Search clinical trials for: VX-509 matching placebo

Total 1910 results

Celldex Therapeutics

Active, not recruiting

A Phase 2 Study of CDX-0159 in Patients With Chronic Spontaneous Urticaria

Chronic Spontaneous Urticaria

Spain, United States, Poland, Georgia, South Africa, Bulgaria, Hungary, Estonia, Germany
Biogen
Denali Therapeutics Inc.

Terminated

A Study to Assess if BIIB122 Tablets Are Safe and Can Slow Worsening of Early-Stage Parkinson's Disease in Participants With Specific LRRK2 Genetic Variants Between the Ages of 30 and 80 Using the Movement Disorder Society-Unified Parkinson's Disease Rating Scale (LIGHTHOUSE)

Parkinson Disease

United States, Italy, Spain, Germany, France, United Kingdom
Idorsia Pharmaceuticals Ltd.

Completed

Single Oral Dose of 4 mg Cenerimod in Healthy Japanese and Caucasian Subjects

Healthy Volunteers

United States
Alzheon Inc.
Quotient Clinical

Completed

Multiple Ascending Dose Study of ALZ-801

Alzheimer Disease

United Kingdom
GlaxoSmithKline

Completed

To Investigate If Single Doses Of GSK618334 Are Safe And To Investigate Blood Levels Of GSK618334

Substance Dependence

United Kingdom
Beech Tree Labs, Inc.
Norwich Clinical Research Associates Ltd.; Hill Top Research

Completed

Evaluation of Cold Sore Treatments on Ultra Violet (UV) Induced Cold Sores

Oral Herpes Simplex

United States
Beech Tree Labs, Inc.
Norwich Clinical Research Associates Ltd.

Completed

Safety and Efficacy Study of a New Treatment for Recurrent Symptoms of Oral Herpes Virus Infection

Oral Herpes Simplex

United States
Midnight Pharma, LLC

Completed

Almorexant (ACT-078573) in Elderly Subjects With Chronic Primary Insomnia

Chronic Primary Insomnia

United States
Vertex Pharmaceuticals Incorporated

Completed

A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of VX-661 in Combination With Ivacaftor

Cystic Fibrosis

United States, United Kingdom, Germany, Spain, Switzerland, Canada, Netherlands, Italy, Ireland, Sweden, France, Denmark
Syneos Health

Recruiting

First-in-Human Study of VB0004 in Healthy Subjects and to Patients With Mild to Moderate Hypertension With Low Cardiovascular Risk

Hypertension

Australia
Karyopharm Therapeutics Inc
Belgium and Luxembourg Gynaecological Oncology Group; North-Eastern German... and other collaborators

Active, not recruiting

Maintenance With Selinexor/Placebo After Combination Chemotherapy in Participants With Endometrial Cancer [SIENDO] (ENGOT-EN5)

Endometrial Cancer

United States, China, Israel, Spain, Belgium, Germany, Greece, Czechia, Italy, Canada
Institut de Recherches Internationales Servier

Active, not recruiting

Study of Vorasidenib (AG-881) in Participants With Residual or Recurrent Grade 2 Glioma With an IDH1 or IDH2 Mutation (INDIGO)

Recurrent Glioma | Grade 2 Glioma | Residual Glioma

United States, Canada, Spain, Italy, United Kingdom, Switzerland, Israel, Japan, Netherlands, Germany, France
Novartis Pharmaceuticals

Completed

Safety and Efficacy of LCI699 for the Treatment of Patients With Cushing's Disease

Cushings Disease

United States, Canada, Italy, India, Japan, Austria, Netherlands, Spain, Korea, Republic of, Germany, Thailand, France, Bulgaria, Turkey, Colombia, China, Argentina, Russian Federation, United Kingdom
Nathura S.p.A
Evidilya S.r.l.

Completed

A New Class IIb MD in Proctological Disorders

Proctological Disorders

Italy
Regeneron Pharmaceuticals

Completed

Study to Assess the Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Effects of a Single Dose of REGN5713-5714-5715 in Healthy Adult Participants

Healthy Volunteers | Birch Pollen Allergy

Belgium
Kubota Vision Inc.
Otsuka Pharmaceutical Co., Ltd.

