Search clinical trials for: High Dose Irinotecan

Total 38996 results

National Cancer Institute (NCI)

Recruiting

Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma

Neuroblastoma | Ganglioneuroblastoma, Nodular

United States
Memorial Sloan Kettering Cancer Center

Recruiting

Irinotecan and Temozolomide in Combination With Existing High Dose Alkylator Based Chemotherapy for Treatment of Patients With Newly Diagnosed Ewing Sarcoma

Newly Diagnosed Ewing Sarcoma

United States
Gustave Roussy, Cancer Campus, Grand Paris

Terminated

Study of Sequential High-dose Chemotherapy in Children With High Risk Medulloblastoma (HR MB-5)

High-risk Medulloblastoma

France
Memorial Sloan Kettering Cancer Center
Genentech, Inc.

Active, not recruiting

Irinotecan, Temozolomide and Bevacizumab in Combination With Existing High Dose Alkylator Based Chemotherapy for Treatment of Newly Diagnosed Patients With Desmoplastic Small Round Cell Tumor

Sarcoma | Desmoplastic Small Round Cell Tumor (DSRCT)

United States
Children's Oncology Group
National Cancer Institute (NCI)

Completed

High-Dose Combination Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Metastatic Rhabdomyosarcoma or Ectomesenchymoma

Sarcoma

United States, Canada, Australia, Switzerland, Puerto Rico
Southwest Oncology Group
National Cancer Institute (NCI)

Completed

S1201: Combination Chemo for Patients W/Advanced or Metastatic Esophageal, Gastric, or Gastroesophageal Junction Cancer

Gastric Cancer | Esophageal Cancer | Adenocarcinoma of the Gastroesophageal Junction

United States
University of California, San Francisco
Thrasher Research Fund

Completed

High-Dose 131I-MIBG Therapy Combined With Vincristine and Five Days of Irinotecan for Resistant/Relapsed Neuroblastoma

Neuroblastoma

United States
Shanghai Changzheng Hospital

Unknown

High-dose FOLFIRI in Advanced Colorectal Cancer Patients With Wild-type UGT1A1*6 and *28

Colorectal Cancer

China
Hoffmann-La Roche

Terminated

A Study of R1507 in Combination With Multiple Standard Chemotherapy Treatments in Patients With Advanced Solid Tumors

Neoplasms

United States
Fundació Institut de Recerca de l'Hospital de la...

Unknown

Study to Evaluate the Efficacy and Safety of FOLFIRI-AD in Patients With Metastatic Colorectal Cancer UGT1A Genotype 1 (FOLFIRI-AD)

Metastatic Colorectal Cancer

Spain
Colorectal Cancer Institute of the Heilongjiang...

Unknown

Standard and High Dose Irinotecan Based on UGT1A1 Genotype for First-line Treatment of Locally Advanced Colon Cancer

Colonic Neoplasms

China
Kentuckiana Cancer Institute

Completed

High Dose Camptothecin-11 (CPT-11) in Recurrent Unresectable Malignant Glioma

Malignant Glioma

United States
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate...
EMD Serono Research & Development Institute, Inc.

Not yet recruiting

Efficacy and Safety of a New Formulation of Oral Cladribine Compared With Placebo in Participants With Generalized Myasthenia Gravis (MyClad)

Generalized Myasthenia Gravis

United States, Germany
Yunpeng Liu
CSPC Ouyi Pharmaceutical Co., Ltd.

Not yet recruiting

Irinotecan Hydrochloride Liposome Combined With Capecitabine and Lenvatinib in Patients With Biliary Tract Carcinoma

Biliary Tract Carcinoma

China
University of Melbourne
Monash University; University of Adelaide; University of Sydney; The University... and other collaborators

Not yet recruiting

PLatform for Adaptive Trials In Perinatal UnitS - [Core Protocol] (PLATIPUS)

Preterm Birth
Samsung Medical Center

Recruiting

Safety of Dose Escalation in Definitive Hypofractionated Radiation Therapy and Hormone Therapy With SpaceOAR TM for Patients With High - Risk Localized Prostate Cancer (DESAR-H) (DESAR-H)

High Risk Prostate Carcinoma

Korea, Republic of
Ruijin Hospital

Not yet recruiting

The Efficacy of Allo-HSCT in ND HR-CBF-AML

Acute Myeloid Leukemia

China
University Health Network, Toronto

Not yet recruiting

A Study of High Dose Radiation Therapy for Locally Advanced Pancreatic Cancer That Responded to Initial Chemotherapy Treatment (ABLATE)

Locally Advanced Pancreatic Adenocarcinoma
Guangzhou Patronus Biotech Co., Ltd.
Yantai Patronus Biotech Co., Ltd.

