Search clinical trials for: local and/or topical anesthetic

Total 20005 results

Jinling Hospital, China

Recruiting

Clinical Study of Bowel Preparation Before Colonoscopy

Bowel Preparation

China
Taizhou Hospital
First Affiliated Hospital of Zhejiang University; Taizhou First People's Hospital and other collaborators

Unknown

A Multi-center Study for Eradication of Refractory Helicobacter Pylori

Gastritis

China
Thomas Jefferson University
Context Therapeutics Inc.

Active, not recruiting

Onapristone and Anastrozole for the Treatment of Refractory Hormone Receptor Positive Endometrial Cancer

Refractory Endometrial Carcinoma | Refractory Endometrial Endometrioid Adenocarcinoma | Refractory Endometrial Adenocarcinoma | Refractory Endometrial Clear Cell Adenocarcinoma | Refractory Endometrial Mixed Cell Adenocarcinoma | Refractory Endometrial Serous Adenocarcinoma | Refractory Endometrial...

United States
Oregon Health and Science University
Oregon Clinical and Translational Research Institute; Pulsion Medical Systems

Completed

Hemodynamics and Extravascular Lung Water in Acute Lung Injury (HEAL)

Acute Lung Injury

United States
King Abdulaziz University

Completed

The Efficacy of Pre-procedural Mouth Rinses on COVID-19 Saliva Viral Load

COVID-19 | Covid19 | SARS-CoV-2 | Coronavirus | Saliva | Viral Load | Polymerase Chain Reaction | Mouthwashes

Saudi Arabia
Brno University Hospital
KDCHOT FN Brno

Completed

Depth of Neuromuscular Blockade and the Perioperative Conditions in Laparoscopic Surgery in Pediatric Population (PedLapBlock)

Neuromuscular Blockade

Czechia
Ziekenhuis Oost-Limburg
Merck Sharp & Dohme LLC

Completed

CURES: The Effect of Deep Curarisation and Reversal With Sugammadex on Surgical Conditions and Perioperative Morbidity (CURES)

Obesity | Surgical Conditions | Respiratory Function | Laparoscopic Gastric Bypass Surgery | Cerebral Tissue Oxygenation

Belgium
University Hospital, Angers

Completed

Mechanisms of Human Cutaneous Microcirculation in Healthy Volunteers

Healthy Volunteers

France
University Clinical Centre of Kosova
University of Ljubljana, Faculty of Medicine

Unknown

FM-SRP and Tooth Extraction Improve Type 2 Diabetes Mellitus in Periodontitis

Type 2 Diabetes Mellitus | Periodontitis

Kosovo
AstraZeneca

Recruiting

A Study to Investigate the Effect on Lung Function of an Approved COPD Treatment (BGF, With HFA Propellant) Compared to BGF Formulated With a New Propellant (HFO) in Participants 40 to 80 Years of Age With COPD

COPD (Chronic Obstructive Pulmonary Disease)

United States, Korea, Republic of, Argentina, Turkey, Vietnam, Malaysia, Philippines, Thailand, Hungary, Mexico, Canada, India, Bulgaria, Poland
Merck Sharp & Dohme LLC

Completed

Placebo-Controlled Crossover Study to Evaluate Donepezil and MK-3134 for Reversal of Cognitive Impairment Associated With Scopolamine Administration (3134-005)(COMPLETED)

Dementia
Pearl Therapeutics, Inc.

Completed

Study to Assess the Efficacy and Safety of PT003, PT005, and PT001 in Subjects With Moderate to Very Severe COPD

Chronic Obstructive Pulmonary Disease

United States, Germany, United Kingdom, China, Taiwan, Korea, Republic of, Japan, Czechia, Hungary, Poland, Russian Federation
Vanderbilt University

Completed

Treatment of Orthostatic Hypotension in Autonomic Failure

Orthostatic Hypotension | Autonomic Failure

United States
St. Stephens Clinical Research

Completed

RIFT: Effect of Rifampicin on Plasma PK of FTC, TAF and Intracellular TFV-DP & FTC-TP (RIFT)

HIV

United Kingdom
Mundipharma Research Limited

Terminated

A Study to Compare Fluticasone /Formoterol Breath Actuated Inhaler (BAI) and Ultibro in Subjects With Fixed Airflow Obstruction and Elevated Eosinophils

ACOS (Fixed Airflow Obstruction and Elevated Eosinophils)

Slovakia
Incyte Corporation

Completed

A Study of Ruxolitinib vs Best Available Therapy (BAT) in Patients With Steroid-refractory Chronic Graft vs. Host Disease (GvHD) After Bone Marrow Transplantation (REACH3)

Graft-versus-host Disease (GVHD)

