Search clinical trials for: Single arm, open-label

Total 954 results

Amgen
Daiichi Sankyo, Inc.

Completed

Denosumab Compared to Zoledronic Acid in the Treatment of Bone Disease in Patients With Multiple Myeloma

Cancer | Multiple Myeloma | Bone Metastases | Hematologic Malignancies | Oncology | Multiple Myeloma Bone Lesions

United States, Germany, Italy, Spain, Canada, France, Czechia, Hungary, Korea, Republic of, Russian Federation, United Kingdom, Taiwan, Australia, Hong Kong, New Zealand, Austria, Slovakia, Portugal, Greece, Bulgaria, Poland, Ukraine and more
Silence Therapeutics GmbH
FGK Clinical Research GmbH; Granzer Regulatory Consulting & Services

Completed

Atu027 Plus Gemcitabine in Advanced or Metastatic Pancreatic Cancer (Atu027-I-02) (Atu027-I-02)

Carcinoma, Pancreatic Ductal

Germany
Teclison Ltd.
Merck Sharp & Dohme LLC

Recruiting

TATE and Pembrolizumab (MK3475) in mCRC and NSCLC

Colorectal Cancer; Lung Cancer

Taiwan, United States
Case Comprehensive Cancer Center

Completed

Carboplatin, Nab-Paclitaxel and Pembrolizumab for Metastatic Triple-Negative Breast Cancer

Metastatic Triple Negative Breast Cancer

United States
Mara Chambers
Novartis

Completed

Study of Combined Fulvestrant and Everolimus in Advanced/Metastatic Breast Cancer After Aromatase Inhibitor Failure (BRE-43)

Breast Cancer

United States
CONRAD
National Institute of Allergy and Infectious Diseases (NIAID); Microbicide...

Completed

Rectal Microbicide Safety and Acceptability Trial of Topically Applied Tenofovir Compared With Oral Tablet (RMP02-MTN006)

HIV Infections | HIV Prevention

United States
Trevena Inc.

Completed

A Safety, Tolerability, PD and PK Study in Healthy Adults

Healthy

United States
Bial - Portela C S.A.

Completed

Efficacy and Safety of Eslicarbazepine Acetate as Adjunctive Therapy for Refractory Partial Epilepsy

Partial Epilepsy

Portugal
Johns Hopkins University
National Institute on Drug Abuse (NIDA)

Completed

Interferon Alfa Sensitivity in HIV/HCV Persons Before and After HIV Meds

HIV Infection | Hepatitis C

United States
Merck Sharp & Dohme LLC

Terminated

A Study of the Co-administration of Sitagliptin and Atorvastatin in Inadequately Controlled Type 2 Diabetes Mellitus (MK-0431E-211)

Type 2 Diabetes Mellitus
Novartis Pharmaceuticals

Withdrawn

An Open Label Study to Evaluate the Pharmacokinetics, Safety, Tolerability and Efficacy of Deferasirox Administered to Chinese Patients With β-thalassemia Major Aged From 2 to Less Than 6 Years Old (MACS2163)

β-thalassemia Major
Syndax Pharmaceuticals
Merck Sharp & Dohme LLC

Completed

Ph1b/2 Dose-Escalation Study of Entinostat With Pembrolizumab in NSCLC With Expansion Cohorts in NSCLC, Melanoma, and Colorectal Cancer

Melanoma | Non-Small Cell Lung Cancer | Mismatch Repair-Proficient Colorectal Cancer

United States
Sun Yat-sen University

Recruiting

Envofolimab and Lenvatinib Combined With Gemcitabine Plus Cisplatin for Advanced BTC as First-Line Treatment(ENLIGHTEN)

Advanced Biliary Tract Cancer

China
Mirum Pharmaceuticals, Inc.

Completed

Study to Evaluate Patients With Cerebrotendinous Xanthomatosis (RESTORE)

CTX

United States, Brazil
IFOM ETS - The AIRC Institute of Molecular Oncology

Active, not recruiting

Pembrolizumab in MMR-Proficient Metastatic Colorectal Cancer Pharmacologically Primed to Trigger Hypermutation Status (ARETHUSA)

Colorectal Neoplasms | Microsatellite Instability

Italy
Organon and Co

Completed

To Determine Long Term Efficacy and Safety of Asenapine in Schizophrenic Patient Population (A7501012)(COMPLETED)(P05770)

Schizophrenia
Massachusetts General Hospital

Completed

Open-Label Study of N-Acetylcysteine in Children and Adolescents 5-17 With Bipolar Spectrum Disorders

Bipolar Disorder

United States
H. Lundbeck A/S

Completed

Study of the Safety, Tolerability, and Pharmacokinetics of Once Weekly Zicronapine in Patients With Schizophrenia

