- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05528367
Tirelizumab in Combination With Chemoradiation in Patients With Unresectable Gastric Cancer or Gastroesophageal Junction Adenocarcinoma
Tirelizumab in Combination With Chemoradiation in Patients With Unresectable Gastric Cancer or Gastroesophageal Junction Adenocarcinoma:A Single Arm Phase II Clinical Study
Study Overview
Status
Conditions
Intervention / Treatment
Study Type
Enrollment (Anticipated)
Phase
- Phase 2
Contacts and Locations
Study Contact
- Name: Liu Lu ying, MD
- Phone Number: +86 0571-88128142
- Email: luyingliu@163.com
Study Locations
-
-
Zhejiang
-
Hangzhou, Zhejiang, China, 310022
- Recruiting
- Liu luying
-
Contact:
- Liu Lu ying, MD
- Phone Number: +86 571-88128142
- Email: luyingliu@163.com
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Male or female patients, aged ≥ 18 years; ≤ 75 years old;
- The histopathology confirmed the diagnosis of previously untreated locally advanced unresectable HER2 negative gastric or gastroesophageal junction adenocarcinoma (imaging evaluation showed that the primary tumor was severely invaded, could not be separated from the surrounding normal tissue, or had surrounded large blood vessels, or regional lymph nodes were fixed and fused, or the metastatic lymph nodes were not within the scope of surgical clearance), and there was no peritoneal metastasis during laparoscopic exploration;
- There is no serious liver and kidney function damage, and the functional level of organs must meet the following requirements: ANC ≥ 1.5 × 109/L; PLT ≥ 90 × 109/L; Hb ≥ 90 g/L; TBIL ≤ 1 × ULN; ALT and AST ≤ 1.5 × ULN,ALP ≤ 2.5 × ULN; Bun and Cr ≤ 1 × ULN and creatinine clearance ≥ 50 ml / min (Cockcroft Gault formula); LVEF ≥ 50%; The QT interval (QTCF) corrected by fridericia method was < 450 ms in males and < 470 MS in females; INR ≤ 1.5 × ULN,APTT ≤ 1.5 × ULN;
- The patient has at least one measurable lesion, which is evaluated by the investigator according to (RECIST) v1.1;
- ECoG PS score 0 or 1;
- Life expectancy ≥ 6 months;
- The investigator assessed that the patient could comply with the protocol requirements;
- Sign the informed consent document.
Exclusion Criteria:
- Received systemic cytotoxic drug chemotherapy;
- Patients with hypersensitivity or hypersensitivity to therapeutic drugs and patients with autoimmune diseases; Have received allogeneic tissue / solid organ transplantation;
- There is third space effusion (such as pleural fluid and ascites) that cannot be controlled by drainage or other methods;
- Use steroids for more than 50 days, or need to use steroids for a long time;
- Uncontrolled symptomatic brain metastases or mental disorders cannot correctly express subjective symptoms;
- The abnormal coagulation function has clinical significance, has bleeding tendency or is receiving thrombolytic or anticoagulant treatment;
- Unable to swallow, chronic diarrhea and intestinal obstruction, and there are many factors affecting drug taking and absorption;
- Other malignant tumors occurred within 5 years before enrollment, except for cervical carcinoma in situ or skin squamous or basal cell carcinoma that had been treated for radical cure before;
- Pregnant or lactating women who have fertility but refuse to take contraceptive measures;
- Those with serious heart disease or medical history, including: recorded history of congestive heart failure, high-risk uncontrollable arrhythmia, angina pectoris requiring medical treatment, clinically clear heart valve disease, history of serious myocardial infarction and stubborn hypertension;
- According to the judgment of the investigator, there are concomitant diseases (such as uncontrolled hypertension, diabetes, thyroid disease, etc.) that seriously endanger the patient's safety or affect the patient's completion of the study;
- The investigator determines that other conditions are not suitable for inclusion in the study.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Prevention
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: CRT with Tirelizumab
Chemotherapy+Tirelizumab:PS regimen:S-1:BSA <=1.25 m2 ,80 mg daily; 1.25 m2 <BSA <1.5 m2,100 mg daily; BSA>=1.5 m2 ,120 mg daily. Nab-PTX:preoperation:130mg/m2,d1,8,q3w;adjuvant:100mg/m2,d1,8,q3w; Tirelizumab:200mg d1 q3w. Concurrent Chemoradiotherapy: Radiation: 45-50Gy/25Fx;During radiation: Nab-PTX:100mg qw,Tirelizumab:200mg d1 q3w. Chemotherapy+Tirelizumab:PS regimen:S-1:BSA <=1.25 m2 ,80 mg daily; 1.25 m2 <BSA <1.5 m2,100 mg daily; BSA>=1.5 m2 ,120 mg daily. Nab-PTX:preoperation:130mg/m2,d1,8,q3w; Tirelizumab:200mg d1 q3w. We will evaluate whether the tumor could be resectable through CT scan and Endoscope after two cycles of Chemotherapy+Tirelizumab and CRT.If it could be resctable,three cycles of adjuvant chemotherapy+Tirelizumab will be arranged;If not,another three cycles of chemotherapy+Tirelizumab will be arranged,then evaluate again. |
S-1:BSA <=1.25 m2 ,80 mg daily; 1.25 m2 Nab-PTX:130mg/m2,d1,8,q3w;100mg qw(during radiation) Tirelizumab:200mg d1 q3w.
