Search clinical trials for: VX-440

Total 8116 results

Janssen Pharmaceutical K.K.

Recruiting

A Study of Bedaquiline Administered as Part of a Treatment Regimen With Clarithromycin and Ethambutol in Adult Patients With Treatment-refractory Mycobacterium Avium Complex-lung Disease (MAC-LD)

Treatment-refractory Mycobacterium Avium Complex-lung Disease (MAC-LD)

Taiwan, Korea, Republic of, Japan
Actelion

Completed

A Clinical Study to Investigate the Effect of Gemfibrozil or Rifampicin on Blood Concentrations of Selexipag in Healthy Subjects

Healthy Subjects

Germany
Servier Bio-Innovation LLC
Institut de Recherches Internationales Servier

Recruiting

A Phase 1, Open-Label Study to Evaluate the Effect of a Low-Fat Meal and Multiple Doses of Ciprofloxacin on the Pharmacokinetics of Vorasidenib in Healthy Subjects

Healthy Subjects

United States
Vertex Pharmaceuticals Incorporated

Completed

A Study to Evaluate the Pharmacokinetic Drug-drug Interactions Between VX-548, Midazolam, and Digoxin

Pain

United States
Vertex Pharmaceuticals Incorporated

Terminated

Efficacy of a 12-Week Regimen of Telaprevir, Pegylated Interferon, and Ribavirin in Treatment-Naive and Prior Relapser Subjects With Interleukin28B (IL28B) CC Genotype (CONCISE)

Hepatitis C, Chronic

United States, Austria, Canada, Germany, Israel, Poland
Vertex Pharmaceuticals Incorporated
Tibotec Pharmaceutical Limited

Completed

A Phase 3 Study of Telaprevir in Combination With Pegasys® and Copegus® in Treatment-Naive Subjects With Genotype 1 Hepatitis C Virus (HCV)

Hepatitis C

Australia, Canada, France, Italy, Poland, United Kingdom, Germany, United States, Spain, Israel, Argentina, Puerto Rico, Austria
Vertex Pharmaceuticals Incorporated
Tibotec, Inc

Completed

A Rollover Study for Subjects Participating in the Control Arm of Study VX06-950-106, VX05-950-104 and VX05-950-104EU Whose Plasma Hepatitis C Virus (HCV) Ribonucleic Acid (RNA) Levels Did Not Respond to Therapy

Hepatitis C

United States, France, United Kingdom, Germany, Canada, Netherlands, Austria, Puerto Rico
Vertex Pharmaceuticals Incorporated

Completed

Phase 2 Study of VX-950, Pegasys®, and Copegus® in Hepatitis C

Chronic Hepatitis C

United States, Puerto Rico
Dr. Reddy's Laboratories Limited

Completed

A Study to Assess the Efficacy and Safety of PPC-06 (Tepilamide Fumarate)

Psoriasis

United States
Tibotec Pharmaceuticals, Ireland

Withdrawn

PEPI-TiDP23-C104 is a First in Human Study With a Single Dose Escalation Part and a Multiple Dosing Part for Compounds TMC589337 and TMC589354.

HIV Infections

Netherlands
University of Virginia
Rutgers University; Haydom Lutheran Hospital

Not yet recruiting

Precision Rifampin Trial for Personalized Dosing (P-RIF)

Tuberculosis
Hospital Universitari Vall d'Hebron Research Institute
Radboud University Medical Center; University Medical Center Groningen; Centro... and other collaborators

Not yet recruiting

Rifampicin at High Dose for Difficult-to-Treat Tuberculosis (RIAlta)

Tuberculosis

Spain, Netherlands, Paraguay, Portugal
Suzhou Yabao Pharmaceutical R&D Co., Ltd.

