Search clinical trials for: Proteasome Inhibitors

Total 64442 results

University Hospital, Geneva

Completed

Pharmacokinetic Interaction Between Ritonavir and Prasugrel in Healthy Volunteers

Healthy Volunteers

Switzerland
University of Wisconsin, Madison
Wisconsin Partnership Program

Recruiting

Lopinavir/Ritonavir in PLWH With High-Grade AIN

High-Grade Anal Intraepithelial Neoplasia

United States
Pfizer

Recruiting

EPIC-Peds: A Study to Learn About the Study Medicine Called PF-07321332 (Nirmatrelvir)/Ritonavir in Patients Under 18 Years of Age With COVID-19 That Are Not Hospitalized But Are at Risk for Severe Disease

COVID-19

United States, United Kingdom, Mexico, South Africa, Japan, Bulgaria, Hungary, Puerto Rico
Harlan M Krumholz
Pfizer

Active, not recruiting

A Decentralized, Randomized Phase 2 Efficacy and Safety Study of Nirmatrelvir/Ritonavir in Adults With Long COVID. (PAXLC)

Long COVID

United States
Janssen Sciences Ireland UC

Completed

TMC114IFD3001 - Study Providing Continued Access to Treatment With Darunavir (DRV)/Ritonavir(Rtv) in HIV1 Infected Adults, Adolescents and Children Aged 3 Years or Above and Coming From Previous Company Sponsored Studies With DRV

HIV-1 Infections

Costa Rica, Panama, South Africa, Ukraine, Malaysia, Brazil, Thailand, Guatemala
National Institute of Allergy and Infectious Diseases...

Completed

The Anti-HIV Effects of Saquinavir Soft Gelatin Capsules Versus Indinavir in Patients Who Have Used Saquinavir Hard Gelatin Capsules for One Year

HIV Infections

United States
National Institute of Allergy and Infectious Diseases...
Bristol-Myers Squibb

Completed

Safety and Effectiveness of a Three-Drug Combination Treatment for Recently Infected or Converted HIV Patients

HIV Infections

United States, Brazil
National Institute of Allergy and Infectious Diseases...
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Completed

A Study to Evaluate the Safety and Tolerance of Nelfinavir (NFV) Given With Zidovudine (ZDV) and Lamivudine (3TC) in HIV-Positive Pregnant Women and Their Infants

HIV Infections | Pregnancy

United States
National Institute of Allergy and Infectious Diseases...

Completed

Safety and Effectiveness of Giving Indinavir Plus Stavudine Plus Lamivudine to HIV-Infected Children

HIV Infections

United States, Puerto Rico
R-Pharm
Almedis

Completed

Efficacy and Safety of All-Oral Combination of Narlaprevir/Ritonavir and Daclatasvir in Treatment-Naїve Patients With Chronic Hepatitis C Genotype 1b

Chronic Hepatitis C Genotype 1b

Russian Federation
National Institute of Diabetes and Digestive and...

Completed

Treatment of Chronic Delta Hepatitis With Lonafarnib and Ritonavir

Hepatitis D

United States
Hoffmann-La Roche

Completed

A Study of Saquinavir/Ritonavir in Liver-Impaired Patients With HIV Infection.

HIV Infections

Canada, United States, Puerto Rico
National Institutes of Health Clinical Center (CC)
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

The Interaction of Two HIV Medications With Blood Clot Medications in Healthy Volunteers

HIV

United States
AbbVie

Withdrawn

Study of Ombitasvir/Paritaprevir/Ritonavir in Japanese Adults With Genotype 1b Chronic Hepatitis C Virus (HCV) Infection With End Stage Renal Disease (ESRD) on Hemodialysis (HD) (GIFT-R)

Chronic Hepatitis C Virus
Hoffmann-La Roche

Completed

A Study of Drug-Drug Interaction Between Darunavir and Danoprevir Administered Together With Low-Dose Ritonavir in Healthy Volunteers

