Search clinical trials for: alpha beta depletion

Total 12121 results

Avanir Pharmaceuticals

Completed

Safety, Tolerability and Effectiveness of Nuedexta in the Treatment of Pseudobulbar Affect (PBA) (PRISM II)

Stroke | Dementia | Traumatic Brain Injury (TBI) | Pseudobulbar Affect (PBA)

United States
Universitaire Ziekenhuizen KU Leuven

Completed

Combined Drug Approach to Prevent Ischemia-reperfusion Injury During Transplantation of Livers (CAPITL)

Reperfusion Injury

Belgium
Shouyao Holdings (Beijing) Co. LTD

Not yet recruiting

A Study to Evaluate the Effect of Itraconazole and Rifampicin on the Pharmacokinetics of SY-5007 in Healthy Subjects

Healthy Subjects

China
Dizal Pharmaceuticals

Recruiting

Drug-drug Interactions Between AZD4205 and Itraconazole/Carbamazepine

Healthy Subjects

United States
Basilea Pharmaceutica

Completed

A Drug-Drug Interaction Study of CYP3A4 Inhibition and Pan-CYP Induction on APX001

Fungal Infection

Netherlands
Celgene

Terminated

A Safety and Efficacy Study of CC-90011 in Participants With Relapsed and/or Refractory Solid Tumors and Non-Hodgkin's Lymphomas

Neoplasms | Lymphoma, Non-Hodgkin

France, Italy, Japan, Spain, United Kingdom
BeiGene

Completed

Interaction Study of Zanubrutinib With Moderate and Strong CYP3A Inhibitors in Participants With B-Cell Malignancies

B-cell Malignancies

Australia
Epizyme, Inc.

Completed

Study to Describe the Interaction Between Tazemetostat and Itraconazole and Between Tazemetostat and Rifampin in Participants With Advanced Cancer

Solid Tumor | Mesothelioma | Rhabdoid Tumor | Hematologic Malignancy | Advanced Malignancies | Synovial Sarcoma | Renal Medullary Carcinoma | Diffuse Large B-Cell Lymphoma (DLBCL) | Follicular Lymphoma (FL) | Non-Hodgkin Lymphoma (NHL) | All Malignancies | Epithelioid Sarcoma (ES)

Spain, United States
Jazz Pharmaceuticals

Completed

An Study to Evaluate the Effects of Fluconazole on the Pharmacokinetics (PK) of Sativex® in Healthy Subjects With Cannabis Experience.

Healthy Subjects

United States
Ciceri Fabio

Completed

Peripheral Blood Stem Cell Transplantation From Family Haploidentical Donors in Patients With Myelodysplastic Syndrome and Acute Leukemia Under Primary Prophylaxis With Posaconazole (SIR-POSA)

Myelodysplastic Syndromes | Fungal Infection | Graft Vs Host Disease | Leukemia, Acute | Transplant-Related Hematologic Malignancy

Italy
Beijing InnoCare Pharma Tech Co., Ltd.

Completed

DDI Study of Orelabrutinib

Healthy Person

China
Bristol-Myers Squibb

Completed

A Study to Assess the Effect of Itraconazole, Phenytoin and Gemfibrozil on the Drug Levels of BMS-986166 in Healthy Participants

Healthy Participants

United States
AnHeart Therapeutics Inc.

Completed

A Study of AB-106 in Chinese Healthy Adult Men Evaluated the Effects of Itraconazole and Rifampicin on AB-106 PK

Solid Tumor

China
Eli Lilly and Company
Loxo Oncology, Inc.

Completed

A Study of Effects of Itraconazole and Rifampin on Selpercatinib (LY3527723) in Healthy Participants

Healthy

United States
University of Florida
ALS Association; Holy Cross Hospital, Florida

Completed

Impact of Nuedexta on Bulbar Physiology and Function in ALS

Amyotrophic Lateral Sclerosis

United States
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Completed

Pembrolizumab and Doxorubicin Hydrochloride in Treating Patients With Sarcoma That is Metastatic or Cannot Be Removed by Surgery

Sarcoma

United States
Azienda Ospedaliero, Universitaria Pisana

Completed

Zinc as Enhancer in Immune Recovery After Stem Cell Transplantation for Hematological Malignancies (ZENITH)

Stem Cell Transplant Complications

Italy
Bayer
Orion Corporation, Orion Pharma

Completed

Drug-drug Interaction (DDI) Study to Assess ODM-201 as a Victim of CYP3A4 Inhibition or Induction

Biological Availability

Germany
Avanir Pharmaceuticals

Completed

Efficacy, Safety, and Tolerability Study of AVP-786 as an Adjunctive Therapy in Patients With Major Depressive Disorder With an Inadequate Response to Antidepressant Treatment

Depressive Disorder, Treatment-Resistant

United States
Avanir Pharmaceuticals

Completed

A Phase 1 Study Comparing AVP-786 With AVP-923

Healthy Volunteer

United States
Sanofi Pasteur, a Sanofi Company

Completed

Study of Intradermal Quadrivalent Influenza Vaccine in Adults Aged 18 Through 64 Years

Influenza

United States
Vanda Pharmaceuticals

Completed

Pharmacokinetics of Tasimelteon Alone and in Combination With a CYP3A4 Inhibitor, Ketoconazole, or a CYP3A4 Inducer, Rifampin.

