Search clinical trials for: Safinamide, MAO-B inhibitor

Total 2306 results

MedSIR

Terminated

A Two-stage Simon Design Phase II Study for Non-BRCA MBC Patients With HRD Treated With Olaparib Single Agent (NOBROLA)

Breast Cancer

Spain
AstraZeneca
Myriad Genetic Laboratories, Inc.

Withdrawn

Olaparib Maintenance Treatment Versus Placebo in Patients With PSR Ovarian Cancer Who Are in CR or PR to Platinum-based Chemotherapy and Whose Tumours Carry sBRCAm or HRR-associated Genes Mutations

Platinum Sensitive Relapsed Ovarian Cancer

United States, Korea, Republic of, Peru, United Kingdom, Philippines
Virginia Commonwealth University
Eli Lilly and Company; Bayer

Terminated

2nd Line Treatment With Pemetrexed and Sorafenib for Recurrent or Metastatic Triple Negative Breast Cancer

Breast Cancer | Metastatic Breast Cancer | Recurrent Breast Cancer

United States
CanariaBio Inc.
Veristat, LLC

Active, not recruiting

A Clinical Study Evaluating a Combination of Oregovomab and Niraparib in Adult Women With Platinum Sensitive Recurrent Ovarian Cancer.

Peritoneal Cancer | Recurrent Ovarian Cancer | Recurrent Fallopian Tube Cancer | Recurrent Epithelial Cancer of Ovary | Recurrent Epithelial Ovarian Cancer | Recurrent Carcinoma of Ovary | Adenocarcinoma of Ovary

United States
Christopher Sweeney, MBBS
Eli Lilly and Company; Walther Cancer Institute

Completed

Pemetrexed as Second-Line Therapy in Treating Patients With Hormone Refractory Prostate Cancer

Prostate Cancer

United States
Asan Medical Center
Dong-A Pharmaceutical Co., Ltd.

Completed

Phase I Study to Investigate the Alcohol Interaction of DA8159 (DA8159_DIA_I)

Erectile Dysfunction | Healthy Volunteers

Korea, Republic of
University of Pavia

Unknown

Antiproteinuric Effect of Imidapril Versus Ramipril in Type 2 Diabetic and Hypertensive Patients With Microalbuminuria

Hypertension | Type 2 Diabetes Mellitus | Microalbuminuria

Italy
Stanford University
National Comprehensive Cancer Network

Completed

Phase I Vorinostat Concurrent With Stereotactic Radiosurgery (SRS) in Brain Metastases From Non-Small Cell Lung Cancer

Carcinoma, Non-Small-Cell Lung | Neoplasm Metastasis | Lung Cancer | Brain Cancer

United States
Zodiac Produtos Farmaceuticos S.A.

Unknown

Evaluate Efficacy, Tolerability & Safety of Combination of Clindamycin and Ketoconazole for the Treatment of Mixed-Type Vaginosis, Bacterial Vaginosis and Candidiasis

Candidiasis | Bacterial Vaginosis

Brazil
Fujian Cancer Hospital

Recruiting

Cadonilimab Plus FOLFOXIRI and Bevacizumab as First Line Therapy for Metastatic MSS Colorectal Cancer

Colorectal Cancer

China
Medicure

Completed

MATCHED (MC-1 and ACE Therapeutic Combination for Hypertensive Diabetics)

Hypertension | Metabolic Syndrome | Diabetes Mellitus Type 2

Canada
Vical

Terminated

VL-2397 Compared to Standard First-Line Treatment for Invasive Aspergillosis (IA) in Adults

Invasive Aspergillosis | Invasive Pulmonary Aspergillosis

United States, Korea, Republic of, Canada, Belgium, France, Germany
Pfizer

Completed

Bioequivalence Study for Crizotinib Encapsulated Microsphere Formulation (eMS)

Healthy Participants

United States
Khon Kaen University
Thai Rheumatism Association

Completed

Prevalence and Predictors of Proton Pump Inhibitor Partial Response in Gastroesophageal Reflux Disease in Systemic Sclerosis

Gastroesophageal Reflux | Systemic Sclerosis | Proton Pubm Inhibitor
AstraZeneca

Completed

Study to Assess the Blood Levels and Safety of Olaparib in Patients With Advanced Solid Tumours and Normal or Impaired Kidney Function

Solid Tumours

Belgium, France, Netherlands, United Kingdom, Denmark
Emilio Vargas Castrillón
Fundación Mutua Madrileña

Completed

Study to Compare the Bioavailability of Omeprazole 20 mg Before and After Undergoing Surgery for Morbid Obesity (OBS-2011/001)

