Search clinical trials for: TNP-2198

Total 1909 results

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TenNor Therapeutics (Suzhou) Limited

Completed

A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of TNP-2198 Capsules in Asymptomatic Participants With Helicobacter Pylori Infection

Helicobacter Pylori Infection

China
TenNor Therapeutics (Suzhou) Limited

Completed

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Food Effect of TNP-2198 Capsules After Single Oral Dose in Healthy Participants

Helicobacter Pylori Infection

China
TenNor Therapeutics (Suzhou) Limited

Completed

Human Mass Balance and Biotransformation Study of [14C]TNP-2198

Helicobacter Pylori Infection

China
Yellow Jersey Therapeutics AG
Kaken Pharmaceutical Co., Ltd.

Terminated

Evaluation of NM26-2198 in Healthy Subjects and in Patients With Moderate-to-severe Atopic Dermatitis (AD)

Atopic Dermatitis

United States, Germany, Poland, Canada
TenNor Therapeutics (Suzhou) Limited

Completed

Efficacy and Safety After Multiple Doses of TNP-2198 Capsules, Rabeprazole Sodium Enteric-coated Tablets and Amoxicillin Capsules in Helicobacter Pylori Infected-positive Participants

Helicobacter Pylori Infection

China
Palisade Bio
Altasciences Company Inc.

Recruiting

Phase 1 Study Evaluating PALI-2108 in Healthy Volunteers and Ulcerative Colitis Patients.

Healthy Volunteer | Ulcerative Colitis (UC)

Canada
Shandong Suncadia Medicine Co., Ltd.

Recruiting

Phase I Clinical Study of HRS-2189 in the Treatment of Patients With Advanced Malignant Tumors

Advanced Malignant Tumor

China
Aclaris Therapeutics, Inc.

Active, not recruiting

Study of ATI-2138 in Adult Participants with Moderate to Severe Atopic Dermatitis

Atopic Dermatitis

United States
TenNor Therapeutics (Suzhou) Limited

Completed

A Study to Evaluate Preliminary Helicobacter Pylori Eradication After Multiple Doses of TNP-2198 Capsules Combined With Rabeprazole Sodium Enteric-coated Tablets, or Rabeprazole Sodium Enteric-coated Tablets and Amoxicillin Capsules

Helicobacter Pylori Infection

China
TenNor Therapeutics (Suzhou) Limited
The First Hospital of Jilin University

Completed

A Phase 1 Study to Evaluate PK Profile of Multiple Oral Administrations of TNP-2092 Capsules in Healthy Subjects

Helicobacter Pylori Infection

China
Aswan University
Aswan University Hospital

Completed

A Comparing Transversalis Fascia Plane Block and Quadratus Lumborum Block for Post-Cesarean Pain Management: Efficacy, Execution Time, and Practicality

Regional Anesthesia Block

Egypt
Hong Kong Baptist University

Recruiting

CHM for Female Stress Urinary Incontinence

Stress Urinary Incontinence (SUI)

Hong Kong
Biomea Fusion Inc.

Active, not recruiting

Phase 2 Trial of BMF-219 in Participants with Type 1 Diabetes Mellitus (BF-MNN-112)

Type 1 Diabetes Mellitus

United States, Canada
Fudan University

Not yet recruiting

Study of HRS-2189 Combined HRS-5041 in Prostate Cancer

Prostate Cancer Metastatic Disease

China
TenNor Therapeutics Limited

Completed

Absorption, Metabolism, and Excretion Study of [14C]-TNP-2092

Healthy

United States
TenNor Therapeutics (Suzhou) Limited

Completed

A Phase 1, Single-center, Double-blind, Placebo-controlled Study of TNP-2092 Capsules, and the Food Effect Study After Single-dose Oral Administration of TNP-2092 Capsules

Hyperammonemia

China
TenNor Therapeutics Limited

Completed

Tissue Distribution, Pharmacokinetics, Safety, and Tolerability After a Single Dose of TNP-2092 in Participants Undergoing Primary Total Hip or Knee Arthroplasty

Prosthetic Joint Infection

United States
NHS Greater Glasgow and Clyde
University of Glasgow; NHS Ayrshire and Arran; Golden Jubilee National Hospital

Not yet recruiting

CharacterisatiON of carDiac funCTion in Intensive Care Unit Survivors of Sepsis. (CONDUCT-ICU)

Heart Failure | Sepsis | Septic Shock | Myocarditis

United Kingdom
Biomea Fusion Inc.

