Search clinical trials for: Sodium Phenylacetate

Total 10475 results

National Center for Research Resources (NCRR)
Johns Hopkins University

Completed

Phase II Study of Sodium Phenylbutyrate, Sodium Benzoate, Sodium Phenylacetate, and Dietary Intervention for Urea Cycle Disorders

Amino Acid Metabolism, Inborn Errors
Horizon Pharma Ireland, Ltd., Dublin Ireland

Terminated

Efficacy and Safety Study of Ammonul® in Patients With Grade 3 or 4 Hepatic Encephalopathy

Hepatic Encephalopathy

United States
Texas Children's Cancer Center
National Cancer Institute (NCI)

Completed

Phenylacetate in Treating Children With Recurrent or Progressive Brain Tumors

Brain and Central Nervous System Tumors

United States
University of Delaware

Completed

Adverse Neurogenic Actions of Dietary Salt

Blood Pressure

United States
Astellas Pharma Inc

Completed

Multiple Oral Administration of ASP7991 to Non-elderly Male Subjects

Healthy | Pharmacokinetics of ASP7991

Japan
Ocera Therapeutics, Inc.

No longer available

Emergency Use of OCR-002 in Acute Liver Failure (ALF)

Acute Liver Failure

United States
Aga Khan University
Zeenat Qureshi Stroke Institute

Recruiting

Best Solution Identification to Prevent Hyperchloremia Combinations of Sodium Chloride and Sodium Acetate IV Fluids Along With Standard of Care Treatment in Acute Stroke Patients (sodium acetate)

Stroke, Acute

Pakistan
Texas A&M University
Ocera Therapeutics

Unknown

Metabolism of Ornithine Phenylacetate (OCERA OP)

Healthy

United States
Hospital Universitari Vall d'Hebron Research Institute

Completed

Effects of the Administration of Ornithine Phenylacetate in Patients With Cirrhosis and Upper Gastrointestinal Bleeding

Cirrhosis | Gastrointestinal Bleeding

Spain
William Lee
Medical University of South Carolina; National Institute of Diabetes and Digestive... and other collaborators

Completed

Safety Study of Ornithine Phenylacetate to Treat Patients With Acute Liver Failure/Severe Acute Liver Injury (STOP-ALF)

Acute Liver Failure | Acute Liver Injury

United States
Ocera Therapeutics, Inc.

Completed

Phase 2B Efficacy/Safety of Ornithine Phenylacetate in Hospitalized Cirrhotic Patients With Hepatic Encephalopathy (STOP-HE) (STOP-HE)

Hepatic Encephalopathy | Acute Episode of Overt Hepatic Encephalopathy

Belgium, Germany, Italy, Spain, United States, France, Austria, Russian Federation, Czechia, Australia, Hungary, Israel, Netherlands, Bulgaria, Estonia, Denmark, New Zealand
Rigel Pharmaceuticals

Completed

Efficacy and Safety Study of Fostamatinib Disodium Tablets to Treat T-Cell Lymphoma

T Cell Lymphoma

United States, Canada
Mallinckrodt

Withdrawn

MNK-6105 for Patients With Cirrhosis and High Ammonia Levels Affecting Brain Function

Hepatic Encephalopathy
Mallinckrodt

Completed

MNK6106 for Liver Disease (Hepatic Cirrhosis) That in the Past Has Affected the Brain (Hepatic Encephalopathy)

Hepatic Cirrhosis | Hepatic Encephalopathy (HE)

United States, Puerto Rico
Ocera Therapeutics, Inc.

Completed

OCR002-SP103 - Oral Immediate Release Study

Cirrhosis

United States
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy

Sarcoma | Ovarian Cancer | Brain Tumor | Ototoxicity | Neuroblastoma | Liver Cancer | Central Nervous System Tumor | Extragonadal Germ Cell Tumor | Childhood Germ Cell Tumor

Canada, United States, Australia
Institut d'Anesthesiologie des Alpes Maritimes
Université de Nice Sophia Antipolis; Medical University of Grenoble

Completed

Preventive Sodium Lactate and Traumatic Brain Injury

Head Trauma

France
University of Delaware

Completed

Effects of Acute Dietary Sodium on Cerebrovascular Reactivity and Blood Pressure Reactivity

Blood Pressure | Cerebrovascular Reactivity

United States
Radboud University Medical Center

Unknown

The Effect Lactate Administration on Cerebral Blood Flow During Hypoglycemia

Type1diabetes | Hypoglycemia Unawareness

Netherlands
McGill University

Completed

Impact of NaHCO3- on Exercise Hyperpnea

Pulmonary Ventilation

Canada
Austin Health

Completed

Bicarbonate and Lipocalin in Systemic Inflammatory Response Syndrome (SIRS) Study (BLISS)

Systemic Inflammatory Response Syndrome | Renal Impairment | Oliguria

Australia
Medical University of Graz

Completed

Blood Gas Analysis and Buffering In Cardiac Arrest (BABICA)

Cardiac Arrest

Austria
Brigham and Women's Hospital

Completed

Dietary Salt Intake and Vascular Function

Healthy

United States
Osaka General Medical Center

Completed

Prevention of Contrast-Induced Nephropathy With Sodium Bicarbonate Bolus Injection

Emergent Coronary Procedure

Japan
Lars Wiuff Andersen
University of Aarhus

Recruiting

Bicarbonate for In-Hospital Cardiac Arrest (BIHCA)

Cardiac Arrest

Denmark
Erasmus Medical Center

Completed

The Effect of Correction of Metabolic Acidosis in CKD on Intrarenal RAS Activity (BIC)

Chronic Kidney Disease

Netherlands
Capital Medical University
Beijing Friendship Hospital; Cancer Institute and Hospital, Chinese Academy...

