Search clinical trials for: recombinant human Epidermal Growth Factor (rhEGF)

Total 873 results

Daewoong Pharmaceutical Co. LTD.

Completed

Efficacy and Safety of rhEGF in Diabetic Foot Ulcer Patients With Uncontrolled Diabetic Mellitus

Diabetic Foot Ulcer Patients With Uncontrolled Diabetes Mellitus

Korea, Republic of
The Immunobiological Technology Institute (Bio-Manguinhos)...

Active, not recruiting

Efficacy and Safety Evaluation of the Intralesional Recombinant Human Epidermal Growth Factor (rhEGF) in Subjects With Diabetic Foot Ulcer.

Foot Ulcer, Diabetic | Epidermal Growth Factor
Children's Oncology Group
National Cancer Institute (NCI)

Withdrawn

Palifermin in Preventing Oral Mucositis Caused by Chemotherapy and/or Radiation Therapy in Young Patients Undergoing Stem Cell Transplant

Malignant Neoplasm | Gastrointestinal Mucositis
Martin, Paul
National Cancer Institute (NCI)

Completed

Palifermin in Preventing Chronic Graft-Versus-Host Disease in Patients Who Have Undergone Donor Stem Cell Transplant for Hematologic Cancer

Primary Myelofibrosis | Stage I Multiple Myeloma | Stage II Multiple Myeloma | Stage III Multiple Myeloma | Chronic Myelomonocytic Leukemia | Recurrent Adult Acute Myeloid Leukemia | Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Nodal Marginal Zone B-cell Lymphoma | Recurrent Adult Burkitt Lymphoma and other conditions

United States
Dompé Farmaceutici S.p.A

Completed

Evaluation of Safety and Efficacy of rhNGF in Patients With Stage 2 and 3 Neurotrophic Keratitis. (REPARO)

Keratitis | Neurotrophic Keratitis | Corneal Ulcer

Germany, Italy, France, Poland, Spain, United Kingdom
Dompé Farmaceutici S.p.A

Completed

A Dose Ranging Study to Evaluate the Safety and Potential Efficacy of rhNGF in Patients With Retinitis Pigmentosa (RP) (Lumos)

Retinitis Pigmentosa

Italy
Dompé Farmaceutici S.p.A
Cross Research S.A.

Completed

Safety and Efficacy of rhNGF Eye Drops at Different Doses in Patients With Dry Eye

Dry Eye Syndrome

Austria
EMD Serono Research & Development Institute, Inc.
Nordic Bioscience A/S

Completed

A Study to Investigate the Safety and Effectiveness of Different Doses of Sprifermin in Participants With Osteoarthritis of the Knee (FORWARD)

Osteoarthritis, Knee

Estonia, Romania, Hong Kong, Czechia, Denmark, Poland, Argentina, United States
Merck KGaA, Darmstadt, Germany

Completed

A Multicenter Study of rhFGF 18 in Patients With Knee Osteoarthritis Not Requiring Surgery

Knee Osteoarthritis

Germany, Croatia, Bulgaria, Canada, Finland, Poland, Serbia, South Africa, Sweden
Dasman Diabetes Institute
Cuban Center for Genetic Engineering and Biotechnology

Completed

Efficacy and Safety of Heberprot-P® in Patients With Advanced Diabetic Foot Ulcer in Dasman Diabetes Institute.

Diabetic Foot
Ennar Pharmaceuticals AF
University of Zurich

Unknown

A Physiological Study on Downregulation of EGF-receptors in the Skin by Topical Exposition With EGF (EGFR)

Plaque Psoriasis

Switzerland
Beijing Tongren Hospital

Recruiting

The Phase I Study of Recombinant Human Nerve Growth Factor Injection

Injury of Optic Nerve

China
Roswell Park Cancer Institute

Recruiting

A Vaccine (CIMAvax-EGF) for the Prevention of Lung Cancer Development or Recurrence

Pneumonia | Chronic Obstructive Pulmonary Disease | Lung Non-Small Cell Carcinoma | Stage II Lung Cancer AJCC v8 | Stage IIA Lung Cancer AJCC v8 | Stage IIB Lung Cancer AJCC v8 | Stage IIIA Lung Cancer AJCC v8 | Stage IB Lung Cancer AJCC v8

United States
G. d'Annunzio University

Completed

An 8-week Follow-up to Evaluate the Renewal of Corneal Nerves Structure and Function in Patients With Neurotrophic Keratopathy Treated With Recombinant Human Nerve Growth Factor (rhNGF) Eyedrops

Neurotrophic Keratopathy

Italy
Ospedale San Raffaele
Dompé Farmaceutici S.p.A

Completed

Nerve Growth Factor Eye Drops Treatment in Patients With Retinitis Pigmentosa and Cystoid Macular Edema (NEMO)