Bariatric Surgery Candidate

Spain
University of Alberta
University of British Columbia; Gilead Sciences

Terminated

B/F/TAF vs Atripla Double-Blind Switch Study in HIV-1 Infected Adults

HIV-1-infection

Canada
Case Comprehensive Cancer Center
National Cancer Institute (NCI)

Completed

Pyridoxine in Preventing Hand-Foot Syndrome in Patients Who Are Receiving Liposomal Doxorubicin for Cancer

Breast Cancer | Ovarian Cancer | Fallopian Tube Cancer | Peritoneal Cavity Cancer | Endometrial Cancer | Drug/Agent Toxicity by Tissue/Organ

United States
Boehringer Ingelheim

Completed

BIBR 1048 in the Prevention of Venous Thromboembolism in Patients Undergoing Primary Elective Total Hip Replacement Surgery

Venous Thromboembolism
Ipsen

Completed

Study of Irinotecan Liposome Injection (ONIVYDE®) in Patients With Small Cell Lung Cancer (RESILIENT)

Small Cell Lung Cancer

Spain, United States, France, Taiwan, Korea, Republic of, Germany, China, Belgium, Italy, Brazil, Ukraine, Australia, Russian Federation, Serbia, Poland, Hungary, Turkey, Romania
Memorial Sloan Kettering Cancer Center
University of Nebraska

Completed

Combination Therapy With Carfilzomib, Romidepsin, Lenalidomide in Patients With Relapsed or Refractory B- and T-cell Lymphomas

T-cell Lymphomas | Relapsed or Refractory

United States
National Institute of Allergy and Infectious Diseases...

Completed

Voriconazole vs. Amphotericin B in the Treatment of Invasive Aspergillosis

HIV Infections | Acquired Immunodeficiency Syndrome | Immunologic Deficiency Syndromes | Neutropenia | Aspergillosis

United States
Janssen, LP

Completed

A Randomized, Open, Comparative Multicenter Study of Initial Treatment With Intravenous Itraconazole Versus Amphotericin B Followed by Consolidation Treatment With Itraconazole Capsules in Patients With Blastomycosis or Histoplasmosis

HIV Infections | Histoplasmosis | Blastomycosis

United States
Xiangya Hospital of Central South University

Recruiting

Effects of Epalrestat on Peripheral Neuropathy and Central Nervous System in Diabetic Patients

Diabetes

China
Jonsson Comprehensive Cancer Center
BeiGene; Driven To Cure

Withdrawn

Pamiparib and Temozolomide for the Treatment of Hereditary Leiomyomatosis and Renal Cell Cancer

Metastatic Renal Cell Carcinoma | Stage IV Renal Cell Cancer AJCC v8 | Papillary Renal Cell Carcinoma | Collecting Duct Carcinoma | Unresectable Renal Cell Carcinoma | Hereditary Leiomyomatosis and Renal Cell Carcinoma | Clear Cell Papillary Renal Neoplasm | Hereditary Papillary Renal Cell Carcinoma and other conditions

United States
University of California, San Francisco
BeiGene USA, Inc.; Pacific Pediatric Neuro-Oncology Consortium

Recruiting

BGB-290 and Temozolomide in Treating Isocitrate Dehydrogenase (IDH)1/2-Mutant Grade I-IV Gliomas (PNOC017)

Glioblastoma | Malignant Glioma | Recurrent Glioblastoma | Recurrent WHO Grade III Glioma | WHO Grade III Glioma | IDH2 Gene Mutation | IDH1 Gene Mutation | Low Grade Glioma | Recurrent WHO Grade II Glioma | WHO Grade II Glioma

United States
Yisheng Biopharma (Singapore) Pte. Ltd.

Completed

A Phase I Study to Evaluate Safety, Tolerability, and Immunogenicity of a PIKA COVID-19 Vaccine in Healthy Individuals

COVID-19 Pandemic

United Arab Emirates
Pfizer

Completed

A Multicenter Comparison of Fluconazole (UK-49,858) and Amphotericin B as Treatment for Acute Cryptococcal Meningitis

HIV Infections | Meningitis, Cryptococcal

United States, Canada
Pfizer

Completed

Multicenter Comparison of Fluconazole (UK-49,858) and Amphotericin B as Maintenance Treatment for the Prevention of Relapse of Cryptococcal Meningitis in Patients With Acquired Immunodeficiency Syndrome

HIV Infections | Meningitis, Cryptococcal

United States, Canada
Pfizer

Completed

A Comparison of Fluconazole and Amphotericin B in the Treatment of Fungal Infections

