Search clinical trials for: beta-Lactamase Inhibitors

Total 68805 results

The University of Queensland
Merck Sharp & Dohme LLC

Withdrawn

Ceftolozane-tazobactam Versus Meropenem for ESBL and AmpC-producing Enterobacterales Bloodstream Infection (MERINO III)

Bacteremia Caused by Gram-Negative Bacteria

Spain, Australia, Singapore, Italy, Saudi Arabia
University Ghent
King Baudouin Foundation; Belgische Vereniging voor Strijd tegen Mucoviscidose

Terminated

LC-MS/MS Based Method Development for the Monitoring of Antibiotic Concentrations in Sputum of Cystic Fibrosis Patients

Cystic Fibrosis

Belgium
Allecra
Medpace, Inc.

Completed

Safety and Efficacy Study of Cefepime-AAI101 in the Treatment of Complicated Urinary Tract Infections

Urinary Tract Infections

United States, Serbia, Hungary, Estonia, South Africa, Belarus, Poland, Ukraine, Argentina, Bulgaria, Croatia, Georgia, Latvia, Lithuania, Mexico, Peru, Russian Federation, Slovakia, Spain
Fundación Pública Andaluza para la gestión de la...

Unknown

Monitoring of Ceftolozane-Tazobactam Plasmatic Levels in Critical Patients

Serious Infection

Spain
Janssen Research & Development, LLC

Completed

A Crossover Study to Assess the Effect of Intravenous Infusion of Piperacillin/Tazobactam on the Pharmacokinetics of Orally Administered Lumicitabine (JNJ-64041575) in Healthy Adult Participants

Healthy

Belgium
Hellenic Institute for the Study of Sepsis

Completed

Anti-inflammatory Action of Oral Clarithromycin in Community-acquired Pneumonia (ACCESS)

Sepsis | Mortality | Inflammatory Response | Biomarkers | SIRS | Community-acquired Pneumonia

Greece
Memorial Sloan Kettering Cancer Center

Recruiting

Choosing the Best Antibiotic to Protect Friendly Gut Bacteria During the Course of Stem Cell Transplant

Febrile Neutropenia | Intestinal Microbiome

United States
Temple University
Medical University of South Carolina; University of Pennsylvania; Research Foundation...

Active, not recruiting

Clavulanic Acid for the Treatment of Cocaine Use Disorder

Cocaine Dependence

United States
Nader Shaikh
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

Efficacy of Antibiotics in Children With Acute Sinusitis: Which Subgroups Benefit?

Respiratory Tract Infections | Sinusitis

United States
University of Santiago de Compostela
Hospital Clinico Universitario de Santiago

Terminated

An Oral Amoxicillin-Clavulanate Regimen to Prevent Bacteremia Following Dental Procedures

Endocarditis | Bacteraemia

Spain
Menzies School of Health Research
University of Malaya; Nanyang Technological University; Griffith University; The... and other collaborators

Active, not recruiting

Hospitalised Pneumonia With Extended Treatment (HOPE) Study (HOPE)

Pneumonia

Australia, Malaysia, New Zealand
Ain Shams University

Completed

Extended-infusion of Piperacillin-Tazobactam Versus Intermittent Infusion

Gram-Negative Infections

Egypt
Royal Brisbane and Women's Hospital
The University of Queensland

Completed

Pharmacokinetics of Ceftolozane/Tazobactam in Plasma and Cerebrospinal Fluid

Pharmacokinetics

Australia
King Abdul Aziz Specialist Hospital

Completed

Usage of Meropenem/Gentamicin Versus Ceftazidime/Avibactam in ARDS

Ventilator Associated Pneumonia

Saudi Arabia
Nantes University Hospital

Unknown

Azithromycin+Amoxicillin/Clavulanate vs Amoxicillin/Clavulanate in COVID19 Patients With Pneumonia in Non-intensive Unit (AziA)

COVID-19 Pneumonia

France
University of Wisconsin, Madison
Thrasher Research Fund

Completed

Short (5 Days) Versus Long (14 Days) Duration of Antimicrobial Therapy for Acute Bacterial Sinusitis in Children

Sinusitis

United States
Sarawak General Hospital
University Malaysia Sarawak

Completed

Antibiotic Prophylaxis in Ragged Placental Membranes

Endometritis | Endometritis Postpartum | Membranes; Retained
Karolinska Institutet

Completed

Piperacllin Versus Placebo in Patients Undergoing Surgery for Acute Cholecystitis (AVAC)

Cholecystitis, Acute

Sweden
University of Pittsburgh
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

Acute Otitis Media (AOM) Therapy Trial in Young Children

Acute Otitis Media

United States
Tianjin Medical University Cancer Institute and...
Zhejiang Hisun Pharmaceutical Co. Ltd.