Retinitis Pigmentosa | Cystoid Macular Edema

Italy
Dompé Farmaceutici S.p.A
Covance

Completed

Study to Evaluate Safety, Tolerability and Pharmacokinetics of rhNGF Eye Drops in Healthy Volunteers (NGF0112)

Healthy

Switzerland, United Kingdom
Massachusetts General Hospital

Completed

Effects of rhIGF-1 on Bone Metabolism in Adolescent Girls With Anorexia Nervosa (814)

Disorder of Bone Density and Structure, Unspecified

United States
Roswell Park Cancer Institute

Recruiting

CIMAvax Vaccine, Nivolumab, and Pembrolizumab in Treating Patients With Advanced Non-small Cell Lung Cancer or Squamous Head and Neck Cancer

Metastatic Lung Non-Small Cell Carcinoma | Stage IVA Lung Cancer AJCC v8 | Stage IVB Lung Cancer AJCC v8 | Lung Non-Small Cell Carcinoma | Stage III Lung Cancer AJCC v8 | Stage IV Lung Cancer AJCC v8 | Stage IIIA Lung Cancer AJCC v8 | Stage IIIB Lung Cancer AJCC v8 | Recurrent Head and Neck Squamous... and other conditions

United States
CardioVascular BioTherapeutics, Inc.

Not yet recruiting

Fibroblast Growth Factor-1 (FGF-1) for the Treatment of Coronary Heart Disease

Myocardial Ischemia | Coronary Disease | Coronary Heart Disease | Coronary Arteriosclerosis
Luye Pharma Group Ltd.
Shan Dong Boan Biotechnology Co., Ltd(Co-sponsor)

Not yet recruiting

A Study to Compare LY09004 and Eylea in the Treatment of Wet Age-related Macular Degeneration（wAMD）

Age Related Macular Degeneration
Novo Nordisk A/S

Completed

Incidence/Magnitude-Haemorrhagic Progression-Cerebral Contusions and Identification (ID) of Safety Issues After Traumatic Brain Injury

Trauma | Acquired Bleeding Disorder

United States, Canada
Novo Nordisk A/S

Completed

Bioequivalence of NovoSeven® and a NovoSeven® Formulation Stable at Room Temperature in Healthy Male Subjects

Healthy | Congenital Bleeding Disorder | Haemophilia A With Inhibitors | Haemophilia B With Inhibitors | Acquired Bleeding Disorder | Acquired Haemophilia | Congenital FVII Deficiency | Glanzmann's Disease

France
Novo Nordisk A/S

Completed

Recombinant Factor VIIa in Acute Intracerebral Haemorrhage

Acquired Bleeding Disorder | Intracerebral Haemorrhage

Spain, Sweden, Singapore, Norway, Italy, Switzerland, Australia, Austria, Belgium, Canada, Denmark, Finland, Germany, Netherlands, United Kingdom
Novo Nordisk A/S

Completed

Dose Response to Recombinant Factor VIIa When Administered for Bleed

Healthy | Congenital Bleeding Disorder

United States
Novo Nordisk A/S

Completed

Intra-subject Variability Following Administrations of Activated Recombinant Human Factor VII in Haemophilia Patients in a Non-bleeding State

Congenital Bleeding Disorder | Haemophilia A | Haemophilia B

France, Israel, Germany
Boston Children's Hospital
International Rett Syndrome Foundation

Completed

Treatment of Rett Syndrome With Recombinant Human IGF-1

Rett Syndrome

United States
Novo Nordisk A/S

Completed

Efficacy and Safety of Activated Recombinant Human Factor VII in Refractory Haemorrhagic Cystitis

Other Haemostasis Disorder | Haemorrhagic Cystitis

United States
Novo Nordisk A/S

Terminated

Use of Activated Recombinant Human Factor VII in Cardiac Surgery

Acquired Bleeding Disorder | Cardiac Surgery Requiring Cardiopulmonary Bypass

United States, Spain, Germany, Sweden, United Kingdom, Argentina, Italy, Brazil, Denmark, France, India, Malaysia, Singapore, South Africa
Novo Nordisk A/S

Completed

High Dose of Activated Recombinant Human Factor VII for Treatment of Mild/Moderate Joint Bleeds in Haemophilia Patients With Inhibitors

Congenital Bleeding Disorder | Haemophilia A With Inhibitors | Haemophilia B With Inhibitors

France, United Kingdom, Spain, Israel, Poland, Turkey, Hungary
Novo Nordisk A/S

Completed

Observational Study on Safety and Efficacy of NovoSeven® in Subjects With Congenital FVII Deficiency

Congenital Bleeding Disorder | Congenital FVII Deficiency

Japan
Novo Nordisk A/S

Completed

Use of NovoSeven® in Active Variceal Bleeding

Cirrhosis | Acquired Bleeding Disorder

Germany, United Kingdom, Spain, Taiwan, France, Italy, Austria, Czech Republic, Poland, Denmark, Finland, Hong Kong
Novo Nordisk A/S