Not yet recruiting

A Safety and Immunogenicity Trial of a Respiratory Syncytial Virus Vaccine, LYB005 in Healthy Adults

Respiratory Syncytial Virus (RSV) | RSV Infection
University of Palermo

Not yet recruiting

SGLT-2 Inhibitor and High-Dose Furosemide Plus Small-Volume Hypertonic Saline Solution in Acute HF (DAPA-TONIC)

Heart Failure With Reduced Ejection Fraction | Heart Failure With Preserved Ejection Fraction | Diabetes Type 2 | Heart Failure Acute
Nuritas Ltd

Recruiting

A Study to Determine the Safety and Tolerability of a Range of Doses of PeptiControl in Pre-diabetic Individuals

Overweight | Pre Diabetes

India
West China Hospital

Recruiting

Use of Bleomycin in the Sclerotherapy of Lymphatic Malformations for Pediatric Patients

Lymphatic Malformation

China
HealthPartners Institute
United States Department of Defense; Uniformed Services University of the Health...

Not yet recruiting

Measurement of Insulin Levels in the Cerebrospinal Fluid of Healthy Adults After a Single Intranasal Dose - Middle Age (INI-CSF-MA)

Healthy

United States
Jiaxing AnDiCon Biotech Co.,Ltd

Recruiting

Comparative Bioavailability Study of Tablet and Granule Formulations of ADC189 and the Study of Ultra-high Dose

Healthy Volunteer

China
China-Japan Friendship Hospital

Recruiting

The Effects of Low-Dose Versus High-Dose Intravenous IRON Therapy With Ferric DerisomaltOSE in Patients With Chronic Heart Failure and Iron Deficiency (IRONDOSE)

Heart Failure | Iron Deficiency

China
Bayer
Regeneron Pharmaceuticals

Recruiting

A Study to Learn More About How Well 8 Milligram Aflibercept Works and How Safe it is in Chinese Participants With Diabetic Macular Edema (PHOTONiC)

Diabetic Macular Edema

China, Hong Kong
N.N. Petrov National Medical Research Center of...

Recruiting

High-dose Chemotherapy as Second-line Drug Therapy for Relapsed Germ Cell Tumors (GERMAN)

Germ Cell Tumor

Russian Federation
University of Kansas Medical Center

Not yet recruiting

Dose-escalation Study of Ultra-high Dose Ablative Radiosurgery With Immunotherapy for Bulky Metastatic Cancer Patients

Solid Tumor

United States
Anqing Municipal Hospital

Recruiting

The Effect of Dexmedetomidine and Esketamine Combined Infusion Quality of Sleep Undergoing Modified Radical Mastectomy

Dexmedetomidine Plus Esketamine Affect Postoperative Sleep Quality

China
XIANG YANQUN

Not yet recruiting

Irinotecan Liposomes in Combination With Nituzumab for the Treatment of Recurrent/Metastatic Nasopharyngeal Carcinoma After Failure of First-Line or Higher Immunotherapy

Nasopharyngeal Cancer

China
Vaxxas Pty Ltd
Biomedical Advanced Research and Development Authority

Not yet recruiting

Influenza A (H7N9) Vaccine Delivered Intradermally by High-density Microarray Patch (HD-MAP) (HD-MAP)

H7N9 Influenza

Australia
Serum Institute of India Pvt. Ltd.

Recruiting

Clinical Study to Assess the Immunogenicity and Safety of Hexavalent Vaccine Containing Reduced Dose IPV

Hepatitis B Immunization | Diptheria Immunization | Tetanus Immunization | Pertussis Immunization | Haemophilus Influenzae Type B Immunization | Polio Immunization

Bangladesh, India
Tongji Hospital

Not yet recruiting

Oliceridine-Enhanced Analgesia and Recovery: A G-Protein Biased μ-Opioid Study

Postoperative Analgesia
Fondazione Policlinico Universitario Agostino Gemelli...

