Search clinical trials for: enzyme inhibitor therapy

Total 82546 results

Novartis Pharmaceuticals

Terminated

This Study Will Evaluate the Efficacy and Safety of LCZ696 Compared to Enalapril on Morbidity and Mortality of Patients With Chronic Heart Failure (PARADIGM-HF)

Heart Failure With Reduced Ejection Fraction

China, Germany, United States, Colombia, Korea, Republic of, Romania, South Africa, Canada, Belgium, Estonia, Hungary, Italy, Russian Federation, Taiwan, Turkey, United Kingdom, Spain, France, Netherlands, Hong Kong, Bulgaria, Israel and more
Alexandria University

Recruiting

Effect of Low Doses of Hypoxia-inducible Factor- Prolyl Hydroxylase Enzyme Inhibitor Plus Iron in the Treatment of Anemia in Dialysis-dependent Chronic Kidney Disease Patients

Anemia in Dialysis-dependent CKD Patients

Egypt
Leiden University Medical Center
Australian and New Zealand Urogenital and Prostate Cancer Trials Group; Anticancer...

Recruiting

Phase II Randomised Controlled Trial of Patient-specific Adaptive vs. Continuous Abiraterone or eNZalutamide in mCRPC (ANZadapt)

Prostatic Neoplasms, Castration-Resistant

Australia, Netherlands
Soroka University Medical Center

Completed

Renin-angiotensin-aldosterone System (RAAS) Blockade and Contrast Induced Nephropathy

Radiographic Contrast Agent Nephropathy
Boehringer Ingelheim

Completed

Effects of Single-dose and Steady-state TPV/r on the Steady-state Pharmacokinetics of Clarithromycin and a Preliminary Assessment of the Effects of a Standard High-fat Test Meal on the Steady-state Pharmacokinetics of Tipranavir

Healthy
National Cancer Institute (NCI)

Completed

Adavosertib and Local Radiation Therapy in Treating Children With Newly Diagnosed Diffuse Intrinsic Pontine Gliomas

Glioblastoma | Gliosarcoma | Anaplastic Oligoastrocytoma | Anaplastic Astrocytoma | Diffuse Intrinsic Pontine Glioma | Diffuse Midline Glioma, H3 K27M-Mutant

United States, Canada
Children's Oncology Group
National Cancer Institute (NCI)

Terminated

Topotecan, G-CSF, and Radiation Therapy in Treating Young Patients With Newly Diagnosed Brain Stem Glioma

Brain Tumors | Central Nervous System Tumors

United States, Australia, Canada, Switzerland
Chinese University of Hong Kong

Terminated

Drug to Prevent Pneumonia in the Tube Fed

Pneumonia | Neurological Dysphagia

Hong Kong
Bristol-Myers Squibb

Completed

Taste Properties of Atazanavir and Cobicistat

HIV in Adults

United States
Chinese Academy of Medical Sciences, Fuwai Hospital

Recruiting

Comparison of Atorvastatin and Pitavastatin on the Effect of HbA1c in AMI Patients With Abnormal Glucose Metabolism (CAPE-AMI)

Glucose Metabolism Disorders | Acute Myocardial Infarction

China
ETOP IBCSG Partners Foundation
Pfizer

Recruiting

Palbociclib for HR Positive / HER2-negative Isolated Locoregional Recurrence of Breast Cancer (POLAR)

Breast Cancer Recurrent

Switzerland, Italy, France, Spain, Hungary, Austria
Columbia University
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Recruiting

Obesogenic Origins of Maternal and Child Metabolic Health Involving Dolutegravir (ORCHID)

Obesity | HIV | Maternal Obesity During Childbirth | Maternal Obesity Complicating Pregnancy | Obesity, Infant

South Africa
University of Miami

Completed

Carboplatin, Irinotecan, and Radiation Therapy Followed By Docetaxel in Treating Patients With Newly Diagnosed Stage III Non-Small Cell Lung Cancer

Lung Cancer

United States
Triangle Pharmaceuticals

Completed

Comparing FTC and Lamivudine in HIV-Infected Patients on a Stable Anti-HIV Drug Combination

HIV Infections

United States
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Completed

Cisplatin and Irinotecan Followed by Carboplatin, Etoposide, and Radiation Therapy in Treating Patients With Limited-Stage Small Cell Lung Cancer

Lung Cancer

United States
Bristol-Myers Squibb

Completed

Bioequivalence Study of Individual Atazanavir and Cobicistat Compared With Atazanavir in Fixed-dose Combination With Cobicistat (Atazanavir)

Human Immunodeficiency Virus Type 1 (HIV-1)

United States
Shire

Completed

Efficacy and Safety Study of Velaglucerase Alfa in Children and Adolescents With Type 3 Gaucher Disease

Gaucher Disease, Type 3

Egypt, India, Tunisia
Shanghai Ninth People's Hospital Affiliated to...