Completed

Safety and Preliminary Efficacy of Recombinant Activated Factor VII in Subjects With Traumatic Brain Injury

Trauma | Acquired Bleeding Disorder

India, Spain, Canada, Finland, Germany, Israel, Italy, Netherlands, Singapore, Switzerland, Taiwan
Novo Nordisk A/S

Withdrawn

Evaluation of Recombinant Factor VIIa in Patients With Severe Bleeding Due to Trauma

Trauma | Acquired Bleeding Disorder

United States
American Scitech International
Johnson & Johnson

Unknown

Efficacy of R-Pdf/Gbb in Healing Wounds Caused by Third Degree Thermal and Electrical Burns

Burns | Electric Burns

United States
Institute of Dermatology, Thailand
Chumsaeng Chumsaengsri

Active, not recruiting

The Effectiveness of Epidermal Growth Factor Serum in Improve Facial Skin Hydration, Elasticity, Pigmentation, and Wrinkles.

Aging

Thailand
Huabo Biopharm Co., Ltd.

Completed

A Study of Single Intravitreal Injection HB002.1M in Subjects With Neovascular Age-Related Macular Degeneration

Neovascular Age-Related Macular Degeneration

China
Ache Laboratorios Farmaceuticos S.A.

Unknown

Non-inferiority Evaluation of Pain Intensity After Biomatrop (Somatropin) Application in Relation to Hormotrop (Somatropin), in Healthy Subjects

Healthy Subjects

Brazil
Novo Nordisk A/S

Completed

Safety and Preliminary Efficacy of Activated Recombinant Human Factor VII in Acute Intracerebral Haemorrhage

Acquired Bleeding Disorder | Intracerebral Haemorrhage

Finland, Singapore, Australia, Spain, Denmark, Germany, Italy, Taiwan, United Kingdom
Novo Nordisk A/S

Completed

Safety and Tolerability of Intravenous Doses of Activated Recombinant Human Factor VII in Healthy Volunteers

Healthy | Congenital Bleeding Disorder | Haemophilia A With Inhibitors | Haemophilia B With Inhibitors

France
Novo Nordisk A/S

Completed

Safety and Preliminary Efficacy of Activated Recombinant Human Factor VII for Preventing Early Hematoma Growth in Acute Intracerebral Haemorrhage

Acquired Bleeding Disorder | Intracerebral Haemorrhage

United States
Novo Nordisk A/S

Completed

Efficacy and Safety of Activated Recombinant Human Factor VII in Severely Injured Trauma Patients

Trauma | Acquired Bleeding Disorder

Germany, Austria, Israel, France, Canada, Singapore, South Africa, Australia, United Kingdom
M.D. Anderson Cancer Center
Amgen

Terminated

Phase I/II Trial rHuKFG for the Treatment of Steroid Refractory Gastrointestinal Acute GVHD

Acute Graft Versus Host Disease

United States
Acorda Therapeutics

Completed

Single Ascending Doses of GGF2 in Patients With Left Ventricular Dysfunction and Symptomatic Heart Failure (GGF2-1101-1)

Heart Failure

United States
Kyoto University, Graduate School of Medicine

Unknown

Phase I/II Study of Recombinant Human Hepatocyte Growth Factor in Fulminant Hepatic Failure

Liver Failure, Acute

Japan
Bioven Sdn. Bhd.

Terminated

Vaccine Therapy in Treating Patients With Non-Small Cell Lung Cancer (NSCLC) Stages IIIB/IV (NSCLC)

Non-small-cell Lung Cancer (NSCLC) Stage IIIb/IV

Malaysia
Bioverativ Therapeutics Inc.
Swedish Orphan Biovitrum

Completed

Study of Recombinant Factor IX Fc Fusion Protein (rFIXFc) in Participants With Hemophilia B

Severe Hemophilia B

Sweden, United States, France, Italy, Russian Federation, United Kingdom, Germany, China, Poland, Japan, Australia, Brazil, Canada, India, South Africa, Hong Kong, Belgium
National Institute of Allergy and Infectious Diseases...

Completed

A Phase II, Double-Blind Trial of Recombinant Human Nerve Growth Factor for Treatment of HIV-Associated Sensory Neuropathy

HIV Infections | Peripheral Nervous System Disease

United States
Amgen

Completed

Recombinant Human Keratinocyte Growth Factor to Reduce Oral Mucositis in Hematologic Malignancy Patients Undergoing Peripheral Blood Stem Cell Transplantation After Radiation and High-dose Chemotherapy

Stomatitis
The Affiliated Hospital of Qingdao University

Completed

Pharmacokinetic Study of Recombinant Monoclonal Antibody Against Human Epidermal Growth Factor Receptor Injection

Healthy Volunteers

China
University of Michigan

Completed

Recombinant Human Keratinocyte Growth Factor in Unrelated and Related Transplants

Graft Versus Host Disease

United States

Search clinical trials for: recombinant human Epidermal Growth Factor (rhEGF)

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