Search clinical trials for: Proton pump inhibitor (PPI)

Total 11336 results

Takeda

Completed

Safety and Efficacy of Dexlansoprazole Delayed-Release Capsules for Healing of Erosive Esophagitis and Maintenance of Healed Erosive Esophagitis and Relief of Heartburn in Adolescents

Gastroesophageal Reflux Disease | Erosive Esophagitis

United States, Poland, Belgium, Portugal, Italy, Hungary, Mexico, Brazil
Hamilton Health Sciences Corporation
McMaster University

Completed

Study of Anti-reflux Medication as a Potential Treatment for Glue Ear in Children

Otitis Media With Effusion

Canada
Boehringer Ingelheim

Completed

Bioavailability of Oral BIRB 796 BS Tablets With and Without Administration of Oral Pantoprazole in Healthy Male Volunteers

Healthy
National Taiwan University Hospital
Takeda

Terminated

Lansoprazole for Subgroups of Functional Dyspepsia

Functional Dyspepsia

Taiwan
Seoul National University Hospital

Completed

Lansoprazole in Preterm Infants With Reflux

Preterm Infants | Gastrointestinal Reflux

Korea, Republic of
Norgine

Completed

Phase III Study Comparing Zegerid® With Losec® for the Relief of Heartburn Associated With Gastroesophageal Reflux Disease

Gastroesophageal Reflux

Poland
AstraZeneca
Parexel

Completed

To Assess the Efficacy of Esomeprazole 20mg Once Daily in Subjects Who Still Had Heartburn After Receiving Rabeprazole

Gastroesophageal Reflux Disease | GERD | Reflux Esophagitis
Il-Yang Pharm. Co., Ltd.

Completed

Efficacy Study of Ilaprazole to Treat Erosive Esophgitis

GERD | Erosive Esophagitis

Korea, Republic of
HSK Wiesbaden

Terminated

APE-Study: Ablation of Barrett's Mucosa vs. Surveillance Without Ablation in Patients Cured From Barrett's Cancer Combined With Randomization of Esomeprazole vs. Placebo for Symptomatic Reflux Control After Successful Barrett's Ablation (APE)

Barrett's Esophagus

Germany
Eisai Inc.

Completed

A Study to Investigate Use Patterns and Safety in Simulated Actual Over-the-counter (OTC) Use of Rabeprazole Sodium for the Treatment of Heartburn Symptoms

Frequent Heartburn

United States
AstraZeneca

Completed

Ulcer Prevention II

NSAID Associated Gastric Ulcers
AstraZeneca

Completed

Esomeprazole for Treatment of GERD in Pediatric Patients

Gastroesophageal Reflux Disease (GERD) | Erosive Esophagitis | Non-erosive Esophagitis

United States, France, Italy, Belgium
AstraZeneca

Completed

Acid-Associated Heartburn Symptoms and Dose of Esomeprazole

Heartburn

United States, Puerto Rico
Novartis

Completed

Efficacy/Safety of Lansoprazole in Patients With Frequent Heartburn

Heartburn

United States
AstraZeneca

Completed

An Open Label pH Comparison of Esomeprazole and Lansoprazole in Barrett's Esophagus Patients

Barrett's Esophagus

United States
AstraZeneca

Completed

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Efficacy Study Comparing 4 Weeks of Treatment With Esomeprazole 20 mg qd and 40 mg qd to Placebo qd in Patients With Heartburn and Sleep Disturbances Associated With Gastroesophageal Reflux Disease (GERD)

Gastroesophageal Reflux Disease (GERD)
AstraZeneca

Completed

Validation of RDQ Questionnaire

Gastroesophageal Reflux

Sweden, United Kingdom, Germany, Canada, Denmark, Norway
Presidio Pharmaceuticals, Inc.

Completed

A Drug Interaction Study of the Effects of PPI-668 on the Pharmacokinetics of Midazolam and Omeprazole

Pharmacokinetic Assessments in Healthy Volunteers

United States
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Unknown

Effect and Safety of Apatinib on Radiation-Induced Brain Injury

Radiation Injuries

China
Wuhan Union Hospital, China
Jiangsu HengRui Medicine Co., Ltd.

Not yet recruiting

Apatinib Combined With Chemotherapy Versus Chemotherapy in Second-line Gastric Cancer Receiving Prior Anti-PD-1 Therapy

Gastric Cancer | Randomized Controlled Study

China
The First Affiliated Hospital of Zhengzhou University
Jiangsu HengRui Medicine Co., Ltd.

Unknown

A Study of Second-line Treatment With Apatinib for Advanced Intrahepatic Cholangiocarcinoma

Intrahepatic Cholangiocarcinoma

China
Fudan University

Unknown

Apatinib for Advanced Biliary Carcinoma

Biliary Tract Neoplasms

China
Shanghai Jiao Tong University School of Medicine

Completed

Amoxicillin/Metronidazole Based Quadruple Therapy for Helicobacter Pylori Eradication

Dyspepsia | Peptic Ulcer

China
Kaohsiung Veterans General Hospital.

Completed

Efficacy of Proton Pump Inhibitor in Prevention of Clopidogrel-related Peptic Ulcer

Peptic Ulcer

Taiwan
Genentech, Inc.