Recruiting

Camrelizumab Combined With Apatinib Mesylate for Head and Neck Squamous Cell Carcinoma (IMplus)

Head and Neck Squamous Cell Carcinoma

China
The Catholic University of Korea

Completed

DPP4 Inhibitor and Coronary Atherosclerosis in Patients Receiving Insulin Therapy

Diabetes Mellitus

Korea, Republic of
University of Roma La Sapienza

Unknown

PPI Therapy Impact on GERD After Sleeve Gastrectomy

Gastro Esophageal Reflux | Bariatric Surgery Candidate | Barrett Esophagus

Italy
Pfizer

Completed

A Study to Assess Pharmacokinetics of PF-04965842 and Its Metabolites and Effect of Probenecid in Healthy Participants

Healthy

United States
Aaron Wolfson

Recruiting

Phase 1 Clinical Trial of Lenvatinib, Pembrolizumab and Hypofractionated Pelvic Radiation Therapy for pMMR Recurrent/Unresectable Endometrial Carcinoma

Recurrent Endometrial Carcinoma | Unresectable Endometrial Carcinoma

United States
Assiut University

Not yet recruiting

Serum Cysteine Rich Protein 61 and Cystatin C for Early Detection of Acute Kidney Injury in Patients With Heart Diseases

Acute Kidney Injury
Masonic Cancer Center, University of Minnesota
GlaxoSmithKline

Completed

Topotecan, Cisplatin, and Radiation Therapy in Treating Patients With Advanced Cervical Cancer

Cervical Cancer

United States
Asian-Pacific Alliance of Liver Disease, Beijing
Beijing Ditan Hospital; National Health and Family Planning Commission, P.R... and other collaborators

Unknown

Emtricitabine for Naive Chinese Pregnant Chronic Hepatitis B Patients

Hepatitis B, Chronic | Pregnancy
Amgen

Completed

A Study of the Effectiveness and Safety of AMG 386 and Sorafenib to Treat Advanced or Inoperable Hepatocellular Cancer

Advanced Hepatocellular Carcinoma | Inoperable Hepatocellular Carcinoma
Shanghai Pulmonary Hospital, Shanghai, China

Recruiting

The Efficacy and Safety of KN046 Combined With Axitinib

NSCLC

China
Massachusetts General Hospital
University of Pennsylvania; Duke University; Sibley Memorial Hospital

Recruiting

Radiation, Immunotherapy and PARP Inhibitor in Triple Negative Breast Cancer (NADiR)

Breast Cancer | Triple Negative Breast Cancer

United States
Geron Corporation

Recruiting

A Study Comparing Imetelstat Versus Best Available Therapy for the Treatment of Intermediate-2 or High-risk Myelofibrosis (MF) Who Have Not Responded to Janus Kinase (JAK)-Inhibitor Treatment

Myelofibrosis

United States, Australia, Italy, India, United Kingdom, Israel, Taiwan, Poland, Malaysia, Argentina, Spain, Turkey, Belgium, Germany, Austria, Brazil, Bulgaria, Colombia, Denmark, France, Georgia, Hungary, Korea, Republic of, Portugal, ... and more
University Hospital Regensburg

Completed

Psychometric Properties of the EORTC QLQ-LC29

Lung Cancer

Germany
University of Colorado, Denver

Completed

Study of Olaparib With Radiation Therapy and Cetuximab in Advanced Head and Neck Cancer With Heavy Smoking History

Squamous Cell Carcinoma of the Head and Neck

United States
Abramson Cancer Center of the University of Pennsylvania
National Cancer Institute (NCI)

Completed

Gene Therapy in Treating Patients With Primary Brain Tumors

Brain and Central Nervous System Tumors

United States
National Cancer Institute (NCI)

Terminated

Cediranib Maleate and Whole Brain Radiation Therapy in Patients With Brain Metastases From Non-Small Cell Lung Cancer

Male Breast Cancer | Stage IV Breast Cancer | Stage IV Melanoma | Stage IV Renal Cell Cancer | Stage IV Non-small Cell Lung Cancer | Stage IVA Colon Cancer | Stage IVA Rectal Cancer | Stage IVB Colon Cancer | Stage IVB Rectal Cancer | Tumors Metastatic to Brain

United States
Seoul National University Hospital

Completed

Comparison of Prophylactic Antiviral Efficacy in Patients Undergoing Chemotherapy: Entecavir Versus Lamivudine

Hepatitis B | Malignancy

Korea, Republic of
Asian-Pacific Alliance of Liver Disease, Beijing
Beijing Ditan Hospital; National Health and Family Planning Commission, P.R... and other collaborators

