Search clinical trials for: naloxone placebo

Total 54063 results

Unity Health Toronto
OCAD University; Toronto Public Health

Completed

SOONER Feasibility Study Protocol (SOONER)

Overdose

Canada
Nasus Pharma

Completed

A Single-Dose, Bioequivalence Study of FMXIN001 4 mg Microspheres Powder

Opioid Overdose

Canada
Mundipharma (China) Pharmaceutical Co. Ltd

Completed

Determine the Safety and Efficacy of Oxy/Nal Tablets Compared to Oxy PR in Subjects With Cancer Pain

Pain | Cancer

China
University of Edinburgh

Completed

A Comparison of Targinact vs. Oxycodone on Gut Function After Colorectal Surgery (TACS)

Postoperative Pain | Postoperative Nausea and Vomiting

United Kingdom
Mundipharma CVA

Completed

A Non-interventional, Observational Study for Targinact® Treatment in Patients With Severe Pain.

Severe Pain

Belgium
Ruth M. Rothstein CORE Center
Health Resources and Services Administration (HRSA); The New York Academy of...

Completed

The CORE Buprenorphine Project - An HIV Primary Care Program Demonstration (BUP)

HIV Infections | Post-Traumatic Stress Disorders | Opiate Dependence | AIDS

United States
University of California, San Francisco

Completed

Biology and Experience of Eating in Women With Obesity (BEE)

Obesity

United States
New York State Psychiatric Institute

Withdrawn

Anti-suicidal Effects of Buprenorphine in Opioid Use Disorder

Suicidal Ideation | Opioid-use Disorder

United States
Kati Järvelä

Completed

A Comparison of PR Oxycodone/Naloxone and PR Oxycodone After Cardiac Surgery

Postoperative Pain | Opioid Related Disorders

Finland
Artoss Inc.

Recruiting

Rate of Bony Fusion Using NanoBone® Synthetic Bone Graft Versus Local Autologous Bone Graft. (BONE)

Degenerative Disc Disease | Spondylolisthesis

United States
Johann Wolfgang Goethe University Hospital

Completed

Evaluation of Fusion After ALIF With an Osteoinductive Material or With Homologus Bone

Fusion of Spine, Lumbar Region
Purdue Pharma LP

Withdrawn

Clinical Outcomes From Nalmefene (COINED)

Opioid Overdose
Mundipharma CVA

Completed

A Non-interventional, Observational Study for Targinact® Treatment in Patients With Chronic Severe Pain

Chronic Severe Pain

Belgium
Mundipharma SAS

Terminated

Efficacy of Oxycodone/Naloxone(OXN), Versus Oxycodone (OXY), for the Reduction of Intensity of Opioid-induced Constipation in Pain Patients (OXN3505)

Pain | Constipation

France
University of Pennsylvania
National Institute of Drug Abuse; The Wistar Institute; Ho Chi Minh City CDC; Institute...

Recruiting

Anti-retroviral Therapy, Medications for Opioid Use Disorder, Opioids and HIV Infection - Study 1 (AMOHI-1)

Inflammation | Opioid-use Disorder | HIV-1-infection | Immune Activation | Buprenorphine | Methadone | Naltrexone | Antiretroviral Treatment

United States, Vietnam
Sunshine Lake Pharma Co., Ltd.

Completed

To Evaluate the Pharmacokinetics and Safety of Yimitasvir Phosphate Capsules in Subjects With Moderate and Severe Liver Function Impairment and in Healthy Subjects

Hepatic Impairment

China
University of British Columbia
Vancouver Coastal Health; International Collaboration on Repair Discoveries; Purdue...

Completed

Targin® for Chronic Pain Management in Patients With Spinal Cord Injury

Chronic Pain

Canada
University of California, Los Angeles
Indivior Inc.

Completed

Randomized, Double-Blind Cross-Over Trial Of Buprenorphine and Low-Dose Naloxone Versus Buprenorphine

Pain

United States
Vanderbilt University Medical Center
National Institute on Drug Abuse (NIDA)

Recruiting

Stress and Opioid Misuse Risk: The Role of Endogenous Opioid and Endocannabinoid Mechanisms

Back Pain | Stress | Opioid Use Disorder

United States
University of Pennsylvania
National Institute of Drug Abuse; Expertise France

Completed

Medication-assisted Treatment for Injecting Drug Users in Vietnam (OIT-HCMC)

HIV Infections | Opioid Use Disorder
University of Alabama at Birmingham

Completed

Increasing Naloxone Access for Persons Who Use Opioids

Naloxone

United States
CAMC Health System

Terminated

Enteral Naloxone Versus a Traditional Bowel Regimen for the Prevention of Opioid Induced Constipation in Trauma Patients

Analgesia | Constipation

United States
Chen Yi Enterprise, Co., Ltd.

Completed

Effectiveness of Nanoone Woman Underwear Using in the Management of Dysmenorrhea

Dysmenorrhea

Taiwan
Artoss Inc.