Completed

A Drug Interaction Study of SY-004 Capsules in Healthy Subjects

Type 2 Diabetes

China
Pfizer

Completed

Study to Evaluate the Effect of Repeat-Dose Rifampin on the Pharmacokinetics (PK) of PF-06651600

Healthy Volunteers

Belgium
Alexandria University

Completed

Effect of Hepatitis C Clearance on Insulin Resistance

Hepatitis C | Insulin Resistance

Egypt
Hospices Civils de Lyon

Completed

Staphylococcal Acute Post-Operative PJI Treated With 'DAIR' And Impact Of Rifampin (IPASTAPH)

Bone and Joint Infection | Antibiotic Resistant Staphylococcus Aureus Infection

France
Idorsia Pharmaceuticals Ltd.

Completed

A Study in Healthy Male Subjects to Investigate Whether Administration of Rifampicin Can Affect the Fate of Clazosentan in the Body of Clazosentan

Healthy Subjects

Netherlands
PTC Therapeutics

Completed

Effects of Rifampin on the Pharmacokinetics of Ataluren

Healthy

Canada
Boehringer Ingelheim

Completed

DDI Strong CYP3A4 Inducer

Healthy

Germany
Drexel University

Completed

Immune Activation and Drug Absorption in HIV-Infected Patients

HIV Infection

United States
Tibotec Pharmaceuticals, Ireland

Completed

TMC278-TiDP6-C215: A Clinical Trial in Treatment Naive HIV-subjects Patients Comparing TMC278 to Efavirenz in Combination With 2 Nucleoside/Nucleotide Reverse Transcriptase Inhibitors

HIV Infections | HIV-1

United States, France, United Kingdom, China, Belgium, Germany, Spain, Chile, Mexico, Portugal, Costa Rica, Panama, South Africa, Canada, Brazil, Puerto Rico, Russian Federation, Thailand, Australia, India
Bayer

Completed

Effect of Rifampin on the Pharmacokinetics of BAY73-4506

Neoplasms

United States
Astellas Pharma Europe B.V.
Medivation, Inc.

Completed

A Study to Evaluate How a Drug That Alters Liver Enzymes (Rifampin) Affects the Metabolism of Enzalutamide in Men

Healthy Subjects | Drug-Drug Interaction (DDI) | Pharmacokinetics of Enzalutamide

Germany
All India Institute of Medical Sciences, New Delhi
National AIDS Control Organisation

Completed

Efficacy and Safety of Concomitant Use of Nevirapine and Rifampicin With HIV-TB ("NVP")

HIV/TB Co-infection

India
University of Oulu

Completed

Effects of Pregnane X Receptor (PXR) Activation on Human Glucose, Lipid and Hormone Homeostasis (Rifa-2)

Glucose Metabolism

Finland
Centers for Disease Control and Prevention

Completed

High Dose Rifapentine Pharmacokinetics, Tolerability and Safety Dosage Rifapentine for Treatment of Tuberculosis (TBTC-29PK)

Smear Positive, Pan-sensitive, Pulmonary Tuberculosis

United States, South Africa, Uganda
Mahidol University

Unknown

Colistin Plus Rifampicin in MDR P. Aeruginosa and A. Baumanii

Drug Safety

Thailand
University of Oulu

Completed

Pregnane X Receptor (PXR) Agonist Rifampicin Effects on Glucose, Lipid and Hormone Homeostasis

Glucose Tolerance

Finland
Glaxo Wellcome

Completed

Safety and Effectiveness of Lamivudine When Given Once a Day Versus Twice a Day in Combination With Other Anti-HIV Drugs in HIV-Infected Adults Who Have Never Received Anti-HIV Drugs

HIV Infections

United States, Canada, Argentina, Brazil, Puerto Rico
Dupont Merck

Completed

A Study of Efavirenz in HIV-Infected Patients Who Have Never Taken Anti-HIV Drugs

HIV Infections

United States
Boehringer Ingelheim

Completed

Effects of Steady-state Efavirenz 600 mg QD (Sustiva®) on Tipranavir Concentration at Steady-state in Healthy Adult Volunteers

Healthy
Pfizer

Recruiting

A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations.

