Clinical Trials Sponsored by Bill & Melinda Gates Medical Research Institute

Total 239 results

Bill & Melinda Gates Medical Research Institute

Not yet recruiting

Study To Evaluate Safety, Tolerability, and Pharmacokinetics of MAM01 in African Population

Healthy Volunteers

Kenya, Uganda
Bill & Melinda Gates Medical Research Institute

Recruiting

Safety, Tolerability, Pharmacokinetics and Protective Efficacy of MAM01 in Healthy Adults

Malaria

United States
Bill & Melinda Gates Medical Research Institute

Active, not recruiting

Impact of Bi-26 Supplementation on Weight Gain in Underweight Infants

Underweight | Paediatrics

Pakistan
Bill & Melinda Gates Medical Research Institute

Completed

Early Bactericidal Activity of TBA-7371 in Pulmonary Tuberculosis

Pulmonary Tuberculosis

South Africa
Bill & Melinda Gates Medical Research Institute

Terminated

A Trial to Evaluate Safety and Efficacy of Rivaroxaban (COVID-19)

COVID-19

United States, United Kingdom
Bill & Melinda Gates Medical Research Institute

Active, not recruiting

Epidemiologic Study to Assess the IGRA Positivity in Populations With a High TB Burden

Tuberculosis, Pulmonary

South Africa, Bangladesh, Brazil, India, Indonesia, Mozambique, Zambia, Congo, The Democratic Republic of the, Gambia, Kenya, Peru, Philippines, Uganda, Vietnam
Bill & Melinda Gates Medical Research Institute

Active, not recruiting

Bacille Calmette Guerin (BCG) Revaccination of Healthy Adolescents for the Prevention of Mycobacterium Tuberculosis Sustained Infection

Tuberculosis

South Africa
Bill & Melinda Gates Medical Research Institute
Bill and Melinda Gates Foundation; Wellcome Trust

Recruiting

Study to Assess Efficacy and Safety of M72/AS01E-4 Mycobacterium Tuberculosis (Mtb) Vaccine in Adolescents and Adults

Tuberculosis

Indonesia, Kenya, South Africa, Vietnam, Malawi, Mozambique, Zambia
Bill & Melinda Gates Medical Research Institute
Wellcome Trust

Completed

Safety and Immunogenicity of a Mycobacterium Tuberculosis Vaccine M72/AS01E in Participants With Well-controlled HIV (MESA-TB)

Human Immunodeficiency Virus

South Africa
Bill & Melinda Gates Medical Research Institute
Iqvia Pty Ltd

Withdrawn

Proof of Concept Trial of Adjuvant Activity of SWE, a Squalene-based -Oil-in-water Emulsion

Influenza
Bill & Melinda Gates Medical Research Institute
Merck Sharp & Dohme LLC

Recruiting

Safety, Tolerability, Pharmacokinetics (PK), and Food Effect of MK-7762 in Healthy Adults

Tuberculosis

United States
St. John's Research Institute
Bill and Melinda Gates Foundation

Completed

m-Health System for Tracking Kangaroo Mother Care and Temperature in Southern India

Fever | Preterm Infant | Hypothermia, Newborn | Kangaroo Mother Care | Low Birth Weight Infant

India
Bill & Melinda Gates Medical Research Institute
PPD Phase I Clinic - Orlando

Completed

Safety, Tolerability, and Pharmacokinetics of RSV Monoclonal Antibody RSM01 in Healthy Adults

RSV Infection

United States
International Food Policy Research Institute
Bill and Melinda Gates Foundation

Recruiting

Improving Birth Outcomes in Bangladesh

Birth Weight | Gestational Weight Gain | Diet; Deficiency | Small for Gestational Age at Delivery

Bangladesh
Massachusetts General Hospital
Bill and Melinda Gates Foundation; Kenya Medical Research Institute

Active, not recruiting

The KEN SHE Study on HPV-vaccine Efficacy

Papillomavirus Infections

Kenya
Radboud University Medical Center
Bill and Melinda Gates Foundation

Completed

Chemoprophylaxis and Plasmodium Falciparum NF54 Sporozoite Immunization Challenged by Heterologous Infection (BMGF2b)

Malaria

Netherlands
Radboud University Medical Center
Bill and Melinda Gates Foundation

Completed

Target Antigens Induced by Plasmodium Falciparum Sporozoite Immunization Under Chemoprophylaxis (BMGF1)

Malaria

Netherlands
D'Or Institute for Research and Education
Bill and Melinda Gates Foundation

Active, not recruiting

Assessment of Immunogenicity, Safety and Reactogenicity of a Booster Dose of Various COVID-19 Vaccine Platforms in Individuals Primed With Several Regimes.