HIV Infections | Mycoses

United States
GlaxoSmithKline

Completed

Drug-drug Interaction Study of Eltrombopag and Cyclosporine in Healthy Subjects

Purpura, Thrombocytopenic, Idiopathic

United States
Boehringer Ingelheim

Completed

Safety and Relative Bioavailability of BIBF 1120 Soft Gelatine Capsules Charge 1, BIBF 1120 Soft Gelatine Capsules Charge 2 and BIBF 1120 Drinking Solution in Healthy Male Volunteers

Healthy
Merck Sharp & Dohme LLC

Completed

A Study to Compare the Efficacy and Safety of a Combination of Ketoconazole and Clindamycin Compared to Tetracycline/Amphotericin B Combination Cream for the Treatment of Bacterial Vaginosis and Vaginal Candidiasis (P08077)

Vaginosis, Bacterial | Candidiasis, Vulvovaginal
National Institute of Allergy and Infectious Diseases...

Completed

Treatment With Cidofovir for Children With Laryngeal Papillomatosis (Warts in the Throat)

Papilloma

United States
Foundation University Islamabad

Completed

Effects of Autogenic and Reciprocal Inhibition, Muscle Energy Techniques in the Management of Mechanical Neck Pain

Neck Pain

Pakistan
University of Pharmacy, Yangon

Completed

Clinical Effectiveness and Safety of Amphotericin B With Flucytosine-Fluconazole Therapy for Cryptococcal Meningitis

Cryptococcal Meningitis

Myanmar
Armando Santoro, MD

Terminated

Study of Oral Vorinostat in Combination With Topotecan in Patients With Chemosensitive Recurrent SCLC

Small Cell Lung Cancer

Italy
Ardelyx
AstraZeneca

Completed

A Phase 1 Study to Examine the Pharmacodynamics of Different AZD1722 Formulations

Healthy

United States
Boehringer Ingelheim

Completed

Pharmacokinetic (PK) Assessment of BIBR 1048 in Patients After Primary Elective Total Hip Replacement Surgery

Venous Thromboembolism
University of Alabama at Birmingham
Amgen; Sanofi-Synthelabo

Completed

Study of Sequential Topoisomerase, Irinotecan/Oxaliplatin - Etoposide /Carboplatin in Extensive Small Cell Lung Cancer (SCLC)

Non-Small Cell Lung Cancer

United States
Institut für Klinische Krebsforschung IKF GmbH...
Bristol-Myers Squibb; Eisai GmbH

Completed

Immunotherapy With Nivolumab in Combination With Lenvatinib for Advanced Stage Hepatocellular Carcinoma

Advanced Hepatocellular Carcinoma

Germany
Tampere University Hospital

Terminated

Intracoronary Administration of Levosimendan in Cardiac Surgery Patients

Myocardial Stunning

Finland
All India Institute of Medical Sciences, New Delhi

Completed

Study of Safety and Efficacy of Different Regimes of Reintroduction of Anti-TB Drugs in Anti-TB Drugs Induced Liver Damage

Tuberculosis | Drug Induced Hepatotoxicity

India
Société des Produits Nestlé (SPN)

Completed

Comparison of MAG and Fish Oil Efficacy

Obesity

Switzerland
First Affiliated Hospital Xi'an Jiaotong University

Not yet recruiting

Blue Laser -5ala Photodynamic Therapy (PDT) in High-Risk Non-muscle Invasive Bladder Cancer (NMIBC) Patients (BL-PDT-RCT)

Non-muscle-invasive Bladder Cancer

China
Roswell Park Cancer Institute
National Comprehensive Cancer Network

Completed

Nintedanib in Treating Patients With Locally Advanced or Metastatic Neuroendocrine Tumors

Carcinoid Tumor | Neuroendocrine Neoplasm | Metastatic Carcinoid Tumor

United States
Kukje Pharma

Completed

KJ-TFC-004 Drug-drug Interaction Study

Ocular Hypertension | Glaucoma | Eye Diseases

Korea, Republic of
University of Louisville

Recruiting

Auricular Acupuncture vs SOC in Migraine HA (MigAcu)

Migraine Headache

United States
BeiGene

Recruiting

Observational Study Evaluating the Efficacy and Safety of Zanubrutinib in Participants With Waldenström Macroglobulinemia

Waldenstrom Macroglobulinemia

United States, Puerto Rico
Gilead Sciences

Not yet recruiting

A Study to Provide Continued Access to Study Drug to Children and Adolescents Who Have Completed Clinical Studies Involving Gilead HIV Treatments

HIV-1-infection

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