45-50Gy/25F
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
the rate of resectable patients with negative incisal margin R0 resection rate
Time Frame: 18 weeks after treatment completion
|
the rate of resectable patients with negative incisal margin
|
18 weeks after treatment completion
|
Collaborators and Investigators
Sponsor
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- ZhejiangCH20211029
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
product manufactured in and exported from the U.S.
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Locally Advanced Gastric Cancer
-
Astellas Pharma Global Development, Inc.AvailableMetastatic Gastroesophageal Junction (GEJ) Adenocarcinoma | Locally Advanced Unresectable Gastroesophageal Junction (GEJ) Adenocarcinoma Cancer | Locally Advanced Unresectable Gastric Adenocarcinoma Cancer | Metastatic Gastric Adenocarcinoma CancerUnited States, Germany
-
Astellas Pharma Global Development, Inc.Active, not recruitingLocally Advanced Unresectable Gastroesophageal Junction (GEJ) Adenocarcinoma or Cancer | Locally Advanced Unresectable Gastric Adenocarcinoma or Cancer | Metastatic Gastric Adenocarcinoma or Cancer | Metastatic Gastroesophageal Junction (GEJ) AdenocarcinomaUnited States, Australia, Belgium, Brazil, Canada, Chile, China, Colombia, France, Germany, Israel, Italy, Japan, Korea, Republic of, Mexico, Peru, Poland, Spain, Taiwan, United Kingdom
-
Astellas Pharma Global Development, Inc.Active, not recruitingLocally Advanced Unresectable Gastroesophageal Junction (GEJ) Adenocarcinoma or Cancer | Locally Advanced Unresectable Gastric Adenocarcinoma or Cancer | Metastatic Gastric Adenocarcinoma or Cancer | Metastatic Gastroesophageal Junction (GEJ) AdenocarcinomaUnited States, Korea, Republic of, China, Spain, Taiwan, Japan, Argentina, Canada, Croatia, Greece, Ireland, Malaysia, Netherlands, Portugal, Romania, Thailand, Turkey, United Kingdom
-
Huashan HospitalSeattle Integrative Cancer CenterUnknownMetastatic Gastric Cancer | Locally Advanced Gastric CancerChina, United States
-
Gruppo Italiano per lo studio dei Carcinomi dell...Regione LombardiaTerminatedMetastatic Gastric Cancer | Locally Advanced Unresectable Gastric CancerItaly
-
Fudan UniversityUnknownMetastatic Gastric Cancer | Locally Advanced Gastric AdenocarcinomaChina
-
Tianshu LiuCompletedLocally Advanced Gastric CancerChina
-
Cai KailinUnknownLocally Advanced Gastric CancerChina
-
Fujian Medical UniversityNot yet recruitingLocally Advanced Gastric CancerChina
-
Fujian Medical UniversityActive, not recruitingLocally Advanced Gastric CancerChina
Clinical Trials on Nab-PTX,S-1,Tirelizumab
-
Ruijin HospitalRecruitingStage IIIC Gastric CancerChina
-
Cook Group IncorporatedCompletedRenal Artery StenosisUnited Kingdom, Germany, Czechia, France
-
Eye & ENT Hospital of Fudan UniversityNot yet recruitingNasopharyngeal Carcinoma
-
SONIRE Therapeutics Inc.RecruitingUnresectable Pancreatic CancerJapan
-
Nagoya UniversityJapan Agency for Medical Research and DevelopmentRecruiting
-
Chang Gung Memorial HospitalRecruitingMetastatic Pancreatic AdenocarcinomaTaiwan
-
Yang Jianjun, PhDRecruiting
-
Tomoshi TsuchiyaCompleted
-
Peking University Cancer Hospital & InstituteRecruitingGastric AdenocarcinomaChina
-
Fudan UniversityThe First Affiliated Hospital of Anhui Medical University; Guangdong Provincial... and other collaboratorsWithdrawn