COVID-19

Brazil
National Cancer Institute (NCI)
Bill and Melinda Gates Foundation

Enrolling by invitation

Comparing One or Two Doses of the Human Papillomavirus Vaccine for the Prevention of Human Papillomavirus Infection, ESCUDDO Study (ESCUDDO)

Human Papillomavirus Infection | Human Papillomavirus-Related Cervical Carcinoma

Costa Rica
Boston University
Bill and Melinda Gates Foundation; Thrasher Research Fund

Completed

Omphalitis Community Based Algorithm Validation Study (OCAVS)

Omphalitis

Zambia
Murdoch Childrens Research Institute
Bill and Melinda Gates Foundation; Royal Children's Hospital

Completed

BCG Vaccination to Protect Healthcare Workers Against COVID-19 (BRACE)

COVID-19 | Corona Virus Infection | Coronavirus Disease 2019 (COVID-19) | Respiratory Illness

Australia, Brazil, Netherlands, Spain, United Kingdom
D'Or Institute for Research and Education
Bill and Melinda Gates Foundation; Instituto Fernandes Figueira

Not yet recruiting

Immunogenicity and Safety of Heterologous and Homologous Boosting With ChAdOx1-S and CoronaVac or a Formulation of SCB-2019 (COVID-19) (TP-SCB-2019001)

Covid19

Brazil
Centers for Disease Control and Prevention
Bill and Melinda Gates Foundation; Kenya Medical Research Institute

Completed

Intermittent Preventive Treatment With Antimalarials in Kenyan Infants

Anemia | Malaria

Kenya
Centers for Disease Control and Prevention
Bill and Melinda Gates Foundation; Kenya Medical Research Institute

Completed

Evaluation of Insecticide Treated Nets and Wall Liners for the Prevention of Malaria (MTC-ITWL)

Malaria

Kenya
International Vaccine Institute
Bill and Melinda Gates Foundation; Thrasher Research Fund; Open Philanthropy

Not yet recruiting

Safety and Immunogenicity of Hecolin® in Healthy Pregnant Women

Hepatitis E Infection

Pakistan
Aga Khan University
Bill and Melinda Gates Foundation; International Food Policy Research Institute

Recruiting

Impact Evaluation of Benazir Nashonuma Program (BNP) on Stunting Among Under-five Children

Anemia | Wasting | Stunting | Nutrient Deficiency

Pakistan
Weill Medical College of Cornell University
Bill and Melinda Gates Foundation

Completed

From Obstacles to Opportunities for Male Circumcision in Tanzania

Male Circumcision

Tanzania
Serum Institute of India Pvt. Ltd.
Bill and Melinda Gates Foundation

Not yet recruiting

Clinical Study to Evaluate SIIPL qHPV Vaccine (CERVAVAC®) in Women Living With HIV Aged 15-25 Years

Human Papillomavirus Infection

Kenya, Mozambique, South Africa
U.S. Army Medical Research and Development Command
Bill and Melinda Gates Foundation; Seattle Children's Research Institute (SCRI)

Completed

Immunization Via Mosquito Bite With Radiation-attenuated Sporozoites (IMRAS)

Malaria

United States
UnitedHealth Group
Bill and Melinda Gates Foundation; Quest Diagnostics-Nichols Insitute

Completed

Impact of Swab Site and Sample Collector on Testing Sensitivity for COVID-19 Virus in Symptomatic Individuals

Cough | Fever | Infections, Respiratory

United States
Kenya Medical Research Institute
United States Agency for International Development (USAID); Bill and Melinda...

Completed

Design and Clinical Evaluation of a School Meal With Deworming Properties

Anemia | Helminthiasis | Tinea Capitis
Armed Forces Research Institute of Medical Sciences...
Bill and Melinda Gates Foundation; World Health Organization

Completed

Artemisinin Resistance in Cambodia II (ARC II)

Falciparum Malaria

Cambodia
International Centre for Diarrhoeal Disease Research...
Bill and Melinda Gates Foundation

Recruiting

Maternal Probiotic Intervention to Improve Gut Health (MPIGH)

Environmental Enteric Dysfunction | Gut Microbiota Dysbiosis

Bangladesh
International Centre for Diarrhoeal Disease Research...
Bill and Melinda Gates Foundation