Belgium, Italy, Spain, Saudi Arabia, Turkey, United Kingdom, Germany, Greece, Canada, Austria, France, Israel, Netherlands, Sweden, Switzerland, Korea, Republic of, Bulgaria, Japan, Norway, Czechia, Russian Federation, Jordan, Hungary, Ind... and more
Umm Al-Qura University

Completed

Alter-G Training on Gait and Balance in Diabetic Neuropathy Patients

Diabetic Peripheral Neuropathy

Saudi Arabia
M.D. Anderson Cancer Center

Completed

Natural Killer (NK) Cell Adback After Allogeneic Stem Cell Transplant With Campath-IH Plus Chemorx for Patients With Lymphoid Malignancies

Lymphoma | Leukemia

United States
Chen Ying

Enrolling by invitation

Efficacy of Anisodamine Hydrobromide Combined With Low-molecular-weight Heparin in the Treatment of Patients With Sepsis

Sepsis

China
Alexandria University
University of Alexandria

Completed

Lactoferrin in Helicobacter Pylori Eradication Either With Standard Triple Therapy or Sequential Therapy

Helicobacter Pylori Infection

Egypt
Emergency NGO Onlus

Withdrawn

Clinical Study to Assess Efficacy and Safety of Amiodarone in Treating Patients With Ebola. Virus Disease (EVD) in Sierra Leone. EASE (EMERGENCY Amiodarone Study Against Ebola) (EASE)

Ebola Virus Disease
Tesaro, Inc.

Completed

An Open Label, Single Dose, Three Part Study to Assess the Effects of Rolapitant (2 mg/mL IV Solution) on the Pharmacokinetics of Digoxin; Sulfasalazine; and the Cooperstown Cocktail (Midazolam, Omeprazole, Warfarin, Caffeine, and Dextromethorphan in Healthy Subjects

Chemotherapy-induced Nausea and Vomiting

United States
Pfizer

Terminated

Assessment Of The Effects Of Single Doses Of An Investigational Drug, Given Alone Or With Donepezil, On Scopolamine-Induced Changes In Memory And Learning In Healthy Adults

Healthy

United States
AnHeart Therapeutics Inc.

Completed

A Study of AB-106 in Chinese Healthy Adult Men Evaluated the Effects of Itraconazole and Rifampicin on AB-106 PK

Solid Tumor

China
Universitas Padjadjaran
Radboud University Medical Center; United States Agency for International Development...

Completed

High-dose Rifampicin for the Treatment of Tuberculous Meningitis: a Dose-finding Study (ReDEFINe)

Tuberculosis, Meningeal

Indonesia
Chiesi Farmaceutici S.p.A.

Withdrawn

TRIMBOW® and RELVAR® on Lung Stiffness Reduction Assessed Through Forced Oscillation Technique in Patients With COPD

COPD
Peking University First Hospital
Peking University Cancer Hospital & Institute

Terminated

Dexamethasone, Flurbiprofen Axetil and Delirium After Lung Cancer Surgery

Delirium | Carcinoma, Non-Small-Cell Lung | Surgery--Complications | Dexamethasone | Flubiprofen Axetil

China
Juul Labs, Inc.

Completed

United States Pre-Market Tobacco Application Pharmacokinetics (US-PMTA-PK)

Tobacco Use | Tobacco Smoking | Nicotine Dependence | Nicotine Dependence, Cigarettes

United States
Pearl Therapeutics, Inc.

Completed

Pharmacokinetics and Safety Study of PT010 and PT003 in Healthy Chinese Adult Subjects

Chronic Obstructive Pulmonary Disease

China
The Cleveland Clinic

Enrolling by invitation

CARNIVAL Study: Gut Flora Dependent Metabolism of Dietary CARNItine and Phosphatidylcholine and cardioVAscuLar Disease (CARNIVAL)

Dietary Modification

United States
University College, London
Society for Cardiothoracic Surgery in Great Britain & Ireland; British Congenital...

Unknown

National Congenital Heart Disease Audit

Congenital Heart Disease (CHD)

United Kingdom
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Completed

Iodine I 131 Tositumomab and Fludarabine Phosphate in Treating Older Patients Who Are Undergoing an Autologous or Syngeneic Stem Cell Transplant for Relapsed or Refractory Non-Hodgkin's Lymphoma

Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Nodal Marginal Zone B-cell Lymphoma | Recurrent Adult Burkitt Lymphoma | Recurrent Adult Diffuse Large Cell Lymphoma | Recurrent Adult Diffuse Mixed Cell Lymphoma | Recurrent Adult Diffuse Small Cleaved Cell Lymphoma and other conditions

United States
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Neoadjuvant Carboplatin and Vincristine and Standard Local Ophthalmic Therapy in Treating Patients With Intraocular Retinoblastoma

Intraocular Retinoblastoma

United States
Beijing Anzhen Hospital

Enrolling by invitation

Safety and Efficacy of Drug-Coated Balloon Angioplasty for the Treatment of Chronic Total Occlusions

Coronary Artery Disease | Percutaneous Coronary Intervention | Coronary Occlusion | Chronic Total Occlusion of Coronary Artery | Drug-Eluting Stents

China
Beijing Anzhen Hospital
Beijing Friendship Hospital; The First Affiliated Hospital of Dalian Medical...

