Search clinical trials for: tazobactam sodium

Total 10649 results

Coordinación de Investigación en Salud, Mexico
Instituto Mexicano del Seguro Social; Hospital Infantil de Mexico Federico... and other collaborators

Completed

Efficacy of Betalactam Antibiotics in Prolonged Infusion Compared to Intermittent in Pediatric Patients With Sepsis

Sepsis

Mexico
Rambam Health Care Campus
Hadassah Medical Organization; Rabin Medical Center; The Chaim Sheba Medical...

Suspended

PipEracillin/Tazobactam Versus mERoPENem for Treatment of AmpC Producing Blood Stream Infections (SPICE-M)

Bacteremia | Enterobacteriaceae Infections | Beta Lactam Resistant Bacterial Infection

Israel
Hamad Medical Corporation
Merck Sharp & Dohme LLC

Withdrawn

CEFtolozane-Tazobactam for the Empiric Anti-bacterial Treatment of Neutropenic Fever in Hematology Patients (CEF-10)

Hematologic Cancer | Neutropenia, Febrile

Qatar
Memorial Sloan Kettering Cancer Center
Johns Hopkins University; Massachusetts General Hospital; Fox Chase Cancer Center and other collaborators

Active, not recruiting

Does Cefoxitin or Piperacillin-Tazobactam Prevent Postoperative Surgical Site Infections After Pancreatoduodenectomy?

Pancreatic Cancer | Pancreatic Diseases | Pancreas Cancer

United States, Canada
Karolinska University Hospital

Recruiting

Pharmacokinetics of Piperacillin and Meropenem in ICU Patients

Antibiotic Pharmacokinetics

Sweden
Phoenix Children's Hospital

Completed

Two Different Antibiotics Versus One Antibiotic for Pediatric Perforated Appendicitis

Postoperative Infection | Perforated Appendicitis

United States
Assistance Publique - Hôpitaux de Paris

Recruiting

Piperacillin-tazobactam and Temocillin as Carbapenem-alternatives for the Treatment of Severe Infections Due to Extended-spectrum Beta-lactamase-Producing Gram-negative Enterobacteriaceae in the Intensive Care Unit (PITAGORE)

Sepsis | Septic Shock

France
The University of Queensland

Completed

Trial of Meropenem Versus Piperacillin-Tazobactam on Mortality and Clinial Response (MERINO II)

Bloodstream Infections

Singapore, Australia
The University of Queensland
Merck Sharp & Dohme LLC

Withdrawn

Ceftolozane-tazobactam Versus Meropenem for ESBL and AmpC-producing Enterobacterales Bloodstream Infection (MERINO III)

Bacteremia Caused by Gram-Negative Bacteria

Spain, Australia, Singapore, Italy, Saudi Arabia
University Ghent
King Baudouin Foundation; Belgische Vereniging voor Strijd tegen Mucoviscidose

Terminated

LC-MS/MS Based Method Development for the Monitoring of Antibiotic Concentrations in Sputum of Cystic Fibrosis Patients

Cystic Fibrosis

Belgium
Allecra
Medpace, Inc.

Completed

Safety and Efficacy Study of Cefepime-AAI101 in the Treatment of Complicated Urinary Tract Infections

Urinary Tract Infections

United States, Serbia, Hungary, Estonia, South Africa, Belarus, Poland, Ukraine, Argentina, Bulgaria, Croatia, Georgia, Latvia, Lithuania, Mexico, Peru, Russian Federation, Slovakia, Spain
Fundación Pública Andaluza para la gestión de la...

Unknown

Monitoring of Ceftolozane-Tazobactam Plasmatic Levels in Critical Patients

Serious Infection

Spain
Janssen Research & Development, LLC

Completed

A Crossover Study to Assess the Effect of Intravenous Infusion of Piperacillin/Tazobactam on the Pharmacokinetics of Orally Administered Lumicitabine (JNJ-64041575) in Healthy Adult Participants

Healthy

Belgium
Qilu Pharmaceutical Co., Ltd.

