Search clinical trials for: Tafenoquine

Total 32 results

U.S. Army Medical Research and Development Command
SmithKline Beecham

Completed

A Randomized, Double-blind, Placebo-controlled Evaluation of Increasing Doses of Weekly Tafenoquine for Chemosuppression of Plasmodium Falciparum

Malaria
GlaxoSmithKline
Parexel; Medicines for Malaria Venture

Completed

A Study to Assess the Effects of Dissolution Profile on the Pharmacokinetics of Single Oral Doses of Tafenoquine Tablets and Tafenoquine Stable Isotope Labelled Solution

Malaria, Vivax

United States
GlaxoSmithKline

Completed

Tafenoquine Thorough QTc Study in Healthy Subjects

Malaria, Vivax

United States
Naval Medical Research Center
The 108 Military Central Hospital; Naval Medical Research Unit TWO (NAMRU-2); Australian Defence Force Malaria and Infectious Disease Institute (ADF MIDI) and other collaborators

Not yet recruiting

Escalating Monthly Doses of Tafenoquine in Healthy Volunteers (TQ)

Prophylaxis

Vietnam
GlaxoSmithKline
Medicines for Malaria Venture

Completed

Assessment of Any Potential Retinal Effects of Tafenoquine (TQ)

Malaria, Vivax

United States
60P Australia Pty Ltd

Not yet recruiting

A Clinical Evaluation of the Safety and Efficacy of Randomized Placebo Versus the 8-aminoquinoline Tafenoquine for Early Symptom Resolution in Patients With Mild to Moderate COVID 19 Disease and Low Risk of Disease Progression

Infectious Disease | SARS-CoV-2 | Severe Acute Respiratory Syndrome Coronavirus 2 | COVID 19 Disease | Mild to Moderate COVID 19 Disease
GlaxoSmithKline
Medicines for Malaria Venture

Completed

Ph 2B/3 Tafenoquine (TFQ) Study in Prevention of Vivax Relapse

Malaria, Vivax

Thailand, India, Brazil, Ethiopia, Peru, Bangladesh, Cambodia, Philippines
60 Degrees Pharmaceuticals LLC

Completed

Tafenoquine in Patients With Mild to Moderate COVID-19

COVID 19 Disease

United States
Shoklo Malaria Research Unit
Mahidol Oxford Tropical Medicine Research Unit

Recruiting

ACT vs CQ With Tafenoquine for P. Vivax Mono-infection (ACTQ)

Malaria | Malaria, Vivax | Plasmodium Vivax Malaria

Thailand
London School of Hygiene and Tropical Medicine

Completed

Single Low Dose Tafenoquine to Reduce P. Falciparum Transmission in Mali (NECTAR2) (NECTAR2)

Malaria, Falciparum

Mali
GlaxoSmithKline
Medicines for Malaria Venture

Completed

Study to Assess the Incidence of Hemolysis, Safety, and Efficacy of Tafenoquine (SB-252263, WR238605) Versus Primaquine in Subjects With Plasmodium Vivax Malaria

Malaria, Vivax

Thailand, Vietnam, Colombia, Brazil, Ethiopia, Peru
60 Degrees Pharmaceuticals LLC

Not yet recruiting

Oral Tafenoquine Plus Standard of Care Versus Placebo Plus Standard of Care for Babesiosis

Babesiosis
60 Degrees Pharmaceuticals LLC

Completed

Long-Term Safety Study of Tafenoquine

Healthy Volunteers

Australia, United States
Fundação de Medicina Tropical Dr. Heitor Vieira...
Ministry of Health, Brazil; Medicines for Malaria Venture; Centro de Pesquisa... and other collaborators

Active, not recruiting

Operational Feasibility of Appropriate Radical Cure of Plasmodium Vivax With Tafenoquine or Primaquine After Quantitative G6PD Testing in Brazil (Trust)

Malaria, Vivax | G6PD Deficiency

Brazil
U.S. Army Medical Research and Development Command
SmithKline Beecham

Completed

Evaluation of Weekly Tafenoquine

Malaria
GlaxoSmithKline
Medicines for Malaria Venture

Completed

Efficacy and Safety Study of Tafenoquine (TQ) Co-administered With Dihydroartemisinin-piperaquine (DHA-PQP) for the Radical Cure of Plasmodium Vivax (P. Vivax) Malaria