Schizophrenia

United States
Columbia University
National Institute of Neurological Disorders and Stroke (NINDS)

Completed

A Pilot Study of Neurocysticercosis Treatment

Neurocysticercosis

Ecuador
National Institute of Mental Health (NIMH)

Completed

Clinical Trial of Pramipexole in Bipolar Depression

Bipolar Disorder

United States
University of Washington
University of Nairobi; Kenyatta National Hospital; Kenya Medical Research Institute

Completed

Treatment of Helminth co-Infection: Short-Term Effects on HIV-1 Progression Markers and Immune Activation

HIV Infections | Helminthiasis

Kenya
Mayo Clinic

Active, not recruiting

Pembrolizumab and Ibrutinib in Treating Patients With Stage III-IV Melanoma That Cannot Be Removed by Surgery

Metastatic Melanoma | Stage III Cutaneous Melanoma AJCC v7 | Stage IV Cutaneous Melanoma AJCC v6 and v7 | Stage IIIC Cutaneous Melanoma AJCC v7 | Unresectable Melanoma | Stage IIIA Cutaneous Melanoma AJCC v7 | Stage IIIB Cutaneous Melanoma AJCC v7

United States
BerGenBio ASA

Recruiting

A Study to Investigate the Safety, Tolerability, and Preliminary Anti-tumor Activity of Bemcentinib in Combination With Pembrolizumab Plus Pemetrexed and Carboplatin in Adult Participants With Untreated Non-squamous Non-small Cell Lung Cancer

Carcinoma, Non-Small-Cell Lung

United States
University of California, Davis
National Cancer Institute (NCI); Merck Sharp & Dohme LLC; Novartis

Active, not recruiting

Pembrolizumab and Trametinib in Treating Patients With Stage IV Non-Small Cell Lung Cancer and KRAS Gene Mutations

KRAS Gene Mutation | Stage IV Non-Small Cell Lung Cancer AJCC v7 | Recurrent Non-Squamous Non-Small Cell Lung Carcinoma | Metastatic Non-Squamous Non-Small Cell Lung Carcinoma

United States
ViiV Healthcare
Pfizer

No longer available

A Treatment Access Program To Provide Maraviroc To Eligible Adult Patients Completing A4001050 Study Until Commercial Availability Of Maraviroc (Celsentri) In India

Human Immunodeficiency Virus (HIV)
Rambam Health Care Campus

Unknown

Viagra for the Treatment of IUGR

IUGR

Israel
Fundacao Champalimaud

Recruiting

Phase II Study of Single-Dose Image-Guided Radiotherapy (SDRT) for Prostate Cancer (PROSINT II)

Prostate Cancer

Portugal
Erasmus Medical Center

Recruiting

TEIPP Immunotherapy in Patients With NSCLC (TEIPP)

Non Small Cell Lung Cancer

Netherlands
Intergroupe Francophone de Cancerologie Thoracique

Recruiting

De-escalation Immunotherapy mAintenance Duration Trial for Stage IV Lung Cancer Patients With Disease Control After Chemo-immunotherapy Induction (DIAL)

Metastatic NSCLC

France
Bristol-Myers Squibb

Completed

A Phase III Study of BMS-188667 in Subjects With Active Rheumatoid Arthritis

Rheumatoid Arthritis

United States
Rene Kahn
King's College London; Ludwig-Maximilians - University of Munich; Technical University... and other collaborators

Completed

Optimization of Treatment and Management of Schizophrenia in Europe (OPTIMISE)

Schizophrenia | Schizoaffective Disorder | Schizophreniform Disorder

Netherlands, United Kingdom, Australia, Austria, Belgium, Bulgaria, Czechia, Denmark, France, Germany, Israel, Italy, Poland, Romania, Spain, Switzerland
ImCheck Therapeutics
ILife Consulting; Exystat

Recruiting

Phase 1/2a Study of ICT01 Plus Low Dose SC IL-2 in Patients With Advanced Solid Tumors (EVICTION-2)

Solid Tumor, Adult

France
Heat Biologics

Completed

A Study of Combination Therapies With Viagenpumatucel-L (HS-110) in Patients With Non-Small Cell Lung Cancer

Non-small Cell Lung Cancer

United States
Merck Sharp & Dohme LLC
Eisai Inc.

