Search clinical trials for: AZD1480

Total 96 results

AstraZeneca

Terminated

A Phase I Study of AZD1480 in Patients With Advanced Solid Malignancies and Advanced Hepatocellular Carcinoma in the Escalation Phase,Non-Small Cell Lung Cancer(NSCLC) and Non-smokers With Lung Metastasis and Gastric Cancer and Solid Tumour in the Expansion Phase.

Gastric Cancer | Advanced Solid Malignancies | Solid Tumour | Child-Pugh A to B7 Advanced Hepatocellular Carcinoma | EGFR and/or ROS Mutant NSCLC | Lung Metastasis Carcinoma

Korea, Republic of
AstraZeneca
University of Texas; Gustave Roussy, Cancer Campus, Grand Paris; New York City...

Completed

Study to Assess the Safety of AZD1480 in Patients With Myeloproliferative Diseases

Primary Myelofibrosis (PMF) | Post-Polycythaemia Vera | Essential Thrombocythaemia Myelofibrosis

United States, France
AstraZeneca

Terminated

Study to Assess Safety, Tolerability and PK of AZD1480 in Patients With Solid Tumours

Solid Malignancies

United States
AstraZeneca

Completed

Proof of Concept Study of Cognitive Improvement in Patients With Schizophrenia (HALO)

Schizophrenia

United States, Canada
AstraZeneca
Targacept Inc.

Completed

An Exploratory Trial of AZD3480 (TC-1734) for the Treatment of Adult Attention-Deficit/Hyperactivity Disorder (ADHD)

ADHD

United States
AstraZeneca
Karolinska Institutet, Quintiles IMS

Completed

AZD1390 Administration of a Microdose [11C]AZD1390 to Healthy Volunteers

Healthy Volunteer Male Subjects

Sweden
AstraZeneca

Completed

Positron Emission Tomography Study Using 2-[18F]-F-A85380 to Determine α4β2 Neuronal Nicotinic Receptor Occupancy of AZD3480 After Oral Administration to Healthy Male Subjects (PET)

Healthy

Sweden
AstraZeneca
Quotient Sciences

Completed

An ADME Study of [14C]AZD0780 in Healthy Male Subjects

Cardiovascular Diseases

United Kingdom
AstraZeneca

Completed

Global Phase1 Study to Assess the Safety and Tolerability of AZD1208 in Advanced Solid Tumors and Malignant Lymphoma

Advanced Solid Malignancies | Malignant Lymphoma

United Kingdom, Japan
AstraZeneca

Terminated

Safety, Tolerability, Pharmacokinetics and Efficacy of AZD1208 in Acute Myelogenous Leukemia (AML) Patients

Acute Myeloid Leukemia

United States, Canada
AstraZeneca

Completed

Study to Assess the Metabolism, Excretion and Pharmacokinetics of [14C]AZD1981 in Healthy Male Volunteers (ADME)

Healthy
AstraZeneca

Recruiting

AZD0486 as Monotherapy in B-cell Acute Lymphoblastic Leukaemia

B-cell Acute Lymphoblastic Leukemia (B-ALL)

Spain, Canada, United Kingdom, Italy, Germany, Australia, United States, Taiwan, France, Korea, Republic of, China
AstraZeneca

Completed

AZD6280 Multiple Ascending Dose Study (MAD)

Healthy Volunteer

United States
AstraZeneca

Completed

Esophageal Hypersensitivity Study in Patients With Gastroesophageal Reflux Disease (GERD)

Sensitivity in Esophagus

Denmark, Sweden
AstraZeneca

Terminated

Study of Uptake, Break Down and Elimination of an Investigational Drug in Healthy Volunteers (MB)

Alzheimer's Disease

United Kingdom
AstraZeneca

Recruiting

AZD3470 as Monotherapy and in Combination With Anticancer Agents in Participants With Relapsed/Refractory Haematologic Malignancies. (PRIMAVERA)

Lymphoma | Hodgkin Lymphoma | Non-Hodgkin

Korea, Republic of, United Kingdom, Italy, Germany, France, Spain, United States, Australia
AstraZeneca

Recruiting

A Study of AZD3470, a PRMT5 Inhibitor, in Patients With MTAP Deficient Advanced/Metastatic Solid Tumours (PRIMROSE)

Advanced Solid Tumours That Are MTAP Deficient

United States, Spain, Korea, Republic of, Australia, Japan, China, Netherlands, France
Nader Sanai
AstraZeneca; Barrow Neurological Institute; Ivy Brain Tumor Center

Recruiting

AZD1390 in Recurrent and Newly Diagnosed WHO Grade 4 Glioma Patients

Glioma | Glioblastoma | Glioblastoma Multiforme | Glioma, Malignant

United States
AstraZeneca

Completed

Study to Assess Safety, Tolerability and Pharmacokinetics After Single Doses of AZD1446 to Healthy Volunteers (SAD)

Healthy

Sweden
AstraZeneca

Completed

14729-D9831C00002- 1 Month Biopsy Study (Biopsy)

Chronic Obstructive Pulmonary Disease

United Kingdom, Germany, Netherlands
AstraZeneca

Completed

One Month Dose Response Study of AZD1981 in Asthma Patients Uncontrolled on Inhaled Steroids (OLIVE)

Asthma

Poland, Argentina, Brazil, Costa Rica
AstraZeneca

Completed

Investigation of Efficacy, Safety and Tolerability of Once and Twice Daily Doses of AZD1981 in Asthmatic Patients (Sweapea)

Asthma Patients

United States, Mexico, Russian Federation, South Africa, Romania, Ukraine, Japan, Argentina, Slovakia, Brazil
AstraZeneca