Unknown

Effect Study of Tigecycline to Treat Severe Sepsis and Septic Shock (Tigecycline)

Abdominal Infection

China
European Organisation for Research and Treatment...

Completed

Prevention of Infection in Patients With Hematologic Cancer and Persistent Fever Caused by a Low White Blood Cell Count

Lymphoma | Unspecified Childhood Solid Tumor, Protocol Specific | Myelodysplastic Syndromes | Leukemia | Unspecified Adult Solid Tumor, Protocol Specific | Infection | Multiple Myeloma and Plasma Cell Neoplasm | Fever, Sweats, and Hot Flashes | Bone Marrow Suppression

Switzerland, United States, Canada, United Kingdom, Belgium, Israel, Slovakia, Finland, Germany, France, Turkey, Czech Republic, Greece
Catalan Society of Family Medicine
Fondo de Investigacion Sanitaria

Completed

Effectiveness of Antibiotic Therapy for Exacerbations of Chronic Obstructive Pulmonary Disease (TRANCE)

Chronic Obstructive Pulmonary Disease

Spain
Entasis Therapeutics

Completed

Evaluation of Safety and Efficacy of Intravenous Sulbactam-ETX2514 in the Treatment of Hospitalized Adults With Complicated Urinary Tract Infections

Acute Pyelonephritis | Complicated Urinary Tract Infection

Bulgaria
Pfizer
Allergan

Terminated

Evaluation of Pharmacokinetics, Safety, and Tolerability of Ceftazidime-avibactam in Neonates and Infants. (NOOR)

Gram-negative Bacterial Infection

United States, Hungary, Slovakia, Taiwan, India, Estonia, Greece, Italy
Menarini Group

Terminated

Delafloxacin IV and OS Administration Compared to Best Available Therapy in Patients With Surgical Site Infections (DRESS)

Surgical Site Infection

Italy
Iterum Therapeutics, International Limited

Completed

Sulopenem Versus Ertapenem for Complicated Intra-abdominal Infection (cIAI)

Intra Abdominal Infections

United States, Bulgaria, Estonia, Georgia, Hungary, Latvia, Poland
Merck Sharp & Dohme LLC

Completed

MK-7625A Versus Meropenem in Pediatric Participants With Complicated Urinary Tract Infection (cUTI) (MK-7625A-034)

Pyelonephritis | Complicated Urinary Tract Infection

United States, Mexico, Russian Federation, Turkey, Greece, Hungary, Poland, Romania, South Africa, Ukraine
The University of Queensland
Australasian Society for Infectious Diseases; International Society of Chemotherapy and other collaborators

Terminated

RCT Meropenem vs Piperacillin-Tazobactam for Definitive Treatment of BSI's Due to Ceftriaxone Non-susceptible Escherichia Coli and Klebsiella Spp. (MERINO)

Bloodstream Infections

Australia, Singapore, South Africa, Italy, Saudi Arabia, Canada, Lebanon, New Zealand, Turkey
University Hospital, Rouen

Not yet recruiting

Postoperative Anti-infective Strategy Following Pancreaticoduodenectomy in Patients With Preoperative Biliary Stent (FRENCH24 ANIS)

Pancreaticoduodenectomy | Antibiotherapy
Ospedale San Carlo Borromeo
Associazione Oncologica Milanese AmoLaVita ONLUS

Not yet recruiting

Antibiotics Continuous Infusion at Home (TAID)

Severe Bacterial Infections

Italy
Uppsala University

Completed

Effects of Phenoximethylpenicillin, Amoxicillin and Amoxicillin-clavulanic Acid on the Gut Microbiota (EPAAC)

Infectious Disease

Sweden
Alejandro Hoberman
National Institute of Allergy and Infectious Diseases (NIAID)

Terminated

Efficacy of Short-Course Antimicrobial Treatment for Children With Acute Otitis Media and Impact on Resistance

Acute Otitis Media

United States
Albany Medical College

Completed

Clinical Trial of the Treatment of Acute Sinusitis With Standard-dose Versus High-dose Amoxicillin/Clavulanate

Sinusitis

United States
Tel-Aviv Sourasky Medical Center

Unknown

Short vs Prolonged Antibiotic Treatment for Hospitalized Hemato-oncology Patients With Febrile Neutropenia (RR)

Fever | Febrile Neutropenia

Israel
Pfizer

Completed

A Single, High-Dose Azithromycin Extended Release (60 mg/kg) Compared With 10 Days of High-Dose Amoxicillin Clavulanate in Children With Ear Infections at High Risk of Persistent/Recurrent Ear Infections

Acute Otitis Media

United States, Costa Rica, Chile, Guatemala, Slovakia, Estonia, Mexico, Russian Federation, Israel, Poland, Argentina, Dominican Republic, Panama
Ranbaxy Laboratories Limited

Completed

Bioequivalence Study of Amoxicillin-Clavulanic Acid 600 mg - 42.9 mg/ 5 mL Oral Suspension Under Fasting Conditions

Healthy

Canada
Ramon Gorter
Amsterdam UMC, location VUmc; ZonMw: The Netherlands Organisation for Health...