Terminated

Study of Covalent Menin Inhibitor BMF-219 in Adult Patients With KRAS Driven Non-Small Cell Lung Cancer, Pancreatic Cancer, and Colorectal Cancer

Colorectal Cancer | Pancreatic Cancer | NSCLC | Non Small Cell Lung Cancer | Stage III Pancreatic Cancer | Stage IV Pancreatic Cancer | CRC | KRAS Mutation-Related Tumors | Relapsed Cancer | Refractory Cancer | Stage IV Non-small Cell Lung Cancer | Stage IV Colorectal Cancer | Stage III Non-small Cell Lung Cancer | Stage III NSCLC and other conditions

United States, Korea, Republic of
Simbec Research
Sensorion SA

Completed

A Single Dose PK Study of SENS-218 in Healthy Volunteers

Inner Ear Diseases
Rapport Therapeutics Inc.

Recruiting

Study Evaluating the Safety and Efficacy of RAP-219 in Adult Participants With Refractory Focal Epilepsy

Focal Onset Seizures

United States
AnHeart Therapeutics Inc.

Terminated

IDH1 Inhibitor AB-218 in Patients With Advanced IDH1 Mutant Cholangiocarcinoma and Other Solid Tumor

Cholangiocarcinoma With IDH1 Mutation | Solid Tumors With IDH1 Mutation

China
Addpharma Inc.

Recruiting

A Study to Evaluate the Efficacy and Safety of AD-218

Mixed Dyslipidemia

Korea, Republic of
Sichuan Haisco Pharmaceutical Group Co., Ltd

Completed

Safety, Tolerability and Pharmacokinetics of FTP-198 in Healthy Australian Volunteers

Healthy

Australia
Merck Sharp & Dohme LLC

Terminated

Study of MK-2118 Administered as Intratumoral Injection as Monotherapy and in Combination With Pembrolizumab (MK-3475) or by Subcutaneous Injection in Combination With Pembrolizumab in the Treatment of Adults With Advanced/Metastatic Solid Tumors or Lymphomas (MK-2118-001)

Lymphoma | Solid Tumor

United States, Israel
Shandong Suncadia Medicine Co., Ltd.

Recruiting

A Trial of HRS-2189 in Combination With Fluvastatin±HRS-6209, or HRS-8080±HRS-6209, or HRS-6209+HRS-1358 in Breast Cancer Patients

Advanced Unresectable or Metastatic Breast Cancer

China
TenNor Therapeutics (Suzhou) Limited
The First Hospital of Jilin University

Completed

PK Profile and Preliminary Efficacy of TNP-2092 Capsules in Liver Cirrhosis Patients With Hyperammonemia

Hyperammonemia

China
Brii Biosciences Limited
TSB Therapeutics (Beijing) CO.LTD

Completed

Safety, Tolerability, and Pharmacokinetics Study of Human Monoclonal Antibody BRII-198

COVID-19

China
Afferent Pharmaceuticals, Inc.

Completed

A Four-Week Multicenter Study Evaluating the Safety and Efficacy of Gefapixant (AF-219/MK-7264) in Subjects With Osteoarthritis of the Knee

Osteoarthritis of the Knee

United States
Biomea Fusion Inc.

Active, not recruiting

Study of BMF-219, a Covalent Menin Inhibitor, in Adult Patients With AML, ALL (With KMT2A/ MLL1r, NPM1 Mutations), DLBCL, MM, and CLL/SLL

Lymphoma | Lymphoma, Non-Hodgkin | Acute Myeloid Leukemia | Cancer | Progression | Multiple Myeloma | Acute Lymphoblastic Leukemia | Chronic Lymphocytic Leukemia | Plasma Cell Myeloma | Diffuse Large B Cell Lymphoma | Small Lymphocytic Lymphoma | Refractory | Myeloma, Plasma-Cell | Myelomatosis | Acute Mixed-Phenotype...

United States, Spain, Netherlands, Greece, Italy
Nuvation Bio Inc.
AnHeart Therapeutics Inc.

