Search clinical trials for: Trypanocidal Agents

Total 187383 results

Immtech Pharmaceuticals, Inc

Completed

Prophylactic Antimalarial Activity of DB289 in Volunteers

Prophylactic Activity Against Malaria

United States
Bayer

Completed

Study to Assess the Food Effect on the Pharmacokinetics of Nifurtimox Tablets in Chronic Chagas' Patients

Chagas Disease

Argentina
University of Maryland, Baltimore
National Cancer Institute (NCI)

Terminated

0794GCC: Pentamidine in Treating Patients With Relapsed or Refractory Melanoma

Melanoma (Skin)

United States
Oncozyme Pharma Inc.

Completed

A Safety Study Using Pentamidine in Patients With Pancreatic Cancer Undergoing Standard Therapy

Pancreatic Cancer

Canada
Immtech Pharmaceuticals, Inc

Terminated

Randomized, Double-Blind Phase 1 Safety and Tolerability Study of Pafuramidine Maleate (DB289) in Healthy Subjects

Healthy

South Africa
Bayer

Not yet recruiting

An Observational Pregnancy Safety Study in Women Who Were Exposed to the Drug Nifurtimox During Pregnancy to Learn About the Risk of Pregnancy Complications and About the Mother's and Baby's Health

Chagas Disease

Spain, Germany, Argentina, Chile, United States, Bolivia, Uruguay, El Salvador, Guatemala, Honduras
Immtech Pharmaceuticals, Inc
Bill and Melinda Gates Foundation

Completed

A Trial of DB289 for the Treatment of Stage I African Trypanosomiasis

Trypanosomiasis, African

Angola, Congo
National Institute of Allergy and Infectious Diseases...

Completed

Aerosols in the Treatment of Asymptomatic Pneumocystis Pneumonia: A Pilot Study Assessing the Effectiveness of Aerosolized Pentamidine as Treatment of Subclinical Pneumocystis Infection in Patients With No Clinical Symptoms

HIV Infections | Pneumonia, Pneumocystis Carinii

United States
Fisons

Completed

A Double-Blind Group Comparative Study To Evaluate the Long-Term Safety and Effectiveness of Two Different Doses of Aerosol Pentamidine in the Prophylaxis of Pneumocystis Carinii Pneumonia in AIDS Patients With Multiple Episodes of PCP

HIV Infections | Pneumonia, Pneumocystis Carinii

United States
Fisons

Completed

A Double-Blind Study To Evaluate the Long-Term Safety and Effectiveness of 60 mg Versus 120 mg of Aerosol Pentamidine in the Prophylaxis of Pneumocystis Carinii Pneumonia in AIDS Patients

HIV Infections | Pneumonia, Pneumocystis Carinii

United States
National Institute of Allergy and Infectious Diseases...

Completed

A Study of Two Forms of Pentamidine in HIV-Infected Children Who May Have Pneumocystis Carinii Pneumonia

HIV Infections | Pneumonia, Pneumocystis Carinii

United States
University of Illinois at Chicago

Completed

Intravenous Pentamidine for Pneumocystis Jirovecii Pneumonia

Hematologic Malignancy

United States
Fisons

Completed

The Safety and Effectiveness of Pentamidine in the Prevention of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS Who Have Had PCP Before

HIV Infections | Pneumonia, Pneumocystis Carinii

United States
LyphoMed

Completed

A Study of Two Forms of Pentamidine in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS

HIV Infections | Pneumonia, Pneumocystis Carinii

United States
University of Vermont
St. Louis University

Completed

Safety Study of Nifurtimox for Relapsed or Refractory Neuroblastoma

Neuroblastoma

United States
Bayer

Completed

Study on Benefits of Therapy With Nifurtimox in Chagas Disease, a Parasitic Illness Mostly Transmitted to Humans by a Bug, Using Information From Patient Medical Records in Argentina