Malaria, Vivax

Indonesia
U.S. Army Medical Research and Development Command
SmithKline Beecham

Completed

An Evaluation of Weekly Tafenoquine

Falciparum Parasitaemia
Menzies School of Health Research
Aga Khan University; University of Melbourne; Universitas Sumatera Utara; Ethiopian... and other collaborators

Recruiting

Effectiveness of Novel Approaches to Radical Cure With Tafenoquine and Primaquine (EFFORT)

Vivax Malaria | Malaria, Vivax | Plasmodium Vivax | Malaria Relapse

Cambodia, Ethiopia, Indonesia, Pakistan
Menzies School of Health Research
University of Melbourne; Curtin University; Addis Ababa University; Fundação de... and other collaborators

Not yet recruiting

A Revised Tafenoquine Dose to Improve Radical Cure for Vivax Malaria (TADORE)

Vivax Malaria

Brazil, Ethiopia, Indonesia, Papua New Guinea
University of Oxford
Mahidol Oxford Tropical Medicine Research Unit

Withdrawn

Tafenoquine and Primaquine in Colostrum and Breast Milk (TBM)

Healthy Lactating Women

Thailand
GlaxoSmithKline
Medicines for Malaria Venture

Completed

Tafenoquine/Chloroquine DDI Study

Malaria

United States
GlaxoSmithKline
Medicines for Malaria Venture

Completed

A Pharmacokinetics, Safety and Efficacy Study of Tafenoquine (TQ) in Pediatric Subjects With Plasmodium Vivax (P. Vivax) Malaria

Malaria, Vivax

Vietnam, Colombia
Centre Hospitalier de Cayenne
Oswaldo Cruz Foundation

Recruiting

Radical CUREfor MAlaria Among Highly Mobile and Hard-to-reach Populations in the Guyanese Shield (CUREMA)

Malaria, Vivax

Brazil, Suriname
Marinus Pharmaceuticals

Completed

A Clinical Trial of Oral Ganaxolone in Women With Postpartum Depression

Behavioral Symptoms | Depressive Disorder | Depression | Mood Disorders | Pregnancy Complications | Depression, Postpartum | Mental Disorder | Postpartum Disorder | PPD | Postpartum Blues

United States
U.S. Army Medical Research and Development Command
GlaxoSmithKline

Terminated

Study to Evaluate the Efficacy and Safety of Tafenoquine for the Treatment of Plasmodium Vivax in Adults

Malaria | Plasmodium Vivax

Thailand
GlaxoSmithKline
Medicines for Malaria Venture

Completed

G6PD (Glucose-6-phosphate Dehydrogenase) Study to Evaluate Hemolysis Potential of TFQ (Tafenoquine)

Malaria

Thailand
Dr. Prayuth Sudathip
Medicines for Malaria Venture

Completed

Operational Feasibility of Appropriate Plasmodium Vivax Radical Cure After G6PD Testing in Thailand (ARCTIC)

Malaria, Vivax | G6PD Deficiency

Thailand
GlaxoSmithKline
Medicines for Malaria Venture

Completed

A Study to Evaluate the Pharmacokinetics of a Single Dose of Tafenoquine Co-administered With Either Artemether + Lumefantrine or Dihydroartemisinin + Piperaquine Tetraphosphate

Malaria, Vivax

United States
University of Oxford
PATH

Not yet recruiting

Southeast Asia Dose Optimization of Tafenoquine (SEADOT)

Plasmodium Vivax Malaria

Cambodia, Lao People's Democratic Republic, Thailand, Vietnam
St. Jude Children's Research Hospital
National Cancer Institute (NCI)

Completed

Gene Therapy in Treating Children With Refractory or Recurrent Neuroblastoma

Neuroblastoma

United States
Medicines for Malaria Venture
UNITAID; Universidad Peruana Cayetano Heredia; ICON plc

Recruiting

Radical Cure (RC) With Tafenoquine or Primaquine After Semi-quantitative G6PD Testing: A Feasibility Study in Peru

Malaria, Vivax

Peru
London School of Hygiene and Tropical Medicine

Completed

Gametocytocidal and Transmission-blocking Efficacy of PQ in Combination With AL and TQ in Combination With SPAQ in Mali (NECTAR3)

Malaria,Falciparum

Mali

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