Completed

Safety and Tolerability of Repeat Doses of ACU-4429 in Healthy Subjects

Healthy

United States
Biogen

Enrolling by invitation

A Study to Evaluate the Continuous Safety and Efficacy of Litifilimab (BIIB059) in Adults With Active Systemic Lupus Erythematosus (EMERALD)

Systemic Lupus Erythematosus (SLE)

Spain, Bulgaria, United States, China, Serbia, Mexico, Korea, Republic of, Chile, Argentina, Poland, Brazil, Japan, Romania, Colombia, Hungary, Czechia, United Kingdom, Taiwan, Philippines, Israel, France
GlaxoSmithKline

Completed

Safety, Tolerability and Pharmacokinetics of GSK3923868 Inhalation Powder in Healthy Participants and Stable Asthmatics

Pulmonary Disease, Chronic Obstructive

United Kingdom
GTx

Withdrawn

Durability Extension Study to Assess Clinical Activity and Safety of Enobosarm (GTx-024) in Stress Urinary Incontinence

Stress Urinary Incontinence

United States
AstraZeneca

Completed

Study With CIN-107 Following Multiple Oral Ascending Doses in Healthy Subjects

Hypertension

United States
Boehringer Ingelheim

Completed

A Study to Test How Healthy Women Tolerate Different Doses of BI 1819479

Healthy

Germany
Cyclerion Therapeutics

Terminated

Study of IW-1701, A Stimulator of Soluble Guanylate Cyclase (sGC), in Patients With Type I or II Achalasia

Achalasia

United States
Boehringer Ingelheim

Completed

Single Rising Dose Study of BI 135585 XX in Health Asian Male Volunteers.

Healthy

Korea, Republic of
Panacea Biotec Ltd

Unknown

Study Of Single Ascending Doses Of PBL 1427 In Healthy Volunteers

Diabetes Mellitus

India
Takeda

Completed

Single-Dose Study of MT203

Healthy Volunteers

Japan
Murdoch Childrens Research Institute
Ministry of Health, Fiji

Completed

Preventing Young Infant Infections Using Azithromycin in Labour (PreYIAL) Trial (PreYIAL)

Bacterial Infections

Fiji
Washington University School of Medicine
Eli Lilly and Company; Hoffmann-La Roche; Avid Radiopharmaceuticals; National Institute... and other collaborators

Recruiting

Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation. Master Protocol DIAN-TU-001 (DIAN-TU)

Dementia | Alzheimers Disease | Alzheimers Disease, Familial

United States, Canada, Italy, Argentina, Australia, Colombia, France, Ireland, Mexico, Netherlands, Puerto Rico, Spain, United Kingdom, Brazil, Japan, Germany
BeiGene

Withdrawn

Efficacy and Safety of Sitravatinib Plus Tislelizumab or Placebo Plus Tislelizumab Versus Placebo as Adjuvant Treatment in Participants With Hepatocellular Carcinoma

Hepatocellular Carcinoma
Vertex Pharmaceuticals Incorporated

Terminated

Study to Evaluate the Safety and Efficacy of CTP-656 in Patients With Cystic Fibrosis With CFTR Gating Mutations

Cystic Fibrosis

United States
Novartis Pharmaceuticals

Active, not recruiting

Efficacy and Safety of Inclisiran as Monotherapy in Chinese Adults With Low or Moderate ASCVD Risk and Elevated Low-density Lipoprotein Cholesterol. (V-Mono China)

Primary Hypercholesterolemia or Mixed Dyslipidemia

China
Otsuka Pharmaceutical Development & Commercialization...