Chagas' Disease

Argentina
Bayer

Completed

Study Will Evaluate the Relative Bioavailability, Safety, and Tolerability of Single Doses of Nifurtimox 30 mg Tablets Exhibiting Different in Vitro Dissolution Characteristics, and to Evaluate the Relative Bioavailability of Nifurtimox 30 mg and 120 mg

Chagas Disease

Argentina
Institute of Tropical Medicine, Belgium
Drugs for Neglected Diseases; Medecins Sans Frontieres, Netherlands; Addis Ababa... and other collaborators

Completed

Prophylaxis of Visceral Leishmaniasis Relapses in HIV Co-infected Patients With Pentamidine: a Cohort Study

HIV-infection/Aids | Visceral Leishmaniosis

Ethiopia
Reinhold Munker

Completed

Pentamidine + Salvage Chemo for Relapsed/Refractory Classical Hodgkin Lymphoma

Hodgkin Lymphoma | Refractory Hodgkin Lymphoma

United States
National Institute of Allergy and Infectious Diseases...

Completed

Aerosols in the Treatment of Pneumocystis Pneumonia: A Pilot Study Quantitating the Deposition of Aerosolized Pentamidine as Delivered in ACTG 040 and Comparing Its Toxicity With Parenteral Pentamidine Therapy

HIV Infections | Pneumonia, Pneumocystis Carinii

United States
Fisons

Completed

An Open Label Study to Evaluate the Long-Term Safety and Effectiveness of Aerosol Pentamidine in the Prophylaxis of Pneumocystis Carinii Pneumonia in AIDS Patients

HIV Infections | Pneumonia, Pneumocystis Carinii

United States
Fisons

Completed

A Double-Blind Placebo-Controlled Group Comparative Study To Evaluate the Safety and Effectiveness of Aerosol Pentamidine in the Prophylaxis of Pneumocystis Carinii Pneumonia in Patients With AIDS Post First Episode PCP

HIV Infections | Pneumonia, Pneumocystis Carinii

United States
Gyongyi Szabo
National Institute on Alcohol Abuse and Alcoholism (NIAAA); The Cleveland Clinic and other collaborators

Withdrawn

A Pilot, Dose Escalating Study on VLX103 in Moderate Alcoholic Steatohepatitis

Hepatic Steatosis

United States
Bayer

Completed

Prospective Study of a Pediatric Nifurtimox Formulation for Chagas' Disease

Chagas Disease

Colombia, Argentina, Bolivia
The Ludwig Boltzmann Institute of Retinology and...

Completed

Trypan Blue Versus Brillant Blue for Epiretinal Membranes

Idiopathic Epiretinal Membranes

Austria
Oncozyme Pharma Inc.

Completed

A Phase I Clinical Study on a New Oral Pentamidine Formulation in Hepatocellular Carcinoma

Hepatocellular Carcinoma

Canada
University of Arkansas
National Cancer Institute (NCI)

Completed

Suramin in Treating Patients With Refractory or Relapsed Multiple Myeloma or Castleman's Disease

Multiple Myeloma and Plasma Cell Neoplasm

United States
National Cancer Institute (NCI)

Completed

A Phase I Trial Using Suramin to Treat Superficial Transitional Cell Carcinoma of the Bladder

Carcinoma, Transitional Cell | Bladder Neoplasms

United States
Emory University
National Cancer Institute (NCI)

Completed

Suramin in Treating Patients With Recurrent Primary Brain Tumors

Brain and Central Nervous System Tumors

United States
Rediscovery Life Sciences

Active, not recruiting

Study of Suramin in Subjects With Furosemide-Resistant AKI

Acute Kidney Injury

United States
National Cancer Institute (NCI)

Completed

A Phase II Trial of Leuprolide + Flutamide + Suramin in Untreated Poor Prognosis Prostate Carcinoma

Prostatic Neoplasm

United States
Cancer Research UK

Completed

Suramin in Treating Patients With Recurrent Bladder Cancer

Bladder Cancer

United Kingdom
National Cancer Institute (NCI)
Eastern Cooperative Oncology Group; Southwest Oncology Group