Healthy Volunteer

United States
Boehringer Ingelheim

Completed

Effect of Multiple Dosing With BI 201335 on the Pharmacokinetics of Darunavir Co-administered With Ritonavir in Healthy Male and Female Volunteers

HIV Infections

Germany
The HIV Netherlands Australia Thailand Research...
Chulalongkorn University; UMC St. Radboud, Nijmegen, The Netherlands

Completed

Lopinavir/Ritonavir (LPV/r) Tablet in HIV Infected Children

HIV-1 Infections

Thailand
Boehringer Ingelheim

Terminated

Safety and Antiviral Activity of TPV in HCV and/or HBV HIV Coinfected Patients TDM Randomised Pilot Evaluation

HIV Infections

United States, Argentina, Brazil, France, Germany, Italy, Spain
Boehringer Ingelheim

Terminated

Comparison of TPV/r to DRV/r in Triple Class Experienced Patient With Resistance to > 1 PI

HIV Infections

United States, Bahamas, Belgium, Canada, France, Germany, Greece, Italy, Portugal, Puerto Rico, Spain, Thailand
Tibotec Pharmaceuticals, Ireland

Completed

TMC114-TiDP3-C176 - A Study in Healthy Volunteers Investigating the Bioequivalence Between Two Commercially Available 400-mg Tablets to One New 800-mg Tablet of Darunavir (DRV) in the Presence of Low-dose Ritonavir Under Fed and Fasted Conditions

Healthy

Germany
Boehringer Ingelheim

Completed

Safety Study of Tipranavir Co-administered With Low-dose Ritonavir (TPV/r) in Patients With Advanced HIV-1 Infection and Limited Treatment Options

HIV Infections

Germany
Harvard School of Public Health (HSPH)
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Completed

Pharmacokinetic Study of Indinavir Drug Levels When Boosted With Ritonavir in Thailand

HIV Infection

Thailand
St Stephens Aids Trust

Completed

Double Protease Inhibitor to Darunavir Switch Study

HIV Infections

United Kingdom
Abbott

Completed

A Study of Two Different Doses of ABT-378/Ritonavir in HIV-Infected Patients Who Have Taken Protease Inhibitors and Non-Nucleoside Reverse Transcriptase Inhibitors

HIV Infections

United States, France, Spain
Merck Sharp & Dohme LLC

Completed

The Effectiveness of Indinavir Plus Zidovudine Plus Lamivudine in HIV-Infected Patients With No Symptoms of Infection

HIV Infections

United States, Canada
Merck Sharp & Dohme LLC

Completed

Safety and Effectiveness of an Anti-HIV Drug Combination in HIV-Positive Patients Who Have Failed Previous Treatment With Protease Inhibitors

HIV Infections

United States
Merck Sharp & Dohme LLC

Completed

A Study of Indinavir Sulfate Given Together With Stavudine to HIV-Positive Patients

HIV Infections

United States
Merck Sharp & Dohme LLC

Completed

Safety and Effectiveness of Giving Indinavir and Nelfinavir to HIV-Infected Patients

HIV Infections

United States
University Hospital, Ghent

Completed

Pathophysiological Mechanisms of Hepatopulmonary Influence in the Fontan Circulation

Children With a Univentricular Heart Undergoing Surgery for Creation of a Fontan Circulation

Belgium
Institut de Médecine et d'Epidémiologie Appliquée...

Completed

Evaluation of the Efficacy and Safety Between Two Antiretroviral Regimens, in HIV-1-infected Treatment-naïve Subjects With Low CD4 Counts (DATA)

HIV-1 Infection | Immunosuppression-related Infectious Disease

France
Radboud University Medical Center

Completed

The Effects of Atazanavir-induced Hyperbilirubinemia During Human Endotoxemia

Sepsis | Inflammation | Endotoxemia | Multi Organ Dysfunction Syndrome

Netherlands
Pfizer

Completed

Relative Bioavailability Study of PF-07321332/Ritonavir Oral Powder Relative to the Commercial Tablets in Healthy Participants

Bioavailability

United States
Fujian Akeylink Biotechnology Co., Ltd.

