevonedistat Combined With Decitabine and Cedazuridine in Adults With Higher-risk Myelodysplastic Syndromes (PEVOBINE)

Myelodysplastic Syndromes (MDS)
Hospital Universitario San Ignacio

Withdrawn

Nocturnal Cyclic Enteral Nutrition Infusion Versus Continuous Infusion of Enteral Nutrition

Critical Illness | Enteral Feeding Intolerance | Nutrition Support

Colombia
Wockhardt

Completed

Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Multiple Ascending Doses of Intravenous WCK 771

Bioavailability

United States
Far Eastern Memorial Hospital

Completed

Comparison of Infusion Methods for Hysteroscopic Procedures

Complication of Surgical Procedure

Taiwan
Millennium Pharmaceuticals, Inc.

Completed

MLN4924 for the Treatment of Acute Myelogenous Leukemia, Myelodysplastic Syndrome, and Acute Lymphoblastic Leukemia

Acute Lymphoblastic Leukemia | Myelodysplastic Syndrome | Acute Myelogenous Leukemia

United States
Baylor College of Medicine
University of Texas, Southwestern Medical Center at Dallas

Completed

Evaluating the Use of RFT5-dgA to Deplete Alloreactive Cells Prior to Haploidentical Stem Cell Transplantation

Leukemia | Cancer

United States
Hospital Israelita Albert Einstein

Recruiting

Expansion of Virus-Specific Lymphocytes for Cell Therapy

CMV | CMV Viremia

Brazil
East Bay Institute for Research and Education

Completed

RCT of Air Insufflation Versus Water Infusion Colonoscopy

Colorectal Cancer

United States
Sheba Medical Center
Medtronic

Completed

Safety and Efficacy of Medtronic Extended Mio 30 Infusion Set

Diabetes Mellitus, Type 1

Israel
University of Sao Paulo

Unknown

Effect of Intermittent Infusion Versus Continuous Infusion of Vancomycin on Kidney Failure in Critically Ill Patients (ETERNITY)

Sepsis | Gram-Positive Bacterial Infections | Nephrotoxicity

Brazil
University of Michigan

Completed

The Effects of Gastric or Duodenal Nutrient Infusion on Food Intake, Obesity and Comorbidities in Obese Individuals

Obesity

United States

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