Search clinical trials for: nab-sirolimus

Total 4083 results

Aadi Bioscience, Inc.

Completed

Nab-sirolimus in Recurrent High Grade Glioma and Newly Diagnosed Glioblastoma

High Grade Recurrent Glioma and Newly Diagnosed Glioblastoma

United States
Aadi Bioscience, Inc.

Approved for marketing

Expanded Access for ABI-009 in Patients With Advanced PEComa and Patients With a Malignancy With Relevant Genetic Mutations or mTOR Pathway Activation

TSC1 | TSC2 | PEComa, Malignant | mTOR Pathway Abberation
Aadi Bioscience, Inc.

Completed

A Phase 2 Study of Nab-sirolimus (ABI-009) in Patients With Advanced Malignant PEComa (AMPECT)

Malignant PEComa

United States
Aadi Bioscience, Inc.

Recruiting

Phase 2 Basket Trial of Nab-sirolimus in Patients With Malignant Solid Tumors With Pathogenic Alterations in TSC1/TSC2 Genes (PRECISION 1)

Malignant Solid Neoplasm | Neoplasms | Cancer | Neoplasm Metastasis | Solid Tumor | Metastatic Cancer | Metastasis | Advanced Solid Tumor | Metastatic Solid Tumor | Advanced Cancer | Tumor | Malignant Neoplasm | Malignant Tumor | Tumors | Cancer Metastatic | Tumor, Solid | Malignant Solid Tumor | TSC | TSC1 | TSC2 | Metastatic Neoplasm

Korea, Republic of, United States, Puerto Rico
Aadi Bioscience, Inc.

Completed

Nab-Sirolimus in Combination With FOLFOX & BEV as 1st Line Therapy in Patients With Advanced or Metastatic Colorectal Cancer

Colorectal Cancer Metastatic

United States
Aadi Bioscience, Inc.

Recruiting

Trial of Nab-Sirolimus in Combination With Letrozole in Patients With Advanced or Recurrent Endometrioid Endometrial Cancer

Cancer | Endometrial Cancer | Tumor | Recurrent Endometrial Carcinoma | Endometrioid Endometrial Cancer | Endometrioid Tumor

United States
Aadi Bioscience, Inc.
National Cancer Institute (NCI)

Completed

Phase 1/2 Study of ABI-009 in Nonmuscle Invasive Bladder Cancer

Non-muscle Invasive Bladder Cancer (NMIBC)

United States
Masaryk University

Unknown

Comparison of Biolimus A9 and Everolimus Drug-Eluting Stents in Patients With ST Segment Elevation Myocardial Infarction (ROBUST)

Coronary Heart Disease | Percutaneous Coronary Intervention

Czech Republic
Aadi Bioscience, Inc.

Recruiting

Trial of Nab-sirolimus in Patients With Well-differentiated Neuroendocrine Tumors (NETs) of the Gastrointestinal Tract, Lung, or Pancreas Who Have Not Received Prior Treatment With mTOR Inhibitors

Neuroendocrine Tumors | Pancreatic Neuroendocrine Tumor | Gastrointestinal Neuroendocrine Tumor | NET | Pulmonary Neuroendocrine Tumor

United States
Aadi Bioscience, Inc.

Recruiting

Dose-escalation Study to Assess Safety and Pharmacokinetics of Nab-Sirolimus in Patients With Locally Advanced or Metastatic Solid Tumors and Moderate Liver Impairment

Advanced Solid Tumor | Tumor | Tumor, Solid

United States
Biosensors Europe SA

Unknown

BioFreedom QCA Study in CAD Patients (BioFreedomQCA)

Myocardial Infarction | Coronary Artery Disease | Cardiac Death

Spain, Denmark
HK inno.N Corporation

Completed

Study to Evaluate the Pharmacokinetic Characteristics and Safety of IN-C004 in Healthy Volunteers

Healthy

Korea, Republic of
Mirati Therapeutics Inc.
Aadi Bioscience, Inc.

Active, not recruiting

Adagrasib in Combination With Nab-Sirolimus in Patients With Advanced Solid Tumors and Non-Small Cell Lung Cancer With a KRAS G12C Mutation (KRYSTAL -19)

NSCLC | Metastatic Cancer | Advanced Cancer | Solid Tumor, Adult | Malignant Neoplastic Disease

United States
SONIRE Therapeutics Inc.

Recruiting

A Study of Suizenji in Patients With Unresectable Pancreatic Cancer

Unresectable Pancreatic Cancer

Japan
Translational Research Center for Medical Innovation...
Wakayama Medical University

Completed

OPtical Frequency Domain Imaging vs. INtravascular Ultrasound in Percutaneous Coronary InterventiON (OPINION)

Coronary Artery Disease

Japan
University of Washington
Aadi Bioscience, Inc.