Unknown

The Success of Opening Concurrent CTO leSion to Improve Cardiac Function Trial in Patients With Multi-vessel Disease (SOS-moral)

Coronary Artery Disease | Percutaneous Coronary Intervention | Chronic Total Occlusion of Coronary Artery | Viable Myocardium

China
Hacettepe University

Completed

Comprehensive Evaluation in Patients With Meniere's Disease

Quality of Life | Physical Disability | Psychosocial Problem | Meniere Disease

Turkey
Ain Shams Maternity Hospital

Completed

Induction of Abortion in the Second Trimester

Abortion, Second Trimester

Egypt
Damanhour Teaching Hospital

Completed

Is Aminophylline More Effective Than Neostigmine/Atropine Mixture in the Treatment of Post-dural Puncture Headache (RCT)

Post-Dural Puncture Headache

Egypt
Masonic Cancer Center, University of Minnesota

Terminated

T-Cell Depleted Double UCB for Refractory AML

Acute Myelogenous Leukemia | Refractory Acute Myelogenous Leukemia

United States
Merck Sharp & Dohme LLC

Completed

Comparison of Sugammadex With Neostigmine During Laparoscopic Cholecystectomy or Appendectomy (P05699)

Anesthesia, General
Peking University First Hospital
Peking University Cancer Hospital & Institute

Terminated

Dexamethasone, Flurbiprofen Axetil and Long-term Survival After Lung Cancer Surgery

Carcinoma, Non-Small-Cell Lung | Surgery | Dexamethasone | Long-term Effects Secondary to Cancer Therapy in Adults | Flubiprofen Axetil

China
Masonic Cancer Center, University of Minnesota

Terminated

Allogeneic Natural Killer Cells in Patients With Recurrent Ovarian Cancer, Fallopian Tube, and Primary Peritoneal Cancer

Ovarian Cancer | Fallopian Tube Cancer | Peritoneal Cavity Cancer

United States
Hospital de Clinicas de Porto Alegre
Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul, Brazil; Conselho...

Unknown

Glycemic And Blood Pressure Control In Type 2 Diabetes, In A Primary Care Unit: A Staged Management Strategy

Diabetes Mellitus | Arterial Hypertension

Brazil
Kaohsiung Veterans General Hospital.

Completed

Comparing the Efficacy of Hybrid, High-dose Dual and Bismuth Quadruple Therapies

Helicobacter Pylori Infection

Taiwan
Jeffrey Moak

Not yet recruiting

Prevention of Post-Operative Cardiac Arrhythmias (POCA)

Cardiac; Dysrhythmia, Postoperative | Congenital Heart Surgery
Shandong University

Unknown

Antimicrobial Susceptibility Testing Guided Therapy Versus Empirical Therapy for the First-line Helicobacter Pylori Eradication.

Helicobacter Pylori Infection | Antimicrobial Susceptibility Testing

China
University of California, San Francisco
Puma Biotechnology, Inc.

Completed

Incidence and Severity of Diarrhea in Patients With HER2 Positive Breast Cancer Treated With Trastuzumab and Neratinib

HER2-positive Breast Cancer | Stage II Breast Cancer AJCC v6 and v7 | Stage IIA Breast Cancer AJCC v6 and v7 | Stage IIB Breast Cancer AJCC v6 and v7 | Stage III Breast Cancer AJCC v7 | Stage IIIA Breast Cancer AJCC v7 | Stage IIIB Breast Cancer AJCC v7 | Stage IIIC Breast Cancer AJCC v7 | Breast Adenocarcinoma

United States
Polarean, Inc.
Aerogen

Recruiting

Comparison of Bronchodilator Response From Three Different Aerosol Delivery Methods in Patients With COPD Using Hyperpolarized Xe 129 MRI Ventilation Imaging

Chronic Obstructive Pulmonary Disease

United States
Cairo University

Not yet recruiting

How to Reduce Pain in Patients Undergoing Office Hysteroscopy.

Pain
Eye & ENT Hospital of Fudan University
Shandong Provincial Hospital; Children's Hospital of Fudan University; Xinhua... and other collaborators

Recruiting

A-eyedrops on Ocular Alignment and Binocular Vision

Myopia | Exotropia | Exophoria

China

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