Not yet recruiting

Meropenem-FL058 Phase 2 Study in the Treatment of Complicated Urinary Tract Infections

Acute Pyelonephritis | Complicated Urinary Tract Infection
Centre Hospitalier Universitaire de Besancon

Unknown

PK/PD of Extended-infusion Meropenem, Piperacillin-tazobactam and Cefepime in the Early Phase of Septic Shock (PAACS)

Septic Shock

France
Merck Sharp & Dohme LLC

Completed

MK-7625A Versus Meropenem in Pediatric Participants With Complicated Urinary Tract Infection (cUTI) (MK-7625A-034)

Pyelonephritis | Complicated Urinary Tract Infection

United States, Mexico, Russian Federation, Turkey, Greece, Hungary, Poland, Romania, South Africa, Ukraine
The University of Queensland
Australasian Society for Infectious Diseases; International Society of Chemotherapy and other collaborators

Terminated

RCT Meropenem vs Piperacillin-Tazobactam for Definitive Treatment of BSI's Due to Ceftriaxone Non-susceptible Escherichia Coli and Klebsiella Spp. (MERINO)

Bloodstream Infections

Australia, Singapore, South Africa, Italy, Saudi Arabia, Canada, Lebanon, New Zealand, Turkey
Semmelweis University

Unknown

Ceftolozane-tazobactam for the Treatment of Respiratory Infections Due to Extensively Drug-resistant Pseudomonas Aeruginosa Among Critically Ill Patients: a Retrospective Study.

Ventilator Associated Pneumonia | Antibiotic Resistant Infection

Hungary
Fundación Pública Andaluza para la gestión de la...

Unknown

Monitoring of Piperacillin-Tazobactam and Meropenem Plasmatic Levels in Critical Patients

Sepsis | Septic Shock

Spain
University of Delaware

Completed

Adverse Neurogenic Actions of Dietary Salt

Blood Pressure

United States
Hospital Universitari de Bellvitge
Baxter Healthcare Corporation

Completed

Antibiotic Plasma Concentrations During Continuous Renal Replacement Therapy With a High Adsorption Membrane (oXiris®)

Sepsis | Acute Kidney Injury | Hemodiafiltration

Spain
Ospedale San Carlo Borromeo
Associazione Oncologica Milanese AmoLaVita ONLUS

Not yet recruiting

Antibiotics Continuous Infusion at Home (TAID)

Severe Bacterial Infections

Italy
Tel-Aviv Sourasky Medical Center

Unknown

Short vs Prolonged Antibiotic Treatment for Hospitalized Hemato-oncology Patients With Febrile Neutropenia (RR)

Fever | Febrile Neutropenia

Israel
M.D. Anderson Cancer Center
National Cancer Institute (NCI); Merck Sharp & Dohme LLC

Completed

Comparative Study To Determine The Efficacy, Safety, And Tolerability Of Ceftolozane-Tazobactam

Other Infectious Diseases

United States
Merck Sharp & Dohme LLC

Recruiting

Safety and Pharmacokinetics of Ceftolozane/Tazobactam in Pediatric Participants With Nosocomial Pneumonia (MK-7625A-036)

Nosocomial Pneumonia

United States, Estonia, Greece, Spain, Ukraine, Chile, Russian Federation, Colombia, Mexico
Texas Tech University Health Sciences Center
Merck Sharp & Dohme LLC

Terminated

Pharmacokinetics of Ceftolozane/Tazobactam in Patients With Burns

Burns | Pharmacokinetics

United States
Emilio Bouza
Merck Sharp & Dohme LLC

Unknown

In Vitro Activity of Ceftolozane/Tazobactam and Imipenem/Relebactam in Clinical Isolates of Pseudomonas Aeruginosa and Enterobacterales Collected From Hematology and Oncology Patients (ACTHEON)

Ceftolozane/Tazobactam | Imipenem/Relebactam | Hematology and Oncology

Spain
Memorial Sloan Kettering Cancer Center

Recruiting

Choosing the Best Antibiotic to Protect Friendly Gut Bacteria During the Course of Stem Cell Transplant

Febrile Neutropenia | Intestinal Microbiome

United States
Royal Brisbane and Women's Hospital
The University of Queensland

Completed

Pharmacokinetics of Ceftolozane/Tazobactam in Plasma and Cerebrospinal Fluid

Pharmacokinetics

Australia
Melinta Therapeutics, Inc.