Unknown

Emtricitabine for Naive Child Chinese Chronic Hepatitis B Patients

Hepatitis B, Chronic
Gynecologic Oncology Group
National Cancer Institute (NCI)

Completed

Radiation Therapy Compared With Combination Chemotherapy in Treating Patients With Advanced Endometrial Cancer

Endometrial Cancer | Psychosocial Effects of Cancer and Its Treatment

United States
Memorial Sloan Kettering Cancer Center
National Cancer Institute (NCI)

Completed

Irinotecan, Radiation Therapy, and Docetaxel With or Without Cisplatin in Treating Patients With Locally Advanced Esophageal Cancer

Esophageal Cancer

United States
St. Jude Children's Research Hospital
National Cancer Institute (NCI)

Completed

Irinotecan Followed by Radiation Therapy and Temozolomide in Treating Children With Newly Diagnosed Brain Tumor

Brain and Central Nervous System Tumors

United States
National Cancer Institute (NCI)

Terminated

RO4929097 and Whole-Brain Radiation Therapy or Stereotactic Radiosurgery in Treating Patients With Brain Metastases From Breast Cancer

Unspecified Adult Solid Tumor, Protocol Specific | HER2-positive Breast Cancer | Recurrent Melanoma | Male Breast Cancer | Stage IV Breast Cancer | Stage IV Melanoma | Extensive Stage Small Cell Lung Cancer | Recurrent Small Cell Lung Cancer | Recurrent Breast Cancer | Estrogen Receptor-negative Breast... and other conditions

United States
PharmaEngine

Completed

Nanoliposomal Irinotecan (Nal-IRI, ONIVYDE®) in Combination With TAS-102 (LONSURF®) in Refractory Solid Tumors

Refractory Solid Tumors

Taiwan
Intarcia Therapeutics

Terminated

The CAT Study: Atamestane Plus Toremifene Versus Letrozole in Advanced Breast Cancer

Breast Neoplasms | Neoplasms, Hormone-Dependent

United States, Romania, Russian Federation, Ukraine, Bulgaria
Xijing Hospital of Digestive Diseases

Recruiting

Effects of High-dose Dual Therapy and Bismuth Quadruple Therapy for Helicobacter Pylori Eradication on Intestinal Microecology

Gastritis | Dyspepsia | Gastric Cancer | Peptic Ulcer | Helicobacter Pylori Infection

China
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Fluoxetine as a Quit Smoking AID for Depression Prone

Heart Diseases | Cardiovascular Diseases
Roseli Shavitt
University of Pernambuco

Completed

Developing Adaptive Treatment Strategies for Children and Adolescents With Obsessive-compulsive Disorder. (SMART)

Obsessive-Compulsive Disorder

Brazil
AstraZeneca

Recruiting

A Study to Assess the Safety and Tolerability of AZD1390 Given With Radiation Therapy in Patients With Brain Cancer

Recurrent Glioblastoma Multiforme | Brain Neoplasms, Malignant | Primary Glioblastoma Multiforme | Leptomeningeal Disease (LMD)

United States, United Kingdom
University Hospital, Brest

Completed

Immune Checkpoint Inhibitors and Pre-existing Autoimmune Diseases

Autoimmune Diseases | Advanced Cancer

France
Intarcia Therapeutics

Completed

Phase III Study of Atamestane Plus Toremifene Versus Letrozole in Advanced Breast Cancer

Breast Neoplasms | Neoplasms, Hormone-dependent

United States, Canada, Russian Federation, Ukraine
University of Washington
National Cancer Institute (NCI)

Completed

Cisplatin and Radiation Therapy With or Without Erlotinib Hydrochloride in Treating Patients With Stage III or Stage IV Head and Neck Cancer

Stage III Squamous Cell Carcinoma of the Hypopharynx | Stage III Squamous Cell Carcinoma of the Larynx | Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity | Stage III Squamous Cell Carcinoma of the Nasopharynx | Stage III Squamous Cell Carcinoma of the Oropharynx | Stage IV Squamous... and other conditions

United States
Wroclaw Medical University

Completed

Evaluation of the Effectiveness of Photodynamic Therapy in the Treatment of Lesions of the Lichen Planus Type in the Oral Mucosa and Its Diagnostics With the Use of Autofluorescence, in Various Wavelength Ranges, in Combination With the Use of Texture Analysis and Fractal Dimension

Oral Lichen Planus

Poland
HK inno.N Corporation

Completed

A Phase 3 Study to Evaluate the Efficacy and Safety of Triple Therapy With CJ-12420 in H. Pylori Positive Patients

Helicobacter Pylori Infection

Korea, Republic of

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