Search clinical trials for: Placebo of Simvastatin

Total 183245 results

University of Maryland, Baltimore
Merck Sharp & Dohme LLC

Completed

Simvastatin With or Without Ezetimibe and Atherothrombotic Biomarker Assessment

Metabolic Syndrome

United States
Peking Union Medical College Hospital

Unknown

Efficacy and Safety of Simvastatin-ezetimibe Combination Therapy Among Patients With SLE

Atherosclerosis

China
Organon and Co

Completed

Effectiveness of Two Approved Drugs in Lowering High Cholesterol (0733-224)

Hypercholesterolemia
Instituto Nacional de Ciencias Medicas y Nutricion...
Merck Sharp & Dohme LLC

Withdrawn

Efficacy of Ezetimibe/Simvastatin 10/20 mg and MK0524A (1-2 g/Day) in Mixed Hyperlipidemia and Two or More Risk Factors

Cardiovascular Diseases | Hyperlipidemia
AstraZeneca

Completed

A Study to Assess Co-Administered AZD9056 (Steady State) and Simvastatin (Single Dose) in Healthy Volunteers

Healthy Volunteers

Germany
Organon and Co

Completed

An Investigational Drug on Clinical Outcomes in Patients With Aortic Stenosis (Narrowing of the Major Blood Vessel of the Heart)(MK-0653A-043 AM4)(COMPLETED)

Aortic Stenosis
Pakistan Institute of Living and Learning
King's College London

Completed

Simvastatin as an Augmentation Treatment for Treatment Resistant Depression: Randomized Controlled Trial. (DepSTAT)

Major Depressive Disorder | Treatment Resistant Depression

Pakistan
Organon and Co
Merck Sharp & Dohme LLC

Terminated

Effect of Ezetimibe Plus Simvastatin on Flow-Mediated Brachial Artery Vasoactivity in Subjects With Primary Hypercholesterolemia (Study P03336)

Atherosclerosis | Hypercholesterolemia
Tehran University of Medical Sciences

Completed

Simvastatin in Relapsing Remitting Multiple Sclerosis (RRMS) Patients Using Avonex Compared to Placebo (irmsrct)

Relapsing Remitting Multiple Sclerosis

Iran, Islamic Republic of
Judit Pich

Completed

Efficacy of the Combination of Simvastatin Plus Rifaximin in Patients With Decompensated Cirrhosis to Prevent ACLF Development (2018-001698-25)

Liver Cirrhoses

Belgium, Spain, United Kingdom, Italy, Netherlands, France, Germany
Organon and Co
Schering-Plough

Completed

The Effects of Ezetimibe/Simvastatin 10/20 mg Versus Simvastatin 40 mg in High Cholesterol and Coronary Heart Disease Study (P04039AM2)(COMPLETED)

Coronary Disease | Hypercholesterolemia
Hue University of Medicine and Pharmacy
Università degli Studi di Sassari

Unknown

Lipid-lowering Therapies in Vietnamese Chronic Kidney Disease Population (VietCKD)

Chronic Kidney Diseases | Hypercholesterolemia

Vietnam
Helsinki University Central Hospital
University of Helsinki; Academy of Finland

Completed

Donor Simvastatin Treatment in Organ Transplantation (SIMVA)

Liver Failure | Heart Failure | Respiratory Failure | Kidney Failure | Transplantation

Finland
Federico II University

Completed

Ezetimibe and Statins on Postprandial Lipemia in Type 2 Diabetes (EZE)

Type 2 Diabetes | Postprandial Lipemia

Italy
Jagiellonian University
Merck Sharp & Dohme LLC

Unknown

Hypolipemic Treatment in Acute Coronary Syndrome (ACS): Antithrombotic Effects

Acute Coronary Syndrome

Poland
Johns Hopkins University
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Recruiting