Completed

A Trial of Centanafadine Efficacy and Safety in Adolescents With Attention- Deficit/Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder

United States
Vertex Pharmaceuticals Incorporated
ViroChem Pharma

Completed

Pharmacokinetics of Multiple Ascending Doses of VCH-222 in Subjects With Chronic Hepatitis C Infection

Hepatitis C

Canada, United States, Argentina, Puerto Rico
Shanghai Pharmaceuticals Holding Co., Ltd

Completed

The Tolerability and Pharmacokinetics of Multiple Doses of SPH3127 in Chinese Healthy People

Hypertension

China
Boehringer Ingelheim

Recruiting

Lunsayil 1: A Study to Test Whether Spesolimab Helps People With a Skin Disease Called Hidradenitis Suppurativa

Hidradenitis Suppurativa

United States, Korea, Republic of, Israel, Spain, Australia, Japan, Italy, Germany, Denmark, Belgium, Lithuania, China, Canada, Malaysia, Singapore, New Zealand, France, Mexico, Netherlands, Greece, United Kingdom, Bulgaria, Philipp... and more
Zambon SpA

Completed

Safinamide for Multiple System Atrophy (MSA)

Multiple System Atrophy

Italy, Spain
Sunshine Lake Pharma Co., Ltd.

Completed

The Tolerability and Pharmacokinetics Study of Kangdaprevir Sodium Tablet in Healthy Adult Subjects

Chronic Hepatitis c

China
Sunshine Lake Pharma Co., Ltd.

Completed

HEC53856 Phase 1 Study - Single and Multiple Oral Dosing in Healthy Volunteers

Healthy

China
Boehringer Ingelheim

Recruiting

A Study in Healthy Men to Test How Different Doses of BI 3031185 Are Tolerated and How Food Influences the Amount of BI 3031185 in the Blood

Healthy

Germany
Boehringer Ingelheim

Recruiting

IRI-EXPLORE: A Study to Test Whether BI 765845 Helps People Who Have Had a Heart Attack (IRI-EXPLORE)

Myocardial Infarction

Korea, Republic of, Germany, Spain, Hungary, United Kingdom, Italy, Canada, Australia, Poland, Slovakia, New Zealand
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Recruiting

A Clinical Trial of TQA3038 Injection in Healthy Adult Subjects

Chronic Hepatitis b

China
Pharmaxis

Recruiting

Effect of PXS-4728A on Microglia Activation in Participants With Isolated Rapid Eye Movement Sleep Behaviour Disorder

REM Sleep Behavior Disorder

Australia, United Kingdom
Aurigene Discovery Technologies Limited

Completed

A Phase II Study to Evaluate Efficacy & Safety of AUR101 in Patients of Moderate-to-Severe Psoriasis (INDUS-2)

Chronic Plaque-type Psoriasis

India
Concert Pharmaceuticals

Completed

Efficacy and Tolerability Study of Two Dose Regimens of CTP-543 in Adults With Alopecia Areata

Alopecia Areata

United States
Concert Pharmaceuticals

Completed

Study to Evaluate the Safety and Efficacy of CTP-543 in Adults With Moderate to Severe Alopecia Areata

Alopecia Areata

United States
Recognify Life Sciences

Completed

Safety, Biomarker Study of RL-007 in Subjects With Schizophrenia

Schizophrenia | Cognitive Impairment

United States
Boehringer Ingelheim

Terminated

This Study Tests How Different Doses of BI 1291583 Are Taken up in the Body and How Well They Are Tolerated

Healthy

Germany
Millennium Pharmaceuticals, Inc.

Terminated

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), and Pharmacodynamics (PD) of Single and Multiple Oral Dose of TAK-418 in Healthy Female Participants

Healthy Volunteers

United States
Allergan

Completed

An Extension Study to Evaluate the Long-Term Safety and Tolerability of Ubrogepant in the Treatment of Migraine

Migraine, With or Without Aura

United States
Zai Lab Pty. Ltd.

Unknown

Study of the Tolerability and Pharmacokinetic of ZL-2102 With an Investigation of Food Effect in Healthy Male Subjects

Chronic Obstructive Pulmonary Disease | Asthma | Idiopathic Pulmonary Fibrosis

Australia
Ono Pharmaceutical Co. Ltd

Terminated

A Study to Evaluate ONO-4474 in Patients With Pain Due to Osteoarthritis of the Knee (MOTION)

Pain | Osteoarthritis, Knee

Poland, Hungary, Spain, Denmark, United Kingdom

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