Active, not recruiting

Food Effects of GST-HG171 Tablets Combined With Ritonavir in Healthy Chinese Participants

COVID-19 Respiratory Infection

China
Fujian Akeylink Biotechnology Co., Ltd.

Completed

Study of GST-HG171/Ritonavir Compared With Placebo in Patients With Mild to Moderate COVID-19

COVID-19 Pneumonia

China
The HIV Netherlands Australia Thailand Research...

Completed

The Pharmacokinetics and Safety of IDV/r With NRTIs in HIV/TB Co-infected Patients Receiving Rifampicin

HIV Infections | Tuberculosis

Thailand
Ascletis Pharmaceuticals Co., Ltd.

Completed

Safety, Tolerability and Pharmacokinetics of Danoprevir/r in Healthy Volunteers China

Healthy
National Institute of Allergy and Infectious Diseases...
AIDS Clinical Trials Group

Completed

Differences in Blood Levels of Lopinavir/Ritonavir in HIV Infected Men and Women

HIV Infections

United States, Puerto Rico
Boehringer Ingelheim

Completed

Pharmacokinetics of Tipranavir/Ritonavir and Its Metabolites in Healthy Male Subjects

Healthy
Boehringer Ingelheim

Completed

A Post Marketing Surveillance Study Assessing the Long-term Efficacy and Safety of Aptivus Co-administered With Low-dose Ritonavir in Treatment Experienced Patients With HIV-1 Infection in the Daily Clinical Practice.

HIV Infections

Romania
Abbott

Completed

Long-term Effectiveness and Safety in Hepatitis-co-infected Patients

Human Immunodeficiency Virus-Infection

Germany
Tibotec Pharmaceuticals, Ireland

Terminated

TMC114-C227: A Study to Evaluate the Effectiveness and Safety of TMC114 (Darunavir) With a Low Dose of Ritonavir as Monotherapy (no Other Anti-HIV Drugs Will be Given) in Patients Who Have Never Been Treated With Antiretrovirals (Anti-HIV Drugs) Previously

HIV Infections
Bristol-Myers Squibb
Merck Sharp & Dohme LLC

Completed

DDI HV (ATV - Merck)

HIV Infections

United States
Abbott

Terminated

Study of Adherence Effects and Clinical Outcomes of Kaletra Based HIV Antiviral Therapy

HIV Infection

United States
Hoffmann-La Roche

Completed

The Safety and Effectiveness of Two Forms of Saquinavir Combined With Other Anti-HIV Drugs in HIV-Infected Infants and Children

HIV Infections

United States
Mario Negri Institute for Pharmacological Research
Agenzia Italiana del Farmaco

Completed

Angiotensin-converting-enzyme (ACE) Inhibitors in Hemodialysis (ARCADIA)

Hypertension | Left Ventricular Hypertrophy

Italy
Shandong Provincial Hospital
Gansu Provincial Hospital; The Affiliated Hospital Of Southwest Medical University and other collaborators

Recruiting

A Study of Efficacy and Safety of Azvudine vs. Nirmatrelvir-Ritonavir in the Treatment of COVID-19 Infection

COVID-19

China
Pfizer

Completed

Study to Estimate the Effects of Hepatic Impairment on the Pharmacokinetics (PK) of PF-07321332

Hepatic Impairment

United States
Pfizer

Completed

Relative Bioavailability Study of Nirmatrelvir/Ritonavir 4 Different Fixed Dose Combination Tablets Relative to the Commercial Tablets in Healthy Participants

Healthy Participants | Biological Availability

United States
Vigonvita Life Sciences

Completed

Efficacy and Safety of JT001 (VV116) Compared With Paxlovid

COVID-19

China
Pfizer

Completed

Relative Bioavailability Study of 4 Different Formulations of PF-07321332 Relative to the Commercial Tablet Formulation

Bioavailability

United States

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