Unknown

Dietary Nitrate on Salivary Flow for Nasopharyngeal Carcinoma Patients

Nasopharyngeal Carcinoma

China
Karolinska Institutet

Completed

Coronary Artery Bypass and Nitrate Oral Supplementation (CABANOS)

Coronary Artery Disease

Sweden
Gladwin, Mark, MD

Completed

Oral Nitrite in Adults With Metabolic Syndrome and Hypertension (ONTX)

Hypertension | Metabolic Syndrome

United States
Azienda Sanitaria ASL Avellino 2

Unknown

Effects of Short-chain Fatty Acids on Inflammatory and Metabolic Parameters in Maintenance Hemodialysis (PLAN)

Endstage Renal Disease
University Hospital Birmingham NHS Foundation Trust

Unknown

Nitrite Mediated Cardioprotection During Coronary Artery Bypass Surgery

Coronary Artery Bypass Surgery

United Kingdom
Pharma VAM

Unknown

Clinical Study in the Treatment of Patients With COVID-19

COVID-19

Russian Federation
Tabriz University of Medical Sciences

Not yet recruiting

Evaluation of the Safety and Efficacy of Sodium Pentaborate Pentahydrate in Patients With Advanced Renal Cell Carcinoma

Renal Cell Carcinoma

Iran, Islamic Republic of
Shandong University

Unknown

Lower Fluorescein Sodium Dose on Confocal Laser Endoscopy Image Quality and Yellow Discoloration of the Skin

Image Quality | Skin Discoloration

China
University of East Anglia

Unknown

Nitrite Effects on Cardiac Muscle in CABG

Vascular Diseases | Coronary Artery Disease | Diabetes Mellitus | Atherosclerosis | Cardiac Disease

United Kingdom
National Institute of Neurological Disorders and...

Completed

Nitrite Infusion in Healthy Volunteers

Healthy

United States
University Hospital, Clermont-Ferrand

Unknown

Comparative Evaluation of the Effect on Blood Pressure of an Equivalent Content of Sodium in the Form of Bicarbonate of Sodium and in the Form of Sodium Chloride, on "Sensitive Sodium" Subjects (SODIVASC)

Healthy

France
National Cancer Institute (NCI)

Recruiting

Radium-223 in Biochemically Recurrent Prostate Cancer

Biochemical Recurrent Prostate Cancer

United States
Texas State University

Recruiting

A Comparison of Sodium-Induced Responses by Sex

Endothelial Dysfunction | Sodium Intake

United States
Medical College of Wisconsin

Recruiting

Renal Metabolism in Salt-sensitive Human Blood Pressure

Hypertension

United States
Imperial College London

Completed

Propionate and Energy Homeostasis (PROEM)

Obesity

United Kingdom
University of Sao Paulo
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.; Fundação de Apoio...

Completed

Dietary Sodium Intake in Acute Heart Failure (SODIC)

Heart Failure; With Decompensation | Heart Failure，Congestive

Brazil
Maastricht University Medical Center

Completed

Aldosterone, Microvascular Function and Salt-sensitivity

Hypertension | Metabolic Syndrome | Insulin Resistance | Abdominal Obesity | Sodium-sensitivity

Netherlands
DongGuk University
Boryung Pharmaceutical Co., Ltd

Completed

Effect of High- and Low-sodium Intake on the Pharmacokinetics and Pharmacodynamic Effects of Fimasartan

Hypertension

Korea, Republic of
Erling Bjerregaard Pedersen

Unknown

The Effect of Sodium Nitrite on Renal Function and Blood Pressure in Hypertensive Versus Healthy Subjects (HYCA)

Hypertension

Denmark
McGill University Health Centre/Research Institute...

Unknown

Preventing Acute Renal Failure After Cardiac Surgery in High Risk Patients Using Sodium Bicarbonate Therapy (PARACHUTE)

Kidney Failure, Acute

Canada
Beijing Tiantan Hospital

Not yet recruiting

Reducing Edema After intraCerebral Hemorrhage

Edema Brain
University of Michigan
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Sodium Diet Effect on Aldosterone and Urinary RNA (SALTY) (SALTY)

Healthy

United States
University of North Carolina, Chapel Hill
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Visual Attention to Text and Pictorial Food Labels: An Eye Tracking Experiment

Health Behavior

United States
Imperial College London
Royal Brompton & Harefield NHS Foundation Trust

Completed

Nebulised Hypertonic Saline in Children and Young People With Neuromuscular Disease and Cerebral Palsy

Neuromuscular Diseases

United Kingdom

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