Search clinical trials for: new local drug delivery

Total 8949 results

Chinese PLA General Hospital
The Second Hospital of Hebei Medical University; Air Force Military Medical... and other collaborators

Completed

First Line Therapy for High Risk Acute GVHD

Stem Cell Transplant Complications | aGVHD

China
Merck Sharp & Dohme LLC

Completed

Evaluation of Immunogenicity and Safety of VARIVAX™ New Seed Process (NSP) in Children (V210-063)

Varicella
Glen Richardson

Withdrawn

Effect of Cutting Blades for Total Knee Arthroplasty on Implant Migration

Osteoarthritis

Canada
AbbVie (prior sponsor, Abbott)

Completed

A Study in Rheumatoid Arthritis (RA) Patients to Compare Two Formulations of Adalimumab for Pharmacokinetic, Pharmacodynamic and Safety

Rheumatoid Arthritis

United States, Belgium, Czech Republic, Germany, Puerto Rico, Romania, Slovakia
US Department of Veterans Affairs
Stanford University

Completed

Guidelines for Drug Therapy of Hypertension: Closing the Loop

Hypertension

United States
Second Affiliated Hospital of Wenzhou Medical University

Unknown

Efficacy of Perioperative Anesthesia Care Bundle on Prognosis in Elderly Undergoing Hip Fracture Surgery (EPAPHUS)

Anesthesia | Hip Fracture Surgery | Nursing

China
Johns Hopkins University
La Jolla Institute for Allergy & Immunology; Myra Reinhardt Foundation

Completed

Baked Milk Oral Immunotherapy for Cow's Milk Allergy

Cow's Milk Allergy

United States
Arne Astrup
University of Aarhus; University Hospital, Gentofte, Copenhagen; Technical University...

Completed

OPUS School Meal Study

Metabolic Syndrome X

Denmark
Bp Consulting, Inc

Completed

Masked Comparison of a New PEG Based Artificial Tear and Optive for Comfort, Vision & Wear Time in Patients Wearing Contact Lenses

Comfort, Vision and Wear Time

United States
NantBioScience, Inc.

Active, not recruiting

QUILT-2.025 NANT Neoepitope Yeast Vaccine (YE-NEO-001): Adjuvant Immunotherapy Using a Personalized Neoepitope Yeast-Based Vaccine To Induce T-Cell Responses In Subjects W/ Previously Treated Cancers.

Melanoma | Breast Cancer | Colorectal Cancer | Pancreatic Cancer | Non Small Cell Lung Cancer | Head and Neck Squamous Cell Carcinoma | Liver Cancer

United States
Delcath Systems Inc.

Terminated

Melphalan for Use With the Hepatic Delivery System Treatment in Patients With Unresectable Hepatocellular Carcinoma or Intra Hepatic Cholangiocarcinoma

Hepatocellular Carcinoma | Intrahepatic Cholangiocarcinoma

Germany
Mayo Clinic

Active, not recruiting

A Study of Detergents in the Pathogenesis of Eosinophilic Esophagitis

Eosinophilic Esophagitis

United States
Shaare Zedek Medical Center

Unknown

Safety, Tolerability and Preliminary Efficacy of Unilateral Latanoprost-loaded Punctual Plug -EXP-LP (EXP-LP)

Ocular Hypertension | Glaucoma | IOP

Israel
Mayo Clinic
George Washington University

Completed

Mobile Educations Effect on Pain Outcomes

Pain, Postoperative | Total Joint Arthroplasty

United States
Ocular Systems, Inc.
Wake Forest University

Unknown

Corneal Endothelium Delivery Instrument

Corneal Transplantation

United States
Mansoor Aman, MD

Recruiting

Prospective Evaluation of Intrathecal Targeted Drug Delivery for Cancer Associated Pain