Completed

A 3-Part Study to Determine the Relative Bioavailability of Capsule and Tablet Formulations of GDC-0980, the Effect of Food, and the Effect of Rabeprazole on the Pharmacokinetics of the Tablet

Healthy Volunteer

United States
Amgen

Completed

Study to Evaluate the Drug-drug Interaction Effect of Omeprazole on the Pharmacokinetics (PK) of AMG 510 in Healthy Participants

Healthy Participants

United States
Icahn School of Medicine at Mount Sinai

Withdrawn

Whether Proton Pump Inhibitors, Administered Prior to or After Surgery, Can Reduce the Incidence and/or Severity of Difficulty Swallowing Foods and/or Liquids,Following Anterior Cervical Surgery

Dysphagia | GERD | Degenerative Joint Disease

United States
Takeda

Withdrawn

Phase 1 Dexlansoprazole Delayed-Release Capsules for Acid-Related Disorders in Infants Aged 1 to 11 Months

Pediatric Gastroesophageal Reflux Disease

United States, Italy, Israel, Mexico, Poland
Stanford University

Completed

Gastric Acid Suppression and Probiotic Colonization (PR)

Probiotics

United States
Genentech, Inc.

Completed

A Study to Investigate the Effect of Formulation, Food, and Rabeprazole on the Pharmacokinetics (PK) of GDC-0853 in Healthy Participants

Healthy Volunteers

United Kingdom
University of Texas Southwestern Medical Center
AstraZeneca

Completed

Efficacy of Esomeprazole for Non-Allergic Rhinitis: A Double-blind, Placebo Controlled Trial

Vasomotor Rhinitis

United States
National Taiwan University Hospital
National Taiwan University

Completed

Pharmacokinetics and Safety Studies of Esomeprazole Use in Schizophrenia Patients

Schizophrenia

Taiwan
University of Kansas Medical Center
TAP Pharmaceutical Products Inc.

Terminated

Dietary Control Alone Versus Dietary Control Plus Use of Proton Pump Inhibitors to Treat Pediatric Hoarseness

Dysphonia

United States
The University of Hong Kong

Completed

PPI for Prevention of Post-sphincterotomy Bleeding

Bleeding | ERCP

China
Soonchunhyang University Hospital

Unknown

Dexlansoprazole MR in Nonerosive Reflux Disease

Nonerosive Reflux Disease

Korea, Republic of
Eisai Co., Ltd.

Completed

Double-blind Comparative Study of E3810 Tablets (10 or 20 mg b.i.d.) to Evaluate Efficacy and Safety in Patients With Refractory Reflux Esophagitis

Refractory Reflux Esophagitis

Japan
Forest Laboratories

Completed

The Safety and Efficacy of Dexloxiglumide for the Relief of Symptoms of Functional Dyspepsia.

Dyspepsia

United States
Mayo Clinic
AstraZeneca

Completed

Which Supraesophageal Reflux Symptoms Reliably Respond to Proton-Pump-Inhibitor (PPI) Therapy

Gastroesophageal Reflux

United States
Eisai Co., Ltd.

Completed

A Comparative Study on the Efficacy and Safety of E3810 in Patients With Non-erosive Gastroesophageal Reflux Disease

Non-erosive Gastroesophageal Reflux Disease

Japan
Janssen-Cilag, S.A.

Terminated

Influence of Hygiene-dietetic Habits and Treatment Adherence on the Effectiveness of the Gastroesophageal Reflux Illness Treatment With Rabeprazol

Gastroesophageal Reflux
AstraZeneca

Completed

Chronic Posterior Laryngitis With Suspected Laryngopharyngeal Reflux

Chronic Posterior Laryngitis (CPL)
Takeda

Completed

Intravenous vs Oral Lansoprazole on Gastric Acid Secretion in Subjects With Erosive Esophagitis

Esophagitis | Reflux
Lotung Poh-Ai Hospital

Completed

Intravenous Proton Pump Inhibitor for Peptic Ulcer Bleeding (PPI)

Peptic Ulcer Hemorrhage

Taiwan
Henan Cancer Hospital
Jiangsu HengRui Medicine Co., Ltd.

Unknown

Apatinib Treatment for Advanced Esophagus Cancer

Advanced Esophagus Cancer

China
Norfolk and Norwich University Hospitals NHS Foundation...
Norwich Clinical Trials Unit

Recruiting

Treating People With Idiopathic Pulmonary Fibrosis With the Addition of Lansoprazole (TIPAL)

Idiopathic Pulmonary Fibrosis

United Kingdom
Universitaire Ziekenhuizen KU Leuven

Recruiting

Neuro-immune Interactions and PPI

Functional Dyspepsia

Belgium
University of Colorado, Denver
Children's Hospital Colorado

Recruiting

Proton Pump Inhibitor (PPI) Response in Eosinophilic Esophagitis Assessed by Transnasal Endoscopy (TNE)

Eosinophilic Esophagitis

United States
Northwestern University
Washington University School of Medicine; Vanderbilt University

Completed

Effectiveness of Physiologic Testing in PPI Non-Responders

Gastro Esophageal Reflux

United States
Jiangsu HengRui Medicine Co., Ltd.
The Third Xiangya Hospital of Central South University

Completed

Effect of Omeprazole on PK of Fluzoparib in Healthy Male Subjects

Advanced Solid Tumor

China
Columbia University

Completed

Effect of Proton Pump Inhibitors on CF Pulmonary Exacerbations

Cystic Fibrosis

United States

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