Active, not recruiting

Saving Lives With Better Gestational Age Estimation

Premature Birth

Bangladesh
International Centre for Diarrhoeal Disease Research...
Bill and Melinda Gates Foundation

Completed

Immunological and Clinical Responses to Zinc in Children With Diarrhoea

Diarrhoea

Bangladesh
Johns Hopkins Bloomberg School of Public Health
Bill and Melinda Gates Foundation; Kenya Medical Research Institute

Completed

Mobile and Scalable Innovations for Measles Immunization: a Randomized Controlled Trial (M-SIMI)

Measles
D'Or Institute for Research and Education
Bill and Melinda Gates Foundation; University of Oxford

Not yet recruiting

An Observer-blind, Cohort Randomized, Exploratory Phase 3 Study to Evaluate the Safety and Immunogenicity of Recombinant Covid-19 Vaccine, mRNA Covid-19 Vaccine and Recombinant SARS-CoV-2 Trimeric S-protein Subunit Vaccine as 4th Dose in Individuals Primed/ Boosted With Various Regimens

COVID-19

Brazil
Statens Serum Institut
Bill and Melinda Gates Foundation; Larix A/S; CCBR Clinical Research

Completed

3 Adjuvated Reduced Dose IPV-Al SSI Vaccines and Non-adjuvated Full Dose IPV SSI, as Booster Vaccination to Adolescents

Immunization, Booster

Denmark
Children's Hospital Medical Center, Cincinnati
Bill and Melinda Gates Foundation; Syngene International

Completed

India Dexamethasone and Betamethasone

Preterm Birth | Antenatal Corticosteroids

India
Jhpiego
Bill and Melinda Gates Foundation; Addis Continental Institute of Public Health

Terminated

Ethiopia Group Antenatal Care Study at the Health Post Level (ARC004)

Antenatal Care

Ethiopia
University of Pittsburgh
Bill and Melinda Gates Foundation; MIMR-PHI Institute, Australia

Completed

Expression of IFN-epsilon in the Female Reproductive Tract (Epsilon)

Interferon Expression in the Female Reproductive Tract

United States
Jhpiego
Bill and Melinda Gates Foundation; Addis Continental Institute of Public Health

Completed

Family Led Postnatal Care in Ethiopia (FPNC)

Postnatal Complication

Ethiopia
International Vaccine Institute
Bill and Melinda Gates Foundation; SK Bioscience Co., Ltd.

Completed

Immune Equivalence Between Multi-dose and Single Dose Formulation of Vi-DT and Their Overall Safety (Phase III)

Typhoid

Philippines
International Vaccine Institute
Bill and Melinda Gates Foundation; SK Bioscience Co., Ltd.

Completed

Safety, Reactogenicity and Immunogenicity of Vi-DT;Typhoid Conjugate Vaccine

Typhoid

Philippines
University of North Carolina, Chapel Hill
Bill and Melinda Gates Foundation; FHI 360; Impact Research & Development Organization

Completed

Economic Compensation to Increase Demand for Voluntary Medical Male Circumcision (CTT-VMMC)

Voluntary Medical Male Circumcision | Circumcision Adult

Kenya
TaiMed Biologics Inc.
Bill and Melinda Gates Foundation; Aaron Diamond AIDS Research Center

Completed

Safety Study of Ibalizumab Subcutaneous Injection in Healthy Volunteers (TMB-108)

Prevention of Infection With HIV-1

United States
JSI Research & Training Institute, Inc.
Bill and Melinda Gates Foundation; Federal Ministry of Health, Nigeria

Completed

The Impact of Sulphadoxine-Pyrimethamine Use At Scale on Newborn Outcomes in Nigeria (MIPP-NG)

Malaria | Stillbirths
International Vaccine Institute
Bill and Melinda Gates Foundation; Xiamen Innovax Biotech Co., Ltd

Not yet recruiting

Immunogenicity and Safety of Hecolin® in HIV Positive/Negative Adults and in Children

Hepatitis E Virus Infection
International Centre for Diarrhoeal Disease Research...
Bill and Melinda Gates Foundation; Thrasher Research Fund

Completed

Zinc Pneumonia Outpatient Trial in Children < 2 Years

Pneumonia

Bangladesh
Ottawa Hospital Research Institute
Canadian Institutes of Health Research (CIHR); Bill and Melinda Gates Foundation and other collaborators

Unknown

Saving Mother and Baby With Text Messaging

Bleeding | Malnutrition | Infection | Complications

Canada

Clinical Trials Sponsored by Bill & Melinda Gates Medical Research Institute

Sponsors and Collaborators

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CROs in France

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