Active, not recruiting

Safety and Efficacy of Lenvatinib (E7080/MK-7902) With Pembrolizumab (MK-3475) in Combination With Transarterial Chemoembolization (TACE) in Participants With Incurable/Non-metastatic Hepatocellular Carcinoma (MK-7902-012/E7080-G000-318/LEAP-012)

Carcinoma, Hepatocellular

Colombia, Israel, Taiwan, United States, Australia, Brazil, Chile, China, Denmark, France, Germany, Hong Kong, Hungary, Ireland, Italy, Japan, Korea, Republic of, Netherlands, New Zealand, Norway, Portugal, Puerto Rico, Spain, Thailand, Turke... and more
ARCAGY/ GINECO GROUP

Active, not recruiting

PEMBRO With Chemo in Neo Adj Treatment of Ovarian Cancer . (NEOPEMBROV)

Ovarian Cancer Stage IV

France
Salvador Gil-Vernet
Roche Pharma AG

Completed

Valganciclovir for Treatment of Cytomegalovirus Infection in Solid Organ Transplant Patients

Cytomegalovirus Infection

Spain
National Cancer Institute, Egypt

Completed

Perioperative Thoracotomy Analgesia; Different Analgesic Modalities

Analgesia

Egypt
Beijing Bio-Fortune Ltd.

Completed

Recombinant Human Serum Albumin/Interferon alpha2a Fusion Protein Phase I Study in Chinese Healthy Volunteers

Healthy Volunteers

China
Federation Francophone de Cancerologie Digestive

Recruiting

Chemotherapy and Immunotherapy as Treatment for MSS Metastatic Colorectal Cancer With High Immune Infiltrate (POCHI)

Colorectal Cancer Metastatic | Microsatellite Stable | High Immune Infiltrate

France
Haukeland University Hospital
BerGenBio ASA

Active, not recruiting

BGB324 in Combination With Pembrolizumab or Dabrafenib/Trametinib in Metastatic Melanoma

Melanoma

Norway
German Breast Group
Novartis

Completed

Dose EScalation Induction of EvERolimus (Desiree)

Breast Cancer | Hormone Receptor Positive Tumor

Germany
Janssen Pharmaceutica N.V., Belgium

Completed

RiSPECT: Risperdal Safety Protocol Evaluation Consta Treatment, a Post Authorization Safety Survey to Obtain Information on the Safety and Efficacy of Risperidone When Used in Routine Clinical Practice

Psychotic Disorders | Schizophrenia | Schizoaffective Disorder
Pfizer

Completed

A Safety, Efficacy And Pharmacokinetics Study Of Tofacitinib In Pediatric Patients With sJIA

Arthritis Juvenile Idiopathic

United States, Belgium, Spain, Canada, Mexico, Turkey, Israel, China, Slovakia, Hungary, India, Argentina, Brazil, Germany, South Africa, Poland, Ukraine, Italy, Costa Rica, Russian Federation, United Kingdom
Novavax

Active, not recruiting

Study to Evaluate Safety and Immunogenicity of COVID-19 Vaccine in Children 6 Months to < 12 Years (COVID-19)

COVID-19

Spain, United States, South Africa, Mexico, United Kingdom, Philippines, Colombia, Dominican Republic, Guatemala, Honduras
Assistance Publique - Hôpitaux de Paris

Unknown

A Biomarker Study of Palbociclib + Fulvestrant for Second, and Third Line of Postmenopausal Women With hr+/her2- Advanced Breast Cancer (PALPETBIO)

Breast Cancer | Metastasis | HR+/HER2-negative Breast Cancer
Furiex Pharmaceuticals, Inc

Terminated

Efficacy and Safety Study of JNJ-32729463 Compared With Moxifloxacin for the Treatment of Subjects Requiring Hospitalization for Community-Acquired Bacterial Pneumonia

Community-Acquired Bacterial Pneumonia (CABP)

United States, Canada, Colombia, Germany, Hungary, Poland
Molnlycke Health Care AB

Completed

Investigation to Evaluate the Efficacy and Safety of Exufiber Versus Aquacel Extra in Moderately or Strongly Exuding Venous and Mixed Ulcers of Predominantly Venous Origin (PD-497314)

Venous Leg Ulcer

Germany, France, Czechia, Denmark, Poland, Sweden
Mayo Clinic
National Cancer Institute (NCI)

Completed

Lisinopril in Reducing Shortness of Breath Caused by Radiation Therapy in Patients With Lung Cancer

Small Cell Lung Cancer | Non-small Cell Lung Cancer | Dyspnea

United States
Haider Mahdi
Merck Sharp & Dohme LLC; ALX Oncology

Recruiting

Safety and Efficacy of Anti-CD47, ALX148 in Combination With Liposomal Doxorubicin and Pembrolizumab in Recurrent Platinum-resistant Ovarian Cancer

Ovarian Cancer

United States
Fudan University
Merck Sharp & Dohme LLC

Recruiting

Induction of Cisplatin/Nab-paclitaxel/Pembrolizumab Followed by Olaparib/Pembrolizumab Maintenance in mTNBC Patients

Triple Negative Breast Cancer

China

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