Active, not recruiting

Nab-Sirolimus and Pazopanib Hydrochloride in Treating Patients With Advanced Nonadipocytic Soft Tissue Sarcomas

Advanced Soft Tissue Sarcoma | Metastatic Soft Tissue Sarcoma | Locally Advanced Soft Tissue Sarcoma

United States
Albert Einstein College of Medicine

Terminated

Study to Evaluate the Efficacy and Safety of Sirolimus in Subjects With Metastatic, Mismatch Repair Deficient Solid Tumors After Immunotherapy

Cancer | Solid Tumor | Metastatic Solid Tumor | Metastatic dMMR Solid Cancer

United States
M.D. Anderson Cancer Center
Aadi Bioscience

Not yet recruiting

A Phase I Trial of Combination Gemcitabine and Nab-Sirolimus in Advanced Leiomyosarcomas or Advanced Soft-Tissue Sarcomas With TSC2 or TSC1 Loss-of-function Mutations or Deletions

Leiomyosarcoma | Soft-tissue Sarcomas

United States
Chong Kun Dang Pharmaceutical

Not yet recruiting

Efficacy and Safety of Sirolimus Plus CNI Compared With MMF Plus CNI in ABO-i Kidney Transplant Recipients.

Kidney Transplantation

Korea, Republic of
Robert Ramirez
Aadi Bioscience, Inc.

Terminated

A Study to testABI-009 in Patients With Metastatic, Unresectable, Low or Intermediate Grade Neuroendocrine Tumors of the Lung or Gastroenteropancreatic System

Neuroendocrine Tumors

United States
Celgene

Completed

ABI-009 Trial in Patients With Advanced Non-hematologic Malignancies

Solid Tumors

United States
Terumo Europe N.V.

Completed

Randomized Study to Assess the Effect of ThRombus Aspiration on Flow Area in STEMI Patients (TROFI)

Myocardial Infarction | Coronary Artery Disease | STEMI

Germany, France, Denmark, Netherlands
Asklepios Biopharmaceutical, Inc.

Recruiting

Phosphatase Inhibition by Intracoronary Gene Therapy in Subjects With Non-Ischemic NYHA Class III Heart Failure (GenePHIT)

Congestive Heart Failure

United States
Odense University Hospital

Unknown

Sirolimus Eluting ORSIRO Stent Versus Biolimus-eluting NOBORI Stent (SORT OUT VII)

Coronary Artery Disease | Ischemic Heart Disease

Denmark
Children's Oncology Group
National Cancer Institute (NCI)

Active, not recruiting

Nanoparticle Albumin-Bound Rapamycin, Temozolomide, and Irinotecan Hydrochloride in Treating Pediatric Patients With Recurrent or Refractory Solid Tumors

Refractory Malignant Solid Neoplasm | Recurrent Malignant Solid Neoplasm | Recurrent Primary Central Nervous System Neoplasm | Refractory Primary Central Nervous System Neoplasm | Childhood Solid Neoplasm

United States
Aadi Bioscience, Inc.

Active, not recruiting

ABI-009, an mTOR Inhibitor, for Patients With Severe Pulmonary Arterial Hypertension

Pulmonary Hypertension

United States
Translational Research Center for Medical Innovation...
Wakayama Medical University

Completed

OPtical Frequency Domain Imaging Versus INtravascular Ultrasound in Percutaneous Coronary InterventiON - OPINION Imaging

Coronary Artery Disease

Japan
Fudan University

Active, not recruiting

An Umbrella Trial Based on Molecular Pathway for Patients With Metastatic TNBC. (FUTURE-SUPER)

TNBC - Triple-Negative Breast Cancer

China
University of Regensburg

Completed

CNI-free de Novo Protocol in Patients Undergoing Liver Transplantation With Renal Impairment (PATRON07)

End Stage Liver Disease | Impaired Renal Function

Germany
Zhejiang Cancer Hospital

Recruiting

Tirelizumab in Combination With Chemoradiation in Patients With Unresectable Gastric Cancer or Gastroesophageal Junction Adenocarcinoma

Locally Advanced Gastric Cancer

China
Universidad de Granada

Completed

Beer or Ethanol Effects on the Response to High Intensity Interval Training: A Controlled Study in Healthy Individuals (BEER-HIIT)

Exercise | Drinking, Alcohol

Spain
National Institute of Allergy and Infectious Diseases...

Completed

Evaluating the Safety and Pharmacokinetics of VRC01, VRC01LS, and VRC07-523LS, Potent Anti-HIV Neutralizing Monoclonal Antibodies, in HIV-1-Exposed Infants

HIV Infections

United States, Puerto Rico, Zimbabwe, South Africa
Yonsei University

Unknown

Impact of Intravascular Ultrasound(IVUS)-Guided Chronic Total Occlusion Intervention With Drug-eluting Stents (CTO)

Coronary Artery Disease

Korea, Republic of
Johns Hopkins University
MacuSight, Inc.