Glioma | Melanoma | Thyroid Cancer | Non-Small-Cell Lung Cancer

United States, Canada, Israel
Universidad de Granada

Not yet recruiting

Ultrasound Achilles Tendon Assessment

Ultrasonography | Achilles Tendon

Spain
Children's Hospital Medical Center, Cincinnati
University of Michigan

Terminated

A Multi-Center Study of a SCD for Immunomodulatory Dysregulation in Pediatric AKI (SCD PED-02)

Acute Kidney Injury

United States
Dalarna County Council, Sweden
Uppsala University

Completed

Basic Bladder Advice and Alarm Therapy in Nocturnal Enuresis (BAAT)

Nocturnal Enuresis

Sweden
480 Biomedical

Completed

480 Biomedical Bioresorbable Scaffold System in the Treatment of de Novo Superficial Femoral Artery (SFA) Lesions (STANCE)

Atherosclerosis of Femoral Artery | Superficial Femoral Artery Lesions

New Zealand, Austria, Australia, Germany
Boehringer Ingelheim

Completed

A Safety, Tolerability and Preliminary Pharmacokinetics of BILR 355 BS Single-rising Dose Study in Healthy Male Volunteers

Healthy
Achaogen, Inc.

Completed

Phase 1 Study for Safety of ACHN-490

Healthy

United States
Leiden University Medical Center
Radboud University Medical Center; University Medical Center Groningen; Erasmus... and other collaborators

Recruiting

Rifampicin Combination Therapy Versus Monotherapy for Staphylococcal Prosthetic Joint Infection (RiCOTTA)

Prosthetic-joint Infection | Infection Hip | Infection; Knee, Joint

Netherlands
Nanjing Sanhome Pharmaceutical, Co., Ltd.

Not yet recruiting

The Effect of Itraconazole and Rifampicin on the Pharmacokinetics of SH-1028

Healthy Male Volunteers

China
National Institute of Allergy and Infectious Diseases...
AIDS Clinical Trials Group

Completed

Safety, Tolerability, and Blood Levels of Ritonavir-Boosted Atazanavir and Rifampin When Taken Together in HIV Uninfected Adults

HIV Infections | Tuberculosis

United States
Ascletis Pharmaceuticals Co., Ltd.

Completed

Study to Evaluate the Effects of Itraconazole and Rifampin on the Pharmacokinetics of ASC40 in Healthy Subjects

Healthy

China
Odonate Therapeutics, Inc.

Terminated

The Effect of Tesetaxel on the QTc Interval and the Effect of Food, Itraconazole, and Rifampin on Tesetaxel Pharmacokinetics in Patients With Advanced Solid Tumors

Advanced Solid Tumors

United States
Bayer

Completed

COPANLISIB (BAY80-6946) Drug-drug Interaction and Cardiovascular Safety Study in Advanced Solid Tumor and Non-Hodgkin's Lymphoma Patients

Medical Oncology

Canada, United States
Janssen Research & Development, LLC

Completed

A Study to Assess the Effects of Itraconazole and Rifampicin on the Single-Dose Pharmacokinetics of JNJ-53718678 in Healthy Adults

Healthy

United States
Vanderbilt University

Completed

Investigation of the Efficacy of Antibiotics on Pulmonary Sarcoidosis (CLEAR Lung)

Pulmonary Sarcoidosis | Lung Function

United States
LG Life Sciences

Completed

Pharmacokinetic Drug Interaction Study in Healthy Male Subjects

Healthy Male Volunteers

Korea, Republic of
Sanofi

Terminated

LEVOS - Levofloxacin and Rifampicin Therapy in the Treatment of OsteoArticular Prothethic Infection

Infection

France
Southern Methodist University
Baylor University

Recruiting

Beetroot Juice NO Cold Study (NCS)

Respiratory Tract Infections | Cold Symptoms | Exhaled Nitric Oxide

United States
Yale University
WHOOP Inc.; ZS Associates, Inc.

Completed

WHOOP Abnormal Rhythm Notification (WARN)

Atrial Fibrillation

United States

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