Completed

Low, Intermediate, or High Dose Suramin in Treating Patients With Hormone-Refractory Prostate Cancer

Prostate Cancer

United States, South Africa
Sidney Kimmel Comprehensive Cancer Center at Johns...
National Cancer Institute (NCI)

Completed

Suramin Plus Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme

Brain and Central Nervous System Tumors

United States
Immtech Pharmaceuticals, Inc
Bill and Melinda Gates Foundation

Completed

Trial of DB289 for the Treatment of Stage I African Trypanosomiasis

African Trypanosomiasis

Congo
Bayer

Completed

Study to Assess Bioequivalence of a New Nifurtimox Oral Tablet Formulation

Bioequivalence

Argentina
Paxmedica

Completed

Double Blind Trial in Children With Autism Spectrum Disorder

Autism Spectrum Disorder

United States
University of California, San Diego

Completed

University of California, San Diego (UCSD) Suramin Autism Treatment-1 (SAT1) Trial (SAT1)

Autism Spectrum Disorders

United States
Barcelona Centre for International Health Research

Completed

Population Pharmacokinetics in Benznidazole-treated Adults With Chronic With Chagas Disease (CINEBENZ)

Chagas Disease

Spain
Bayer

Completed

Study to Assess the Food Effect on the Pharmacokinetics of Nifurtimox Tablets in Chronic Chagas' Patients - Dietary Habits Study

Chagas' Disease

Argentina
Population Health Research Institute
Canadian Institutes of Health Research (CIHR); University of Sao Paulo; World... and other collaborators

Completed

BENEFIT: Evaluation of the Use of Antiparasital Drug (Benznidazole) in the Treatment of Chronic Chagas' Disease (BENEFIT)

Heart Disease | Chagas Disease | Trypanosomiasis

Argentina, Bolivia, Brazil, Colombia, El Salvador
Assiut University

Completed

Safety of Trypan Blue on Endothelium of Diabetic Retinopathy Patients

Cataract Diabetic

Egypt
Barcelona Centre for International Health Research

Completed

New Tools for the Diagnosis, Prognosis and Treatment Follow-up in Chagas Disease (BIOMARCHA)

Chagas Disease

Spain
IC-MedTech Corporation

Recruiting

A Phase 1 Study of the Safety and Tolerability of ICM20 in Adults

Safety Issues

United States
Jonathan Berman

Completed

Miltefosine Plus IL Pentamidine for Bolivian CL

Leishmaniasis, Cutaneous
Oncozyme Pharma Inc.

Completed

A Safety Study of Pentamidine in Patients With Metastatic Colon Cancer Undergoing Standard Chemotherapy as Second-line and/or Third-line Treatment

Colorectal Cancer

Canada
Oncozyme Pharma Inc.

Completed

Using OCZ103-OS in Patients With Unresectable and Locally Recurrent or Metastatic Colorectal Cancer Undergoing Standard Chemotherapy

Colorectal Cancer

Canada
Exeltis France
Insud Pharma

Completed

Benznidazole Absorption, Metabolism and Excretion Study

Healthy Male Subjects

United Kingdom
National Institute of Allergy and Infectious Diseases...
Fujisawa Pharmaceutical Co

Completed

A Study of Pentamidine in the Prevention of Pneumocystis Carinii Pneumonia (PCP) in HIV-Infected Children Who Cannot Take Trimethoprim-Sulfamethoxazole

HIV Infections | Pneumonia, Pneumocystis Carinii

United States, Puerto Rico
Hospital Universitari Vall d'Hebron Research Institute

Completed

Evaluation of Different Benznidazole Regimens for the Treatment of Chronic Chagas Disease. (MULTIBENZ)

Chagas Disease | Trypanosoma Cruzi Infection

Argentina, Spain, Brazil, Colombia

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