Search clinical trials for: Tezepelumab

Total 31 results

AstraZeneca
Amgen

Completed

Extension Study to Evaluate the Safety and Tolerability of Tezepelumab in Adults and Adolescents With Severe, Uncontrolled Asthma (DESTINATION)

Asthma

United States, Austria, Canada, France, Germany, Taiwan, Vietnam, Korea, Republic of, Brazil, Turkey, Argentina, Australia, Israel, Poland, Russian Federation, Saudi Arabia, South Africa, Ukraine
Asger Sverrild
AstraZeneca; University Hospitals, Leicester; University Hospital, Antwerp

Recruiting

Effects of Blocking TSLP on Airway Inflammation and the Epithelial Immune-response to Exacerbation Triggers in Patients With COPD (UPSTREAM-COPD)

COPD | COPD Exacerbation | Immune System Disorder | Airway Disease | COPD Bronchitis

United Kingdom, Belgium, Denmark
AstraZeneca
Amgen

Recruiting

Tezepelumab Efficacy and Safety in Reducing Oral Corticosteroid Use in Adults With Oral Corticosteroid Dependent Asthma (SUNRISE)

Asthma

United States, Canada, Czechia, Korea, Republic of, India, Mexico, Turkey, Chile, Brazil, Thailand, Colombia, Poland, Peru, Malaysia, Philippines
AstraZeneca
Amgen

Completed

Study to Evaluate Tezepelumab on Airway Inflammation in Adults With Uncontrolled Asthma (CASCADE) (CASCADE)

Respiratory Tract Diseases | Immune System Diseases | Lung Diseases | Hypersensitivity | Hypersensitivity, Immediate | Bronchial Diseases | Lung Diseases, Obstructive | Asthma | Respiratory Hypersensitivity

United States, Canada, Denmark, United Kingdom, Germany
AstraZeneca

Active, not recruiting

Study to Evaluate Efficacy and Safety of Tezepelumab in Reducing Oral Corticosteroid Use in Adult Patients With Severe Asthma (WAYFINDER)

Asthma

United States, Belgium, Spain, United Kingdom, France, Argentina, Bulgaria, Germany, Poland, Mexico, Latvia
AstraZeneca
Amgen

Completed

Study to Evaluate the Pharmacokinetics of Tezepelumab in Children With Asthma (TRAILHEAD)

Asthma

United Kingdom, South Africa, Hungary
AstraZeneca
Amgen

Completed

A Study to Evaluate the Pharmacokinetics of Tezepelumab After Being Delivered by an Accessorized Pre Filled Syringe or Autoinjector Compared With Vial and Syringe in Healthy Adult Subjects (PATH-BRIDGE)

Asthma

Germany
University Hospital, Montpellier

Recruiting

REVErsing Airway Remodelling With Tezepelumab (REVERT)

Airway Remodelling, Asthmatic

France
Imperial College London
AstraZeneca

Enrolling by invitation

Explore the Efficacy and Mechanism of Action of Tezepelumab in Eosinophilic Granulomatosis With Polyangiitis (RACEMATE)

EGPA - Eosinophilic Granulomatosis With Polyangiitis

United Kingdom
AstraZeneca
Amgen

Completed

Tezepelumab COPD Exacerbation Study (COURSE)

Chronic Obstructive Pulmonary Disease (COPD)

United States, Canada, Denmark, France, United Kingdom, Korea, Republic of, Germany, Israel, Spain, Netherlands
AstraZeneca
Amgen

Completed

Study to Evaluate the Efficacy and Safety of Tezepelumab in Reducing Oral Corticosteroid Use in Adults With Oral Corticosteroid Dependent Asthma (SOURCE)

Asthma

United States, Korea, Republic of, Turkey, Germany, Argentina, Poland, Ukraine
AstraZeneca
Amgen

Completed

Study to Assess the Effect of Tezepelumab on the Immune Response to Influenza Vaccination in Participants With Asthma (VECTOR)

Moderate to Severe Asthma

United States
AstraZeneca
Amgen

Completed

Long-term Safety of Tezepelumab in Japanese Subjects With Inadequately Controlled Severe Asthma (NOZOMI)

Severe Asthma

Japan
AstraZeneca
Parexel

Recruiting

Effectiveness and Safety Study of Tezepelumab in Adults & Adolescent Participants With Severe Asthma in the United States (PASSAGE)