Active, not recruiting

Initial Non-operative Treatment Strategy Versus Appendectomy Treatment Strategy for Simple Appendicitis in Children (APAC)

Appendicitis

Netherlands
Abbott

Completed

Comparative Study of the Safety and Efficacy of Clarithromycin Extended-Release Tablets Versus Amoxicillin-Clavulanate for the Treatment of Acute Bacterial Sinusitis

Acute Bacterial Sinusitis (ABS)

Italy, Spain, Greece, United States, Canada, Poland, Lithuania, Hungary, Romania
University of Florida
Food and Drug Administration (FDA)

Terminated

BL Infusion Trial:Beta-lactam Continuous Versus Intermittent Infusion and Associated Bacterial Resistance and Therapy Outcomes in Critically Ill Patients With Severe Pneumonia

Pneumonia

United States
Yung Shin Pharm. Ind. Co., Ltd.

Active, not recruiting

Evaluate Bioequivalence of Burotam (1/1 g/Vial)

Infectious Diseases

Taiwan
Joseph L. Kuti, PharmD
Cubist Pharmaceuticals LLC; Indiana University Health; University of North Carolina and other collaborators

Completed

Population Pharmacokinetics and Safety of Intravenous Ceftolozane/Tazobactam in Adult Cystic Fibrosis Patients

Cystic Fibrosis | Cystic Fibrosis Pulmonary Exacerbation | Pseudomonas Aeruginosa Infection

United States
Cubist Pharmaceuticals LLC

Completed

Safety and Efficacy Study of Ceftolozane/Tazobactam to Treat Ventilated Nosocomial Pneumonia (MK-7625A-008) (ASPECT-NP)

Lung Diseases | Healthcare-Associated Pneumonia | Ventilator-Associated Pneumonia
University of Malaya
Menzies School of Health Research

Completed

Trial on the Ideal Duration of Oral Antibiotics in Children With Pneumonia

Pneumonia

Malaysia
Universidad del Norte

Unknown

Piperacillin/Tazobactam Versus Carbapenems in Non-bacteremic UTI Due to -ESBL-producing Enterobacteriaceae (CAPITIS)

Urinary Tract Infections | Enterobacteriaceae Infections | Clinical Trial | Carbapenem | Klebsiella Pneumoniae Infection | Infection Due to ESBL Bacteria | Escherichia Coli Infection | Drug Resistance, Bacterial

Colombia
Nabriva Therapeutics AG
Medpace, Inc.

Completed

Safety and Efficacy of ZTI-01 (IV Fosfomycin) vs Piperacillin/Tazobactam for Treatment cUTI/AP Infections (ZEUS)

Acute Pyelonephritis | Urinary Tract Infection Complicated | Urinary Tract Infection Symptomatic

Poland, Ukraine, Belarus, Bulgaria, Romania, Greece, United States, Russian Federation, Hungary, Lithuania, Slovakia, Czechia, Latvia, Croatia, Georgia, Estonia
Pfizer

Completed

A Study Comparing Ceftazidime-Avibactam Versus Meropenem in Hospitalized Adults With Nosocomial Pneumonia

Ventilator-associated Pneumonia (VAP) | Nosocomial Pneumonia (NP)

Bulgaria, France, Italy, Korea, Republic of, Mexico, Peru, Poland, Russian Federation, Spain, Turkey, United Kingdom, Vietnam, Philippines, China, Ukraine, Argentina, Brazil, Hungary, Romania, India, Japan, Taiwan, Latvia, Czechia, Slov... and more
Seoul National University Hospital

Completed

The Impact of Antibiotic Prophylaxis on Incidence of Post-bronchoscopy Fever and Change of Serum Cytokines

Pneumonia | Fever
Chronic Obstructive Pulmonary Disease Trial Network...
Center for Genomic Medicine, Rigshospitalet, Denmark

Terminated

Targeted AntiBiotics for Chronic Pulmonary Diseases (Target-ABC)

Respiratory Tract Infections | Bronchiectasis | Asthma | COPD | Pseudomonas Aeruginosa

Denmark
GlaxoSmithKline

Completed

AUGMENTIN™ in Dental Infections (AUGDENT)

Focal Infection, Dental

Philippines, Malaysia, Thailand, Vietnam
University Hospital Tuebingen

Terminated

Steady State Serum and Epithelial Lining Fluid (ELF) Antibiotics Concentrations Under Continous Infusion

Pneumonia | Bacteremia

Germany

Search clinical trials for: beta-Lactamase Inhibitors

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