Healthy

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Combination Chemotherapy With Ketoconazole in Treating Patients With Prostate Cancer

Prostate Cancer

United States
Boryung Pharmaceutical Co., Ltd

Completed

A Study to Evaluate the Effect of Ketoconazole and Rifampicin on the Pharmacokinetics of Fimasartan in Healthy Male Volunteers

Essential Hypertension
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Lenalidomide, Thalidomide and Dexamethasone in Treating Participants With Relapsed or Refractory Multiple Myeloma

Refractory Plasma Cell Myeloma | Recurrent Plasma Cell Myeloma

United States
Ministry of Health & Welfare, Korea

Terminated

Effect of Antidepressants on the Treatment for Korean Major Depressive Disorder Patients

Major Depressive Disorder

Korea, Republic of
Michael Schneider, DC, PhD
Patient-Centered Outcomes Research Institute

Completed

Study Comparing 3 Different Treatments for Arthritis of the Lower Back (Lumbar Spinal Stenosis)

Lumbar Spinal Stenosis

United States
Hospital de Clinicas de Porto Alegre

Unknown

Interpersonal Psychotherapy for Treatment Resistant Depression

Treatment Resistant Depression

Brazil
University of Miami

Completed

Smartphone Intervention for Smoking Cessation and Improving Adherence to Treatment Among HIV Patients

Smoking | Smoking Cessation | HIV

United States
GlaxoSmithKline

Withdrawn

Legend: TRELEGY Real World Chronic Obstructive Pulmonary Disease (COPD) Effectiveness Study (LEGEND)

Pulmonary Disease, Chronic Obstructive

United States
Shandong Suncadia Medicine Co., Ltd.

Not yet recruiting

Drug-drug Interaction Study of HRS-1780 Tablets in Healthy Subjects

Chronic Kidney Disease(CKD)

China
Aeovian Pharmaceuticals, Inc.

Recruiting

Assessment of the Safety, Tolerability and Pharmacokinetics of AV078 in Healthy Volunteers

Healthy Participants

Australia
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Not yet recruiting

A Study to Evaluate Drug-Drug Interaction of TQB3909 Tablets

Advanced Malignant Neoplasm

China
Humanity and Health Research Centre
Beijing 302 Hospital; Nanfang Hospital of Southern Medical University

Recruiting

Switching Regimen in Treating Cirrhotic HCV GT1b Subjects (SWITCH-1)

Chronic Hepatitis C Infection

China
Shanghai Henlius Biotech

Completed

Study on Food Influence and Drug-drug Interaction of HLX208 Tablets in Chinese Healthy Subjects

NSCLC

China
Cerevel Therapeutics, LLC

Completed

A Trial to Evaluate the Effects of Itraconazole and Carbamazepine on the Pharmacokinetics of Emraclidine and of Emraclidine on the Pharmacokinetics of Metformin in Healthy Adult Participants

Healthy Volunteers

United States
The University of Texas Health Science Center,...
Cures Within Reach

Completed

Evaluating the Efficacy of Dextromethorphan/Quinidine in Treating Irritability in Huntington's Disease

Irritability | Huntington Disease

United States
Assiut University

Completed

Detection of Bloodstream Pathogens in Hematological Malignancies

Bloodstream Infection

Egypt
Alexion Pharmaceuticals

Completed

Drug Interaction Study of ALXN2050 With Fluconazole and Rifampin in Healthy Adult Participants

Healthy

United States
Sunshine Lake Pharma Co., Ltd.

Active, not recruiting

A Study to Evaluate Drug-Drug Interaction of Larotinib With Itraconazole and Rifampin in Healthy Adult Participants (Z650)

Healthy Volunteers

China
Mylan Inc.
Mylan Bertek Pharmaceuticals

Terminated

Effects of Therapy With Sulfamylon® 5% Topical Solution Compared to a Historical Control Group

Burns

United States
Rush University Medical Center
National Cancer Institute (NCI)

Withdrawn

Combination Chemotherapy Plus Biological Therapy in Treating Patients With Acute Myelogenous Leukemia

Leukemia

United States
Hutchison Medipharma Limited
Covance

Completed

Fruquintinib CYP3A Inhibitor and Inducer Study

Drug Drug Interaction

United States
Millennium Pharmaceuticals, Inc.

Completed

A Study to Evaluate Drug-Drug Interaction of TAK-788 With Itraconazole and Rifampin in Healthy Adult Participants

Healthy Volunteers

United States
Case Comprehensive Cancer Center

Completed

Treating Patients With Prostate Cancer That Did Not Respond to Hormone Therapy

Prostate Cancer

United States
Hoffmann-La Roche

Completed

A Safety Study of Balsamic Bactrim in Pediatric Participants With Acute Bronchitis

Bronchitis

Peru
Agios Pharmaceuticals, Inc.

Completed

Study to Evaluate the Effect of Multiple Doses of Itraconazole and Rifampin on the Single-Dose Pharmacokinetics of Mitapivat Sulfate (AG-348) in Healthy Adult Participants

Healthy Volunteers

United States
Universitaire Ziekenhuizen KU Leuven

Completed

Phenotypic Drug Probes as Predictors of Drug-drug Interactions With Tacrolimus

Kidney Transplantation | Drug Interactions

Belgium
Food and Drug Administration (FDA)
Spaulding Clinical Research LLC

Completed

Study of the Electrocardiographic Effects of Ranolazine, Dofetilide, Verapamil, and Quinidine in Healthy Subjects

Drug-induced Surface ECG Changes
Bristol-Myers Squibb

Completed

A Study to Evaluate the Effect of 2 Drugs on the Pharmacokinetics of BMS-986205 in Healthy Subjects

Malignancies Multiple

United States

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