Chronic Pain | Neuropathic Pain | Cancer Pain | Cancer Associated Pain

United States
AbbVie
Pfizer

Active, not recruiting

An Efficacy and Safety Study of Cofetuzumab Pelidotin in Participants With PTK7-Expressing, Recurrent Non-Small Cell Lung Cancer

Cancer | Non-small Cell Lung Cancer (NSCLC)

United States, Israel, Japan, Korea, Republic of, Spain, Taiwan
University of Cambridge
Cambridge University Hospitals NHS Foundation Trust

Completed

Automated Overnight Closed-loop Glucose Control in Young People With Type 1 Diabetes (APCam05)

Type 1 Diabetes

United Kingdom
University of Cambridge
Cambridge University Hospitals NHS Foundation Trust; Diabetes UK

Completed

Closing the Loop in Adults With Type 1 Diabetes (ANGELA01)

Type 1 Diabetes

United Kingdom
Sanofi

Completed

Euglycemic Clamp Study Comparing Two New Insulin Glargine Formulations in Subjects With Type 1 Diabetes Mellitus

Type1 Diabetes

Germany
National University of Singapore
KHANA Center for Population Health Research

Recruiting

Community-Based Model for Delivery of Antiretroviral Therapy in Cambodia

HIV Infections | AIDS

Cambodia
University Health Network, Toronto
Princess Margaret Hospital, Canada; Ortho Biotech, Inc.

Completed

Combination Bortezomib-containing Regimens in Newly Diagnosed Patients With t (4; 14) Positive Multiple Myeloma

Multiple Myeloma

Canada
Centre Suisse de Recherches Scientifiques en Cote...
Swiss Tropical & Public Health Institute

Unknown

Strategies to Increase Antenatal Iron and Folic Acid Supplementation and Malaria Prophylaxis (AIFASMaP)

Antenatal Care
Aimen F. Shaaban, MD

Recruiting

Trial of FETO for Severe Congenital Diaphragmatic Hernia (FETO)

Congenital Diaphragmatic Hernia

United States
Engeneic Pty Limited
Johns Hopkins University

Unknown

A Study to Evaluate the Safety, Tolerability and Immunogenicity of EGFR(V)-EDV-Dox in Subjects With Recurrent Glioblastoma Multiforme (GBM) (CerebralEDV)

Glioblastoma | Astrocytoma, Grade IV

United States
H. Lee Moffitt Cancer Center and Research Institute
National Cancer Institute (NCI); Millennium Pharmaceuticals, Inc.

Terminated

A Combination of Zarnestra With Velcade for Patients With Relapsed Multiple Myeloma

Multiple Myeloma

United States
Cancer Institute and Hospital, Chinese Academy...

Unknown

Combination of Nimotuzumab,Capecitabine and Radiotherapy for Inoperable or Recurrent Gastric Cancer

Gastric Cancer | Concurrent Chemoradiotherapy

China
Children's Hospital of Philadelphia
Pennsylvania Department of Health

Completed

Parent eReferral to Tobacco Quitline

Secondhand Smoke

United States
First Affiliated Hospital of Wenzhou Medical University

Recruiting

Development and Application of a New Balloon Catheter for Intraairway Hemostasis

Hemoptysis

China
University of Washington
National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Terminated

The College, Alcohol and Peers Study (CAPS)

Alcohol Drinking

United States
Population Council

Completed

An Open-label Study to Evaluate the Effects of Concurrent Administration of Vaginal Antimycotic Medication Miconazole Nitrate on the Pharmacokinetics of Nestorone and Ethinyl Estradiol Delivered by a Contraceptive Vaginal Ring in Normal Ovulating Women

Antifungal Drug Adverse Reaction

United States
University Hospital, Strasbourg, France

Terminated

A Comparative Study of the Effect of Two Partographs on the Cesarean Section Rate in Women in Spontaneous Labour (PARTODYS)

Dystocia

France
Boston Children's Hospital
Tufts Medical Center; University of Vermont; Cambridge Health Alliance; Fallon... and other collaborators

Completed

Screening and Brief Advice to Reduce Teen Substance Use

Substance Related Disorders

United States, Czechia
Alcon Research

Completed

Pharmacokinetic and Safety Study of Travoprost 0.004% in Pediatric Glaucoma Patients

Ocular Hypertension | Glaucoma
TaiGen Biotechnology Co., Ltd.