Terminated

Study to Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetics of AZD1386 in Patients With Osteoarthritis (OA) of the Knee (OA19)

Pain

Bulgaria, Poland, Hungary, Finland, Canada, Slovakia, Japan
AstraZeneca

Completed

A Bioavailability Study Comparing Modified-release Capsules and Immediate Release Capsules in Fed and Fasting Conditions

Healthy

Sweden
AstraZeneca

Completed

AZD1419 Ph2a Study (INCONTRO)

Asthma

Denmark, Sweden, Hungary, Poland
AstraZeneca

Completed

Study to Assess the Efficacy and Safety of AZD1981 in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD) (Columbus)

Moderate to Severe COPD

Sweden, Bulgaria, Poland, Denmark, Slovakia
AstraZeneca

Completed

A Study to Assess the Safety, Tolerability and Pharmacokinetics of Modified-Release Formulations of AZD1446 After Oral Single and Repeated Doses

Healthy

Japan
AstraZeneca

Completed

Study to Investigate the Safety, Tolerability and Pharmacokinetics of AZD1386 (MAD)

Chronic Pain

United Kingdom
AstraZeneca

Completed

Single and Multiple Ascending Doses of AZD1981 in Japan (JSAD/JMAD)

Healthy

United Kingdom
AstraZeneca
AstraZeneca K.K.

Recruiting

A Study to Assess the Efficacy, Safety and Tolerability of Different Doses of AZD0780 in Patients With Dyslipidemia (PURSUIT)

Dyslipidemia

Denmark, Hungary, Spain, United States, Japan, Czechia, Slovakia, Canada
AstraZeneca

Completed

AZD1386 Japanese Multiple Ascending Dosing Study (JMAD)

Chronic Pain

Japan
AstraZeneca

Completed

Study to Investigate Safety and Tolerability of a Single Dose of AZD6482

Antiplatelet Effect
AstraZeneca

Completed

Drug Interaction Study Between AZD3480 and Warfarin (DDI)

Alzheimer's Disease

Sweden
AstraZeneca

Completed

A Drug-drug Interaction Study to Investigate the Effects of AZD1981 on the Metabolism and Pharmacodynamics of Oral Contraceptives

Oral Contraceptives

Sweden
AstraZeneca

Completed

A Bioavailability Study Comparing 3 Different AZD1981 Tablets

Healthy

Sweden
Memorial Sloan Kettering Cancer Center
AstraZeneca

Recruiting

A Study of AZD1390 and Stereotactic Body Radiotherapy (SBRT) for People With Metastatic Solid Tumor Cancer

Solid Tumor | Metastatic Cancer | Metastatic Solid Tumor | Solid Tumor, Adult | Solid Carcinoma | Metastatic Tumor

United States
AstraZeneca

Completed

Study to Investigate the Efficacy and Tolerability of AZD1446 in Adult ADHD Patients.

Adult ADHD

United States
AstraZeneca

Completed

AZD1981 Bioavailability Study of Intravenous (IV) and Oral Formulations

Healthy | Postmenopausal | Surgically Sterile Women

Sweden
AstraZeneca

Completed

Investigation of Rate+Extent of Excretion of Radioactivity in Urine+Faeces After Oral Administration of [14C]AZD1386

Pain

United Kingdom
The Netherlands Cancer Institute
Leiden University Medical Center; University Medical Center Nijmegen

Recruiting

Sarcomas and DDR-Inhibition; a Combined Modality Study (SADDRIN-1)

Soft Tissue Sarcoma Adult

Netherlands
AstraZeneca

Completed

Formulation and Food Effect Study of AZD1386 in Healthy Volunteers

Pharmacokinetics
AstraZeneca

Terminated

Study to Evaluate Efficacy, Safety, Tolerability and Pharmacokinetics of AZD1386 in Patients With Peripheral Neuropathic Pain (AVANT)

Pain | Neuropathic Pain

France, United Kingdom, Canada, Denmark
AstraZeneca

Recruiting

A Study of AZD0486 in Subjects With Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma

Follicular Lymphoma | Diffuse Large B Cell Lymphoma | High-grade B-cell Lymphoma | B-cell Non Hodgkin Lymphoma

Korea, Republic of, United States, Japan, Australia, Taiwan
AstraZeneca

Completed

4 Week, Safety and Tolerability Study in Patients With Mild to Moderate Alzheimer's Disease (ROBIN)

Mild to Moderate Alzheimer's Disease

Czech Republic, Hungary, Slovakia
AstraZeneca

Completed

Study to Investigate Safety, Tolerability and Pharmacokinetics With Single and Multiple Ascending Doses of AZD1446

Healthy

Sweden
AstraZeneca

Completed

Study to Assess Safety, Tolerability and Pharmacokinetics After Single and Multiple Doses of AZD1446 to Japanese Subject

Healthy

Japan
AstraZeneca

Completed

Esophageal Hypersensitivity Study in Healthy Volunteers

Pain | Esophageal Sensitivity

Sweden, Denmark
AstraZeneca

Completed

A Study to Investigate Safety, Tolerability and Pharmacokinetics of AZD1446 Administered for 4 Weeks in Elderly Healthy Volunteers

Healthy

Sweden
Johns Hopkins University
AstraZeneca

Completed

Efficacy and Safety of Chemoattractant Receptor-homologous Molecule Expressed on T Helper Type 2 (CRTh2) Antagonist AZD1981 in Chronic Idiopathic Urticaria (CIU) Antihistamines

Chronic Idiopathic Urticaria

United States
AstraZeneca

Completed

Pharmacokinetics in Adolescents (PEAK)

Asthma

Sweden

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