Completed

Sirolimus as Therapeutic Approach to Uveitis (SAVE)

Panuveitis | Uveitis | Posterior Uveitis | Intermediate Uveitis

United States
Stefan Schieke MD

Withdrawn

Therapeutic Efficacy of Topical Sirolimus in Early Stage Cutaneous T-cell Lymphoma (CTCL)

Cutaneous T-cell Lymphoma (CTCL)

United States
Mayo Clinic
National Cancer Institute (NCI)

Completed

Nanoparticle Albumin-Bound Rapamycin in Treating Patients With Advanced Cancer With mTOR Mutations

Recurrent Ovarian Carcinoma | Recurrent Head and Neck Carcinoma | Recurrent Renal Cell Carcinoma | Stage III Renal Cell Cancer | Endometrial Carcinoma | Stage III Bladder Cancer | Cervical Squamous Cell Carcinoma | Stage IV Breast Cancer | Malignant Uterine Neoplasm | Recurrent Bladder Carcinoma | Recurrent... and other conditions

United States
Phillip Freeman
Odense University Hospital; Aarhus University Hospital; Biosensors International and other collaborators

Active, not recruiting

Sort Out XI - Combo Stent Versus BioMatrix Alpha Stent (SORTOUTXI)

Coronary Artery Disease

Denmark
Brigham and Women's Hospital
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Safety Study of Sirolimus and Hydroxychloroquine in Women With Lymphangioleiomyomatosis (SAIL)

Lymphangioleiomyomatosis

United States
Sarcoma Oncology Research Center, LLC
Aadi Bioscience, Inc.

Completed

Nivolumab (Opdivo®) Plus ABI-009 (Nab-rapamycin) for Advanced Sarcoma and Certain Cancers

Melanoma | Renal Cell Carcinoma | Hepatocellular Carcinoma | Colorectal Cancer | Ewing Sarcoma | Non Small Cell Lung Cancer | Chordoma | Urothelial Carcinoma | Classical Hodgkin Lymphoma | PEComa | Desmoid Tumor | Epithelioid Sarcoma | Squamous Cell Carcinoma | MTOR Activating Mutation

United States
AgelessRx
University of California, Los Angeles

Completed

Participatory Evaluation (of) Aging (With) Rapamycin (for) Longevity Study (PEARL)

Aging

United States
Xijing Hospital
Air Force Military Medical University, China; Shanghai MicroPort Medical (Group)... and other collaborators

Unknown

Long Term Efficacy and Safety of Firebird Sirolimus-Eluting Stent In Complex Coronary Lesions (FIREMAN)

Coronary Disease

China
The University of Texas Health Science Center,...
Society for Pediatric Dermatology

Completed

Topical Rapamycin Therapy to Alleviate Cutaneous Manifestations of Tuberous Sclerosis Complex (TSC) and Neurofibromatosis I (NF1)

Tuberous Sclerosis | Neurofibromatoses | Neurofibroma | Angiofibroma

United States
Paul S Teirstein, MD
Cordis Corporation

Completed

The SCRIPPS DES REAL WORLD Registry

Coronary Artery Disease | Coronary Thrombosis | Coronary Restenosis

United States
Shanghai Jiao Tong University School of Medicine

Unknown

Firebird 2 Versus Excel Sirolimus-eluting Stent in Treating Real-world Patients With Coronary Artery Disease (FESTA)

Coronary Artery Disease

China
Meril Life Sciences Pvt. Ltd.
Lifecare Institute of Medical Sciences and Research Ahmedabad Gujarat India

Completed

Study Safety and Performance of the Biomime Stent in Patients With Single, De Novo, Non-Complex Coronary Lesions (meriT-1)

Coronary Artery Disease

India
OrbusNeich
CCRF Inc., Beijing, China; OrbusNeich Medical (Shenzhen), Co. Ltd.

Completed

Safety and Efficacy of the Combo Bio-engineered Sirolimus-eluting Stent Versus the Nano Polymer-free Sirolimus-eluting Stent in the Treatment of Patients With de Novo Stenotic Lesions (RECOVERY)

Coronary Arteriosclerosis

China
Cordis Corporation

Completed

FIM-BR - First-in-Man Study (Brazil Part) With Sirolimus-Coated BX VELOCITY Stent

Coronary Artery Disease

Brazil
Aucta Pharmaceuticals, Inc

Terminated

Topical Sirolimus Ointment for Cutaneous Angiofibromas in Subjects With Tuberous Sclerosis Complex

Tuberous Sclerosis | Angiofibroma of Face

United States, China
HK inno.N Corporation

Completed

PK and PD Interaction Between Tegoprazan and NOACs After Multiple Oral Dosing in Healthy Volunteers

Healthy

Korea, Republic of
National Institute of Allergy and Infectious Diseases...

Completed

Evaluating the Safety and Efficacy of the VRC01 Antibody in Reducing Acquisition of HIV-1 Infection in Women

HIV Infections

South Africa, Zimbabwe, Malawi, Botswana, Kenya, Mozambique, Tanzania

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