- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04615260
Rate of Bony Fusion Using NanoBone® Synthetic Bone Graft Versus Local Autologous Bone Graft. (BONE)
February 10, 2023 updated by: Artoss Inc.
Comparison of Fusion Success Between NanoBone Synthetic Bone Graft and Local Autogenous Bone Graft in Posterolateral Spinal Fusion
The objectives of this longitudinal study are to assess and measure fusion status (fused or not fused) and rate of bony fusion using NanoBone® Synthetic Bone Graft in patients requiring one to two level lumbar posterolateral fusion procedures with or without commercially available rigid spinal instrumentation.
Our hypothesis is that the Nanobone synthetic bone graft will be as effective at creating a fusion in the lumbar spine as compared with a local bone graft.
Each subject will serve as their own control during this study, as patients will receive the Nanobone graft on the right side of their spine and the local bone graft on their left side.
Study Overview
Status
Recruiting
Conditions
Intervention / Treatment
Detailed Description
Subjects will be recruited for this study from among those scheduled to undergo 1-2 level posterolateral spinal fusion procedures with bone grafting for degenerative disc disease or grade 1-3 spondylolisthesis.
The study will entail each subject having a local bone graft placed on the left side of their spine, with Nanobone placed on the right side of their spine during the procedure.
Eligible and consenting patients recruited for this study will be subject to the standard of care.
This includes the following visits: preoperative, operative, post-discharge, 4 months postoperative, 1-year postoperative, and 2-years postoperative.
They will be subject to standard of care imaging modalities including AP, lateral, and flexion/extension lumbar radiographs at pre-operative, post-discharge, 4-months postoperative, 1-year postoperative, and 2-year postoperative time points.
Standard of care advanced imaging including a CT scan or magnetic resonance imaging (MRI) scan will be performed pre-operatively.
Patients will also receive standard of care clinical examinations and self-assessments at all clinic visits.
Imaging obtained outside the standard of care for this study will include 1-year and 2-year lumbar CT scans to evaluate fusion.
The 2-year lumbar CT scan will only be required if fusion has not been demonstrated at the time of the 1-year lumbar CT scan.
Patients enrolled in this study who are treated with rigid pedicle screw fixation must be treated using rigid pedicle screw instrumentation appropriate for posterolateral spinal fusions.
Study Type
Interventional
Enrollment (Anticipated)
40
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: Saharsh Mehta
- Phone Number: (508) 334-9761
- Email: Saharsh.Mehta@umassmemorial.org
Study Contact Backup
- Name: Jim Cassidy, Ph.D..
- Email: jcassidy@artossinc.com
Study Locations
-
-
Massachusetts
-
Worcester, Massachusetts, United States, 01605
- Recruiting
- UMass Memorial Health Care
-
Contact:
- Patrick Connelly, MD
-
Contact:
- Michael Stauff, MD
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 85 years (ADULT, OLDER_ADULT)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- The individual has signed and dated a study specific informed consent form approved by the Institutional Review Board at UMMHC.
- The individual is 18 to 85 years of age.
- The individual is skeletally mature.
- The individual has been diagnosed with 1 or 2 level degenerative disc disease or spondylolisthesis grade 1-3 with or without spinal stenosis, requiring posterolateral spinal fusion surgery with bone grafting.
- The individual is physically and mentally willing and able to comply with the postoperative scheduled clinical and radiographic evaluations and rehabilitation.
Exclusion Criteria:
- The individual has had any previous attempts at fusion, at any lumbar levels.
- The individual is morbidly obese (defined as 100 lbs over the recommended ideal weight as described in the Metropolitan Life Height and Weight Tables for Men and Women and or having a BMI >39).
- Patients with osteopenia, osteoporosis, or osteomalacia to a degree that spinal instrumentation would be contraindicated.
- Patients with systemic collagen, bone or mineralization dysfunction (such as Paget's disease, osteogenesis imperfecta, Ehlers-Danlos Syndrome).
- Patients who suffer from uncontrolled diabetes mellitus type I or insulin-dependent diabetes mellitus type II. (definition based on the glycosylated Haemoglobin level)
- Patients who are suffering from autoimmune disease.
- Patients who previously underwent chemotherapy, immunosuppressive disease or radiation to the local area.
- Patients who received or are currently receiving corticosteroids (> 2 years > 5 mg prednisolone equivalent/d).
- Patients with active local or systemic infection.
- Patients with any known active malignancy.
- Patients with other concurrent physical or mental conditions which are likely to affect their outcome.
- Patient unable to consent for themselves
- Pregnant women
- Non-English speaking subjects. These subjects are excluded because they would not be able to complete the English-language surveys required during this study. Only English language versions of these surveys have been validated.
- Prisoners
- Patients less than 18 years old
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: TREATMENT
- Allocation: NA
- Interventional Model: SINGLE_GROUP
- Masking: NONE
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
OTHER: Single arm subject is own control
Posterolateral fusion is bilateral, patients will receive the Nanobone graft on the right side of their spine and the local bone graft on their left side.
|
Nanobone® Synthetic Bone Graft is a nanocrystalline hydroxyapatite imbedded in a silica gel matrix.
The nanocrystalline structure accurately replicates autologous hydroxyapatite and the silica gel matrix that rapidly transforms into an osteogenic matrix post-implantation.
NanoBone promotes remodeling by acting as a strong osteoinductive material.
NanoBone® is available as a putty.
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Radiographic Fusion
Time Frame: 12 months
|
Fusion will be defined as:
|
12 months
|
Oswestry Disability Index (ODI) 0% lowest, no disability to 100% disabled, bedridden
Time Frame: 12 months
|
Change from pre-operative score
|
12 months
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Visual Analog Scale (VAS) 0-no pain to 10-worst possible pain
Time Frame: 12 months
|
Change from pre-operative score
|
12 months
|
SF-36 (Short Form 36)
Time Frame: 12 months
|
Change from pre-operative score
|
12 months
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Principal Investigator: Patrick Connelly, MD, UMass Memorial Health Care
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (ACTUAL)
July 19, 2021
Primary Completion (ANTICIPATED)
December 1, 2024
Study Completion (ANTICIPATED)
April 1, 2025
Study Registration Dates
First Submitted
October 29, 2020
First Submitted That Met QC Criteria
October 29, 2020
First Posted (ACTUAL)
November 4, 2020
Study Record Updates
Last Update Posted (ACTUAL)
February 13, 2023
Last Update Submitted That Met QC Criteria
February 10, 2023
Last Verified
February 1, 2023
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- H0015310
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
Yes
product manufactured in and exported from the U.S.
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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