Not yet recruiting

Evaluation of Ultraaccelerated High Dose Rate Intrauterine Interventional Radiotherapy (EROS3)

Locally Advanced Cervical Carcinoma
University Of Perugia

Not yet recruiting

D-chiro-inositol and AUB

Abnormal Uterine Bleeding
Ohio State University

Not yet recruiting

Improvement of PPROM Management With Prophylactic Antimicrobial Therapy (iPROMPT)

Preterm Birth | Pregnancy, High Risk | Preterm Premature Rupture of Membrane

United States
Changhai Hospital
Shanghai Chest Hospital; Shanghai Changzheng Hospital; First Affiliated Hospital... and other collaborators

Recruiting

High-dose Furmonertinib in the Treatment in Patients With Advanced, Metastatic NSCLC With Progressed After First- or Second-line Treatment With Osimertinib

Non-Small Cell Lung Cancer

China
Pfizer

Recruiting

Real-World Effectiveness of High-Dose Tafamidis on Neurologic Disease Progression in Mixed-Phenotype Transthyretin Amyloid Cardiomyopathy

Transthyretin Amyloidosis Cardiomyopathy (ATTR-CM)

United States
Boehringer Ingelheim

Recruiting

A Study in Healthy People to Compare How 2 Different High Dose Formulations of BI 1015550 Are Taken up in the Body

Healthy

Germany
Ferring Pharmaceuticals

Not yet recruiting

A Phase 4, Multi-center, Open Label Trial to Evaluate Efficacy of Retreatment With Nadofaragene Firadenovec in Subjects With CIS ± High-grade Ta/T1 and no Complete Response to First Nadofaragene Firadenovec Dose (ABLE-42)

Bladder Cancer | CIS | Ta/T1
Lidian Chen
Peking University Third Hospital

Not yet recruiting

Efficacy of Different Doses of Tai Chi Chuan on Cognitive Function in Persons With Mild Cognitive Impairment

Mild Cognitive Impairment
Apollo Therapeutics Ltd

Not yet recruiting

A Study to Investigate APL-4098 Alone and/or in Combination With Azacitidine in R/R AML and High-Risk MDS

Myelodysplastic Syndrome With Excess Blasts | Acute Myeloid Leukemia, in Relapse | Acute Myeloid Leukemia Refractory | Myelodysplastic Syndrome Acute Myeloid Leukemia
Andrea DeCensi
Herbert Irving Comprehensive Cancer Center; Breast Cancer Research Foundation; Istituto Europeo di Oncologia and other collaborators

Not yet recruiting

Low Dose Tamoxifen vs Low Dose Exemestane in Post-menopausal Women at High Risk for Breast Cancer. (BabyTears)

Breast Cancer

Italy
University Health Network, Toronto

Not yet recruiting

Ultra-high Dose Radiation for Liver Metastasis Using MR-guided TReatment With Stereotactic Ablative Single-fraction (ULTRAS)

Liver Metastases
Anhui Provincial Hospital

Not yet recruiting

The Efficacy and Safety of Desensitation Regimen for Patients With High Titers of Anti-HLA Antibodies Prior to Allo-HSCT

High Titers of Anti-HLA Antibody (MFI ≥5000)

China
Sanofi Pasteur, a Sanofi Company

Recruiting

A Study to Investigate the Safety and Immunogenicity of the Quadrivalent Influenza mRNA Vaccines in Adults Aged 18 Years and Above

Influenza Immunization

United States, Puerto Rico
M.D. Anderson Cancer Center
Incyte Corporation

Not yet recruiting

High Dose Ruxolitinib and Allogeneic Stem Cell Transplantation in Myelofibrosis Patients With Splenomegaly

Myelofibrosis | Splenomegaly

United States
Gilead Sciences

Not yet recruiting

A Study to Provide Continued Access to Study Drug to Children and Adolescents Who Have Completed Clinical Studies Involving Gilead HIV Treatments

HIV-1-infection
Swansea University

Recruiting

Isometric Handgrip Training Frequency and Blood Pressure in People With Hypertension

Hypertension

United Kingdom
Denise Fabian

Not yet recruiting

Hypofractionated Radiochemotherapy

Uterine Cervix Cancer

United States

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