Withdrawn

A Study of Meropenem-Vaborbactam Versus Piperacillin/Tazobactam in Participants With Hospital-Acquired and Ventilator-Associated Bacterial Pneumonia (TANGOIII)

Hospital-Acquired Bacterial Pneumonia | Ventilator-Associated Bacterial Pneumonia | Hospital-Acquired Pneumonia | Ventilator-Associated Pneumonia
University Hospital, Montpellier

Completed

Pharmacokinetic of Doripenem and Piperacillin/Tazobactam in More Than 120 kg Critically Ill Patients

Septic Shock

France
Hospital Universitari de Bellvitge
Institut d'Investigació Biomèdica de Bellvitge; Instituto de Salud Carlos III

Recruiting

Efficacy of Extended Infusion of β-lactam Antibiotics for the Treatment of Febrile Neutropenia in Hematologic Patients (BEATLE)

Febrile Neutropenia

Spain
Wyeth is now a wholly owned subsidiary of Pfizer

Completed

Study Evaluating Vancomycin-Resistant Enterococci in a Hematology Unit

Gram-Positive Bacterial Infections

Korea, Republic of
Case Comprehensive Cancer Center

Recruiting

eXtended Antibiotic Prophylaxis for Intermediate- and High-risk Glands After Pancreatoduodenectomy to Reduce CR-POPF

Pancreatic Fistula

United States
University of Florida
Food and Drug Administration (FDA)

Terminated

BL Infusion Trial:Beta-lactam Continuous Versus Intermittent Infusion and Associated Bacterial Resistance and Therapy Outcomes in Critically Ill Patients With Severe Pneumonia

Pneumonia

United States
Gruppo Italiano per la Valutazione degli Interventi...

Completed

AbioKin - Antibiotic Kinetics

Critical Illness | Infection

Italy
Joseph L. Kuti, PharmD
Cubist Pharmaceuticals LLC; Indiana University Health; University of North Carolina and other collaborators

Completed

Population Pharmacokinetics and Safety of Intravenous Ceftolozane/Tazobactam in Adult Cystic Fibrosis Patients

Cystic Fibrosis | Cystic Fibrosis Pulmonary Exacerbation | Pseudomonas Aeruginosa Infection

United States
Cubist Pharmaceuticals LLC

Completed

Safety and Efficacy Study of Ceftolozane/Tazobactam to Treat Ventilated Nosocomial Pneumonia (MK-7625A-008) (ASPECT-NP)

Lung Diseases | Healthcare-Associated Pneumonia | Ventilator-Associated Pneumonia
University Hospital, Rouen

Recruiting

Population Pharmacokinetic Modeling to Optimize the Dosage of the Piperacillin / Tazobactam Combination in Patients With Sepsis in Intensive Care (OPT-TAZ)

Resuscitation Patients With Sepsis

France
Wockhardt
Clinartis

Completed

A Single-dose Study to Investigate the Pharmacokinetics of Intravenous FEP-TAZ in Patients With Renal Impairment

Renal Impairment

United States
McMaster Children's Hospital

Not yet recruiting

Piperacillin/Tazobactam Versus ceftriAxone and Metronidazole for Children With Perforated Appendicitis (ALPACA) (ALPACA)

Appendicitis Perforated
Menarini Group

Terminated

Delafloxacin IV and OS Administration Compared to Best Available Therapy in Patients With Surgical Site Infections (DRESS)

Surgical Site Infection

Italy
Hartford Hospital
Merck Sharp & Dohme LLC

Completed

Tissue Penetration of Ceftolozane/Tazobactam in Diabetic Patients With Lower Limb Infections

Diabetes | Healthy Volunteers | Wound Infection

United States
Yuhan Corporation

Terminated

A Clinical Trial of YH1177 in Patients With Otitis Media and Otorrhea

Otitis Media | Otorrhea

Korea, Republic of
University Hospital Tuebingen

Terminated

Steady State Serum and Epithelial Lining Fluid (ELF) Antibiotics Concentrations Under Continous Infusion

Pneumonia | Bacteremia

Germany
Tri-Service General Hospital

Completed

A Single-Dose Pharmacokinetics Study of Tapimycin Injection

Healthy
First Affiliated Hospital Xi'an Jiaotong University
Second Affiliated Hospital of Xi'an Jiaotong University

Completed

Safety and Efficacy of Vancomycin Plus Beta-lactams (SEVPB)

Critical Illness

China
Forest Laboratories

Terminated

Comparative Study of Ceftazidime-Avibactam Versus Standard of Care as Therapy in Febrile Neutropenic Adults With Cancer

Neoplasms | Febrile Neutropenia

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Withdrawn

Fecal Transplant +/- Gut Decontamination in Preventing Acute Graft Versus Host Disease in Patients Given Broad-Spectrum Antibiotics

Graft-versus-host Disease Prevention

United States
Merck Sharp & Dohme LLC

Completed

Ceftolozane/Tazobactam (MK-7625A) Plus Metronidazole Versus Meropenem for Participants With Complicated Intra-abdominal Infection (MK-7625A-015) (7625ACNPhase3)

Complicated Intra-abdominal Infections

China

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