Asthma

United States
Amgen

Completed

Double-blind, Multiple Dose Study of Tezepelumab (AMG 157) in Adults With Mild Atopic Asthma

Asthma

Canada
Amgen

Completed

Safety Study of Tezepelumab (AMG 157) in Healthy Adults and Adults With Atopic Dermatitis

Healthy Volunteers | Atopic Dermatitis
Dr. Anne Ellis

Recruiting

Tezepelumab in Allergic Rhinitis and Asthma Study (TEZARS) (TEZARS)

Asthma With Allergic Rhinitis

Canada
AstraZeneca
Amgen

Active, not recruiting

Study to Evaluate Tezepelumab in Adults With Severe Uncontrolled Asthma (DIRECTION)

Asthma

Korea, Republic of, Philippines, China
AstraZeneca
Amgen

Completed

Tezepelumab Home Use Study (PATH-HOME)

Asthma

United States, Canada, Poland, Japan
Amgen

Completed

Safety Study of Tezepelumab (AMG 157) in Healthy Adults

Healthy Volunteers
AstraZeneca
Amgen

Completed

Study to Evaluate Tezepelumab in Adults & Adolescents With Severe Uncontrolled Asthma (NAVIGATOR)

Asthma

United States, Austria, Canada, France, Germany, Taiwan, Vietnam, Korea, Republic of, Brazil, Japan, Argentina, Australia, Israel, Russian Federation, Saudi Arabia, South Africa, Ukraine, United Kingdom
AstraZeneca
Amgen

Completed

Tezepelumab Phase 1 PK Study in Healthy Chinese Subjects (DIRECTION-CK)

Healthy Subjects

China
AstraZeneca
Amgen

Active, not recruiting

Efficacy and Safety of Tezepelumab in Participants With Severe Chronic Rhinosinusitis With Nasal Polyposis (WAYPOINT)

Chronic Rhinosinusitis With Nasal Polyps

United States, Canada, Denmark, Spain, United Kingdom, Germany, Hungary, China, Japan, Poland
McMaster University

Recruiting

Tezepelumab on Airway Structure and Function in Patients With Uncontrolled Moderate-to-severe Asthma

Asthma

Canada
AstraZeneca
Amgen

Recruiting

A Study to Investigate the Efficacy and Safety of Tezepelumab Compared With Placebo in Children 5 to < 12 Years Old With Severe Asthma (HORIZON)

Asthma

United States, Poland, Korea, Republic of, Spain, France, China, United Kingdom, Canada, Netherlands, Argentina, Mexico, Brazil, Hungary, Japan, Philippines, South Africa, Colombia
McMaster University
University of Saskatchewan

Not yet recruiting

Tezepelumab and Methacholine Airway Hyperresponsiveness in Participants With Mild Allergic Asthma

Asthma, Allergic

Canada
AstraZeneca
Amgen

Recruiting

Efficacy and Safety of Tezepelumab in Patients With Eosinophilic Esophagitis (CROSSING)

Eosinophilic Esophagitis

United States, Czechia, Spain, China, Australia, Italy, Belgium, Finland, Norway, Japan, Brazil, Austria, Greece, Canada, Netherlands, Sweden, Israel, Germany, Denmark, Slovakia, New Zealand, United Kingdom
Amgen
AstraZeneca

Terminated

A Dose Ranging Placebo-Controlled Double-Blind Study to Evaluate the Safety and Efficacy of Tezepelumab in Atopic Dermatitis

Atopic Dermatitis

United Kingdom, Spain, Australia, Hungary, Switzerland, United States, Germany, Korea, Republic of, Canada, Czechia, Poland, Japan, Estonia, Latvia, Ukraine
Amgen

Completed

Study to Evaluate Tezepelumab in Adults With Chronic Spontaneous Urticaria (INCEPTION)

Chronic Spontaneous Urticaria

United States, Korea, Republic of, Spain, Italy, Canada, Poland, Japan, France, Greece, Germany
Children's Hospital of Orange County

Recruiting

Treatment of Refractory Infantile Spasms With Fenfluramine

Infantile Spasm

United States
Tel-Aviv Sourasky Medical Center
Genzyme, a Sanofi Company; Wolfson Medical Center

Completed

Sevelamer Hydrochloride and Femoral and Carotid Intima Media Thickness Progression in End Stage Renal Disease (SUMMER)

Hemodialysis | End Stage Renal Disease | Intimal Media Thickness

Israel

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