Completed

Study to Evaluate the PK, Relative Bioavailability and Safety of TG-2349 With Single Oral Dose Under Fed Condition in Healthy Volunteers

Healthy

United States
University of Miami
Pacira Pharmaceuticals, Inc

Withdrawn

Post-Operative Pain Management Following Spine Surgery (EXPAREL)

Analgesia | Pain Management | Anesthetic

United States
Imperial College London

Completed

Clinical Assessment of a Closed-loop Insulin Delivery System

Type 1 Diabetes Mellitus

United Kingdom
Joon Oh Park

Recruiting

Multi-center, Open-label, Phase 1b Clinical Trial to Evaluate the Safety, Tolerability, and Exploratory Efficacy of TEW-7197 in Combination With FOLFOX in Patients With Metastatic Pancreatic Ductal Adenocarcinoma Who Have Failed First-Line Gemcitabine and Nab-Paclitaxel (MP-PDAC-01)

Metastatic Pancreatic Cancer

Korea, Republic of
Federal University of Paraíba
Unilever R&D

Completed

Efficacy of a Whitening Dentifrice on Tooth Discoloration

Tooth Discoloration
Indonesia University

Completed

Fractionated Vs Single Dose Injection for Spinal C-Section in Patients With Pregnancy-Induced Hypertension

Pregnancy Induced Hypertension

Indonesia
Tandem Diabetes Care, Inc.

Completed

Adaptation of Insulin Delivery Settings to Improve Clinical Outcomes With AID Use

Type 1 Diabetes

United States
Singapore Institute for Clinical Sciences

Recruiting

Postbiotic Intervention for Acute Stress Management (PIAS)

Sleep | Stress Response | Cognition | Mood State

Singapore
Mati Therapeutics Inc.

Completed

Safety and Intraocular Lowering Effect of Delivery of Travoprost Evolute® in Subjects With Elevated Intraocular Pressure

Elevated Intraocular Pressure (IOP)

United States
Ministry of Health, Brazil
Hospital de Clinicas de Porto Alegre; Instituto de Cardiologia do Rio Grande... and other collaborators

Terminated

Cell Therapy in Myocardial Infarction (EMRTCC)

Acute Myocardial Infarction

Brazil
Janssen Scientific Affairs, LLC

Completed

Research and Evaluation of Antipsychotic Treatment in Community Behavioral Health Organizations

Schizophrenia | Bipolar Disorder

United States
University of Washington

Completed

Randomized Trial to Evaluate Suppressive Effect of High-Dose Acyclovir Versus Once-Daily Valacyclovir on Persons With HSV-2

Genital Herpes

United States
University of Michigan

Completed

Tackling 30-day Readmissions in Patients With Cirrhosis: The SALTYFOOD Trial

Liver Diseases | Hepatic Encephalopathy | Cirrhosis | Ascites

United States
Peking Union Medical College Hospital

Recruiting

A Study on the Safety and Effectiveness of Temozolomide for Neoadjuvant Treatment of PPGL

Pheochromocytoma | Paraganglioma

China
Sangamo Therapeutics

Completed

Safety and Efficacy of CERE-120 in Subjects With Parkinson's Disease

Idiopathic Parkinson's Disease

United States
London School of Hygiene and Tropical Medicine
DBL -Institute for Health Research and Development

Completed

Different Approaches for Delivery of IPT in Pregnancy in Burkina Faso

Birth Weight | Anaemia | Malaria Parasitaemia

Burkina Faso

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