Effects of Simvastatin on Uterine Leiomyoma Size

Leiomyoma | Fibroid Uterus | Leiomyoma, Uterine | Fibroid Tumor | Fibromyoma

United States
Washington University School of Medicine

Completed

Statins and Cerebral Blood Flow in Subarachnoid Hemorrhage (SAH)

Subarachnoid Hemorrhage

United States
Organon and Co

Completed

A Study of MK0653A (Ezetimibe (+) Simvastatin) in Patients With Hypercholesterolemia (0653A-038)

Hypercholesterolemia
Azienda Ospedaliero Universitaria di Sassari

Unknown

Ezetimibe/Simvastatin Combination in Proteinuric Nephropathy (VICTORY)

Hypercholesterolemia | Chronic Nephropathy

Italy
Solvay Pharmaceuticals

Completed

Interaction Study SLV337/Simvastatin

Type 2 Diabetes Mellitus

United Kingdom
Organon and Co
Schering-Plough

Completed

A Research Study to Evaluate MK0653 (Ezetimibe) and Simvastatin, Given Together and Alone, on Intestinal Absorption of Cholesterol (0653-050)(COMPLETED)

Cholesterol
Government Dental College and Research Institute...

Completed

Comparative Evaluation Of 1.2% Atorvastatin and 1.2% Simvastatin Gel Local Drug Delivery And Redelivery In Chronic Periodontitis Subjects With Diabetes Mellitus: A Randomized Controlled Clinical Trial.

Chronic Periodontitis Wth Diabetes Mellitus

India
Organon and Co
Merck Sharp & Dohme LLC

Completed

Effects of Ezetimibe With Simvastatin in the Therapy of Adolescents With HeFH (Study P02579)

Hypercholesterolemia
Brasilia Heart Study Group

Completed

Effect of Statin Treatment on Insulin Sensitivity During Myocardial Infarction

Myocardial Infarction

Brazil
Pfizer

Completed

Phase 1, Single and Multiple Doses Study of Sitaxentan in Japanese and Western Subjects

Healthy

United States
University of Cologne
Merck Sharp & Dohme LLC

Completed

LDL Receptor Under Ezetimibe and Simvastatin

Healthy Men

Germany
University of California, San Diego
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Effects of Statin Medications on Mental Processes, Behavior, and Serotonin Levels

Dyslipidemias

United States
University of Leipzig
Institut für Gesundheits- und Praxismanagement GmbH

Withdrawn

Pioglitazone in Impaired Glucose Tolerance

Glucose Metabolism Disorders

Germany
Mitsubishi Tanabe Pharma Corporation

Completed

Efficacy and Safety Study of MCI-196 Versus Simvastatin for Dyslipidaemia in Chronic Kidney Disease (CKD) Subjects on Dialysis

Chronic Kidney Disease

Belarus, Bulgaria, Romania, Malaysia, Singapore, Thailand, Italy, Lithuania, Latvia, Croatia, Denmark, Israel, Indonesia
Fasa University of Medical Sciences
Shiraz University of Medical Sciences

Completed

Effects of Metformin Plus Simvastatin on Polycystic Ovarian Syndrome (PCOS): A Prospective, Randomized, Double-Blind, Placebo-Controlled Study

Polycystic Ovary Syndrome

Iran, Islamic Republic of
Centre hospitalier de l'Université de Montréal...
Centre de Recherche du Centre Hospitalier de l'Université de Montréal

Terminated

Efficacy Study of SIMVASTATIN to Treat Chronic Rhinosinusitis After Failure of Optimal Treatment

Rhinosinusitis

Canada
Mahidol University

Completed

The Effects of Simvastatin on Th17 Cytokines and Th17 Polarizing Cytokine in COPD Patients

COPD

Thailand
Institute of Liver and Biliary Sciences, India

Recruiting

To Study the Safety and Efficacy of Simvastatin in Patients With Hepatopulmonary Syndrome in Cirrhosis.