Recruiting

Prospective Registry to Evaluate Outcomes of NanoBone® Bone Graft in Acute Trauma (ARTIST)

Fractures, Bone

United States
University of California, San Francisco

Not yet recruiting

Naloxone for Opioid Associated Out of Hospital Cardiac Arrest (NOPACA)

Heart Arrest, Out-Of-Hospital | Naloxone | Opioid Overdose

United States
Mitovie Pharma Ltd

Unknown

Naloxone Nasal Spray Pharmacokinetic Study

Opioid Overdose

Jordan
MetroHealth Medical Center
National Institute on Drug Abuse (NIDA)

Completed

Effect of Heroin Use on Immune Activation and Cardiovascular Risk in HIV

Cardiovascular Diseases | HIV Infection | Opioid-use Disorder

United States
Teva Pharmaceuticals USA

Withdrawn

An Open-Label, Single-Center Study to Evaluate the Exposure-Response Relationship Between the Plasma Drug Concentrations and the Change From Baseline in QTc at Steady State Following Once-daily Administration of CASSIPA® in Opioid Dependent Subjects.

Evaluation of QTc Interval
Mundipharma Korea Ltd

Completed

A Study to Assess the Efficacy and Safety of Oxycodone/Naloxone in Korean Patients With Chemotherapy-Induced Peripheral Neuropathy (CIPN)

Cancer

Korea, Republic of
Mundipharma Pharmaceuticals B.V.

Completed

Oxycodone/Naloxone (OXN) Combination in Moderate to Severe Non-malignant Pain

Pain

Netherlands
Bausch Health Americas, Inc.

Completed

Naloxone and Intravenous Methylnaltrexone Effects on Bladder Function

Healthy Males

United States
Institut National de la Santé Et de la Recherche...

Completed

Double Blind Randomized, Monocentric, Cross-over, Placebo-controlled Study to Evaluate the Effect of Morphine and Naloxone on Motivation (MBBAnalgesic) (MBBAnalgesic)

Healthy

France
University of Cincinnati
National Institute on Drug Abuse (NIDA)

Completed

A Tailored, Peer-delivered Intervention to Reduce Recurring Opioid Overdoses (TTIP-PRO)

Opioid-Related Disorders | Substance Abuse | Drug Overdose | Drug Abuse | Drug Addiction

United States
Mundipharma Research GmbH & Co KG

Completed

A Study to Demonstrate Improvement in Symptoms of Constipation in Subjects That Require Around-the-clock Opioid Pain Killer Therapy

Pain | Constipation

United Kingdom
University of North Carolina, Chapel Hill
National Institute on Drug Abuse (NIDA)

Completed

Nalox-Comm: Naloxone Communication Training for Pharmacists (Nalox-Comm)

Naloxone

United States
University of Washington
U.S. National Science Foundation

Completed

Naloxone Auto-injection in Healthy Volunteers

Overdose Antidote

United States
VA Office of Research and Development

Recruiting

A Study Comparing Oral Buprenorphine and Injectable Buprenorphine for the Treatment of Opioid Use Disorder (VA-BRAVE)

Opioid Use Disorder

United States
Mundipharma Korea Ltd

Completed

A Study to Evaluate Efficacy and Safety of Oxycodone/Naloxone Compared to OxyContin in Korean Cancer Patients (TOP)

Cancer

Korea, Republic of
Medical University of Vienna

Completed

Oral Oxycodone After Major Cardiac Surgery

Heart; Dysfunction Postoperative, Cardiac Surgery

Austria
Mundipharma Oy

Completed

OXN PR Compared to OXY PR in Subjects With Postoperative Pain After Knee Arthroplasty (OXN4505)

Post Operative Pain

Finland
Tanta University

Completed

Effect of Intrathecal Naloxone in the Incidence of Pruritis After C.S

Pruritis

Egypt
Janssen-Cilag A.G., Switzerland

Completed

Comparison of Two Dosage Strengths of Transdermal Fentanyl Versus Transdermal Buprenorphine and Placebo in Acute Pain Models in Healthy Volunteers.

Pain
AstraZeneca
Parexel

Recruiting

Drug-Drug Interaction and Safety of AZD4041 Study (Part 1) and Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of AZD4041 Study in Opioid Use Disorder (Part 2).

Opioid Use Disorder

United States
Artoss Inc.

Completed

Artoss Foot and Ankle Surgery Registry (ARK)

Trauma Injury | Deformity; Bone | Arthritis Foot

United States
Artoss Inc.

Active, not recruiting

Artoss Prospective Spine Registry Outcomes (ASTRO)

Spinal Fusion

United States
Kasr El Aini Hospital
Mansoura University

Completed

Influence Of Low Dose Intrathecal Naloxone On Bupivacaine - Fentanyl Spinal Anaesthesia For Lower Limb Orthopedic Surgery In Elderly Patients

Elderly | Anesthesia, Spinal

Egypt
Stephanie B. Seminara, MD

Enrolling by invitation

Opioid Antagonism in Hypogonadotropic Hypogonadism

Hypogonadotropic Hypogonadism

United States
Dartmouth-Hitchcock Medical Center

Completed

Role of Endorphins in Perception of Dyspnea With Resistive Loading in Chronic Obstructive Pulmonary Disease (COPD)

Chronic Obstructive Pulmonary Disease

United States
Indivior Inc.

Completed

Treatment Seeking Participants With Opioid Use Disorders Assessing Tolerability of Depot Injections of Buprenorphine

Opioid Dependence | Opioid Related Disorders

United States
Cairo University

Unknown

Evaluation of Marginal Bone Loss After Immediate Implant Placement in Maxillary Esthetic Zone With Nanobone Versus Xenograft

Implant Placement in Maxillary Esthetic Zone

Egypt

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