Active, not recruiting

Safusidenib Phase 2 Study in IDH1 Mutant Glioma

Glioma

United States
Afferent Pharmaceuticals, Inc.

Completed

A Study to Assess the Tolerability of a Single Dose of Gefapixant (AF-219/MK-7264) in Subjects With Idiopathic Pulmonary Fibrosis (IPF)

Idiopathic Pulmonary Fibrosis

United States
Afferent Pharmaceuticals, Inc.

Completed

Effect of Gefapixant (AF-219/MK-7264) on Cough Reflex Sensitivity (MK-7264-015)

Refractory Chronic Cough

United Kingdom
Afferent Pharmaceuticals, Inc.

Completed

A Study to Assess the Efficacy of Gefapixant (MK-7264/AF-219), in Participants With Chronic Cough (MK-7264-006) (EPICC)

Chronic Cough
TC Erciyes University

Recruiting

Analgesic Efficacy of Transvers Abdominis Plane Block and Transversalis Fascia Plane Block in Cesarean Section

Obstetric

Turkey
Afferent Pharmaceuticals, Inc.

Completed

A Study of Gefapixant (AF-219/MK-7264) in Participants With Idiopathic Pulmonary Fibrosis (IPF) With Persistent Cough (MK-7264-016)

Cough | Idiopathic Pulmonary Fibrosis
Biomea Fusion Inc.

Active, not recruiting

Study of BMF-219 in Healthy Adult Subjects and in Adult Subjects With Type 2 Diabetes Mellitus (T2D)

Type 2 Diabetes Mellitus

United States, Canada
Brii Biosciences, Inc.

Withdrawn

A Safety and Efficacy Study of Human Monoclonal Antibodies, BRII-196 and BRII-198 for the Treatment of Patients With COVID-19

COVID-19

China
TenNor Therapeutics Inc.

Completed

Drug-Drug Interactions Between TNP-2198 and Midazolam, Clarithromycin

Helicobacter Pylori Infection

China
Afferent Pharmaceuticals, Inc.

Completed

A Dose Escalation Study of Gefapixant (AF-219/MK-7264) in Refractory Chronic Cough (MK-7264-010)

Refractory Chronic Cough
Afferent Pharmaceuticals, Inc.

Completed

An 8-Week Refractory Chronic Cough Study (MK-7264-021)

Refractory Chronic Cough

United States
Afferent Pharmaceuticals, Inc.

Completed

Effect of Gefapixant (MK-7264/AF-219) on Cough Reflex Sensitivity in Healthy and Chronic Cough Participants (MK-7264-014)

Refractory Chronic Cough
TAO CHEN

Unknown

SIL-TEP vs TEP for Inguinal Hernia Repair in Day Surgery

Hernia, Inguinal

China
Mansoura University

Unknown

Laparoscopic Versus US-Guided Subcostal TAP Block After Laparoscopic Cholecystectomy

Cholecystitis; Gallstone

Egypt
Shengjing Hospital

Recruiting

The Efficiency for Stage II-III HR+/HER2+ Early Breast Cancer Patient With Standard Neoadjuvant Therapy in Real World.

Breast Cancer

China
Siemens Healthcare Diagnostics Inc

Terminated

Serial BNP Testing for Heart Failure Management (USE-BNP)

Heart Failure

United States, Canada
MedMira Laboratories Inc.

Not yet recruiting

Cross-sectional Investigational Study to Evaluate the Sensitivity, Specificity, and Utility of the MedMira Inc. Multiplo® Complete Syphilis (TP/nTP) Antibody Test (POCT) to Diagnose Infectious Syphilis in Participants Attending the Sexual Health Clinic in Ottawa, Ontario.

Treponema Pallidum

Canada
U.S. Army Medical Research and Development Command
US Army Medical Research Institute of Infectious Diseases

Withdrawn

ID Recombinant Ricin Toxin A-Chain Vaccine RVEc™ - 3-Dose Primary Series With Boost

Ricin Poisoning

United States
Aldeyra Therapeutics, Inc.

Completed

A Study in Subjects With Retinitis Pigmentosa

Retinitis Pigmentosa

United States
University of Florida
Florida Probe Corporation

Completed

The Impact of a Modified Probe Tip Design on Patient Perception of Discomfort on Probing and Clinical Parameters Using the Florida Probe® System

Periodontitis | Diagnoses Disease

United States

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