Liver Cirrhosis

India
University of Washington
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Carotid Plaque Characteristics by MRI in AIM-HIGH (Carotid MRI Substudy)

Coronary Artery Disease | Atherosclerosis | Carotid Artery Diseases

United States, Canada
Charite University, Berlin, Germany
NeuroCure Clinical Research Center, Charite, Berlin; University Medical Center...

Recruiting

Simvastatin add-on Treatment to Standard Antidepressant Therapy in Patients With Comorbid Obesity and Major Depression (SIMCODE)

Obesity | Depressive Disorder, Major

Germany
UMC Utrecht

Completed

Effects of Ezetimibe on Postprandial Hyperlipidemia and Endothelial Function

Metabolic Syndrome

Netherlands
University of Sao Paulo

Completed

Antiplatelet and Anti-inflammatory Effects of Statins and Ezetimibe

Stable Angina

Brazil
University of Ioannina

Completed

Comparison of Simvastatin Versus Simvastatin/Ezetimibe on Small Dense Low -Density Lipoprotein (LDL)

Hypercholesterolemia

Greece
Fundación para el Fomento de la Investigación Sanitaria...

Completed

Effects of Simvastatin and Ezetimibe on Cardiovascular Risk Markers in Patients With Dyslipidemia

Dyslipidemia
Novartis Pharmaceuticals

Completed

Safety, Pharmacokinetics and Pharmacodynamics of LGT209 in Healthy Volunteers With Elevated Cholesterol and in Hypercholesterolemic Patients Treated With Statins

Hypercholesterolemia | LDL Cholesterol

United States
University of California, San Diego
American Heart Association

Completed

Effects of Epicatechin on Statins for Mitochondrial Dysfunction and Impaired Exercise Capacity

Statin Intolerance

United States
Hospital Universitario 12 de Octubre
Merck Sharp & Dohme LLC

Completed

Vytorin on Carotid Intima-media Thickness and Overall Rigidity (VYCTOR)

Cardiovascular Diseases
University of Guadalajara

Completed

Statins for Oxidative Stress and Mitochondrial Function in Diabetic Polyneuropathy

Oxidative Stress | Diabetic Polyneuropathy

Mexico
Korea University

Withdrawn

Effects on Atherosclerosis Regression of Ezetimibe or Ezetimibe Plus Simvastatin; Evaluated by Fluorodeoxyglucose Positron Emission Tomography (FDG-PET)

Atherosclerosis

Korea, Republic of
Merck Sharp & Dohme LLC

Completed

A Randomized, Double-Blinded Study of Simvastatin 20 mg/Day Versus Vytorin 10/20 in Subjects With Lipid Profiles Not Meeting Current NCEP Guidelines, Following a Low-Carbohydrate Diet (LOCUST)

Hyperlipidemia
Merck Sharp & Dohme LLC

Terminated

Efficacy and Safety of Extended-Release Niacin/ Laropiprant/Simvastatin Tablets in Participants With Hypercholesterolemia or Mixed Dyslipidemia (MK-0524B-143)

Mixed Dyslipidemia | Primary Hypercholesterolemia
Organon and Co

Completed

Effect Of Ezetimibe Coadministration With Simvastatin In A Middle Eastern Population: A Prospective, Multicentre, Randomized, Double-Blind, Placebo-Controlled Trial (0653-151)

Hypercholesterolemia
Merck Sharp & Dohme LLC

Completed

MK-0524B Lipid Study (MK-0524B-063)

Mixed Dyslipidemia | Primary Hypercholesterolemia
University of Oxford
Merck Sharp & Dohme LLC

Completed

Treatment of HDL to Reduce the Incidence of Vascular Events HPS2-THRIVE (HPS2-THRIVE)

Cardiovascular Disease | Diabetes Mellitus | Peripheral Arterial Disease | Coronary Heart Disease

United Kingdom
Organon and Co

Withdrawn

A Study to Evaluate the Efficacy and Safety of Vytorin Versus Standard Treatment of Other Statins in Moderate, Moderately High and High Risk Participants (MK-0653A-406) (VYCTORY)

Dyslipidemia

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